Name

IL4R Gene

interleukin 4 receptor

This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2012]

il4r Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il4r in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

IL4R Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for IL4R from the Pathway Commons Protein-Protein Interactions dataset.

IL4-IL4R complex Gene Set

From CORUM Protein Complexes

proteins in the IL4-IL4R complex protein complex from the CORUM Protein Complexes dataset.

IL4-IL4R-IL2RG complex Gene Set

From CORUM Protein Complexes

proteins in the IL4-IL4R-IL2RG complex protein complex from the CORUM Protein Complexes dataset.

il4r allele frequency Gene Set

From GAD Gene-Disease Associations

genes associated with the disease il4r allele frequency in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

il4responsive Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il4responsive in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il4rq551 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il4rq551 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il4ra Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il4ra in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il4rs Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il4rs in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il4ralphail13ralpha1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il4ralphail13ralpha1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il4ralpha1902 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il4ralpha1902 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il4ralpha Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il4ralpha in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.