Name

ENCODE Histone Modification Site Profiles Dataset

From Encyclopedia of DNA Elements

histone modification profiles for cell lines

Roadmap Epigenomics Histone Modification Site Profiles Dataset

From Roadmap Epigenomics

histone modification profiles for primary cells and tissues

LOC390956 Gene

peptidyl-prolyl cis-trans isomerase A pseudogene

LOC101927654 Gene

peptidyl-prolyl cis-trans isomerase A pseudogene

LOC105374327 Gene

peptidyl-prolyl cis-trans isomerase A pseudogene

LOC100996503 Gene

peptidyl-prolyl cis-trans isomerase A pseudogene

LOC105371242 Gene

peptidyl-prolyl cis-trans isomerase A-like 4G

PTRH2 Gene

peptidyl-tRNA hydrolase 2

The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos. After loss of cell attachment to the ECM, this protein is phosphorylated, is released from the mitochondria into the cytosol, and promotes caspase-independent apoptosis through interactions with transcriptional regulators. This gene has been implicated in the development and progression of tumors, and mutations in this gene have been associated with an infantile multisystem neurologic, endocrine, and pancreatic disease (INMEPD) characterized by intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency (PMID: 25574476). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

PTRH1 Gene

peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)

LOC101060458 Gene

peptidyl-prolyl cis-trans isomerase A-like

LOC101928610 Gene

peptidyl-prolyl cis-trans isomerase A pseudogene

LOC105374236 Gene

peptidyl-prolyl cis-trans isomerase A pseudogene

PADI1 Gene

peptidyl arginine deiminase, type I

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]

PADI3 Gene

peptidyl arginine deiminase, type III

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]

PADI2 Gene

peptidyl arginine deiminase, type II

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]

PADI4 Gene

peptidyl arginine deiminase, type IV

This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. [provided by RefSeq, Jul 2008]

PADI6 Gene

peptidyl arginine deiminase, type VI

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. This protein may play a role in cytoskeletal reorganization in the egg and in early embryo development. [provided by RefSeq, Sep 2012]

LOC101928624 Gene

peptidyl-prolyl cis-trans isomerase A pseudogene

LOC100287361 Gene

peptidyl-prolyl cis-trans isomerase A pseudogene

LOC105369232 Gene

peptidyl-prolyl cis-trans isomerase FKBP4 pseudogene

LOC101060363 Gene

peptidyl-prolyl cis-trans isomerase A pseudogene

LOC101926910 Gene

peptidyl-prolyl cis-trans isomerase A pseudogene

LOC442744 Gene

peptidyl-prolyl cis-trans isomerase A pseudogene

LOC105378561 Gene

peptidyl-prolyl cis-trans isomerase A pseudogene

ACE3P Gene

angiotensin I converting enzyme (peptidyl-dipeptidase A) 3, pseudogene

LOC100996727 Gene

peptidyl-prolyl cis-trans isomerase A pseudogene

PTRHD1 Gene

peptidyl-tRNA hydrolase domain containing 1

LOC101927689 Gene

peptidyl-prolyl cis-trans isomerase A pseudogene

LOC101928064 Gene

peptidyl-prolyl cis-trans isomerase A pseudogene

PTPN18 Gene

protein tyrosine phosphatase, non-receptor type 18 (brain-derived)

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

PTPN13 Gene

protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]

PTPN12 Gene

protein tyrosine phosphatase, non-receptor type 12

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]

PTPN11 Gene

protein tyrosine phosphatase, non-receptor type 11

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

PTPN14 Gene

protein tyrosine phosphatase, non-receptor type 14

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia. [provided by RefSeq, Sep 2010]

PTPMT1 Gene

protein tyrosine phosphatase, mitochondrial 1

LOC105369264 Gene

tyrosine-protein phosphatase non-receptor type 20

PPFIA4 Gene

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4

PPFIA4, or liprin-alpha-4, belongs to the liprin-alpha gene family. See liprin-alpha-1 (LIP1, or PPFIA1; MIM 611054) for background on liprins.[supplied by OMIM, Mar 2008]

ROS1 Gene

ROS proto-oncogene 1 , receptor tyrosine kinase

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq, Jul 2008]

LOC105379539 Gene

tyrosine-protein phosphatase non-receptor type 23-like

RYK Gene

receptor-like tyrosine kinase

The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]

TRNAY-GUA Gene

transfer RNA tyrosine (anticodon GUA)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

LYN Gene

LYN proto-oncogene, Src family tyrosine kinase

This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

YWHAQ Gene

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]

YWHAH Gene

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and bovine orthologs. This gene contains a 7 bp repeat sequence in its 5' UTR, and changes in the number of this repeat have been associated with early-onset schizophrenia and psychotic bipolar disorder. [provided by RefSeq, Jun 2009]

YWHAB Gene

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta

This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

YWHAG Gene

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]

YWHAE Gene

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]

TH Gene

tyrosine hydroxylase

The protein encoded by this gene is involved in the conversion of tyrosine to dopamine. It is the rate-limiting enzyme in the synthesis of catecholamines, hence plays a key role in the physiology of adrenergic neurons. Mutations in this gene have been associated with autosomal recessive Segawa syndrome. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]

FGR Gene

FGR proto-oncogene, Src family tyrosine kinase

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

PTPN22 Gene

protein tyrosine phosphatase, non-receptor type 22 (lymphoid)

This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]

PTPN23 Gene

protein tyrosine phosphatase, non-receptor type 23

PTPN20 Gene

protein tyrosine phosphatase, non-receptor type 20

The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes. The encoded protein appears to be targeted to sites of actin polymerization. A pseudogene of this gene has been defined on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

PTPN21 Gene

protein tyrosine phosphatase, non-receptor type 21

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008]

CYYR1-AS1 Gene

cysteine/tyrosine-rich 1 antisense RNA 1

TAT Gene

tyrosine aminotransferase

This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible mental retardation. A regulator gene for tyrosine aminotransferase is X-linked. [provided by RefSeq, Jul 2008]

HCK Gene

HCK proto-oncogene, Src family tyrosine kinase

The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]

FERP1 Gene

fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) pseudogene 1

ABL1 Gene

ABL proto-oncogene 1, non-receptor tyrosine kinase

This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]

ABL2 Gene

ABL proto-oncogene 2, non-receptor tyrosine kinase

This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

LOC100422713 Gene

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 pseudogene

LOC100422710 Gene

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 pseudogene

CABYRP1 Gene

calcium binding tyrosine-(Y)-phosphorylation regulated pseudogene 1

LOC442113 Gene

protein tyrosine phosphatase, non-receptor type 11 pseudogene

PTPRCAP Gene

protein tyrosine phosphatase, receptor type, C-associated protein

The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein. [provided by RefSeq, Jul 2008]

TRNAY-AUA Gene

transfer RNA tyrosine (anticodon AUA)

This record serves to anchor the annotations of this class of tRNAs at multiple locations on the human genome. The placements are predicted using tRNAscan-SE (Lowe, T.M. and Eddy, S.R. 1997. Nucleic Acids Res. 25:955-964, PubMed 9023104).

TTLL11 Gene

tubulin tyrosine ligase-like family member 11

TTLL10 Gene

tubulin tyrosine ligase-like family member 10

TTLL12 Gene

tubulin tyrosine ligase-like family member 12

YWHAZP8 Gene

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pseudogene 8

YWHAZP9 Gene

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pseudogene 9

YWHAZP2 Gene

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pseudogene 2

YWHAZP3 Gene

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pseudogene 3

YWHAZP1 Gene

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pseudogene 1

YWHAZP6 Gene

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pseudogene 6

YWHAZP5 Gene

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pseudogene 5

PTPRZ2 Gene

protein tyrosine phosphatase, receptor-type, Z polypeptide 2

PTPRZ1 Gene

protein tyrosine phosphatase, receptor-type, Z polypeptide 1

This gene encodes a member of the receptor protein tyrosine phosphatase family. Expression of this gene is restricted to the central nervous system (CNS), and it may be involved in the regulation of specific developmental processes in the CNS. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011]

BMX Gene

BMX non-receptor tyrosine kinase

This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Sep 2009]

AXL Gene

AXL receptor tyrosine kinase

The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

MET Gene

MET proto-oncogene, receptor tyrosine kinase

The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

LMTK3 Gene

lemur tyrosine kinase 3

LMTK2 Gene

lemur tyrosine kinase 2

The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]

ROR2 Gene

receptor tyrosine kinase-like orphan receptor 2

The protein encoded by this gene is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance. [provided by RefSeq, Jul 2008]

ROR1 Gene

receptor tyrosine kinase-like orphan receptor 1

This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012]

PTPN3 Gene

protein tyrosine phosphatase, non-receptor type 3

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

LOC100422495 Gene

protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) pseudogene

TYRO3 Gene

TYRO3 protein tyrosine kinase

The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010]

TYK2 Gene

tyrosine kinase 2

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]

PTPN2P2 Gene

protein tyrosine phosphatase, non-receptor type 2 pseudogene 2

FER Gene

fer (fps/fes related) tyrosine kinase

The protein encoded by this gene is a member of the FPS/FES family of non-transmembrane receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Apr 2015]

FES Gene

FES proto-oncogene, tyrosine kinase

This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009]

LOC442263 Gene

protein tyrosine phosphatase, non-receptor type 11 pseudogene

PTPN9 Gene

protein tyrosine phosphatase, non-receptor type 9

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis. [provided by RefSeq, Jul 2008]

PTPN2 Gene

protein tyrosine phosphatase, non-receptor type 2

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]

