Name

MAP3K8 Gene

mitogen-activated protein kinase kinase kinase 8

This gene is an oncogene that encodes a member of the serine/threonine protein kinase family. The encoded protein localizes to the cytoplasm and can activate both the MAP kinase and JNK kinase pathways. This protein was shown to activate IkappaB kinases, and thus induce the nuclear production of NF-kappaB. This protein was also found to promote the production of TNF-alpha and IL-2 during T lymphocyte activation. This gene may also utilize a downstream in-frame translation start codon, and thus produce an isoform containing a shorter N-terminus. The shorter isoform has been shown to display weaker transforming activity. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2011]

map3k8 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term map3k8 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

MAP3K8 Gene Set

From KEA Substrates of Kinases

substrates of the kinase MAP3K8 from the curated KEA Substrates of Kinases dataset.

MAP3K8 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for MAP3K8 from the Pathway Commons Protein-Protein Interactions dataset.

MAP3K8 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase MAP3K8 from the curated PhosphoSitePlus Substrates of Kinases dataset.

TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) Gene Set

From CORUM Protein Complexes

proteins in the TNF-alpha/Nf-kappa B signaling complex (RPL6, RPL30, RPS13, CHUK, DDX3X, NFKB2, NFKBIB, REL, IKBKG, NFKB1, MAP3K8, RELB, GLG1, NFKBIA, RELA, TNIP2, GTF2I) protein complex from the CORUM Protein Complexes dataset.

REL-MAP3K8-RELA-TNIP2-PAPOLA complex Gene Set

From CORUM Protein Complexes

proteins in the REL-MAP3K8-RELA-TNIP2-PAPOLA complex protein complex from the CORUM Protein Complexes dataset.

ABIN2-NFKB1-MAP3K8 complex Gene Set

From CORUM Protein Complexes

proteins in the ABIN2-NFKB1-MAP3K8 complex protein complex from the CORUM Protein Complexes dataset.

map3k8induced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term map3k8induced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.