Name

MC1R Gene

melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)

This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008]

mc1r Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mc1r in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

MC1R Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for MC1R from the Pathway Commons Protein-Protein Interactions dataset.

mc1rmelanoma Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mc1rmelanoma in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

mc1rcoordinated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mc1rcoordinated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

mc1rmc5r Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mc1rmc5r in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

mc1ralphamsh Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mc1ralphamsh in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.