PTPN1 Gene

protein tyrosine phosphatase, non-receptor type 1

The protein encoded by this gene is the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs catalyze the hydrolysis of the phosphate monoesters specifically on tyrosine residues. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

PTPN7 Gene

protein tyrosine phosphatase, non-receptor type 7

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010]

PTPN6 Gene

protein tyrosine phosphatase, non-receptor type 6

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

PTPN5 Gene

protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)

PTPN4 Gene

protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008]

TTLL13P Gene

tubulin tyrosine ligase-like family member 13, pseudogene

LOC158781 Gene

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide pseudogene

LOC344593 Gene

protein tyrosine phosphatase, non-receptor type 11 pseudogene

TXK Gene

TXK tyrosine kinase

LOC100129526 Gene

protein tyrosine phosphatase, receptor type, D pseudogene

DYRK3 Gene

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3

This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

DYRK2 Gene

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

DYRK2 belongs to a family of protein kinases whose members are presumed to be involved in cellular growth and/or development. The family is defined by structural similarity of their kinase domains and their capability to autophosphorylate on tyrosine residues. DYRK2 has demonstrated tyrosine autophosphorylation and catalyzed phosphorylation of histones H3 and H2B in vitro. Two isoforms of DYRK2 have been isolated. The predominant isoform, isoform 1, lacks a 5' terminal insert. [provided by RefSeq, Jul 2008]

DYRK4 Gene

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4

This gene encodes an enzyme that belongs to a conserved family of serine/threonine protein kinases. Members of this dual specificity kinase family are thought to function in the regulation of cell differentiation and proliferation, survival, and in development. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Aug 2013]

FLT4 Gene

fms-related tyrosine kinase 4

This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]

FLT1 Gene

fms-related tyrosine kinase 1

This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.[provided by RefSeq, May 2009]

LCK Gene

LCK proto-oncogene, Src family tyrosine kinase

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described. [provided by RefSeq, Jul 2008]

STYXL1 Gene

serine/threonine/tyrosine interacting-like 1

TIE1 Gene

tyrosine kinase with immunoglobulin-like and EGF-like domains 1

This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

IBTK Gene

inhibitor of Bruton agammaglobulinemia tyrosine kinase

Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

PTP4A1P2 Gene

protein tyrosine phosphatase type IVA, member 1 pseudogene 2

PTP4A1P3 Gene

protein tyrosine phosphatase type IVA, member 1 pseudogene 3

PTP4A1P1 Gene

protein tyrosine phosphatase type IVA, member 1 pseudogene 1

PTP4A1P6 Gene

protein tyrosine phosphatase type IVA, member 1 pseudogene 6

PTP4A1P7 Gene

protein tyrosine phosphatase type IVA, member 1 pseudogene 7

PTP4A1P4 Gene

protein tyrosine phosphatase type IVA, member 1 pseudogene 4

PTP4A1P5 Gene

protein tyrosine phosphatase type IVA, member 1 pseudogene 5

PTK2 Gene

protein tyrosine kinase 2

This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only three of them have been determined. [provided by RefSeq, Dec 2010]

PTK7 Gene

protein tyrosine kinase 7 (inactive)

This gene encodes a member of the receptor protein tyrosine kinase family of proteins that transduce extracellular signals across the cell membrane. The encoded protein lacks detectable catalytic tyrosine kinase activity, is involved in the Wnt signaling pathway and plays a role in multiple cellular processes including polarity and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

PTK6 Gene

protein tyrosine kinase 6

The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

TTLL5 Gene

tubulin tyrosine ligase-like family member 5

This gene encodes a member of the tubulin tyrosine ligase like protein family. This protein interacts with two glucocorticoid receptor coactivators, transcriptional intermediary factor 2 and steroid receptor coactivator 1. This protein may function as a coregulator of glucocorticoid receptor mediated gene induction and repression. This protein may also function as an alpha tubulin polyglutamylase.[provided by RefSeq, Feb 2010]

TTLL4 Gene

tubulin tyrosine ligase-like family member 4

TTLL7 Gene

tubulin tyrosine ligase-like family member 7

TTLL6 Gene

tubulin tyrosine ligase-like family member 6

TTLL1 Gene

tubulin tyrosine ligase-like family member 1

TTLL3 Gene

tubulin tyrosine ligase-like family member 3

TTLL2 Gene

tubulin tyrosine ligase-like family member 2

TTLL9 Gene

tubulin tyrosine ligase-like family member 9

TTLL8 Gene

tubulin tyrosine ligase-like family member 8

IBTKP1 Gene

inhibitor of Bruton agammaglobulinemia tyrosine kinase pseudogene 1

LOC102725179 Gene

tyrosine-protein phosphatase non-receptor type 20-like

LOC391771 Gene

protein tyrosine phosphatase, non-receptor type 11 pseudogene

LOC100422669 Gene

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide pseudogene

YWHAZ Gene

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]

YWHAZP7 Gene

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pseudogene 7

YWHAZP4 Gene

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pseudogene 4

MUSK Gene

muscle, skeletal, receptor tyrosine kinase

This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009]

PTPN2P1 Gene

protein tyrosine phosphatase, non-receptor type 2 pseudogene 1

TTL Gene

tubulin tyrosine ligase

TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).[supplied by OMIM, Mar 2008]

DDR2 Gene

discoidin domain receptor tyrosine kinase 2

Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

DDR1 Gene

discoidin domain receptor tyrosine kinase 1

Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

MATK Gene

megakaryocyte-associated tyrosine kinase

The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

TEC Gene

tec protein tyrosine kinase

The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008]

PTP4A2P1 Gene

protein tyrosine phosphatase type IVA, member 2 pseudogene 1

PTP4A2P2 Gene

protein tyrosine phosphatase type IVA, member 2 pseudogene 2

LOC100128076 Gene

protein tyrosine phosphatase pseudogene

PKMYT1 Gene

protein kinase, membrane associated tyrosine/threonine 1

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein is a membrane-associated kinase that negatively regulates the G2/M transition of the cell cycle by phosphorylating and inactivating cyclin-dependent kinase 1. The activity of the encoded protein is regulated by polo-like kinase 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

DSTYK Gene

dual serine/threonine and tyrosine protein kinase

This gene encodes a dual serine/threonine and tyrosine protein kinase which is expressed in multiple tissues. It is thought to function as a regulator of cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

BLK Gene

BLK proto-oncogene, Src family tyrosine kinase

This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010]

LOC100130210 Gene

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide pseudogene

TNK2 Gene

tyrosine kinase, non-receptor, 2

This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]

TNK1 Gene

tyrosine kinase, non-receptor, 1

The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

PPFIA2 Gene

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein has been shown to bind the calcium/calmodulin-dependent serine protein kinase (MAGUK family) protein (also known as CASK) and proposed to regulate higher-order brain functions in mammals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

PPFIA3 Gene

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. Liprin family protein has been shown to localize phosphatase LAR to cell focal adhesions and may be involved in the molecular organization of presynaptic active zones. [provided by RefSeq, Jul 2008]

PPFIA1 Gene

protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

HGS Gene

hepatocyte growth factor-regulated tyrosine kinase substrate

The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010]

BTK Gene

Bruton agammaglobulinemia tyrosine kinase

The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]

DYRK1A Gene

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]

DYRK1B Gene

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B

This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

MERTK Gene

MER proto-oncogene, tyrosine kinase

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]

YWHAEP5 Gene

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon pseudogene 5

YWHAEP7 Gene

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon pseudogene 7

YWHAEP1 Gene

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon pseudogene 1

YES1 Gene

YES proto-oncogene 1, Src family tyrosine kinase

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

NYAP1 Gene

neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 1

NYAP2 Gene

neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2

ALK Gene

anaplastic lymphoma receptor tyrosine kinase

This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]

SRMS Gene

src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites

FLT3 Gene

fms-related tyrosine kinase 3

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]

SRC Gene

SRC proto-oncogene, non-receptor tyrosine kinase

This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

RYKP1 Gene

receptor-like tyrosine kinase pseudogene 1

NTRK1 Gene

neurotrophic tyrosine kinase, receptor, type 1

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]

NTRK2 Gene

neurotrophic tyrosine kinase, receptor, type 2

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

NTRK3 Gene

neurotrophic tyrosine kinase, receptor, type 3

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

PTPRVP Gene

protein tyrosine phosphatase, receptor type, V, pseudogene

ERBB2 Gene

erb-b2 receptor tyrosine kinase 2

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

ERBB3 Gene

erb-b2 receptor tyrosine kinase 3

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

ERBB4 Gene

erb-b2 receptor tyrosine kinase 4

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

PTPRR Gene

protein tyrosine phosphatase, receptor type, R

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011]

PTPRU Gene

protein tyrosine phosphatase, receptor type, U

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. [provided by RefSeq, Aug 2010]

PTPRT Gene

protein tyrosine phosphatase, receptor type, T

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. The protein domain structure and the expression pattern of the mouse counterpart of this PTP suggest its roles in both signal transduction and cellular adhesion in the central nervous system. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

PTPRS Gene

protein tyrosine phosphatase, receptor type, S

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

PTPRQ Gene

protein tyrosine phosphatase, receptor type, Q

This locus encodes a member of the type III receptor-like protein-tyrosine phosphatase family. The encoded protein catalyzes the dephosphorylation of phosphotyrosine and phosphatidylinositol and plays roles in cellular proliferation and differentiation. Mutations at this locus have been linked to autosomal recessive deafness. [provided by RefSeq, Mar 2014]

PTPRG Gene

protein tyrosine phosphatase, receptor type, G

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]

