Name

CTSH Gene

cathepsin H

The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. [provided by RefSeq, Mar 2010]

CTSK Gene

cathepsin K

The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. [provided by RefSeq, Apr 2013]

CTSL Gene

cathepsin L

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]

CTSO Gene

cathepsin O

The protein encoded by the gene is a cysteine proteinase and a member of the papain superfamily. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases and its proteolytic activity was abolished by an inhibitor of cyteine proteinase. [provided by RefSeq, Jul 2008]

CTSA Gene

cathepsin A

This gene encodes a glycoprotein which associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high molecular weight multimers. The formation of this complex provides a protective role for stability and activity. Deficiencies in this gene are linked to multiple forms of galactosialidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CTSB Gene

cathepsin B

The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

CTSC Gene

cathepsin C

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CTSD Gene

cathepsin D

This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008]

CTSE Gene

cathepsin E

The protein encoded by this gene is a gastric aspartyl protease that functions as a disulfide-linked homodimer. This protease, which is a member of the peptidase C1 family, has a specificity similar to that of pepsin A and cathepsin D. It is an intracellular proteinase that does not appear to be involved in the digestion of dietary protein and is found in highest concentration in the surface of epithelial mucus-producing cells of the stomach. It is the first aspartic proteinase expressed in the fetal stomach and is found in more than half of gastric cancers. It appears, therefore, to be an oncofetal antigen. Transcript variants utilizing alternative polyadenylation signals and two transcript variants encoding different isoforms exist for this gene. [provided by RefSeq, Jul 2008]

CTSF Gene

cathepsin F

Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W. [provided by RefSeq, Jul 2008]

CTSG Gene

cathepsin G

The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. In addition, the encoded protein is antimicrobial, with bacteriocidal activity against S. aureus and N. gonorrhoeae. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Sep 2014]

CTSZ Gene

cathepsin Z

The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008]

CTSS Gene

cathepsin S

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

CTSV Gene

cathepsin V

The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may play an important role in corneal physiology. This gene is expressed in colorectal and breast carcinomas but not in normal colon, mammary gland, or peritumoral tissues, suggesting a possible role for this gene in tumor processes. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2011]

CTSW Gene

cathepsin W

The protein encoded by this gene, a member of the peptidase C1 family, is a cysteine proteinase that may have a specific function in the mechanism or regulation of T-cell cytolytic activity. The encoded protein is found associated with the membrane inside the endoplasmic reticulum of natural killer and cytotoxic T-cells. Expression of this gene is up-regulated by interleukin-2. [provided by RefSeq, Jul 2008]

CTSLP6 Gene

cathepsin L pseudogene 6

CTSLP4 Gene

cathepsin L pseudogene 4

CTSLP2 Gene

cathepsin L pseudogene 2

CTSLP1 Gene

cathepsin L pseudogene 1

CTSLP8 Gene

cathepsin L pseudogene 8

CTSL3P Gene

cathepsin L family member 3, pseudogene

CTSLP3 Gene

cathepsin L pseudogene 3

cts Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cts in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SERPINA3-CTSG complex Gene Set

From CORUM Protein Complexes

proteins in the SERPINA3-CTSG complex protein complex from the CORUM Protein Complexes dataset.

SERPINA1-CTSG complex Gene Set

From CORUM Protein Complexes

proteins in the SERPINA1-CTSG complex protein complex from the CORUM Protein Complexes dataset.

CTS-21166 Gene Set

From DrugBank Drug Targets

interacting proteins for the CTS-21166 drug from the curated DrugBank Drug Targets dataset.

ctslmediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctslmediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctshmediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctshmediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctsh Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctsh in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctsk Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctsk in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctsb Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctsb in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctsd Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctsd in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctsg Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctsg in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctsz Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctsz in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctsv Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctsv in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctss Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctss in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctsdt Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctsdt in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctsdwere Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctsdwere in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctsl Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctsl in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctse Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctse in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctsspar2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctsspar2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ctsl2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ctsl2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CTSB Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for CTSB from the MSigDB Cancer Gene Co-expression Modules dataset.

CTSD Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for CTSD from the NURSA Protein-Protein Interactions dataset.

CTSD Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CTSD from the Pathway Commons Protein-Protein Interactions dataset.

CTSF Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CTSF from the Pathway Commons Protein-Protein Interactions dataset.

CTSS Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CTSS from the Pathway Commons Protein-Protein Interactions dataset.

CTSH Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CTSH from the Pathway Commons Protein-Protein Interactions dataset.

CTSK Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CTSK from the Pathway Commons Protein-Protein Interactions dataset.

CTSO Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CTSO from the Pathway Commons Protein-Protein Interactions dataset.

CTSA Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CTSA from the Pathway Commons Protein-Protein Interactions dataset.

CTSB Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CTSB from the Pathway Commons Protein-Protein Interactions dataset.

CTSC Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CTSC from the Pathway Commons Protein-Protein Interactions dataset.

CTSE Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CTSE from the Pathway Commons Protein-Protein Interactions dataset.

CTSZ Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CTSZ from the Pathway Commons Protein-Protein Interactions dataset.

CTSW Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CTSW from the Pathway Commons Protein-Protein Interactions dataset.

CTSG Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CTSG from the Pathway Commons Protein-Protein Interactions dataset.