Name

LOC100130121 Gene

solute carrier family 19 (thiamine transporter), member 3 pseudogene

THTPA Gene

thiamine triphosphatase

This gene encodes an enzyme which catalyzes the biosynthesis of thiamine disphophate (vitamin B1) by hydrolysis of thiamine triphosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

SLC19A2 Gene

solute carrier family 19 (thiamine transporter), member 2

This gene encodes the thiamin transporter protein. Mutations in this gene cause thiamin-responsive megaloblastic anemia syndrome (TRMA), which is an autosomal recessive disorder characterized by diabetes mellitus, megaloblastic anemia and sensorineural deafness. [provided by RefSeq, Jul 2008]

SLC19A3 Gene

solute carrier family 19 (thiamine transporter), member 3

This gene encodes a ubiquitously expressed transmembrane thiamine transporter that lacks folate transport activity. Mutations in this gene cause biotin-responsive basal ganglia disease (BBGD); a recessive disorder manifested in childhood that progresses to chronic encephalopathy, dystonia, quadriparesis, and death if untreated. Patients with BBGD have bilateral necrosis in the head of the caudate nucleus and in the putamen. Administration of high doses of biotin in the early progression of the disorder eliminates pathological symptoms while delayed treatment results in residual paraparesis, mild mental retardation, or dystonia. Administration of thiamine is ineffective in the treatment of this disorder. Experiments have failed to show that this protein can transport biotin. Mutations in this gene also cause a Wernicke's-like encephalopathy.[provided by RefSeq, Jan 2010]

SLC25A19 Gene

solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19

This gene encodes a mitochondrial protein that is a member of the solute carrier family. Although this protein was initially thought to be the mitochondrial deoxynucleotide carrier involved in the uptake of deoxynucleotides into the matrix of the mitochondria, further studies have demonstrated that this protein instead functions as the mitochondrial thiamine pyrophosphate carrier, which transports thiamine pyrophosphates into mitochondria. Mutations in this gene cause microcephaly, Amish type, a metabolic disease that results in severe congenital microcephaly, severe 2-ketoglutaric aciduria, and death within the first year. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

LOC100420667 Gene

solute carrier family 19 (thiamine transporter), member 3 pseudogene

SIDT1 Gene

SID1 transmembrane family, member 1

SIDT2 Gene

SID1 transmembrane family, member 2

LOC391600 Gene

transmembrane epididymal protein 1 pseudogene

TMEM200B Gene

transmembrane protein 200B

TMEM160 Gene

transmembrane protein 160

TMEM163 Gene

transmembrane protein 163

TMEM165 Gene

transmembrane protein 165

This gene encodes a predicted transmembrane protein with a perinuclear Golgi-like distribution in fibroblasts. Mutations in this gene are associated with the autosomal recessive disorder congenital disorder of glycosylation, type IIk. Knockdown of this gene's expression causes decreased sialylation in HEK cells and suggests this gene plays a role in terminal Golgi glycosylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

TMEM164 Gene

transmembrane protein 164

TMEM168 Gene

transmembrane protein 168

TMEM255B Gene

transmembrane protein 255B

TMEM255A Gene

transmembrane protein 255A

TMEM167AP1 Gene

transmembrane protein 167A pseudogene 1

LOC100313942 Gene

transmembrane protein 92 pseudogene

LOC440181 Gene

transmembrane protein 98 pseudogene

GHITM Gene

growth hormone inducible transmembrane protein

TMC5 Gene

transmembrane channel-like 5

TM4SF18 Gene

transmembrane 4 L six family member 18

TM4SF19 Gene

transmembrane 4 L six family member 19

LOC391020 Gene

interferon induced transmembrane protein 3 pseudogene

CLMN Gene

calmin (calponin-like, transmembrane)

LOC100419882 Gene

transmembrane protein 98 pseudogene

FAM205CP Gene

transmembrane protein C9orf144B pseudogene

TMEM258 Gene

transmembrane protein 258

TMEM257 Gene

transmembrane protein 257

This intronless gene is expressed in the hippocampus and maps close to a candidate region for several X-linked mental retardation (XLMR) syndromes. It is conserved in primates, cow, and horse, but not found in mouse and rat. The exact function of this gene is not known, but on the basis of its physical location and expression pattern, it is proposed to have an important function in the brain. [provided by RefSeq, Jan 2010]

TMEM256 Gene

transmembrane protein 256

TMEM254 Gene

transmembrane protein 254

TMEM253 Gene

transmembrane protein 253

TMEM252 Gene

transmembrane protein 252

TMEM251 Gene

transmembrane protein 251

TMUB1 Gene

transmembrane and ubiquitin-like domain containing 1

TMUB2 Gene

transmembrane and ubiquitin-like domain containing 2

FLRT1 Gene

fibronectin leucine rich transmembrane protein 1

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain. [provided by RefSeq, Jul 2008]

FLRT3 Gene

fibronectin leucine rich transmembrane protein 3

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRTs may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. This gene is expressed in many tissues. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2010]

FLRT2 Gene

fibronectin leucine rich transmembrane protein 2

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRT family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. [provided by RefSeq, Jul 2008]

IFITM8P Gene

interferon induced transmembrane protein 8 pseudogene

TMPPE Gene

transmembrane protein with metallophosphoesterase domain

LOC100419975 Gene

transmembrane protein 192 pseudogene

TMEM247 Gene

transmembrane protein 247

TMEM241 Gene

transmembrane protein 241

TMEM242 Gene

transmembrane protein 242

POM121L4P Gene

POM121 transmembrane nucleoporin-like 4 pseudogene

TMEM185B Gene

transmembrane protein 185B

TMEM185A Gene

transmembrane protein 185A

The protein encoded by this gene is predicted to be a transmembrane protein. This gene is best known for localizing to the CpG island of the fragile site FRAXF. The 5' untranslated region of this gene contains a CGG trinucleotide repeat sequence that normally consists of 7-40 tandem CGG repeats but which can expand to greater than 300 repeats. Methylation of the CpG island leads to transcriptional silencing of this gene, but neither the silencing nor an expanded repeat region appear to manifest itself in a clear phenotypic manner. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Aug 2013]

OSTM1 Gene

osteopetrosis associated transmembrane protein 1

This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis. [provided by RefSeq, Jul 2008]

TMEM37 Gene

transmembrane protein 37

TMEM31 Gene

transmembrane protein 31

TMEM33 Gene

transmembrane protein 33

TMEM169 Gene

transmembrane protein 169

TPTE2 Gene

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2

TPIP is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.[supplied by OMIM, Jul 2002]