PTPRF Gene

protein tyrosine phosphatase, receptor type, F

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

PTPRE Gene

protein tyrosine phosphatase, receptor type, E

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Jul 2008]

PTPRD Gene

protein tyrosine phosphatase, receptor type, D

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chicken and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple alternatively spliced transcript variants of this gene have been reported. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jan 2010]

PTPRC Gene

protein tyrosine phosphatase, receptor type, C

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]

PTPRB Gene

protein tyrosine phosphatase, receptor type, B

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

PTPRA Gene

protein tyrosine phosphatase, receptor type, A

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

PTPRO Gene

protein tyrosine phosphatase, receptor type, O

This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]

PTPRN Gene

protein tyrosine phosphatase, receptor type, N

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]

PTPRM Gene

protein tyrosine phosphatase, receptor type, M

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]

PTPRK Gene

protein tyrosine phosphatase, receptor type, K

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]

PTPRJ Gene

protein tyrosine phosphatase, receptor type, J

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PTPRH Gene

protein tyrosine phosphatase, receptor type, H

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. The extracellular region contains eight fibronectin type III-like repeats and multiple N-glycosylation sites. The gene was shown to be expressed primarily in brain and liver, and at a lower level in heart and stomach. It was also found to be expressed in several cancer cell lines, but not in the corresponding normal tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

FYN Gene

FYN proto-oncogene, Src family tyrosine kinase

This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]

PTP4A1 Gene

protein tyrosine phosphatase type IVA, member 1

This gene encodes a member of a small class of prenylated protein tyrosine phosphatases (PTPs), which contain a PTP domain and a characteristic C-terminal prenylation motif. The encoded protein is a cell signaling molecule that plays regulatory roles in a variety of cellular processes, including cell proliferation and migration. The protein may also be involved in cancer development and metastasis. This tyrosine phosphatase is a nuclear protein, but may associate with plasma membrane by means of its prenylation motif. Pseudogenes related to this gene are located on chromosomes 1, 2, 5, 7, 11 and X. [provided by RefSeq, Jun 2013]

PTP4A3 Gene

protein tyrosine phosphatase type IVA, member 3

This gene encodes a member of the protein-tyrosine phosphatase family. Protein tyrosine phosphatases are cell signaling molecules that play regulatory roles in a variety of cellular processes. Studies of this class of protein tyrosine phosphatase in mice demonstrates that they are prenylated in vivo, suggesting their association with cell plasma membrane. The encoded protein may enhance cell proliferation, and overexpression of this gene has been implicated in tumor metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

PTP4A2 Gene

protein tyrosine phosphatase type IVA, member 2

The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]

TYRO3P Gene

TYRO3P protein tyrosine kinase pseudogene

STYK1 Gene

serine/threonine/tyrosine kinase 1

Receptor protein tyrosine kinases, like STYK1, play important roles in diverse cellular and developmental processes, such as cell proliferation, differentiation, and survival (Liu et al., 2004 [PubMed 15150103]).[supplied by OMIM, Mar 2008]

TEK Gene

TEK tyrosine kinase, endothelial

This gene encodes a receptor that belongs to the protein tyrosine kinase Tie2 family. The encoded protein possesses a unique extracellular region that contains two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin type III repeats. The ligand angiopoietin-1 binds to this receptor and mediates a signaling pathway that functions in embryonic vascular development. Mutations in this gene are associated with inherited venous malformations of the skin and mucous membranes. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]

SYK Gene

spleen tyrosine kinase

This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

FLT3LG Gene

fms-related tyrosine kinase 3 ligand

Dendritic cells (DCs) provide the key link between innate and adaptive immunity by recognizing pathogens and priming pathogen-specific immune responses. FLT3LG controls the development of DCs and is particularly important for plasmacytoid DCs and CD8 (see MIM 186910)-positive classical DCs and their CD103 (ITGAE; MIM 604682)-positive tissue counterparts (summary by Sathaliyawala et al., 2010 [PubMed 20933441]).[supplied by OMIM, Jan 2011]

PTPRN2 Gene

protein tyrosine phosphatase, receptor type, N polypeptide 2

This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

CABYR Gene

calcium binding tyrosine-(Y)-phosphorylation regulated

To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

CYYR1 Gene

cysteine/tyrosine-rich 1

PTPN20CP Gene

protein tyrosine phosphatase, non-receptor type 20C, pseudogene

FRK Gene

fyn-related Src family tyrosine kinase

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]

FLT1P1 Gene

fms-related tyrosine kinase 1 pseudogene 1

STYX Gene

serine/threonine/tyrosine interacting protein

The protein encoded by this gene is a pseudophosphatase, able to bind potential substrates but lacking an active catalytic loop. The encoded protein may be involved in spermiogenesis. Two transcript variants encoding the same protein have been found for these genes. [provided by RefSeq, Oct 2011]

LTK Gene

leukocyte receptor tyrosine kinase

The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

PTK2B Gene

protein tyrosine kinase 2 beta

This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CSK Gene

c-src tyrosine kinase

AATK Gene

apoptosis-associated tyrosine kinase

The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

DOK1 Gene

docking protein 1, 62kDa (downstream of tyrosine kinase 1)

The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

YWHABP2 Gene

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta pseudogene 2

YWHABP1 Gene

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta pseudogene 1

LOC100421822 Gene

protein tyrosine phosphatase, non-receptor type 11 pseudogene

PTPDC1 Gene

protein tyrosine phosphatase domain containing 1

The protein encoded by this gene contains a characteristic motif of protein tyrosine phosphatases (PTPs). PTPs regulate activities of phosphoproteins through dephosphorylation. They are signaling molecules involved in the regulation of a wide variety of biological processes. The specific function of this protein has not yet been determined. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

TYROBP Gene

TYRO protein tyrosine kinase binding protein

This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]

peptidyl-tyrosine modification Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-tyrosine modification biological process from the curated GO Biological Process Annotations dataset.

peptidyl-lysine modification to peptidyl-hypusine Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-lysine modification to peptidyl-hypusine biological process from the curated GO Biological Process Annotations dataset.

peptidyl-glycine modification Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-glycine modification biological process from the curated GO Biological Process Annotations dataset.

peptidyl-glutamine modification Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-glutamine modification biological process from the curated GO Biological Process Annotations dataset.

peptidyl-methionine modification Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-methionine modification biological process from the curated GO Biological Process Annotations dataset.

peptidyl-alanine modification Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-alanine modification biological process from the curated GO Biological Process Annotations dataset.

peptidyl-lysine modification Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-lysine modification biological process from the curated GO Biological Process Annotations dataset.

peptidyl-tryptophan modification Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-tryptophan modification biological process from the curated GO Biological Process Annotations dataset.

peptidyl-asparagine modification Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-asparagine modification biological process from the curated GO Biological Process Annotations dataset.

peptidyl-aspartic acid modification Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-aspartic acid modification biological process from the curated GO Biological Process Annotations dataset.

peptidyl-amino acid modification Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-amino acid modification biological process from the curated GO Biological Process Annotations dataset.

peptidyl-threonine modification Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-threonine modification biological process from the curated GO Biological Process Annotations dataset.

peptidyl-serine modification Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-serine modification biological process from the curated GO Biological Process Annotations dataset.

peptidyl-proline modification Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-proline modification biological process from the curated GO Biological Process Annotations dataset.

peptidyl-glutamic acid modification Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-glutamic acid modification biological process from the curated GO Biological Process Annotations dataset.

peptidyl-histidine modification Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-histidine modification biological process from the curated GO Biological Process Annotations dataset.

peptidyl-cysteine modification Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-cysteine modification biological process from the curated GO Biological Process Annotations dataset.

peptidyl-arginine modification Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-arginine modification biological process from the curated GO Biological Process Annotations dataset.

peptidyl-s-diacylglycerol-l-cysteine biosynthetic process from peptidyl-cysteine Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-s-diacylglycerol-l-cysteine biosynthetic process from peptidyl-cysteine biological process from the curated GO Biological Process Annotations dataset.

peptidyl-diphthamide biosynthetic process from peptidyl-histidine Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-diphthamide biosynthetic process from peptidyl-histidine biological process from the curated GO Biological Process Annotations dataset.

peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of peptidyl-tyrosine autophosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of peptidyl-tyrosine autophosphorylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-tyrosine dephosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-tyrosine dephosphorylation biological process from the curated GO Biological Process Annotations dataset.

positive regulation of peptidyl-tyrosine autophosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of peptidyl-tyrosine autophosphorylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-tyrosine autophosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-tyrosine autophosphorylation biological process from the curated GO Biological Process Annotations dataset.

regulation of peptidyl-tyrosine autophosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the regulation of peptidyl-tyrosine autophosphorylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-tyrosine sulfation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-tyrosine sulfation biological process from the curated GO Biological Process Annotations dataset.

negative regulation of peptidyl-tyrosine phosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of peptidyl-tyrosine phosphorylation biological process from the curated GO Biological Process Annotations dataset.

positive regulation of peptidyl-tyrosine phosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of peptidyl-tyrosine phosphorylation biological process from the curated GO Biological Process Annotations dataset.

regulation of peptidyl-tyrosine phosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the regulation of peptidyl-tyrosine phosphorylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-tyrosine phosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-tyrosine phosphorylation biological process from the curated GO Biological Process Annotations dataset.

the prc2 complex sets long-term gene silencing through modification of histone tails Gene Set

From Biocarta Pathways

proteins participating in the the prc2 complex sets long-term gene silencing through modification of histone tails pathway from the Biocarta Pathways dataset.

