Name

GLI2 Gene

GLI family zinc finger 2

This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]

gli2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gli2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

GLI2 Gene Set

From MotifMap Predicted Transcription Factor Targets

target genes of the GLI2 transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

GLI2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for GLI2 from the Pathway Commons Protein-Protein Interactions dataset.

GLI2 Gene Set

From TRANSFAC Predicted Transcription Factor Targets

target genes of the GLI2 transcription factor predicted using known transcription factor binding site motifs from the TRANSFAC Predicted Transcription Factor Targets dataset.

gli2driven Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gli2driven in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Degradation of GLI2 by the proteasome Gene Set

From Reactome Pathways

proteins participating in the Degradation of GLI2 by the proteasome pathway from the Reactome Pathways dataset.