Name

CD40 Gene

CD40 molecule, TNF receptor superfamily member 5

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014]

CD40LG Gene

CD40 ligand

The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome. [provided by RefSeq, Jul 2008]

cd40 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CD40 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CD40 from the Pathway Commons Protein-Protein Interactions dataset.

Multicomponent signaling complex, anti-CD40 stimulated,(Birc2, Birc3, Cd40, Ikbkg, Map3k1, Traf2, Ube2n) Gene Set

From CORUM Protein Complexes

proteins in the Multicomponent signaling complex, anti-CD40 stimulated,(Birc2, Birc3, Cd40, Ikbkg, Map3k1, Traf2, Ube2n) protein complex from the CORUM Protein Complexes dataset.

Multicomponent signaling complex, anti-CD40 stimulated (Birc2, Birc3, Cd40, Ikbkg, Map2k4, Map2k7, Map3k1, Traf2, Ube2n) Gene Set

From CORUM Protein Complexes

proteins in the Multicomponent signaling complex, anti-CD40 stimulated (Birc2, Birc3, Cd40, Ikbkg, Map2k4, Map2k7, Map3k1, Traf2, Ube2n) protein complex from the CORUM Protein Complexes dataset.

Membrane-associated multicomponent signaling complex, anti-CD40 stimulated (Cd40, Ikbkg, Map3k1, Traf2, Ube2n) Gene Set

From CORUM Protein Complexes

proteins in the Membrane-associated multicomponent signaling complex, anti-CD40 stimulated (Cd40, Ikbkg, Map3k1, Traf2, Ube2n) protein complex from the CORUM Protein Complexes dataset.

cd40l signaling pathway Gene Set

From Biocarta Pathways

proteins participating in the cd40l signaling pathway pathway from the Biocarta Pathways dataset.

cd40 receptor complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the cd40 receptor complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

cd40 receptor complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cd40 receptor complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Cytosolic multicomponent signaling complex, anti-CD40 stimulated, (Ikbkg, Map3k1, Traf2, Ube2n) Gene Set

From CORUM Protein Complexes

proteins in the Cytosolic multicomponent signaling complex, anti-CD40 stimulated, (Ikbkg, Map3k1, Traf2, Ube2n) protein complex from the CORUM Protein Complexes dataset.

CD40 Ligand Gene Set

From dbGAP Gene-Trait Associations

genes associated with the trait CD40 Ligand in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

cd40 ligand deficiency Gene Set

From DISEASES Curated Gene-Disease Assocation Evidence Scores

genes involed in the disease cd40 ligand deficiency from the DISEASES Curated Gene-Disease Assocation Evidence Scores dataset.

cd40 deficiency Gene Set

From DISEASES Text-mining Gene-Disease Assocation Evidence Scores

genes co-occuring with the disease cd40 deficiency in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

cd40 ligand deficiency Gene Set

From DISEASES Text-mining Gene-Disease Assocation Evidence Scores

genes co-occuring with the disease cd40 ligand deficiency in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

hyper-igm syndrome can form oligomers and trigger cd40-mediated signals Gene Set

From GAD Gene-Disease Associations

genes associated with the disease hyper-igm syndrome can form oligomers and trigger cd40-mediated signals in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

cd40 ligand Gene Set

From GAD Gene-Disease Associations

genes associated with the disease cd40 ligand in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

cd40lg Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40lg in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40lstimulated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40lstimulated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40activated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40activated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40lipid Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40lipid in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40cd40 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40cd40 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40lalpha Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40lalpha in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40lexpressing Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40lexpressing in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40stimulated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40stimulated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40cd40l Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40cd40l in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40binding Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40binding in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40positive Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40positive in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40cd154 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40cd154 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40traf6 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40traf6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40l Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40l in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40linduced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40linduced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd4040l Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd4040l in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40related Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40related in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40traf23 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40traf23 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40nfkappab Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40nfkappab in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd408086 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd408086 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40lmediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40lmediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40induced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40induced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40cd40lmediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40cd40lmediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40crosslinking Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40crosslinking in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40lprovoked Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40lprovoked in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40lcd40 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40lcd40 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40inducible Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40inducible in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40activation Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40activation in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cd40triggering Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cd40triggering in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

negative regulation of cd40 signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of cd40 signaling pathway biological process from the curated GO Biological Process Annotations dataset.

regulation of cd40 signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the regulation of cd40 signaling pathway biological process from the curated GO Biological Process Annotations dataset.

positive regulation of cd40 signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of cd40 signaling pathway biological process from the curated GO Biological Process Annotations dataset.

cd40 signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the cd40 signaling pathway biological process from the curated GO Biological Process Annotations dataset.

cd40 receptor complex Gene Set

From GO Cellular Component Annotations

proteins localized to the cd40 receptor complex cellular component from the curated GO Cellular Component Annotations dataset.

cd40 receptor binding Gene Set

From GO Molecular Function Annotations

genes performing the cd40 receptor binding molecular function from the curated GO Molecular Function Annotations dataset.

CD40LG Gene Set

From Guide to Pharmacology Protein Ligands of Receptors

receptors of the CD40LG ligand (protein) from the curated Guide to Pharmacology Protein Ligands of Receptors dataset.

CD40LG Gene Set

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein CD40LG from the curated Hub Proteins Protein-Protein Interactions dataset.

CD40 ligand Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the CD40 ligand protein domain from the InterPro Predicted Protein Domain Annotations dataset.

CD40LG Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CD40LG from the Pathway Commons Protein-Protein Interactions dataset.

CD40/CD40L signaling Gene Set

From PID Pathways

proteins participating in the CD40/CD40L signaling pathway from the PID Pathways dataset.