modification Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term modification in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

modifications Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term modifications in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

modificationsmutations Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term modificationsmutations in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

positive regulation of histone modification Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of histone modification biological process from the curated GO Biological Process Annotations dataset.

trna thio-modification Gene Set

From GO Biological Process Annotations

genes participating in the trna thio-modification biological process from the curated GO Biological Process Annotations dataset.

protein modification by small protein conjugation Gene Set

From GO Biological Process Annotations

genes participating in the protein modification by small protein conjugation biological process from the curated GO Biological Process Annotations dataset.

trna wobble base modification Gene Set

From GO Biological Process Annotations

genes participating in the trna wobble base modification biological process from the curated GO Biological Process Annotations dataset.

modification of morphology or physiology of other organism involved in symbiotic interaction Gene Set

From GO Biological Process Annotations

genes participating in the modification of morphology or physiology of other organism involved in symbiotic interaction biological process from the curated GO Biological Process Annotations dataset.

positive regulation of protein modification process Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of protein modification process biological process from the curated GO Biological Process Annotations dataset.

negative regulation of histone modification Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of histone modification biological process from the curated GO Biological Process Annotations dataset.

regulation of histone modification Gene Set

From GO Biological Process Annotations

genes participating in the regulation of histone modification biological process from the curated GO Biological Process Annotations dataset.

regulation of mrna modification Gene Set

From GO Biological Process Annotations

genes participating in the regulation of mrna modification biological process from the curated GO Biological Process Annotations dataset.

mitochondrial rna modification Gene Set

From GO Biological Process Annotations

genes participating in the mitochondrial rna modification biological process from the curated GO Biological Process Annotations dataset.

mitochondrial trna modification Gene Set

From GO Biological Process Annotations

genes participating in the mitochondrial trna modification biological process from the curated GO Biological Process Annotations dataset.

covalent chromatin modification Gene Set

From GO Biological Process Annotations

genes participating in the covalent chromatin modification biological process from the curated GO Biological Process Annotations dataset.

negative regulation of protein modification process Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of protein modification process biological process from the curated GO Biological Process Annotations dataset.

negative regulation of mrna modification Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of mrna modification biological process from the curated GO Biological Process Annotations dataset.

lipoprotein modification Gene Set

From GO Biological Process Annotations

genes participating in the lipoprotein modification biological process from the curated GO Biological Process Annotations dataset.

rrna modification Gene Set

From GO Biological Process Annotations

genes participating in the rrna modification biological process from the curated GO Biological Process Annotations dataset.

actin modification Gene Set

From GO Biological Process Annotations

genes participating in the actin modification biological process from the curated GO Biological Process Annotations dataset.

heparan sulfate proteoglycan biosynthetic process, enzymatic modification Gene Set

From GO Biological Process Annotations

genes participating in the heparan sulfate proteoglycan biosynthetic process, enzymatic modification biological process from the curated GO Biological Process Annotations dataset.

modification of morphology or physiology of other organism Gene Set

From GO Biological Process Annotations

genes participating in the modification of morphology or physiology of other organism biological process from the curated GO Biological Process Annotations dataset.

snrna modification Gene Set

From GO Biological Process Annotations

genes participating in the snrna modification biological process from the curated GO Biological Process Annotations dataset.

negative regulation of chromatin modification Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of chromatin modification biological process from the curated GO Biological Process Annotations dataset.

mrna modification Gene Set

From GO Biological Process Annotations

genes participating in the mrna modification biological process from the curated GO Biological Process Annotations dataset.

protein modification process Gene Set

From GO Biological Process Annotations

genes participating in the protein modification process biological process from the curated GO Biological Process Annotations dataset.

negative regulation of protein modification by small protein conjugation or removal Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of protein modification by small protein conjugation or removal biological process from the curated GO Biological Process Annotations dataset.

lipid modification Gene Set

From GO Biological Process Annotations

genes participating in the lipid modification biological process from the curated GO Biological Process Annotations dataset.

charged-trna amino acid modification Gene Set

From GO Biological Process Annotations

genes participating in the charged-trna amino acid modification biological process from the curated GO Biological Process Annotations dataset.

chromatin modification Gene Set

From GO Biological Process Annotations

genes participating in the chromatin modification biological process from the curated GO Biological Process Annotations dataset.

regulation of post-translational protein modification Gene Set

From GO Biological Process Annotations

genes participating in the regulation of post-translational protein modification biological process from the curated GO Biological Process Annotations dataset.

post-translational protein modification Gene Set

From GO Biological Process Annotations

genes participating in the post-translational protein modification biological process from the curated GO Biological Process Annotations dataset.

n-terminal protein amino acid modification Gene Set

From GO Biological Process Annotations

genes participating in the n-terminal protein amino acid modification biological process from the curated GO Biological Process Annotations dataset.

negative regulation of transcription from rna polymerase ii promoter by histone modification Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of transcription from rna polymerase ii promoter by histone modification biological process from the curated GO Biological Process Annotations dataset.

c-terminal protein amino acid modification Gene Set

From GO Biological Process Annotations

genes participating in the c-terminal protein amino acid modification biological process from the curated GO Biological Process Annotations dataset.

modification by host of symbiont morphology or physiology Gene Set

From GO Biological Process Annotations

genes participating in the modification by host of symbiont morphology or physiology biological process from the curated GO Biological Process Annotations dataset.

modification by host of symbiont molecular function Gene Set

From GO Biological Process Annotations

genes participating in the modification by host of symbiont molecular function biological process from the curated GO Biological Process Annotations dataset.

modification by virus of host mrna processing Gene Set

From GO Biological Process Annotations

genes participating in the modification by virus of host mrna processing biological process from the curated GO Biological Process Annotations dataset.

trna wobble uridine modification Gene Set

From GO Biological Process Annotations

genes participating in the trna wobble uridine modification biological process from the curated GO Biological Process Annotations dataset.

cellular protein modification process Gene Set

From GO Biological Process Annotations

genes participating in the cellular protein modification process biological process from the curated GO Biological Process Annotations dataset.

dna modification Gene Set

From GO Biological Process Annotations

genes participating in the dna modification biological process from the curated GO Biological Process Annotations dataset.

histone modification Gene Set

From GO Biological Process Annotations

genes participating in the histone modification biological process from the curated GO Biological Process Annotations dataset.

positive regulation of protein modification by small protein conjugation or removal Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of protein modification by small protein conjugation or removal biological process from the curated GO Biological Process Annotations dataset.

trna modification Gene Set

From GO Biological Process Annotations

genes participating in the trna modification biological process from the curated GO Biological Process Annotations dataset.

co-translational protein modification Gene Set

From GO Biological Process Annotations

genes participating in the co-translational protein modification biological process from the curated GO Biological Process Annotations dataset.

regulation of protein modification process Gene Set

From GO Biological Process Annotations

genes participating in the regulation of protein modification process biological process from the curated GO Biological Process Annotations dataset.

macromolecule modification Gene Set

From GO Biological Process Annotations

genes participating in the macromolecule modification biological process from the curated GO Biological Process Annotations dataset.

mitochondrial trna wobble uridine modification Gene Set

From GO Biological Process Annotations

genes participating in the mitochondrial trna wobble uridine modification biological process from the curated GO Biological Process Annotations dataset.

rna modification Gene Set

From GO Biological Process Annotations

genes participating in the rna modification biological process from the curated GO Biological Process Annotations dataset.

modification-dependent protein catabolic process Gene Set

From GO Biological Process Annotations

genes participating in the modification-dependent protein catabolic process biological process from the curated GO Biological Process Annotations dataset.

negative regulation of post-translational protein modification Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of post-translational protein modification biological process from the curated GO Biological Process Annotations dataset.

modification-dependent macromolecule catabolic process Gene Set

From GO Biological Process Annotations

genes participating in the modification-dependent macromolecule catabolic process biological process from the curated GO Biological Process Annotations dataset.

regulation of protein modification by small protein conjugation or removal Gene Set

From GO Biological Process Annotations

genes participating in the regulation of protein modification by small protein conjugation or removal biological process from the curated GO Biological Process Annotations dataset.

regulation of chromatin modification Gene Set

From GO Biological Process Annotations

genes participating in the regulation of chromatin modification biological process from the curated GO Biological Process Annotations dataset.

peptide modification Gene Set

From GO Biological Process Annotations

genes participating in the peptide modification biological process from the curated GO Biological Process Annotations dataset.

positive regulation of chromatin modification Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of chromatin modification biological process from the curated GO Biological Process Annotations dataset.

regulation of transcription from rna polymerase ii promoter by histone modification Gene Set

From GO Biological Process Annotations

genes participating in the regulation of transcription from rna polymerase ii promoter by histone modification biological process from the curated GO Biological Process Annotations dataset.

protein modification by small protein removal Gene Set

From GO Biological Process Annotations

genes participating in the protein modification by small protein removal biological process from the curated GO Biological Process Annotations dataset.

histone h3-k9 modification Gene Set

From GO Biological Process Annotations

genes participating in the histone h3-k9 modification biological process from the curated GO Biological Process Annotations dataset.

modification by symbiont of host morphology or physiology Gene Set

From GO Biological Process Annotations

genes participating in the modification by symbiont of host morphology or physiology biological process from the curated GO Biological Process Annotations dataset.

protein modification by small protein conjugation or removal Gene Set

From GO Biological Process Annotations

genes participating in the protein modification by small protein conjugation or removal biological process from the curated GO Biological Process Annotations dataset.

terminal O-glycans residues modification Gene Set

From HumanCyc Pathways

proteins participating in the terminal O-glycans residues modification pathway from the HumanCyc Pathways dataset.

tRNA-i(6)A37 modification enzyme MiaB Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the tRNA-i(6)A37 modification enzyme MiaB protein domain from the InterPro Predicted Protein Domain Annotations dataset.

tRNA modification GTPase MnmE domain 2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the tRNA modification GTPase MnmE domain 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Chromatin modification-related protein Eaf7/MRGBP Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Chromatin modification-related protein Eaf7/MRGBP protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Ribosomal S6 modification enzyme RimK/Lysine biosynthesis enzyme LysX Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Ribosomal S6 modification enzyme RimK/Lysine biosynthesis enzyme LysX protein domain from the InterPro Predicted Protein Domain Annotations dataset.

tRNA modification GTPase MnmE C-terminal domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the tRNA modification GTPase MnmE C-terminal domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Modification methylase HemK Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Modification methylase HemK protein domain from the InterPro Predicted Protein Domain Annotations dataset.

tRNA modification GTPase MnmE Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the tRNA modification GTPase MnmE protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Post-translational modification: synthesis of GPI-anchored proteins Gene Set

From Reactome Pathways

proteins participating in the Post-translational modification: synthesis of GPI-anchored proteins pathway from the Reactome Pathways dataset.