TMCC1P1 Gene

transmembrane and coiled-coil domain family 1 pseudogene 1

TMTC2 Gene

transmembrane and tetratricopeptide repeat containing 2

TAPT1 Gene

transmembrane anterior posterior transformation 1

This gene encodes a highly conserved, putative transmembrane protein. A mutation in the mouse ortholog of this gene results in homeotic, posterior-to-anterior transformations of the axial skeleton which are similar to the phenotype of mouse homeobox C8 gene mutants. This gene is proposed to function downstream of homeobox C8 to transduce extracellular patterning information during axial skeleton development. An alternatively spliced transcript variant encoding a substantially different isoform has been described, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]

GS1-259H13.2 Gene

transmembrane protein 225-like

AMN Gene

amnion associated transmembrane protein

The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila. [provided by RefSeq, Jul 2008]

LOC100420252 Gene

transmembrane channel-like 6 pseudogene

TMEM178B Gene

transmembrane protein 178B

LOC100131216 Gene

transmembrane protein 38B pseudogene

VSTM5 Gene

V-set and transmembrane domain containing 5

VSTM4 Gene

V-set and transmembrane domain containing 4

VSTM1 Gene

V-set and transmembrane domain containing 1

LOC642515 Gene

proline-rich transmembrane protein 1-like

LOC100422352 Gene

transmembrane and tetratricopeptide repeat containing 1 pseudogene

LIME1 Gene

Lck interacting transmembrane adaptor 1

This gene encodes a transmembrane adaptor protein that links the T and B-cell receptor stimulation to downstream signaling pathways via its association with the Src family kinases Lck and Lyn, respectively. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2015]

LOC442017 Gene

interferon induced transmembrane protein 3 pseudogene

IFITM5 Gene

interferon induced transmembrane protein 5

This gene encodes a membrane protein thought to play a role in bone mineralization. This gene is located on chromosome 11 in a cluster of related genes which are induced by interferon, however, this gene has not been shown to be interferon inducible. A similar gene, located in a gene cluster on mouse chromosome 7, is a member of the interferon-inducible fragilis gene family. The mouse gene encodes a transmembrane protein described as participating in germ cell competence. A mutation in the 5' UTR of this gene has been associated with osteogenesis imperfecta type V (PMID: 22863190, 22863195). [provided by RefSeq, Aug 2012]

TMEM133 Gene

transmembrane protein 133

There is evidence that this intronless gene is transcribed but the protein is predicted. The gene function is unknown. [provided by RefSeq, Jul 2008]

TMEM130 Gene

transmembrane protein 130

TMEM131 Gene

transmembrane protein 131

TMEM136 Gene

transmembrane protein 136

TMEM134 Gene

transmembrane protein 134

TMEM135 Gene

transmembrane protein 135

TMEM138 Gene

transmembrane protein 138

This gene encodes a multi-pass transmembrane protein. Reduced expression of this gene in mouse fibroblasts causes short cilia and failure of ciliogenesis. Expression of this gene is tightly coordinated with expression of the neighboring gene TMEM216. Mutations in this gene are associated with the autosomal recessive neurodevelopmental disorder Joubert Syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

TMEM139 Gene

transmembrane protein 139

LOC100286958 Gene

transmembrane protein 183A pseudogene

TMBIM6 Gene

transmembrane BAX inhibitor motif containing 6

TMBIM4 Gene

transmembrane BAX inhibitor motif containing 4

TMBIM1 Gene

transmembrane BAX inhibitor motif containing 1

TMEFF1 Gene

transmembrane protein with EGF-like and two follistatin-like domains 1

TMEFF2 Gene

transmembrane protein with EGF-like and two follistatin-like domains 2

This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

LOC100419853 Gene

transmembrane protein 69 pseudogene

TMEM50B Gene

transmembrane protein 50B

TMEM50A Gene

transmembrane protein 50A

This gene is located in the RH gene locus, between the RHD and RHCE genes. The function of its protein product is unknown; however, its sequence has potential transmembrane domains suggesting that it may be an integral membrane protein. Its position between the RH genes suggests that polymorphisms in this gene may be tightly linked to RH haplotypes and may contribute to selective pressure for or against certain RH haplotypes. [provided by RefSeq, Jul 2008]

TMED7 Gene

transmembrane emp24 protein transport domain containing 7

TMED6 Gene

transmembrane emp24 protein transport domain containing 6

TMED5 Gene

transmembrane emp24 protein transport domain containing 5

TMED4 Gene

transmembrane emp24 protein transport domain containing 4

TMED3 Gene

transmembrane emp24 protein transport domain containing 3

TMED2 Gene

transmembrane emp24 domain trafficking protein 2

TMED1 Gene

transmembrane emp24 protein transport domain containing 1

This gene belongs to the TMED (transmembrane emp24 domain-containing) protein family, which is involved in the vesicular trafficking of proteins. The protein encoded by this gene was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1) and may play a role in innate immunity. This protein lacks any similarity to other interleukin 1 ligands. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

TMED9 Gene

transmembrane emp24 protein transport domain containing 9

TMED8 Gene

transmembrane emp24 protein transport domain containing 8

PLGRKT Gene

plasminogen receptor, C-terminal lysine transmembrane protein

LOC100420062 Gene

transmembrane protein 160 pseudogene

POM121L9P Gene

POM121 transmembrane nucleoporin-like 9, pseudogene

This locus is inferred to be a transcribed pseudogene based on the observation that protein homology is limited to the first of seven exons (indicated by alignment of AL117401.1 to the assembled human genome). This pattern suggests rapid turnover by the nonsense-mediated decay pathway. [provided by RefSeq, Jul 2008]

TMED10P1 Gene

transmembrane emp24-like trafficking protein 10 (yeast) pseudogene 1

TMED10P2 Gene

transmembrane emp24-like trafficking protein 10 (yeast) pseudogene 2

TMEM201 Gene

transmembrane protein 201

TMEM202 Gene

transmembrane protein 202

TMEM203 Gene

transmembrane protein 203

TMEM204 Gene

transmembrane protein 204

C16ORF30 plays a role in cell adhesion and cellular permeability at adherens junctions (Kearsey et al., 2004 [PubMed 15206924]).[supplied by OMIM, Mar 2008]

