Name

GEM Gene

GTP binding protein overexpressed in skeletal muscle

The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

GEMIN8P2 Gene

gem (nuclear organelle) associated protein 8 pseudogene 2

GEMIN7 Gene

gem (nuclear organelle) associated protein 7

The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear "gems" (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GEMIN8 Gene

gem (nuclear organelle) associated protein 8

The protein encoded by this gene is part of the SMN complex, which is necessary for spliceosomal snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. The encoded protein binds to both SMN1 and the GEMIN6/GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

GEMIN2 Gene

gem (nuclear organelle) associated protein 2

This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011]

GEMIN6 Gene

gem (nuclear organelle) associated protein 6

GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM, Jul 2002]

GEMIN4 Gene

gem (nuclear organelle) associated protein 4

The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

GEMIN5 Gene

gem (nuclear organelle) associated protein 5

This gene encodes a WD repeat protein that is a component of the survival of motor neurons (SMN) complex. The SMN complex plays a critical role in mRNA splicing through the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), and may also mediate the assembly and transport of other classes of ribonucleoproteins. The encoded protein is the snRNA-binding component of the SMN complex. Dysregulation of this gene may play a role in alternative mRNA splicing and tumor cell motility. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

GEMIN8P4 Gene

gem (nuclear organelle) associated protein 8 pseudogene 4

GEMIN8P3 Gene

gem (nuclear organelle) associated protein 8 pseudogene 3

GEMIN8P1 Gene

gem (nuclear organelle) associated protein 8 pseudogene 1

GEMIN2P2 Gene

gem (nuclear organelle) associated protein 2 pseudogene 2

GEMIN2P1 Gene

gem (nuclear organelle) associated protein 2 pseudogene 1

gem Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gem in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

GEM Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for GEM from the Pathway Commons Protein-Protein Interactions dataset.

gemfibrozil-2277 Gene Set

From CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the gemfibrozil-2277 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

gemfibrozil-5488 Gene Set

From CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the gemfibrozil-5488 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

gemfibrozil-1430 Gene Set

From CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the gemfibrozil-1430 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

gemfibrozil-2113 Gene Set

From CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the gemfibrozil-2113 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

gemfibrozil-5069 Gene Set

From CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the gemfibrozil-5069 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

gemin3-gemin4-gemin5 complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the gemin3-gemin4-gemin5 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

smn-gemin2 complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the smn-gemin2 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

gemin6-gemin7-unrip complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the gemin6-gemin7-unrip complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

gemmule Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the gemmule cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

SMN complex (GEMIN5,2,3,4, SMN) Gene Set

From CORUM Protein Complexes

proteins in the SMN complex (GEMIN5,2,3,4, SMN) protein complex from the CORUM Protein Complexes dataset.

SMN complex (GEMIN2,5, SMN) Gene Set

From CORUM Protein Complexes

proteins in the SMN complex (GEMIN2,5, SMN) protein complex from the CORUM Protein Complexes dataset.

SMN complex (GEMIN6,7, UNRIP), SMN-independent intermediate Gene Set

From CORUM Protein Complexes

proteins in the SMN complex (GEMIN6,7, UNRIP), SMN-independent intermediate protein complex from the CORUM Protein Complexes dataset.

SMN complex (GEMIN5,4,3), SMN-independent intermediate Gene Set

From CORUM Protein Complexes

proteins in the SMN complex (GEMIN5,4,3), SMN-independent intermediate protein complex from the CORUM Protein Complexes dataset.

PPP4C-PPP4R2-Gemin3-Gemin4 complex Gene Set

From CORUM Protein Complexes

proteins in the PPP4C-PPP4R2-Gemin3-Gemin4 complex protein complex from the CORUM Protein Complexes dataset.

gemcitabine Gene Set

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical gemcitabine from the curated CTD Gene-Chemical Interactions dataset.

Gemfibrozil Gene Set

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Gemfibrozil from the curated CTD Gene-Chemical Interactions dataset.

gemfibrozil 1-O-acylglucuronide Gene Set

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical gemfibrozil 1-O-acylglucuronide from the curated CTD Gene-Chemical Interactions dataset.

gemistocytic astrocytoma Gene Set

From DISEASES Text-mining Gene-Disease Assocation Evidence Scores

genes co-occuring with the disease gemistocytic astrocytoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Gemfibrozil Gene Set

From DrugBank Drug Targets

interacting proteins for the Gemfibrozil drug from the curated DrugBank Drug Targets dataset.

GEM-231 Gene Set

From DrugBank Drug Targets

interacting proteins for the GEM-231 drug from the curated DrugBank Drug Targets dataset.