Post-translational protein modification Gene Set

From Reactome Pathways

proteins participating in the Post-translational protein modification pathway from the Reactome Pathways dataset.

Transport to the Golgi and subsequent modification Gene Set

From Reactome Pathways

proteins participating in the Transport to the Golgi and subsequent modification pathway from the Reactome Pathways dataset.

Histone modifications(Mus musculus) Gene Set

From Wikipathways Pathways

proteins participating in the Histone modifications(Mus musculus) pathway from the Wikipathways Pathways dataset.

Histone Modifications(Homo sapiens) Gene Set

From Wikipathways Pathways

proteins participating in the Histone Modifications(Homo sapiens) pathway from the Wikipathways Pathways dataset.

peptidyl Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term peptidyl in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

n-terminal peptidyl-serine dimethylation Gene Set

From GO Biological Process Annotations

genes participating in the n-terminal peptidyl-serine dimethylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-arginine n-methylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-arginine n-methylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-diphthamide metabolic process Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-diphthamide metabolic process biological process from the curated GO Biological Process Annotations dataset.

peptidyl-glutamic acid carboxylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-glutamic acid carboxylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-cysteine s-trans-nitrosylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-cysteine s-trans-nitrosylation biological process from the curated GO Biological Process Annotations dataset.

n-terminal peptidyl-glycine n-myristoylation Gene Set

From GO Biological Process Annotations

genes participating in the n-terminal peptidyl-glycine n-myristoylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-serine phosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-serine phosphorylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-histidine dephosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-histidine dephosphorylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-threonine phosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-threonine phosphorylation biological process from the curated GO Biological Process Annotations dataset.

n-terminal peptidyl-serine trimethylation Gene Set

From GO Biological Process Annotations

genes participating in the n-terminal peptidyl-serine trimethylation biological process from the curated GO Biological Process Annotations dataset.

regulation of peptidyl-serine phosphorylation of stat protein Gene Set

From GO Biological Process Annotations

genes participating in the regulation of peptidyl-serine phosphorylation of stat protein biological process from the curated GO Biological Process Annotations dataset.

peptidyl-lysine trimethylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-lysine trimethylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-l-cysteine s-palmitoylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-l-cysteine s-palmitoylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-lysine n6-acetylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-lysine n6-acetylation biological process from the curated GO Biological Process Annotations dataset.

n-terminal peptidyl-serine methylation Gene Set

From GO Biological Process Annotations

genes participating in the n-terminal peptidyl-serine methylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-lysine desuccinylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-lysine desuccinylation biological process from the curated GO Biological Process Annotations dataset.

negative regulation of peptidyl-cysteine s-nitrosylation Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of peptidyl-cysteine s-nitrosylation biological process from the curated GO Biological Process Annotations dataset.

n-terminal peptidyl-proline dimethylation Gene Set

From GO Biological Process Annotations

genes participating in the n-terminal peptidyl-proline dimethylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-lysine monomethylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-lysine monomethylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-lysine methylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-lysine methylation biological process from the curated GO Biological Process Annotations dataset.

n-terminal peptidyl-glutamic acid acetylation Gene Set

From GO Biological Process Annotations

genes participating in the n-terminal peptidyl-glutamic acid acetylation biological process from the curated GO Biological Process Annotations dataset.

negative regulation of peptidyl-serine phosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of peptidyl-serine phosphorylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-arginine omega-n-methylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-arginine omega-n-methylation biological process from the curated GO Biological Process Annotations dataset.

regulation of n-terminal peptidyl-lysine acetylation Gene Set

From GO Biological Process Annotations

genes participating in the regulation of n-terminal peptidyl-lysine acetylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-cysteine s-nitrosylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-cysteine s-nitrosylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase biological process from the curated GO Biological Process Annotations dataset.

peptidyl-serine acetylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-serine acetylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-pyrromethane cofactor linkage Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-pyrromethane cofactor linkage biological process from the curated GO Biological Process Annotations dataset.

n-terminal peptidyl-serine acetylation Gene Set

From GO Biological Process Annotations

genes participating in the n-terminal peptidyl-serine acetylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-serine trans-autophosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-serine trans-autophosphorylation biological process from the curated GO Biological Process Annotations dataset.

regulation of peptidyl-threonine phosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the regulation of peptidyl-threonine phosphorylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-serine octanoylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-serine octanoylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-aspartic acid hydroxylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-aspartic acid hydroxylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-proline hydroxylation to 3-hydroxy-l-proline Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-proline hydroxylation to 3-hydroxy-l-proline biological process from the curated GO Biological Process Annotations dataset.

peptidyl-proline hydroxylation to 4-hydroxy-l-proline Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-proline hydroxylation to 4-hydroxy-l-proline biological process from the curated GO Biological Process Annotations dataset.

peptidyl-arginine methylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-arginine methylation biological process from the curated GO Biological Process Annotations dataset.

negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation biological process from the curated GO Biological Process Annotations dataset.

regulation of peptidyl-serine phosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the regulation of peptidyl-serine phosphorylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-serine autophosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-serine autophosphorylation biological process from the curated GO Biological Process Annotations dataset.

n-terminal peptidyl-methionine acetylation Gene Set

From GO Biological Process Annotations

genes participating in the n-terminal peptidyl-methionine acetylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-lysine acetylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-lysine acetylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-histidine hydroxylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-histidine hydroxylation biological process from the curated GO Biological Process Annotations dataset.

protein-pyridoxal-5-phosphate linkage via peptidyl-n6-pyridoxal phosphate-l-lysine Gene Set

From GO Biological Process Annotations

genes participating in the protein-pyridoxal-5-phosphate linkage via peptidyl-n6-pyridoxal phosphate-l-lysine biological process from the curated GO Biological Process Annotations dataset.

negative regulation of peptidyl-serine dephosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of peptidyl-serine dephosphorylation biological process from the curated GO Biological Process Annotations dataset.

positive regulation of peptidyl-serine phosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of peptidyl-serine phosphorylation biological process from the curated GO Biological Process Annotations dataset.

positive regulation of peptidyl-cysteine s-nitrosylation Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of peptidyl-cysteine s-nitrosylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-lysine deacetylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-lysine deacetylation biological process from the curated GO Biological Process Annotations dataset.

n-terminal peptidyl-l-cysteine n-palmitoylation Gene Set

From GO Biological Process Annotations

genes participating in the n-terminal peptidyl-l-cysteine n-palmitoylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-asparagine hydroxylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-asparagine hydroxylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-lysine dimethylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-lysine dimethylation biological process from the curated GO Biological Process Annotations dataset.

regulation of peptidyl-cysteine s-nitrosylation Gene Set

From GO Biological Process Annotations

genes participating in the regulation of peptidyl-cysteine s-nitrosylation biological process from the curated GO Biological Process Annotations dataset.

n-terminal peptidyl-proline methylation Gene Set

From GO Biological Process Annotations

genes participating in the n-terminal peptidyl-proline methylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-lysine demalonylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-lysine demalonylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-serine dephosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-serine dephosphorylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-threonine dephosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-threonine dephosphorylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-arginine methylation, to symmetrical-dimethyl arginine Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-arginine methylation, to symmetrical-dimethyl arginine biological process from the curated GO Biological Process Annotations dataset.

positive regulation of peptidyl-serine dephosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of peptidyl-serine dephosphorylation biological process from the curated GO Biological Process Annotations dataset.

n-terminal peptidyl-lysine acetylation Gene Set

From GO Biological Process Annotations

genes participating in the n-terminal peptidyl-lysine acetylation biological process from the curated GO Biological Process Annotations dataset.

regulation of peptidyl-lysine acetylation Gene Set

From GO Biological Process Annotations

genes participating in the regulation of peptidyl-lysine acetylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-glutamine methylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-glutamine methylation biological process from the curated GO Biological Process Annotations dataset.

positive regulation of n-terminal peptidyl-lysine acetylation Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of n-terminal peptidyl-lysine acetylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-arginine methylation, to asymmetrical-dimethyl arginine Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-arginine methylation, to asymmetrical-dimethyl arginine biological process from the curated GO Biological Process Annotations dataset.

internal peptidyl-lysine acetylation Gene Set

From GO Biological Process Annotations

genes participating in the internal peptidyl-lysine acetylation biological process from the curated GO Biological Process Annotations dataset.