TMEM205 Gene

transmembrane protein 205

TMEM206 Gene

transmembrane protein 206

TMEM207 Gene

transmembrane protein 207

TMEM208 Gene

transmembrane protein 208

TMEM209 Gene

transmembrane protein 209

TMEM65 Gene

transmembrane protein 65

TMEM64 Gene

transmembrane protein 64

TMEM62 Gene

transmembrane protein 62

TMEM61 Gene

transmembrane protein 61

TMEM60 Gene

transmembrane protein 60

TMEM69 Gene

transmembrane protein 69

TMEM68 Gene

transmembrane protein 68

LOC100288935 Gene

transmembrane protein 258 pseudogene

TMEM67 Gene

transmembrane protein 67

The protein encoded by this gene localizes to the primary cilium and to the plasma membrane. The gene functions in centriole migration to the apical membrane and formation of the primary cilium. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6). [provided by RefSeq, Nov 2008]

TMEM161BP1 Gene

transmembrane protein 161B pseudogene 1

RNFT1 Gene

ring finger protein, transmembrane 1

TMEM183AP1 Gene

transmembrane protein 183A pseudogene 1

LAPTM4A Gene

lysosomal protein transmembrane 4 alpha

This gene encodes a protein that has four predicted transmembrane domains. The function of this gene has not yet been determined; however, studies in the mouse homolog suggest a role in the transport of small molecules across endosomal and lysosomal membranes. [provided by RefSeq, Jul 2008]

LAPTM4B Gene

lysosomal protein transmembrane 4 beta

POM121L1P Gene

POM121 transmembrane nucleoporin-like 1, pseudogene

This locus appears to be a pseudogene related to DKFZp434K191, which is of unknown function. This pseudogene lies in the immunoglobulin lambda gene cluster on chromosome 22q11.21. [provided by RefSeq, Jul 2008]

POM121L11P Gene

POM121 transmembrane nucleoporin-like 11, pseudogene

POM121L12 Gene

POM121 transmembrane nucleoporin-like 12

TMPRSS11GP Gene

transmembrane protease, serine 11G, pseudogene

POM121 Gene

POM121 transmembrane nucleoporin

This gene encodes a transmembrane protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex, which mediates transport to and from the nucleus. The encoded protein may anchor this complex to the nuclear envelope. There are multiple related genes and pseudogenes for this gene on chromosomes 5, 7, 15, and 22. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]

LOC100132025 Gene

transmembrane domain-containing protein ENSP00000320207-like

LOC100420074 Gene

transmembrane protein 183A pseudogene

LETM2 Gene

leucine zipper-EF-hand containing transmembrane protein 2

SIT1 Gene

signaling threshold regulating transmembrane adaptor 1

TMEM161A Gene

transmembrane protein 161A

TMEM161B Gene

transmembrane protein 161B

TM7SF3 Gene

transmembrane 7 superfamily member 3

TM7SF2 Gene

transmembrane 7 superfamily member 2

LRTM2 Gene

leucine-rich repeats and transmembrane domains 2

LOC100421730 Gene

transmembrane emp24 domain trafficking protein 2 pseudogene

TMEM179B Gene

transmembrane protein 179B

TMEM132E Gene

transmembrane protein 132E

TMEM132D Gene

transmembrane protein 132D

TMEM132A Gene

transmembrane protein 132A

This gene encodes a protein that is highly similar to the rat Grp78-binding protein (GBP). Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

TMEM132B Gene

transmembrane protein 132B

LOC645900 Gene

lysosomal protein transmembrane 4 beta pseudogene

LOC100130437 Gene

transmembrane protein 126A pseudogene

TMEM109 Gene

transmembrane protein 109

TMEM108 Gene

transmembrane protein 108

TMEM102 Gene

transmembrane protein 102

TMEM101 Gene

transmembrane protein 101

TMEM107 Gene

transmembrane protein 107

TMEM105 Gene

transmembrane protein 105

TMEM104 Gene

transmembrane protein 104

LOC650293 Gene

seven transmembrane helix receptor

TMCC1 Gene

transmembrane and coiled-coil domain family 1

TMCC2 Gene

transmembrane and coiled-coil domain family 2

TMCC3 Gene

transmembrane and coiled-coil domain family 3

LOC100113397 Gene

vezatin, adherens junctions transmembrane protein pseudogene

TMEM74B Gene

transmembrane protein 74B

POM121B Gene

POM121 transmembrane nucleoporin B (pseudogene)

RNFT2 Gene

ring finger protein, transmembrane 2

LETM1P2 Gene

leucine zipper-EF-hand containing transmembrane protein 1, pseudogene 2

LETM1P3 Gene

leucine zipper-EF-hand containing transmembrane protein 1, pseudogene 3

TMEM259 Gene

transmembrane protein 259

TM9SF4 Gene

transmembrane 9 superfamily protein member 4

TM9SF1 Gene

transmembrane 9 superfamily member 1

TM9SF3 Gene

transmembrane 9 superfamily member 3

TM9SF2 Gene

transmembrane 9 superfamily member 2

This gene encodes a member of the transmembrane 9 superfamily. The encoded 76 kDa protein localizes to early endosomes in human cells. The encoded protein possesses a conserved and highly hydrophobic C-terminal domain which contains nine transmembrane domains. The protein may play a role in small molecule transport or act as an ion channel. A pseudogene associated with this gene is located on the X chromosome. [provided by RefSeq, Oct 2012]

CMTM8 Gene

CKLF-like MARVEL transmembrane domain containing 8

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]

CMTM2 Gene

CKLF-like MARVEL transmembrane domain containing 2

This gene belongs to the chemokine-like factor gene superfamily, a novel family that links the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role in testicular development. [provided by RefSeq, Jul 2008]

CMTM3 Gene

CKLF-like MARVEL transmembrane domain containing 3

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants containing different 5' UTRs, but encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

CMTM1 Gene

CKLF-like MARVEL transmembrane domain containing 1

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role in testicular development. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CKLF (chemokine-like factor).[provided by RefSeq, Feb 2011]

CMTM6 Gene

CKLF-like MARVEL transmembrane domain containing 6

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]

CMTM4 Gene

CKLF-like MARVEL transmembrane domain containing 4

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

CMTM5 Gene

CKLF-like MARVEL transmembrane domain containing 5

This gene encodes a member of the chemokine-like factor superfamily. This family of genes encodes multi-pass membrane proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules. The encoded protein may exhibit tumor suppressor activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

TMEM150A Gene

transmembrane protein 150A

TMEM150C Gene

transmembrane protein 150C

TMEM150B Gene

transmembrane protein 150B

This gene encodes a protein that belongs to the DRAM (damage-regulated autophagy modulator) family of membrane-spanning proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

