Name

IRF4 Gene

interferon regulatory factor 4

The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]

IRF4 Gene Set

From ENCODE Transcription Factor Targets

target genes of the IRF4 transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

irf4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term irf4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

IRF4 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for IRF4 from the Pathway Commons Protein-Protein Interactions dataset.

IRF4_GM12878_hg19_1 Gene Set

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the IRF4_GM12878_hg19_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

IRF4_GM12878_hg19_2 Gene Set

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the IRF4_GM12878_hg19_2 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.