negative regulation of peptidyl-threonine phosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of peptidyl-threonine phosphorylation biological process from the curated GO Biological Process Annotations dataset.

protein peptidyl-prolyl isomerization Gene Set

From GO Biological Process Annotations

genes participating in the protein peptidyl-prolyl isomerization biological process from the curated GO Biological Process Annotations dataset.

n-terminal peptidyl-alanine methylation Gene Set

From GO Biological Process Annotations

genes participating in the n-terminal peptidyl-alanine methylation biological process from the curated GO Biological Process Annotations dataset.

positive regulation of peptidyl-lysine acetylation Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of peptidyl-lysine acetylation biological process from the curated GO Biological Process Annotations dataset.

regulation of peptidyl-serine dephosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the regulation of peptidyl-serine dephosphorylation biological process from the curated GO Biological Process Annotations dataset.

negative regulation of peptidyl-lysine acetylation Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of peptidyl-lysine acetylation biological process from the curated GO Biological Process Annotations dataset.

positive regulation of peptidyl-threonine phosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of peptidyl-threonine phosphorylation biological process from the curated GO Biological Process Annotations dataset.

positive regulation of peptidyl-serine phosphorylation of stat protein Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of peptidyl-serine phosphorylation of stat protein biological process from the curated GO Biological Process Annotations dataset.

peptidyl-cysteine methylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-cysteine methylation biological process from the curated GO Biological Process Annotations dataset.

n-terminal peptidyl-alanine trimethylation Gene Set

From GO Biological Process Annotations

genes participating in the n-terminal peptidyl-alanine trimethylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-proline hydroxylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-proline hydroxylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-cysteine oxidation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-cysteine oxidation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-lysine hydroxylation Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-lysine hydroxylation biological process from the curated GO Biological Process Annotations dataset.

peptidyl-lysine hydroxylation to 5-hydroxy-l-lysine Gene Set

From GO Biological Process Annotations

genes participating in the peptidyl-lysine hydroxylation to 5-hydroxy-l-lysine biological process from the curated GO Biological Process Annotations dataset.

peptidyl-prolyl cis-trans isomerase activity Gene Set

From GO Molecular Function Annotations

genes performing the peptidyl-prolyl cis-trans isomerase activity molecular function from the curated GO Molecular Function Annotations dataset.

peptidyl-cysteine s-nitrosylase activity Gene Set

From GO Molecular Function Annotations

genes performing the peptidyl-cysteine s-nitrosylase activity molecular function from the curated GO Molecular Function Annotations dataset.

peptidyl-dipeptidase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the peptidyl-dipeptidase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

peptidyl-proline 3-dioxygenase activity Gene Set

From GO Molecular Function Annotations

genes performing the peptidyl-proline 3-dioxygenase activity molecular function from the curated GO Molecular Function Annotations dataset.

peptidyl-lysine n-acetyltransferase activity, acting on acetyl phosphate as donor Gene Set

From GO Molecular Function Annotations

genes performing the peptidyl-lysine n-acetyltransferase activity, acting on acetyl phosphate as donor molecular function from the curated GO Molecular Function Annotations dataset.

peptidyl-dipeptidase activity Gene Set

From GO Molecular Function Annotations

genes performing the peptidyl-dipeptidase activity molecular function from the curated GO Molecular Function Annotations dataset.

peptidyl-lysine 5-dioxygenase activity Gene Set

From GO Molecular Function Annotations

genes performing the peptidyl-lysine 5-dioxygenase activity molecular function from the curated GO Molecular Function Annotations dataset.

peptidyl-proline 4-dioxygenase activity Gene Set

From GO Molecular Function Annotations

genes performing the peptidyl-proline 4-dioxygenase activity molecular function from the curated GO Molecular Function Annotations dataset.

peptidyl-histidine dioxygenase activity Gene Set

From GO Molecular Function Annotations

genes performing the peptidyl-histidine dioxygenase activity molecular function from the curated GO Molecular Function Annotations dataset.

peptidyl-asparagine 3-dioxygenase activity Gene Set

From GO Molecular Function Annotations

genes performing the peptidyl-asparagine 3-dioxygenase activity molecular function from the curated GO Molecular Function Annotations dataset.

peptidyl-proline dioxygenase activity Gene Set

From GO Molecular Function Annotations

genes performing the peptidyl-proline dioxygenase activity molecular function from the curated GO Molecular Function Annotations dataset.

Peptidyl-glycine alpha-amidating monooxygenase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Peptidyl-glycine alpha-amidating monooxygenase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Peptidyl-prolyl cis-trans isomerase, PpiC-type, conserved site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Peptidase M2, peptidyl-dipeptidase A Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Peptidase M2, peptidyl-dipeptidase A protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Peptidyl-tRNA hydrolase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Peptidyl-tRNA hydrolase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Peptidyl-prolyl cis-trans isomerase, PpiC-type Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Peptidyl-prolyl cis-trans isomerase, PpiC-type protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Peptidyl-tRNA hydrolase, conserved site Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Peptidyl-tRNA hydrolase, conserved site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Cyclophilin-type peptidyl-prolyl cis-trans isomerase E Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Cyclophilin-type peptidyl-prolyl cis-trans isomerase E protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Cyclophilin-type peptidyl-prolyl cis-trans isomerase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Cyclophilin-type peptidyl-prolyl cis-trans isomerase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Peptidyl-tRNA hydrolase, PTH2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Peptidyl-tRNA hydrolase, PTH2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Peptidyl-prolyl cis-trans isomerase, FKBP-type Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Peptidyl-prolyl cis-trans isomerase, FKBP-type protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Peptidyl-tRNA hydrolase II domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Peptidyl-tRNA hydrolase II domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

lck and fyn tyrosine kinases in initiation of tcr activation Gene Set

From Biocarta Pathways

proteins participating in the lck and fyn tyrosine kinases in initiation of tcr activation pathway from the Biocarta Pathways dataset.

sprouty regulation of tyrosine kinase signals Gene Set

From Biocarta Pathways

proteins participating in the sprouty regulation of tyrosine kinase signals pathway from the Biocarta Pathways dataset.

EGFR tyrosine kinase inhibitor 324674 Gene Set

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical EGFR tyrosine kinase inhibitor 324674 from the curated CTD Gene-Chemical Interactions dataset.

Tyrosine Kinase 2 Deficiency Gene Set

From CTD Gene-Disease Associations

genes/proteins associated with the disease Tyrosine Kinase 2 Deficiency from the curated CTD Gene-Disease Associations dataset.

Meta-Nitro-Tyrosine Gene Set

From DrugBank Drug Targets

interacting proteins for the Meta-Nitro-Tyrosine drug from the curated DrugBank Drug Targets dataset.

D-Tyrosine Gene Set

From DrugBank Drug Targets

interacting proteins for the D-Tyrosine drug from the curated DrugBank Drug Targets dataset.

Meta-Tyrosine Gene Set

From DrugBank Drug Targets

interacting proteins for the Meta-Tyrosine drug from the curated DrugBank Drug Targets dataset.

L-Tyrosine Gene Set

From DrugBank Drug Targets

interacting proteins for the L-Tyrosine drug from the curated DrugBank Drug Targets dataset.

BENZOYL-TYROSINE-ALANINE-METHYL KETONE Gene Set

From DrugBank Drug Targets

interacting proteins for the BENZOYL-TYROSINE-ALANINE-METHYL KETONE drug from the curated DrugBank Drug Targets dataset.

N-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE Gene Set

From DrugBank Drug Targets

interacting proteins for the N-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE drug from the curated DrugBank Drug Targets dataset.

tyrosine Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tyrosine in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

collagen-activated tyrosine kinase receptor signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the collagen-activated tyrosine kinase receptor signaling pathway biological process from the curated GO Biological Process Annotations dataset.

positive regulation of tyrosine phosphorylation of stat1 protein Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of tyrosine phosphorylation of stat1 protein biological process from the curated GO Biological Process Annotations dataset.

histone-tyrosine phosphorylation Gene Set

From GO Biological Process Annotations

genes participating in the histone-tyrosine phosphorylation biological process from the curated GO Biological Process Annotations dataset.

regulation of tyrosine phosphorylation of stat protein Gene Set

From GO Biological Process Annotations

genes participating in the regulation of tyrosine phosphorylation of stat protein biological process from the curated GO Biological Process Annotations dataset.

tyrosine metabolic process Gene Set

From GO Biological Process Annotations

genes participating in the tyrosine metabolic process biological process from the curated GO Biological Process Annotations dataset.

positive regulation of tyrosine 3-monooxygenase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of tyrosine 3-monooxygenase activity biological process from the curated GO Biological Process Annotations dataset.

dopamine biosynthetic process from tyrosine Gene Set

From GO Biological Process Annotations

genes participating in the dopamine biosynthetic process from tyrosine biological process from the curated GO Biological Process Annotations dataset.

regulation of tyrosine phosphorylation of stat5 protein Gene Set

From GO Biological Process Annotations

genes participating in the regulation of tyrosine phosphorylation of stat5 protein biological process from the curated GO Biological Process Annotations dataset.

positive regulation of tyrosine phosphorylation of stat protein Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of tyrosine phosphorylation of stat protein biological process from the curated GO Biological Process Annotations dataset.

transmembrane receptor protein tyrosine phosphatase signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the transmembrane receptor protein tyrosine phosphatase signaling pathway biological process from the curated GO Biological Process Annotations dataset.

positive regulation of tyrosine phosphorylation of stat3 protein Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of tyrosine phosphorylation of stat3 protein biological process from the curated GO Biological Process Annotations dataset.