FAM205BP Gene

transmembrane protein C9orf144B pseudogene

LOC100996337 Gene

transmembrane protein 191B-like

TMEM182 Gene

transmembrane protein 182

TMEM181 Gene

transmembrane protein 181

The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009 [PubMed 19965467]; Wollscheid et al., 2009 [PubMed 19349973]).[supplied by OMIM, Jan 2010]

TMEM180 Gene

transmembrane protein 180

TMEM187 Gene

transmembrane protein 187

This gene consists of two exons and encodes a multi-pass membrane protein. An alternatively spliced transcript variant encoding the same protein has been found, but its biological validity is not determined. [provided by RefSeq, May 2010]

TMEM186 Gene

transmembrane protein 186

This gene encodes a potential transmembrane protein. [provided by RefSeq, Dec 2012]

TMEM189 Gene

transmembrane protein 189

Co-transcription of this gene and the neighboring downstream gene (ubiquitin-conjugating enzyme E2 variant 1) generates a rare read-through transcript, which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. The protein encoded by this individual gene lacks a UEV1 domain but includes three transmembrane regions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

TMEM59 Gene

transmembrane protein 59

This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

TMEM57 Gene

transmembrane protein 57

TMEM54 Gene

transmembrane protein 54

TMEM52 Gene

transmembrane protein 52

TMEM53 Gene

transmembrane protein 53

TMEM51 Gene

transmembrane protein 51

TMEM198B Gene

transmembrane protein 198B, pseudogene

TMEM154 Gene

transmembrane protein 154

PMEPA1 Gene

prostate transmembrane protein, androgen induced 1

This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

MCTP1 Gene

multiple C2 domains, transmembrane 1

MCTP2 Gene

multiple C2 domains, transmembrane 2

LOC100287335 Gene

transmembrane protein 183A pseudogene

NDC1 Gene

NDC1 transmembrane nucleoporin

RNFT1P1 Gene

ring finger protein, transmembrane 1 pseudogene 1

RNFT1P2 Gene

ring finger protein, transmembrane 1 pseudogene 2

TMIGD3 Gene

transmembrane and immunoglobulin domain containing 3

This gene encodes a transmembrane and immunoglobulin domain-containing protein. Alternative splicing results in multiple transcript variants, one of which shares its 5' terminal exon with that of the overlapping adenosine A3 receptor gene (GeneID:140), thus resulting in a fusion product. [provided by RefSeq, Nov 2014]

TMIGD2 Gene

transmembrane and immunoglobulin domain containing 2

TMEM55A Gene

transmembrane protein 55A

TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]

TMEM55B Gene

transmembrane protein 55B

TMEM55B catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]

LOC440683 Gene

seven transmembrane helix receptor

TMEM30B Gene

transmembrane protein 30B

FITM2 Gene

fat storage-inducing transmembrane protein 2

FIT2 belongs to an evolutionarily conserved family of proteins involved in fat storage (Kadereit et al., 2008 [PubMed 18160536]).[supplied by OMIM, May 2008]

FITM1 Gene

fat storage-inducing transmembrane protein 1

FIT1 belongs to an evolutionarily conserved family of proteins involved in fat storage (Kadereit et al., 2008 [PubMed 18160536]).[supplied by OMIM, May 2008]

LOC100420020 Gene

transmembrane protein 55B pseudogene

DCSTAMP Gene

dendrocyte expressed seven transmembrane protein

This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

LOC101929203 Gene

RING finger and transmembrane domain-containing protein 1-like

TMX4 Gene

thioredoxin-related transmembrane protein 4

TMX1 Gene

thioredoxin-related transmembrane protein 1

TXNDC1 is a thioredoxin (TXN; see MIM 187700)-related protein with disulfide reductase activity (Matsuo et al., 2001 [PubMed 11152479]).[supplied by OMIM, Mar 2008]

TMX3 Gene

thioredoxin-related transmembrane protein 3

TMX2 Gene

thioredoxin-related transmembrane protein 2

LOC100130176 Gene

transmembrane protein 188 pseudogene

TMEM86A Gene

transmembrane protein 86A

TMEM86B Gene

transmembrane protein 86B

TMEM45A Gene

transmembrane protein 45A

TMEM45B Gene

transmembrane protein 45B

GPNMB Gene

glycoprotein (transmembrane) nmb

The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

TMEM155 Gene

transmembrane protein 155

TMEM156 Gene

transmembrane protein 156

TMEM158 Gene

transmembrane protein 158 (gene/pseudogene)

Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under other conditions that induce senescence. The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway. [provided by RefSeq, Jul 2008]

TMEM159 Gene

transmembrane protein 159

TMPRSS12 Gene

transmembrane (C-terminal) protease, serine 12

TMPRSS13 Gene

transmembrane protease, serine 13

This gene encodes a member of the type II transmembrane serine protease family. Transmembrane serine proteases are regulated by protease inhibitors and known to function in development, homeostasis, infection, and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

TMPRSS15 Gene

transmembrane protease, serine 15

This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq, Jul 2008]

LOC100101247 Gene

interferon induced transmembrane protein pseudogene

LOC100101246 Gene

interferon induced transmembrane protein 3 pseudogene

TEDDM2P Gene

transmembrane epididymal protein 2, pseudogene

IFITM10 Gene

interferon induced transmembrane protein 10

TMPRSS11CP Gene

transmembrane protease, serine 11C, pseudogene

TMEM213 Gene

transmembrane protein 213

TMEM210 Gene

transmembrane protein 210

TMEM215 Gene

transmembrane protein 215

LOC442389 Gene

interferon induced transmembrane protein pseudogene

LETM1 Gene

leucine zipper-EF-hand containing transmembrane protein 1

This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19. [provided by RefSeq, Oct 2009]

