Name

IRAK4 Gene

interleukin-1 receptor-associated kinase 4

This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

irak4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term irak4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

IRAK4 Gene Set

From KEA Substrates of Kinases

substrates of the kinase IRAK4 from the curated KEA Substrates of Kinases dataset.

IRAK4 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for IRAK4 from the Pathway Commons Protein-Protein Interactions dataset.

IRAK4 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase IRAK4 from the curated PhosphoSitePlus Substrates of Kinases dataset.

IRAK4 deficiency Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the IRAK4 deficiency phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

IRAK4 Deficiency Gene Set

From CTD Gene-Disease Associations

genes/proteins associated with the disease IRAK4 Deficiency from the curated CTD Gene-Disease Associations dataset.

irak4deficient Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term irak4deficient in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

irak4independent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term irak4independent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

IRAK4_Deficiency_GDS2641_653_mouse_Embryonic fibroblasts Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the IRAK4_Deficiency_GDS2641_653_mouse_Embryonic fibroblasts gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

IRAK4_defectivemutant_200_GSE6789 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the IRAK4_defectivemutant_200_GSE6789 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

IRAK4_knockout_41_GSE12124 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the IRAK4_knockout_41_GSE12124 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

irak4 deficiency Gene Set

From OMIM Gene-Disease Associations

genes associated with the irak4 deficiency phenotype from the curated OMIM Gene-Disease Associations dataset.