tyrosine catabolic process Gene Set

From GO Biological Process Annotations

genes participating in the tyrosine catabolic process biological process from the curated GO Biological Process Annotations dataset.

melanin biosynthetic process from tyrosine Gene Set

From GO Biological Process Annotations

genes participating in the melanin biosynthetic process from tyrosine biological process from the curated GO Biological Process Annotations dataset.

positive regulation of tyrosine phosphorylation of stat6 protein Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of tyrosine phosphorylation of stat6 protein biological process from the curated GO Biological Process Annotations dataset.

regulation of tyrosine phosphorylation of stat6 protein Gene Set

From GO Biological Process Annotations

genes participating in the regulation of tyrosine phosphorylation of stat6 protein biological process from the curated GO Biological Process Annotations dataset.

regulation of tyrosine phosphorylation of stat4 protein Gene Set

From GO Biological Process Annotations

genes participating in the regulation of tyrosine phosphorylation of stat4 protein biological process from the curated GO Biological Process Annotations dataset.

tyrosine phosphorylation of stat2 protein Gene Set

From GO Biological Process Annotations

genes participating in the tyrosine phosphorylation of stat2 protein biological process from the curated GO Biological Process Annotations dataset.

negative regulation of tyrosine phosphorylation of stat1 protein Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of tyrosine phosphorylation of stat1 protein biological process from the curated GO Biological Process Annotations dataset.

tyrosine phosphorylation of stat5 protein Gene Set

From GO Biological Process Annotations

genes participating in the tyrosine phosphorylation of stat5 protein biological process from the curated GO Biological Process Annotations dataset.

regulation of tyrosine phosphorylation of stat1 protein Gene Set

From GO Biological Process Annotations

genes participating in the regulation of tyrosine phosphorylation of stat1 protein biological process from the curated GO Biological Process Annotations dataset.

activation of transmembrane receptor protein tyrosine kinase activity Gene Set

From GO Biological Process Annotations

genes participating in the activation of transmembrane receptor protein tyrosine kinase activity biological process from the curated GO Biological Process Annotations dataset.

transmembrane receptor protein tyrosine kinase signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the transmembrane receptor protein tyrosine kinase signaling pathway biological process from the curated GO Biological Process Annotations dataset.

positive regulation of tyrosine phosphorylation of stat4 protein Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of tyrosine phosphorylation of stat4 protein biological process from the curated GO Biological Process Annotations dataset.

negative regulation of tyrosine phosphorylation of stat protein Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of tyrosine phosphorylation of stat protein biological process from the curated GO Biological Process Annotations dataset.

tyrosine phosphorylation of stat1 protein Gene Set

From GO Biological Process Annotations

genes participating in the tyrosine phosphorylation of stat1 protein biological process from the curated GO Biological Process Annotations dataset.

tyrosine transport Gene Set

From GO Biological Process Annotations

genes participating in the tyrosine transport biological process from the curated GO Biological Process Annotations dataset.

tyrosine phosphorylation of stat3 protein Gene Set

From GO Biological Process Annotations

genes participating in the tyrosine phosphorylation of stat3 protein biological process from the curated GO Biological Process Annotations dataset.

tyrosine phosphorylation of stat protein Gene Set

From GO Biological Process Annotations

genes participating in the tyrosine phosphorylation of stat protein biological process from the curated GO Biological Process Annotations dataset.

negative regulation of tyrosine phosphorylation of stat3 protein Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of tyrosine phosphorylation of stat3 protein biological process from the curated GO Biological Process Annotations dataset.

regulation of tyrosine 3-monooxygenase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of tyrosine 3-monooxygenase activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of tyrosine phosphorylation of stat6 protein Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of tyrosine phosphorylation of stat6 protein biological process from the curated GO Biological Process Annotations dataset.

negative regulation of tyrosine phosphorylation of stat5 protein Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of tyrosine phosphorylation of stat5 protein biological process from the curated GO Biological Process Annotations dataset.

negative regulation of protein tyrosine kinase activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of protein tyrosine kinase activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of tyrosine phosphorylation of stat5 protein Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of tyrosine phosphorylation of stat5 protein biological process from the curated GO Biological Process Annotations dataset.

regulation of tyrosine phosphorylation of stat3 protein Gene Set

From GO Biological Process Annotations

genes participating in the regulation of tyrosine phosphorylation of stat3 protein biological process from the curated GO Biological Process Annotations dataset.

regulation of protein tyrosine kinase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of protein tyrosine kinase activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of protein tyrosine kinase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of protein tyrosine kinase activity biological process from the curated GO Biological Process Annotations dataset.

tyrosine binding Gene Set

From GO Molecular Function Annotations

genes performing the tyrosine binding molecular function from the curated GO Molecular Function Annotations dataset.

l-tyrosine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the l-tyrosine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

tubulin-tyrosine ligase activity Gene Set

From GO Molecular Function Annotations

genes performing the tubulin-tyrosine ligase activity molecular function from the curated GO Molecular Function Annotations dataset.

tyrosine 3-monooxygenase activator activity Gene Set

From GO Molecular Function Annotations

genes performing the tyrosine 3-monooxygenase activator activity molecular function from the curated GO Molecular Function Annotations dataset.

receptor signaling protein tyrosine phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the receptor signaling protein tyrosine phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

protein serine/threonine/tyrosine kinase activity Gene Set

From GO Molecular Function Annotations

genes performing the protein serine/threonine/tyrosine kinase activity molecular function from the curated GO Molecular Function Annotations dataset.

prenylated protein tyrosine phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the prenylated protein tyrosine phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

transmembrane receptor protein tyrosine phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the transmembrane receptor protein tyrosine phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

map kinase tyrosine/serine/threonine phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the map kinase tyrosine/serine/threonine phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

protein tyrosine kinase collagen receptor activity Gene Set

From GO Molecular Function Annotations

genes performing the protein tyrosine kinase collagen receptor activity molecular function from the curated GO Molecular Function Annotations dataset.

receptor tyrosine kinase-like orphan receptor binding Gene Set

From GO Molecular Function Annotations

genes performing the receptor tyrosine kinase-like orphan receptor binding molecular function from the curated GO Molecular Function Annotations dataset.

receptor signaling protein tyrosine kinase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the receptor signaling protein tyrosine kinase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

receptor signaling protein tyrosine kinase activity Gene Set

From GO Molecular Function Annotations

genes performing the receptor signaling protein tyrosine kinase activity molecular function from the curated GO Molecular Function Annotations dataset.

l-tyrosine aminotransferase activity Gene Set

From GO Molecular Function Annotations

genes performing the l-tyrosine aminotransferase activity molecular function from the curated GO Molecular Function Annotations dataset.

protein tyrosine phosphatase activator activity Gene Set

From GO Molecular Function Annotations

genes performing the protein tyrosine phosphatase activator activity molecular function from the curated GO Molecular Function Annotations dataset.

receptor tyrosine kinase binding Gene Set

From GO Molecular Function Annotations

genes performing the receptor tyrosine kinase binding molecular function from the curated GO Molecular Function Annotations dataset.

protein-tyrosine sulfotransferase activity Gene Set

From GO Molecular Function Annotations

genes performing the protein-tyrosine sulfotransferase activity molecular function from the curated GO Molecular Function Annotations dataset.

receptor signaling protein tyrosine kinase activator activity Gene Set

From GO Molecular Function Annotations

genes performing the receptor signaling protein tyrosine kinase activator activity molecular function from the curated GO Molecular Function Annotations dataset.

non-membrane spanning protein tyrosine kinase activity Gene Set

From GO Molecular Function Annotations

genes performing the non-membrane spanning protein tyrosine kinase activity molecular function from the curated GO Molecular Function Annotations dataset.

protein tyrosine/serine/threonine phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the protein tyrosine/serine/threonine phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

transmembrane receptor protein tyrosine kinase activity Gene Set

From GO Molecular Function Annotations

genes performing the transmembrane receptor protein tyrosine kinase activity molecular function from the curated GO Molecular Function Annotations dataset.

protein tyrosine/threonine phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the protein tyrosine/threonine phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

protein tyrosine kinase activity Gene Set

From GO Molecular Function Annotations

genes performing the protein tyrosine kinase activity molecular function from the curated GO Molecular Function Annotations dataset.

protein tyrosine kinase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the protein tyrosine kinase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

protein tyrosine phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the protein tyrosine phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

protein tyrosine kinase activator activity Gene Set

From GO Molecular Function Annotations

genes performing the protein tyrosine kinase activator activity molecular function from the curated GO Molecular Function Annotations dataset.

transmembrane receptor protein tyrosine kinase activator activity Gene Set

From GO Molecular Function Annotations

genes performing the transmembrane receptor protein tyrosine kinase activator activity molecular function from the curated GO Molecular Function Annotations dataset.

non-membrane spanning protein tyrosine phosphatase activity Gene Set

From GO Molecular Function Annotations

genes performing the non-membrane spanning protein tyrosine phosphatase activity molecular function from the curated GO Molecular Function Annotations dataset.

transmembrane receptor protein tyrosine kinase adaptor activity Gene Set

From GO Molecular Function Annotations

genes performing the transmembrane receptor protein tyrosine kinase adaptor activity molecular function from the curated GO Molecular Function Annotations dataset.

tyrosine-trna ligase activity Gene Set

From GO Molecular Function Annotations

genes performing the tyrosine-trna ligase activity molecular function from the curated GO Molecular Function Annotations dataset.

l-tyrosine:2-oxoglutarate aminotransferase activity Gene Set

From GO Molecular Function Annotations

genes performing the l-tyrosine:2-oxoglutarate aminotransferase activity molecular function from the curated GO Molecular Function Annotations dataset.

tyrosine 3-monooxygenase activity Gene Set

From GO Molecular Function Annotations

genes performing the tyrosine 3-monooxygenase activity molecular function from the curated GO Molecular Function Annotations dataset.

histone tyrosine kinase activity Gene Set

From GO Molecular Function Annotations

genes performing the histone tyrosine kinase activity molecular function from the curated GO Molecular Function Annotations dataset.