LOC101930080 Gene

GPS, PLAT and transmembrane domain-containing protein FLJ00285-like

TMEM88 Gene

transmembrane protein 88

TMEM81 Gene

transmembrane protein 81

TMEM80 Gene

transmembrane protein 80

TMEM8A Gene

transmembrane protein 8A

TMEM8C Gene

transmembrane protein 8C

TMEM8B Gene

transmembrane protein 8B

TMEM87B Gene

transmembrane protein 87B

TMEM87A Gene

transmembrane protein 87A

IFITM9P Gene

interferon induced transmembrane protein 9 pseudogene

TMEM52B Gene

transmembrane protein 52B

LOC442309 Gene

interferon induced transmembrane protein 3 pseudogene

TMEM97P1 Gene

transmembrane protein 97 pseudogene 1

TMEM184A Gene

transmembrane protein 184A

TMEM184B Gene

transmembrane protein 184B

TMEM184C Gene

transmembrane protein 184C

TMEM222 Gene

transmembrane protein 222

TMEM223 Gene

transmembrane protein 223

TMEM220 Gene

transmembrane protein 220

TMEM221 Gene

transmembrane protein 221

LOC646616 Gene

transmembrane protein 183A pseudogene

LRTM1 Gene

leucine-rich repeats and transmembrane domains 1

TMED10 Gene

transmembrane emp24-like trafficking protein 10 (yeast)

This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]

LOC728048 Gene

interferon induced transmembrane protein pseudogene

TMEM167B Gene

transmembrane protein 167B

TMEM167A Gene

transmembrane protein 167A

LOC729707 Gene

transmembrane and tetratricopeptide repeat containing 4 pseudogene

GPA33 Gene

glycoprotein A33 (transmembrane)

The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily. [provided by RefSeq, Jul 2008]

TMEM132C Gene

transmembrane protein 132C

TENM3 Gene

teneurin transmembrane protein 3

TENM2 Gene

teneurin transmembrane protein 2

TENM1 Gene

teneurin transmembrane protein 1

The protein encoded by this gene belongs to the tenascin family and teneurin subfamily. It is expressed in the neurons and may function as a cellular signal transducer. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

TENM4 Gene

teneurin transmembrane protein 4

STEAP1 Gene

six transmembrane epithelial antigen of the prostate 1

This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [provided by RefSeq, Jul 2008]

P4HTM Gene

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

TMEM39B Gene

transmembrane protein 39B

TMEM39A Gene

transmembrane protein 39A

POM121L13P Gene

POM121 transmembrane nucleoporin-like 13, pseudogene

SERTM1 Gene

serine-rich and transmembrane domain containing 1

LOC100420053 Gene

transmembrane protein 126A pseudogene

TMC4 Gene

transmembrane channel-like 4

TMC6 Gene

transmembrane channel-like 6

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008]

TMC7 Gene

transmembrane channel-like 7

TMC1 Gene

transmembrane channel-like 1

This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, it is known to be required for normal function of cochlear hair cells. Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual deafness. [provided by RefSeq, Jul 2008]

TMC2 Gene

transmembrane channel-like 2

This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, expression in the inner ear suggests that it may be crucial for normal auditory function. Mutations in this gene may underlie hereditary disorders of balance and hearing. [provided by RefSeq, Jul 2008]

TMC3 Gene

transmembrane channel-like 3

TMC8 Gene

transmembrane channel-like 8

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008]

CYSTM1 Gene

cysteine-rich transmembrane module containing 1

IFITM4P Gene

interferon induced transmembrane protein 4 pseudogene

LOC100420119 Gene

transmembrane protein 132B pseudogene

TMCO5B Gene

transmembrane and coiled-coil domains 5B, pseudogene

TMCO5A Gene

transmembrane and coiled-coil domains 5A

TMEM200C Gene

transmembrane protein 200C

LOC724105 Gene

cysteine-rich transmembrane module containing 1 pseudogene

TMEM125 Gene

transmembrane protein 125

TMEM127 Gene

transmembrane protein 127

This gene encodes a transmembrane protein with 3 predicted transmembrane domains. The protein is associated with a subpopulation of vesicular organelles corresponding to early endosomal structures, with the Golgi, and with lysosomes, and may participate in protein trafficking between these structures. Mutations in this gene and several other genes cause pheochromocytomas. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2010]

TMEM121 Gene

transmembrane protein 121

TMEM123 Gene

transmembrane protein 123

This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]

TMEM129 Gene

transmembrane protein 129, E3 ubiquitin protein ligase

TMEM128 Gene

transmembrane protein 128

TMEM35 Gene

transmembrane protein 35

TMEM14E Gene

transmembrane protein 14E

TMEM143 Gene

transmembrane protein 143

TMEM140 Gene

transmembrane protein 140

TMEM89 Gene

transmembrane protein 89

TMEM82 Gene

transmembrane protein 82

OCSTAMP Gene

osteoclast stimulatory transmembrane protein

TPTEP1 Gene

transmembrane phosphatase with tensin homology pseudogene 1

POM121L8P Gene

POM121 transmembrane nucleoporin-like 8 pseudogene

LOC100420118 Gene

transmembrane protein 132C pseudogene

TMEM211 Gene

transmembrane protein 211

TMEM217 Gene

transmembrane protein 217

TMEM216 Gene

transmembrane protein 216

This locus encodes a transmembrane domain-containing protein. Mutations at this locus have been associated with Meckel-Gruber Syndrome Type 2, and Joubert Syndrome 2, also known as Cerebello-oculorenal Syndrome 2. [provided by RefSeq, Aug 2010]

TMEM214 Gene

transmembrane protein 214

TMEM219 Gene

transmembrane protein 219

TMEM218 Gene

transmembrane protein 218

TMEM78 Gene

transmembrane protein 78

TMEM79 Gene

transmembrane protein 79

TMEM70 Gene

transmembrane protein 70

This gene likely encodes a mitochondrial membrane protein. The encoded protein may play a role in biogenesis of mitochondrial ATP synthase. Mutations in this gene have been associated with neonatal mitochondrial encephalocardiomyopathy due to ATP synthase deficiency. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]

TMEM71 Gene

transmembrane protein 71

TMEM72 Gene

transmembrane protein 72

TMEM74 Gene

transmembrane protein 74

TMEM75 Gene

transmembrane protein 75

LOC121296 Gene

transmembrane protein 132B pseudogene

LOC100129118 Gene

transmembrane protein 167A pseudogene

CRIM1 Gene

cysteine rich transmembrane BMP regulator 1 (chordin-like)

This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins. [provided by RefSeq, Nov 2010]

TRAT1 Gene

T cell receptor associated transmembrane adaptor 1

TMEM63A Gene

transmembrane protein 63A

TMEM63C Gene

transmembrane protein 63C

TMEM63B Gene

transmembrane protein 63B

LOC100996401 Gene

transmembrane protein 191B

SEMA5B Gene

sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B

This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

SEMA5A Gene

sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A

This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.[provided by RefSeq, Jan 2010]

