Name

FGFR3 Gene

fibroblast growth factor receptor 3

This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009]

FGFR3P5 Gene

fibroblast growth factor receptor 3 pseudogene 5

FGFR3P6 Gene

fibroblast growth factor receptor 3 pseudogene 6

FGFR3P4 Gene

fibroblast growth factor receptor 3 pseudogene 4

FGFR3P3 Gene

fibroblast growth factor receptor 3 pseudogene 3

FGFR3P2 Gene

fibroblast growth factor receptor 3 pseudogene 2

FGFR3P1 Gene

fibroblast growth factor receptor 3 pseudogene 1

fgfr3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fgfr3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

FGFR3 Gene Set

From KEA Substrates of Kinases

substrates of the kinase FGFR3 from the curated KEA Substrates of Kinases dataset.

FGFR3 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for FGFR3 from the Pathway Commons Protein-Protein Interactions dataset.

FGFR3 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase FGFR3 from the curated PhosphoSitePlus Substrates of Kinases dataset.

fgfr3tacc3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fgfr3tacc3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fgfr3a3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fgfr3a3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fgfr3mutated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fgfr3mutated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fgfr3ras Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fgfr3ras in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fgfr3p53 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fgfr3p53 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fgfr3mutant Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fgfr3mutant in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fgfr3baiap2l1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fgfr3baiap2l1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

fgfr3c Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term fgfr3c in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

FGFR3_KD_GDS4454_79_human_RT112 Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the FGFR3_KD_GDS4454_79_human_RT112 gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

FGFR3_KD_GSE41035_77_human_RT112 Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the FGFR3_KD_GSE41035_77_human_RT112 gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

FGFR3_KD_GDS4454_78_human_RT112 Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the FGFR3_KD_GDS4454_78_human_RT112 gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

FGFR3_knockdown_174_GSE41035 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the FGFR3_knockdown_174_GSE41035 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

FGFR3_knockdown_173_GSE41035 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the FGFR3_knockdown_173_GSE41035 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

FGFR3_knockdown_34_GDS4454 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the FGFR3_knockdown_34_GDS4454 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

FGFR3_druginhibition_36_GDS5023 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the FGFR3_druginhibition_36_GDS5023 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

Signaling by FGFR3 mutants Gene Set

From Reactome Pathways

proteins participating in the Signaling by FGFR3 mutants pathway from the Reactome Pathways dataset.

FGFR3c ligand binding and activation Gene Set

From Reactome Pathways

proteins participating in the FGFR3c ligand binding and activation pathway from the Reactome Pathways dataset.

FGFR3 ligand binding and activation Gene Set

From Reactome Pathways

proteins participating in the FGFR3 ligand binding and activation pathway from the Reactome Pathways dataset.

FGFR3b ligand binding and activation Gene Set

From Reactome Pathways

proteins participating in the FGFR3b ligand binding and activation pathway from the Reactome Pathways dataset.

t(4;14) translocations of FGFR3 Gene Set

From Reactome Pathways

proteins participating in the t(4;14) translocations of FGFR3 pathway from the Reactome Pathways dataset.

Signaling by activated point mutants of FGFR3 Gene Set

From Reactome Pathways

proteins participating in the Signaling by activated point mutants of FGFR3 pathway from the Reactome Pathways dataset.