Name

GO Cellular Component Annotations Dataset

From Gene Ontology

curated annotations of genes with cellular components

GHRH Gene

growth hormone releasing hormone

The protein encoded by this gene belongs to the glucagon family and is a preproprotein that is produced in the hypothalamus. The preproprotein is cleaved to form a 44 aa factor, also called somatocrinin, that acts to stimulate growth hormone release from the pituitary. Variant receptors for somatocrinin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. [provided by RefSeq, Jul 2008]

GHRHR Gene

growth hormone releasing hormone receptor

This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010]

SRF Gene

serum response factor (c-fos serum response element-binding transcription factor)

This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

EGR2 Gene

early growth response 2

The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

EGR3 Gene

early growth response 3

This gene encodes a transcriptional regulator that belongs to the EGR family of C2H2-type zinc-finger proteins. It is an immediate-early growth response gene which is induced by mitogenic stimulation. The protein encoded by this gene participates in the transcriptional regulation of genes in controling biological rhythm. It may also play a role in a wide variety of processes including muscle development, lymphocyte development, endothelial cell growth and migration, and neuronal development. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2010]

EGR1 Gene

early growth response 1

The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]

EGR4 Gene

early growth response 4

PTHLH Gene

parathyroid hormone-like hormone

The protein encoded by this gene is a member of the parathyroid hormone family. This hormone, via its receptor, PTHR1, regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. It is responsible for most cases of humoral hypercalcemia of malignancy, and mutations in this gene are associated with brachydactyly type E2 (BDE2). Alternatively spliced transcript variants have been found for this gene. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, downstream of the initiator AUG codon, resulting in nuclear forms of this hormone. [provided by RefSeq, Nov 2013]

GNRH1 Gene

gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)

The protein encoded by this gene is secreted and then cleaved to form the 10 aa luteinizing hormone-releasing hormone (LHRH, also known as gonadoliberin-1), and prolactin release-inhibiting factor (also known as GnRH-associated peptide 1). LHRH stimulates the release of luteinizing and follicle stimulating hormones, which are important for reproduction. Mutation in this gene are associated with hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2012]

GHITM Gene

growth hormone inducible transmembrane protein

GRTP1 Gene

growth hormone regulated TBC protein 1

GHR Gene

growth hormone receptor

This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]

GH1 Gene

growth hormone 1

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature. [provided by RefSeq, Jul 2008]

GH2 Gene

growth hormone 2

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency. [provided by RefSeq, Jul 2008]

AGMX2 Gene

agammaglobulinemia, X-linked 2 (with growth hormone deficiency)

GHSR Gene

growth hormone secretagogue receptor

This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.[provided by RefSeq, Apr 2010]

CRABP1 Gene

cellular retinoic acid binding protein 1

This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. [provided by RefSeq, Jul 2008]

CREG1 Gene

cellular repressor of E1A-stimulated genes 1

The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008]

CREG2 Gene

cellular repressor of E1A-stimulated genes 2

HAVCR1 Gene

hepatitis A virus cellular receptor 1

The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4, 12 and 19. [provided by RefSeq, Apr 2015]

SEN2 Gene

senescence (cellular)-related 2

SEN3 Gene

senescence (cellular)-related 3

SEN6 Gene

senescence (cellular)-related 6

FLVCR2 Gene

feline leukemia virus subgroup C cellular receptor family, member 2

This gene encodes a member of the major facilitator superfamily. The encoded transmembrane protein is a calcium transporter. Unlike the related protein feline leukemia virus subgroup C receptor 1, the protein encoded by this locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may play a role in development of brain vascular endothelial cells, as mutations at this locus have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Aug 2010]

FLVCR1 Gene

feline leukemia virus subgroup C cellular receptor 1

This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein is a heme transporter that may play a critical role in erythropoiesis by protecting developing erythroid cells from heme toxicity. This gene may play a role in posterior column ataxia with retinitis pigmentosa and the hematological disorder Diamond-Blackfan syndrome. [provided by RefSeq, Jan 2011]

CRABP2 Gene

cellular retinoic acid binding protein 2

This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2010]

HAVCR1P2 Gene

hepatitis A virus cellular receptor 1 pseudogene 2

SEN6A Gene

senescence (cellular)-related 6A

SEN6B Gene

senescence (cellular)-related 6B

RBP1 Gene

retinol binding protein 1, cellular

This gene encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

RBP2 Gene

retinol binding protein 2, cellular

RBP2 is an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. RBP2 may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle. [provided by RefSeq, Jul 2008]

RBP5 Gene

retinol binding protein 5, cellular

RBP7 Gene

retinol binding protein 7, cellular

Due to its chemical instability and low solubility in aqueous solution, vitamin A requires cellular retinol-binding proteins (CRBPs), such as RBP7, for stability, internalization, intercellular transfer, homeostasis, and metabolism.[supplied by OMIM, May 2004]

