Name

GADD45B Gene

growth arrest and DNA-damage-inducible, beta

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]

gadd45b Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gadd45b in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

GADD45B Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for GADD45B from the Pathway Commons Protein-Protein Interactions dataset.

CDC2-PCNA-CCNB1-GADD45B complex Gene Set

From CORUM Protein Complexes

proteins in the CDC2-PCNA-CCNB1-GADD45B complex protein complex from the CORUM Protein Complexes dataset.

gadd45beta Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term gadd45beta in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SC-33172 (GADD45B) Gene Set

From NURSA Protein Complexes

proteins in the SC-33172 (GADD45B) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.