TMX2P1 Gene

thioredoxin-related transmembrane protein 2 pseudogene 1

LOC100420008 Gene

transmembrane protein 126B pseudogene

DSPA2D Gene

interferon induced transmembrane protein 3 pseudogene

LOC100420909 Gene

transmembrane protein 251 pseudogene

KREMEN1 Gene

kringle containing transmembrane protein 1

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]

CLPTM1 Gene

cleft lip and palate associated transmembrane protein 1

TMEM262 Gene

transmembrane protein 262

TMEM198 Gene

transmembrane protein 198

TMEM177 Gene

transmembrane protein 177

TMEM174 Gene

transmembrane protein 174

TMEM175 Gene

transmembrane protein 175

TMEM171 Gene

transmembrane protein 171

TMEM100 Gene

transmembrane protein 100

TMEM191B Gene

transmembrane protein 191B

TMEM191C Gene

transmembrane protein 191C

TMEM191A Gene

transmembrane protein 191A (pseudogene)

VSTM2L Gene

V-set and transmembrane domain containing 2 like

VSTM2A Gene

V-set and transmembrane domain containing 2A

VSTM2B Gene

V-set and transmembrane domain containing 2B

LETM1P1 Gene

leucine zipper-EF-hand containing transmembrane protein 1, pseudogene 1

TM4SF20 Gene

transmembrane 4 L six family member 20

LOC100506400 Gene

transmembrane protein 258 pseudogene

LOC388104 Gene

transmembrane protein 183A pseudogene

TMEM151B Gene

transmembrane protein 151B

TMEM151A Gene

transmembrane protein 151A

TM4SF1 Gene

transmembrane 4 L six family member 1

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008]

TM4SF4 Gene

transmembrane 4 L six family member 4

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]

TM4SF5 Gene

transmembrane 4 L six family member 5

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells. [provided by RefSeq, Jul 2008]

TMEM248 Gene

transmembrane protein 248

TMEM249 Gene

transmembrane protein 249

TMEM244 Gene

transmembrane protein 244

TMEM245 Gene

transmembrane protein 245

TMEM246 Gene

transmembrane protein 246

TMEM240 Gene

transmembrane protein 240

This gene encodes a transmembrane-domain containing protein found in the brain and cerebellum. Mutations in this gene result in spinocerebellar ataxia 21. [provided by RefSeq, Dec 2014]

TMEM243 Gene

transmembrane protein 243, mitochondrial

LRTOMT Gene

leucine rich transmembrane and O-methyltransferase domain containing

This gene includes two transcript forms. The short form has one open reading frame (ORF), which encodes the leucine-rich repeats (LRR)-containing protein of unknown function. This protein is called LRTOMT1 or LRRC51. The long form has two alternative ORFs; the upstream ORF has the same translation start codon as used in the short form and the resulting transcript is a candidate for nonsense-mediated decay, and the downstream ORF encodes a different protein, which is a transmembrane catechol-O-methyltransferase and is called LRTOMT2, TOMT or COMT2. The COMT2 is essential for auditory and vestibular function. Defects in the COMT2 can cause nonsyndromic deafness. Alternatively spliced transcript variants from each transcript form have been found for this gene. [provided by RefSeq, Sep 2012]

TMTC4 Gene

transmembrane and tetratricopeptide repeat containing 4

TMTC3 Gene

transmembrane and tetratricopeptide repeat containing 3

This gene encodes a protein that belongs to the transmembrane and tetratricopeptide repeat-containing protein family. [provided by RefSeq, May 2010]

TMTC1 Gene

transmembrane and tetratricopeptide repeat containing 1

TMEM97P2 Gene

transmembrane protein 97 pseudogene 2

CFTRP1 Gene

cystic fibrosis transmembrane conductance regulator pseudogene 1

TMEM176A Gene

transmembrane protein 176A

TMEM176B Gene

transmembrane protein 176B

VEZT Gene

vezatin, adherens junctions transmembrane protein

This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]

TMEM120B Gene

transmembrane protein 120B

TMEM120A Gene

transmembrane protein 120A

KREMEN2 Gene

kringle containing transmembrane protein 2

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

TMEM248P1 Gene

transmembrane protein 248 pseudogene 1

LRRTM4 Gene

leucine rich repeat transmembrane neuronal 4

LRRTM1 Gene

leucine rich repeat transmembrane neuronal 1

LRRTM3 Gene

leucine rich repeat transmembrane neuronal 3

LRRTM2 Gene

leucine rich repeat transmembrane neuronal 2

TMEM173 Gene

transmembrane protein 173

This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

SEMA6D Gene

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010]

SEMA6B Gene

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B

This gene encodes a member of the semaphorin family, a group of proteins characterized by the presence of a conserved semaphorin (sema) domain. Whereas some semaphorins are transmembrane proteins, others are secreted. Semaphorins play a major role in axon guidance. The protein encoded by this gene may be involved in both peripheral and central nervous system development. [provided by RefSeq, Jul 2008]

SEMA6C Gene

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C

This gene encodes a member of the semaphorin family. Semaphorins represent important molecular signals controlling multiple aspects of the cellular response that follows CNS injury, and thus may play an important role in neural regeneration. [provided by RefSeq, May 2010]

SEMA6A Gene

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011]

IFITM3 Gene

interferon induced transmembrane protein 3

The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. [provided by RefSeq, May 2012]

IFITM1 Gene

interferon induced transmembrane protein 1

LOC100127982 Gene

transmembrane protein 69 pseudogene

POM121C Gene

POM121 transmembrane nucleoporin C

TMEM27 Gene

transmembrane protein 27

This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells. [provided by RefSeq, Jun 2013]

TMEM26 Gene

transmembrane protein 26

TMEM25 Gene

transmembrane protein 25

LOC100287541 Gene

POM121 transmembrane nucleoporin pseudogene

LAX1 Gene

lymphocyte transmembrane adaptor 1

TMEM225 Gene

transmembrane protein 225

TMEM256P1 Gene

transmembrane protein 256 pseudogene 1

LAPTM5 Gene

lysosomal protein transmembrane 5

This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as E3 protein, may play a role in hematopoiesis. [provided by RefSeq, Feb 2009]

TMPRSS11A Gene

transmembrane protease, serine 11A

TMPRSS11B Gene

transmembrane protease, serine 11B

TMPRSS11D Gene

transmembrane protease, serine 11D

This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. [provided by RefSeq, Jul 2008]

TMPRSS11E Gene

transmembrane protease, serine 11E

TMPRSS11F Gene

transmembrane protease, serine 11F

TMEM212 Gene

transmembrane protein 212

TMEM14D Gene

transmembrane protein 14D (pseudogene)