3,5-Diiodo-L-tyrosine Gene Set

From HMDB Metabolites of Enzymes

interacting proteins for the 3,5-Diiodo-L-tyrosine metabolite from the curated HMDB Metabolites of Enzymes dataset.

L-Tyrosine Gene Set

From HMDB Metabolites of Enzymes

interacting proteins for the L-Tyrosine metabolite from the curated HMDB Metabolites of Enzymes dataset.

N-Acetyl-L-tyrosine Gene Set

From HMDB Metabolites of Enzymes

interacting proteins for the N-Acetyl-L-tyrosine metabolite from the curated HMDB Metabolites of Enzymes dataset.

abnormality of tyrosine metabolism Gene Set

From HPO Gene-Disease Associations

genes associated with the abnormality of tyrosine metabolism phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

tyrosine degradation Gene Set

From HumanCyc Pathways

proteins participating in the tyrosine degradation pathway from the HumanCyc Pathways dataset.

phenylalanine degradation/tyrosine biosynthesis Gene Set

From HumanCyc Pathways

proteins participating in the phenylalanine degradation/tyrosine biosynthesis pathway from the HumanCyc Pathways dataset.

ALK tyrosine kinase receptor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the ALK tyrosine kinase receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Leukocyte tyrosine kinase receptor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Leukocyte tyrosine kinase receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein tyrosine phosphatase, receptor type, N-terminal Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein tyrosine phosphatase, receptor type, N-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter, C-terminal domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter, C-terminal domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase, receptor class V, conserved site Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase, receptor class V, conserved site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine hydroxylase, conserved site Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine hydroxylase, conserved site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Dual specificity tyrosine-phosphorylation-regulated kinase 1A Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Dual specificity tyrosine-phosphorylation-regulated kinase 1A protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase, receptor ROR Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase, receptor ROR protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase-like, PTPLA Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase-like, PTPLA protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-tRNA ligase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-tRNA ligase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase, receptor class III, conserved site Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase, receptor class III, conserved site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase, non-receptor type-3, -4 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase, non-receptor type-3, -4 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase, non-receptor type-6, -11 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase, non-receptor type-6, -11 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tubulin-tyrosine ligase/Tubulin polyglutamylase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tubulin-tyrosine ligase/Tubulin polyglutamylase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase, non-receptor type-1/2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase, non-receptor type-1/2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Heparan sulphate 6-sulfotransferase/Protein-tyrosine sulfotransferase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Heparan sulphate 6-sulfotransferase/Protein-tyrosine sulfotransferase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase, Ret receptor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase, Ret receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine 3-monooxygenase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine 3-monooxygenase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase, neurotrophic receptor, type 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase, neurotrophic receptor, type 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase, neurotrophic receptor, type 2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase, neurotrophic receptor, type 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase, neurotrophic receptor, type 3 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase, neurotrophic receptor, type 3 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Receptor tyrosine-protein phosphatase, alpha/epsilon-type Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Receptor tyrosine-protein phosphatase, alpha/epsilon-type protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase Fgr Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase Fgr protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase, Fes/Fps type Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase, Fes/Fps type protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-tRNA ligase, bacterial-type Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-tRNA ligase, bacterial-type protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase Fer Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase Fer protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase, HGF/MSP receptor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase, HGF/MSP receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase/arsenate reductase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase/arsenate reductase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase, receptor/non-receptor type Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase, receptor/non-receptor type protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine/Dual specificity phosphatase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine/Dual specificity phosphatase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase, receptor class II, conserved site Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase, receptor class II, conserved site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Cytoplasmic tyrosine-protein kinase BMX Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Cytoplasmic tyrosine-protein kinase BMX protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Non-receptor tyrosine-protein phosphatase 22 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Non-receptor tyrosine-protein phosphatase 22 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase, KIM-containing Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase, KIM-containing protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase, catalytic domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase, catalytic domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase receptor IA-2 ectodomain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase receptor IA-2 ectodomain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein phosphatase non-receptor type 23 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein phosphatase non-receptor type 23 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase, non-receptor type-12 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase, non-receptor type-12 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase, receptor Tie-2, Ig-like domain 1, N-terminal Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase, receptor Tie-2, Ig-like domain 1, N-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Serine-threonine/tyrosine-protein kinase catalytic domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Serine-threonine/tyrosine-protein kinase catalytic domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase, non-receptor, TYK2, N-terminal Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase, non-receptor, TYK2, N-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase, low molecular weight Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase, low molecular weight protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase, CSF-1/PDGF receptor family Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase, CSF-1/PDGF receptor family protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine aminotransferase ubiquitination region Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine aminotransferase ubiquitination region protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Cysteine and tyrosine-rich protein 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Cysteine and tyrosine-rich protein 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase-like Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase-like protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase, neurotrophic receptor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase, neurotrophic receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine/nicotianamine aminotransferase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine/nicotianamine aminotransferase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine protein kinase, EGF/ERB/XmrK receptor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine protein kinase, EGF/ERB/XmrK receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine sulfotransferase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine sulfotransferase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase, non-receptor SYK/ZAP-70 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase, non-receptor SYK/ZAP-70 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Receptor tyrosine-protein phosphatase alpha Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Receptor tyrosine-protein phosphatase alpha protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Hepatocyte growth factor-regulated tyrosine kinase substrate, helical domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Receptor tyrosine-protein phosphatase C-associated protein CD45-AP Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Receptor tyrosine-protein phosphatase C-associated protein CD45-AP protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase, non-receptor Jak/Tyk2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase, non-receptor Jak/Tyk2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine aminotransferase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine aminotransferase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase, insulin-like receptor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase, insulin-like receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase, non-receptor type-14, -21 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase, non-receptor type-14, -21 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase, active site Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase, active site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Dual specificity/tyrosine protein phosphatase, N-terminal Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Dual specificity/tyrosine protein phosphatase, N-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase, non-receptor Jak2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase, non-receptor Jak2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase, non-receptor Jak3 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase, non-receptor Jak3 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase, non-receptor Jak1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase, non-receptor Jak1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase ephrin type A/B receptor-like Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase ephrin type A/B receptor-like protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase, low molecular weight, mammalian Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase, low molecular weight, mammalian protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine/threonine-protein kinase, Cdc2 inhibitor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine/threonine-protein kinase, Cdc2 inhibitor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein phosphatase non-receptor type 13 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein phosphatase non-receptor type 13 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine-protein kinase, active site Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine-protein kinase, active site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Receptor-type tyrosine-protein phosphatase C Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Receptor-type tyrosine-protein phosphatase C protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein-tyrosine phosphatase, receptor type R/non-receptor type 5 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein-tyrosine phosphatase, receptor type R/non-receptor type 5 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

TYRO protein tyrosine kinase-binding protein Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the TYRO protein tyrosine kinase-binding protein protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine 3-monooxygenase-like Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine 3-monooxygenase-like protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1/2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 1/2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Receptor-type tyrosine-protein kinase FLT3 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Receptor-type tyrosine-protein kinase FLT3 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tubulin--tyrosine ligase-like protein 12 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tubulin--tyrosine ligase-like protein 12 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

phenylalanine tyrosine and tryptophan biosynthesis Gene Set

From KEGG Pathways

proteins participating in the phenylalanine tyrosine and tryptophan biosynthesis pathway from the KEGG Pathways dataset.

tyrosine metabolism Gene Set

From KEGG Pathways

proteins participating in the tyrosine metabolism pathway from the KEGG Pathways dataset.

BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_HCC515_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_PC3_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_VCAP_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_HA1E_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_HA1E_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_PC3_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_PC3_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_VCAP_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_PC3_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_VCAP_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_HCC515_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

adenocarcinoma of lung, response to tyrosine kinase inhibitor in Gene Set

From OMIM Gene-Disease Associations

genes associated with the adenocarcinoma of lung, response to tyrosine kinase inhibitor in phenotype from the curated OMIM Gene-Disease Associations dataset.

nonsmall cell lung cancer, response to tyrosine kinase inhibitor in Gene Set

From OMIM Gene-Disease Associations

genes associated with the nonsmall cell lung cancer, response to tyrosine kinase inhibitor in phenotype from the curated OMIM Gene-Disease Associations dataset.

receptor-protein-tyrosine-kinases Gene Set

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term receptor-protein-tyrosine-kinases in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

tyrosine-phosphorylated Gene Set

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term tyrosine-phosphorylated in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

zap-70-protein-tyrosine-kinase Gene Set

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term zap-70-protein-tyrosine-kinase in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Signaling events regulated by Ret tyrosine kinase Gene Set

From PID Pathways

proteins participating in the Signaling events regulated by Ret tyrosine kinase pathway from the PID Pathways dataset.

Phenylalanine and tyrosine catabolism Gene Set

From Reactome Pathways

proteins participating in the Phenylalanine and tyrosine catabolism pathway from the Reactome Pathways dataset.