Name

IL13 Gene

interleukin 13

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]

IL13RA2 Gene

interleukin 13 receptor, alpha 2

The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008]

IL13RA1 Gene

interleukin 13 receptor, alpha 1

The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008]

il13 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il13 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

IL13 Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for IL13 from the MSigDB Cancer Gene Co-expression Modules dataset.

IL13 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for IL13 from the Pathway Commons Protein-Protein Interactions dataset.

il13il4r Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il13il4r in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il13ra2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il13ra2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il13ra1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il13ra1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il13producing Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il13producing in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il13r110q Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il13r110q in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il13ralpha1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il13ralpha1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il13il22coproducing Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il13il22coproducing in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il13alpha2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il13alpha2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il13dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il13dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il13mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il13mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il13r Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il13r in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il13s Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il13s in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il13induced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il13induced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il13stimulated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il13stimulated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il13ralpha2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il13ralpha2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il13il13r Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il13il13r in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il13pe Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il13pe in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il13il13ralpha1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il13il13ralpha1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il13il4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il13il4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

il13independent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term il13independent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

IL13RA2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for IL13RA2 from the Pathway Commons Protein-Protein Interactions dataset.

IL13RA1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for IL13RA1 from the Pathway Commons Protein-Protein Interactions dataset.