Rho guanine nucleotide exchange factor (GEF) 11

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

ARHGEF11 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for ARHGEF11 from the Pathway Commons Protein-Protein Interactions dataset.

BL7814 (ARHGEF11) Gene Set

From NURSA Protein Complexes

proteins in the BL7814 (ARHGEF11) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.