Name

CDC27 Gene

cell division cycle 27

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014]

CDC27P10 Gene

cell division cycle 27 pseudogene 10

CDC27P11 Gene

cell division cycle 27 pseudogene 11

CDC27P7 Gene

cell division cycle 27 pseudogene 7

CDC27P2 Gene

cell division cycle 27 pseudogene 2

CDC27P3 Gene

cell division cycle 27 pseudogene 3

CDC27P1 Gene

cell division cycle 27 pseudogene 1

CDC27P6 Gene

cell division cycle 27 pseudogene 6

CDC27P4 Gene

cell division cycle 27 pseudogene 4

CDC27P5 Gene

cell division cycle 27 pseudogene 5

CDC27P8 Gene

cell division cycle 27 pseudogene 8

CDC27P9 Gene

cell division cycle 27 pseudogene 9

cdc27 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdc27 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CDC27 Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for CDC27 from the MSigDB Cancer Gene Co-expression Modules dataset.

CDC27 Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for CDC27 from the NURSA Protein-Protein Interactions dataset.

CDC27 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDC27 from the Pathway Commons Protein-Protein Interactions dataset.

Cell division cycle complex (CDC27, CDC16, ANAPC7) Gene Set

From CORUM Protein Complexes

proteins in the Cell division cycle complex (CDC27, CDC16, ANAPC7) protein complex from the CORUM Protein Complexes dataset.

DNA polymerase subunit Cdc27 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the DNA polymerase subunit Cdc27 protein domain from the InterPro Predicted Protein Domain Annotations dataset.