Name

MCM4 Gene

minichromosome maintenance complex component 4

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

mcm4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mcm4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

MCM4 Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for MCM4 from the MSigDB Cancer Gene Co-expression Modules dataset.

MCM4 Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for MCM4 from the NURSA Protein-Protein Interactions dataset.

MCM4 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for MCM4 from the Pathway Commons Protein-Protein Interactions dataset.

MCM2-MCM4-MCM6-MCM7 complex Gene Set

From CORUM Protein Complexes

proteins in the MCM2-MCM4-MCM6-MCM7 complex protein complex from the CORUM Protein Complexes dataset.

MCM4-MCM6-MCM7 complex Gene Set

From CORUM Protein Complexes

proteins in the MCM4-MCM6-MCM7 complex protein complex from the CORUM Protein Complexes dataset.

mcm4prkdc Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mcm4prkdc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.