Gemtuzumab ozogamicin Gene Set

From DrugBank Drug Targets

interacting proteins for the Gemtuzumab ozogamicin drug from the curated DrugBank Drug Targets dataset.

Gemcitabine Gene Set

From DrugBank Drug Targets

interacting proteins for the Gemcitabine drug from the curated DrugBank Drug Targets dataset.

gemifloxacin Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gemifloxacin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gemtuzumab Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gemtuzumab in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

geminin Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term geminin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gemfibrozil Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gemfibrozil in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gemcitabine Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gemcitabine in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gemcitabinecisplatin Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gemcitabinecisplatin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gemin2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gemin2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

geminate Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term geminate in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gemcitabineinduced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gemcitabineinduced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gemcitabines Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gemcitabines in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gemcitabineresistant Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gemcitabineresistant in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gemgmiprhoa Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gemgmiprhoa in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gemresistant Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gemresistant in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gemin8 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gemin8 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gemin3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gemin3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gemin7 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gemin7 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gemin4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gemin4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gemin5 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gemin5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gemcitabinecisplatintreated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gemcitabinecisplatintreated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gemcitabinetreated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gemcitabinetreated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gemistocytic Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gemistocytic in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gemcitabineplatinum Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gemcitabineplatinum in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gems Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gems in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

geme Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term geme in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gemcitabinebased Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gemcitabinebased in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gemfibrozilrepaglinide Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gemfibrozilrepaglinide in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gemin6 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gemin6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

gemcitabine_homo sapiens_gpl96_gse6914 Gene Set

From GEO Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the gemcitabine_homo sapiens_gpl96_gse6914 small molecule perturbation from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.

gemini of coiled bodies Gene Set

From GO Cellular Component Annotations

proteins localized to the gemini of coiled bodies cellular component from the curated GO Cellular Component Annotations dataset.

gemfibrozil Gene Set

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the gemfibrozil ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

gemcitabine Gene Set

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the gemcitabine ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

gemtuzumab ozogamicin Gene Set

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the gemtuzumab ozogamicin ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

Response to gemcitabine in pancreatic cancer Gene Set

From GWAS Catalog SNP-Phenotype Associations

genes associated with the Response to gemcitabine in pancreatic cancer phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.

Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) Gene Set

From GWAS Catalog SNP-Phenotype Associations

genes associated with the Adverse response to chemotherapy (neutropenia/leucopenia) (gemcitabine) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.

Response to cytidine analogues (gemcitabine) Gene Set

From GWAS Catalog SNP-Phenotype Associations

genes associated with the Response to cytidine analogues (gemcitabine) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.

Gemfibrozil Gene Set

From HMDB Metabolites of Enzymes

interacting proteins for the Gemfibrozil metabolite from the curated HMDB Metabolites of Enzymes dataset.

Gemcitabine Gene Set

From HMDB Metabolites of Enzymes

interacting proteins for the Gemcitabine metabolite from the curated HMDB Metabolites of Enzymes dataset.

SMN complex, gem-associated protein 7 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the SMN complex, gem-associated protein 7 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Geminin coiled-coil domain-containing protein 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Geminin coiled-coil domain-containing protein 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

CDT1 Geminin-binding domain-like Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the CDT1 Geminin-binding domain-like protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Small GTPase superfamily, GEM/REM/Rad Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Small GTPase superfamily, GEM/REM/Rad protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Geminin Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Geminin protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Gemin6 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Gemin6 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Gem-associated protein 2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Gem-associated protein 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Geminin/Multicilin Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Geminin/Multicilin protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Gem-associated protein 2, metazoa Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Gem-associated protein 2, metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset.

BL5439 (GEMIN5) Gene Set

From NURSA Protein Complexes

proteins in the BL5439 (GEMIN5) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

GEMIN5 Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for GEMIN5 from the NURSA Protein-Protein Interactions dataset.

GEMIN4 Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for GEMIN4 from the NURSA Protein-Protein Interactions dataset.

GEMIN8 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for GEMIN8 from the Pathway Commons Protein-Protein Interactions dataset.

GEMIN6 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for GEMIN6 from the Pathway Commons Protein-Protein Interactions dataset.

GEMIN2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for GEMIN2 from the Pathway Commons Protein-Protein Interactions dataset.

GEMIN7 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for GEMIN7 from the Pathway Commons Protein-Protein Interactions dataset.

GEMIN4 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for GEMIN4 from the Pathway Commons Protein-Protein Interactions dataset.

GEMIN5 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for GEMIN5 from the Pathway Commons Protein-Protein Interactions dataset.