Name

MAP2K1 Gene

mitogen-activated protein kinase kinase 1

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]

MAP2K1P1 Gene

mitogen-activated protein kinase kinase 1 pseudogene 1

map2k1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term map2k1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

MAP2K1 Gene Set

From KEA Substrates of Kinases

substrates of the kinase MAP2K1 from the curated KEA Substrates of Kinases dataset.

MAP2K1 Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for MAP2K1 from the NURSA Protein-Protein Interactions dataset.

MAP2K1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for MAP2K1 from the Pathway Commons Protein-Protein Interactions dataset.

MAP2K1 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase MAP2K1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

RAF1-MAP2K1-YWHAE complex Gene Set

From CORUM Protein Complexes

proteins in the RAF1-MAP2K1-YWHAE complex protein complex from the CORUM Protein Complexes dataset.

BRAF-MAP2K1-MAP2K2-YWHAE complex Gene Set

From CORUM Protein Complexes

proteins in the BRAF-MAP2K1-MAP2K2-YWHAE complex protein complex from the CORUM Protein Complexes dataset.

MAP2K1-BRAF-RAF1-YWHAE-KSR1 complex Gene Set

From CORUM Protein Complexes

proteins in the MAP2K1-BRAF-RAF1-YWHAE-KSR1 complex protein complex from the CORUM Protein Complexes dataset.

map2k12 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term map2k12 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

MAP2K1_knockdown_134_GSE31534 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the MAP2K1_knockdown_134_GSE31534 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

MAP2K1_knockdown_105_GSE27869 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the MAP2K1_knockdown_105_GSE27869 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

MAP2K1_druginhibition_172_GSE39984 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the MAP2K1_druginhibition_172_GSE39984 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

BL8445 (MAP2K1) Gene Set

From NURSA Protein Complexes

proteins in the BL8445 (MAP2K1) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.