TMEM14C Gene

transmembrane protein 14C

TMEM14B Gene

transmembrane protein 14B

TMEM14A Gene

transmembrane protein 14A

TMEM147 Gene

transmembrane protein 147

TMEM145 Gene

transmembrane protein 145

TMEM144 Gene

transmembrane protein 144

TMEM141 Gene

transmembrane protein 141

LOC123862 Gene

interferon induced transmembrane protein pseudogene

TMEM194A Gene

transmembrane protein 194A

LOC100420958 Gene

transmembrane 9 superfamily member 2 pseudogene

TMEM59L Gene

transmembrane protein 59-like

This gene encodes a predicted type-I membrane glycoprotein. The encoded protein may play a role in functioning of the central nervous system. [provided by RefSeq, Jul 2008]

IFITM2 Gene

interferon induced transmembrane protein 2

TMEM229A Gene

transmembrane protein 229A

TMEM229B Gene

transmembrane protein 229B

TM6SF1 Gene

transmembrane 6 superfamily member 1

TM6SF2 Gene

transmembrane 6 superfamily member 2

SECTM1 Gene

secreted and transmembrane 1

This gene encodes a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein. It is found in a perinuclear Golgi-like pattern and thought to be involved in hematopoietic and/or immune system processes. [provided by RefSeq, Jul 2008]

TMEM98 Gene

transmembrane protein 98

This gene encodes a transmembrane protein. A missense mutation in this gene result in Nanophthalmos 4 (NNO4). Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2014]

TMEM99 Gene

transmembrane protein 99

TMEM92 Gene

transmembrane protein 92

TMEM91 Gene

transmembrane protein 91

TMEM97 Gene

transmembrane protein 97

TMEM97 is a conserved integral membrane protein that plays a role in controlling cellular cholesterol levels (Bartz et al., 2009 [PubMed 19583955]).[supplied by OMIM, Aug 2009]

TMEM95 Gene

transmembrane protein 95

TMIE Gene

transmembrane inner ear

This gene encodes a transmembrane inner ear protein. Studies in mouse suggest that this gene is required for normal postnatal maturation of sensory hair cells in the cochlea, including correct development of stereocilia bundles. This gene is one of multiple genes responsible for recessive non-syndromic deafness (DFNB), also known as autosomal recessive nonsyndromic hearing loss (ARNSHL), the most common form of congenitally acquired inherited hearing impairment. [provided by RefSeq, Mar 2009]

TMEM88B Gene

transmembrane protein 88B

CMTM7 Gene

CKLF-like MARVEL transmembrane domain containing 7

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. The protein encoded by this gene is highly expressed in leukocytes, but its exact function is unknown. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

TPTE2P5 Gene

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 5

LOC105369277 Gene

transmembrane protein C16orf54

PRRG4 Gene

proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)

PRRG3 Gene

proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)

This gene encodes a protein which contains a vitamin K-dependent carboxylation/gamma-carboxyglutamic domain. The encoded protein is a member of a family of vitamin K-dependent transmembrane proteins which contain a glutamate-rich extracellular domain. [provided by RefSeq, Aug 2011]

TMEM261P1 Gene

transmembrane protein 261 pseudogene 1

POM121L6P Gene

POM121 transmembrane nucleoporin-like 6 pseudogene

LOC100101126 Gene

thioredoxin-related transmembrane protein 1 pseudogene

LOC100101127 Gene

thioredoxin-related transmembrane protein 1 pseudogene

TMEM239 Gene

transmembrane protein 239

TMEM238 Gene

transmembrane protein 238

TMEM235 Gene

transmembrane protein 235

TMEM234 Gene

transmembrane protein 234

TMEM237 Gene

transmembrane protein 237

The protein encoded by this gene is a tetraspanin protein that is thought to be involved in WNT signaling. Defects in this gene are a cause of Joubert syndrome-14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

TMEM236 Gene

transmembrane protein 236

TMEM231 Gene

transmembrane protein 231

This gene encodes a transmembrane protein, which is a component of the B9 complex involved in the formation of the diffusion barrier between the cilia and plasma membrane. Mutations in this gene cause Joubert syndrome (JBTS). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]

TMEM230 Gene

transmembrane protein 230

TMEM233 Gene

transmembrane protein 233

TMEM232 Gene

transmembrane protein 232

TMCO1 Gene

transmembrane and coiled-coil domains 1

This locus encodes a transmembrane protein. Mutations at this locus have been associated with craniofacial dysmorphism, skeletal anomalies, and mental retardation. Mutations at this locus have also been associated with open angle glaucoma blindness. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

TMCO2 Gene

transmembrane and coiled-coil domains 2

TMCO4 Gene

transmembrane and coiled-coil domains 4

TMCO6 Gene

transmembrane and coiled-coil domains 6

LRIT2 Gene

leucine-rich repeat, immunoglobulin-like and transmembrane domains 2

LRIT3 Gene

leucine-rich repeat, immunoglobulin-like and transmembrane domains 3

This gene encodes a protein that has a fibronectin type III domain and a C-terminal transmembrane domain, as well as a leucine-rich repeat domain and immunoglobulin-like domain near the N-terminus. The encoded protein may regulate fibroblast growth factor receptors and affect the modification of these receptors, which are glycosylated differently in the Golgi and endoplasmic reticulum. Mutations in this gene are associated with congenital stationary night blindness, type 1F. [provided by RefSeq, May 2013]

LRIT1 Gene

leucine-rich repeat, immunoglobulin-like and transmembrane domains 1

TMEM11 Gene

transmembrane protein 11

TMEM17 Gene

transmembrane protein 17

TMEM18 Gene

transmembrane protein 18

TMEM19 Gene

transmembrane protein 19

TMEM194B Gene

transmembrane protein 194B

TMEM200A Gene

transmembrane protein 200A

LOC643058 Gene

interferon induced transmembrane protein 3 pseudogene

TPTE Gene

transmembrane phosphatase with tensin homology

This gene encodes a PTEN-related tyrosine phosphatase which may play a role in the signal transduction pathways of the endocrine or spermatogenic function of the testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

LOC100129133 Gene

transmembrane protein 184C pseudogene

TMEM9 Gene

transmembrane protein 9

TMEM2 Gene

transmembrane protein 2

TMEM5 Gene

transmembrane protein 5

This gene encodes a type II transmembrane protein that is thought to have glycosyltransferase function. Mutations in this gene result in cobblestone lissencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

TMEM38A Gene

transmembrane protein 38A

TMEM38B Gene

transmembrane protein 38B

This gene encodes an intracellular monovalent cation channel that functions in maintenance of intracellular calcium release. Mutations in this gene may be associated with autosomal recessive osteogenesis. [provided by RefSeq, Oct 2012]

PRRT4 Gene

proline-rich transmembrane protein 4

PRRT1 Gene

proline-rich transmembrane protein 1

PRRT3 Gene

proline-rich transmembrane protein 3

PRRT2 Gene

proline-rich transmembrane protein 2

This gene encodes a transmembrane protein containing a proline-rich domain in its N-terminal half. Studies in mice suggest that it is predominantly expressed in brain and spinal cord in embryonic and postnatal stages. Mutations in this gene are associated with episodic kinesigenic dyskinesia-1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

CFTR Gene

cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)

This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene. [provided by RefSeq, Jul 2008]

POM121L10P Gene

POM121 transmembrane nucleoporin-like 10, pseudogene

TMEM183A Gene

transmembrane protein 183A

TMEM183B Gene

transmembrane protein 183B

This locus was thought to represent a pseudogene of chromosome 1 open reading frame 37 because it is intronless and retains a polyA tail at the 3' end. It does however contain a complete open reading frame that subsequent research has demonstrated to be transcribed in a limited number of human tissues. The encoded protein may represent a transmembrane protein associated with cell membranes and be involved in cell-cell or cell-environment interactions. [provided by RefSeq, Jul 2010]

TMEM41A Gene

transmembrane protein 41A

TMEM41B Gene

transmembrane protein 41B

LOC100420067 Gene

transmembrane protein 231 pseudogene

LOC100420066 Gene

transmembrane protein 111 pseudogene

TMEM179 Gene

transmembrane protein 179

TMEM56 Gene

transmembrane protein 56

TMEM178A Gene

transmembrane protein 178A

TMEM30A Gene

transmembrane protein 30A

TMEM30C Gene

transmembrane protein 30C

LOC100379290 Gene

transmembrane and coiled-coil domain family 1 pseudogene

TMEM119 Gene

transmembrane protein 119

TMEM110 Gene

transmembrane protein 110

TMEM114 Gene

transmembrane protein 114

This gene encodes a glycosylated transmembrane protein that plays a role in lens and eye development. Mutations in this gene, including a t(16;22)(p13.3;q11.2) translocation, are associated with congenital and juvenile cataract disorders. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

TMEM115 Gene

transmembrane protein 115

TMEM116 Gene

transmembrane protein 116

TMEM117 Gene

transmembrane protein 117

TMEM170B Gene

transmembrane protein 170B

TMEM170A Gene

transmembrane protein 170A

POM121L14P Gene

POM121 transmembrane nucleoporin-like 14, pseudogene

LOC642975 Gene

transmembrane protein 230 pseudogene

LOC100420116 Gene

transmembrane protein 132B pseudogene

LOC100996634 Gene

transmembrane protein FLJ37396

GAPT Gene

GRB2-binding adaptor protein, transmembrane

LOC100132789 Gene

transmembrane protein 126A pseudogene

TMEM265 Gene

transmembrane protein 265

TMEM263 Gene

transmembrane protein 263

TMEM260 Gene

transmembrane protein 260

TMEM261 Gene

transmembrane protein 261

TMEM190 Gene

transmembrane protein 190

TMEM192 Gene

transmembrane protein 192

TMEM196 Gene

transmembrane protein 196

TMEM199 Gene

transmembrane protein 199

TMEM44 Gene

transmembrane protein 44

TMEM47 Gene

transmembrane protein 47

This gene encodes a member of the PMP22/EMP/claudin protein family. The encoded protein is localized to the ER and the plasma membrane. In dogs, transcripts of this gene exist at high levels in the brain. [provided by RefSeq, Jul 2008]

TMEM40 Gene

transmembrane protein 40

TMEM43 Gene

transmembrane protein 43

This gene belongs to the TMEM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC. [provided by RefSeq, Oct 2008]

TMEM42 Gene

transmembrane protein 42

TEDDM1 Gene

transmembrane epididymal protein 1

TMPRSS9 Gene

transmembrane protease, serine 9

TMPRSS2 Gene

transmembrane protease, serine 2

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

TMPRSS3 Gene

transmembrane protease, serine 3

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

TMPRSS4 Gene

transmembrane protease, serine 4

This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

TMPRSS5 Gene

transmembrane protease, serine 5

This gene encodes a protein that belongs to the serine protease family. Serine proteases are known to be involved in many physiological and pathological processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

TMPRSS6 Gene

transmembrane protease, serine 6

The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

TMPRSS7 Gene

transmembrane protease, serine 7

LOC100422730 Gene

sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A pseudogene

TMEM126A Gene

transmembrane protein 126A

The protein encoded by this gene is a mitochondrial membrane protein of unknown function. Defects in this gene are a cause of optic atrophy type 7 (OPA7). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

TMEM126B Gene

transmembrane protein 126B

TMIGD1 Gene

transmembrane and immunoglobulin domain containing 1

POM121L7 Gene

POM121 transmembrane nucleoporin-like 7

POM121L2 Gene

POM121 transmembrane nucleoporin-like 2

TPTE2P2 Gene

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 2

TPTE2P3 Gene

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 3

TPTE2P1 Gene

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 1

TPTE2P6 Gene

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 6

TPTE2P4 Gene

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 4

POM121L3P Gene

POM121 transmembrane nucleoporin-like 3, pseudogene

TMEM106B Gene

transmembrane protein 106B

TMEM106C Gene

transmembrane protein 106C

TMEM106A Gene

transmembrane protein 106A

SEMA4A Gene

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A

This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]

SEMA4B Gene

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B

SEMA4C Gene

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C

SEMA4D Gene

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D

SEMA4F Gene

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F

This gene encodes a transmembrane class IV semaphorin family protein, which plays a role in neural development. This gene may be involved in neurogenesis in prostate cancer, the development of neurofibromas, and breast cancer tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

SEMA4G Gene

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

TMCO3 Gene

transmembrane and coiled-coil domains 3

LOC100420011 Gene

transmembrane protein 38A pseudogene

LOC100130326 Gene

transmembrane protein 183A pseudogene

TPRA1 Gene

transmembrane protein, adipocyte asscociated 1

TMEM185AP1 Gene

transmembrane protein 185A pseudogene 1

TMED11P Gene

transmembrane emp24 protein transport domain containing 11, pseudogene