HAVCR2 Gene

hepatitis A virus cellular receptor 2

The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]

LOC100421061 Gene

hepatitis A virus cellular receptor 1 pseudogene

HAVCR1P1 Gene

hepatitis A virus cellular receptor 1 pseudogene 1

FIGF Gene

c-fos induced growth factor (vascular endothelial growth factor D)

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus. [provided by RefSeq, Feb 2011]

IGAT Gene

Immune response to synthetic polypeptide--IRGAT

IER3IP1 Gene

immediate early response 3 interacting protein 1

This gene encodes a small protein that is localized to the endoplasmic reticulum (ER) and may play a role in the ER stress response by mediating cell differentiation and apoptosis. Transcription of this gene is regulated by tumor necrosis factor alpha and specificity protein 1 (Sp1). Mutations in this gene may play a role in microcephaly, epilepsy, and diabetes syndrome (MEDS), and a pseudogene of this gene is located on the long arm of chromosome 12. [provided by RefSeq, Dec 2011]

SPHAR Gene

S-phase response (cyclin related)

SDPR Gene

serum deprivation response

This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.[provided by RefSeq, Sep 2009]

IER5L Gene

immediate early response 5-like

AIR Gene

Acute insulin response (2)

MYD88 Gene

myeloid differentiation primary response 88

This gene encodes a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and Toll-like receptor signaling pathways. These pathways regulate that activation of numerous proinflammatory genes. The encoded protein consists of an N-terminal death domain and a C-terminal Toll-interleukin1 receptor domain. Patients with defects in this gene have an increased susceptibility to pyogenic bacterial infections. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

NRIR Gene

negative regulator of interferon response (non-protein coding)

This gene is thought to produce a functional long non-coding RNA. This transcript may be a negative regulator of interferon response. [provided by RefSeq, Feb 2015]

CRMP1 Gene

collapsin response mediator protein 1

This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

NRAV Gene

negative regulator of antiviral response (non-protein coding)

IGLP1 Gene

immune response to synthetic polypeptides 1

IGLP2 Gene

immune response to synthetic polypeptides 2

IER5 Gene

immediate early response 5

This gene encodes a protein that is similar to other immediate early response proteins. In the mouse, a similar gene may play an important role in mediating the cellular response to mitogenic signals. Studies in rats found the expression of a similar gene to be increased after waking and sleep deprivation. [provided by RefSeq, Jul 2008]

IER2 Gene

immediate early response 2

IER3 Gene

immediate early response 3

This gene functions in the protection of cells from Fas- or tumor necrosis factor type alpha-induced apoptosis. Partially degraded and unspliced transcripts are found after virus infection in vitro, but these transcripts are not found in vivo and do not generate a valid protein. [provided by RefSeq, Jul 2008]

SRFBP1 Gene

serum response factor binding protein 1

MIER3 Gene

mesoderm induction early response 1, family member 3

BAS Gene

Beta-adrenergic stimulation, response to

PPR2 Gene

Photoparoxysmal response 2

PPR3 Gene

photoparoxysmal response 3

PPR1 Gene

Photoparoxysmal response 1

MIER1 Gene

mesoderm induction early response 1, transcriptional regulator

This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013]

MIER2 Gene

mesoderm induction early response 1, family member 2

LOC724085 Gene

immediate early response 3 interacting protein 1 pseudogene

MYOC Gene

myocilin, trabecular meshwork inducible glucocorticoid response

MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma. [provided by RefSeq, Jul 2008]

MTF2 Gene

metal response element binding transcription factor 2

STAT3 Gene

signal transducer and activator of transcription 3 (acute-phase response factor)

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

TRHR Gene

thyrotropin-releasing hormone receptor

This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011]

LOC100421595 Gene

thyroid hormone receptor associated protein 3 pseudogene

CSHL1 Gene

chorionic somatomammotropin hormone-like 1

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. This particular family member is expressed in placental villi, although it was originally thought to be a pseudogene. In fact, alternative splicing suggests that the majority of the transcripts would be unable to express a secreted protein. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GNRHR2P1 Gene

gonadotropin-releasing hormone (type 2) receptor 2 pseudogene 1

GPHA2 Gene

glycoprotein hormone alpha 2

GPHA2 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).[supplied by OMIM, Mar 2008]

THRB Gene

thyroid hormone receptor, beta

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]

THRA Gene

thyroid hormone receptor, alpha

The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

THRAP3P1 Gene

thyroid hormone receptor associated protein 3 pseudogene 1

LOC100310835 Gene

thyroid hormone receptor interactor 13 pseudogene

CRHBP Gene

corticotropin releasing hormone binding protein

Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]

AMH Gene

anti-Mullerian hormone

Anti-Mullerian hormone is a member of the transforming growth factor-beta gene family which mediates male sexual differentiation. Anti-Mullerian hormone causes the regression of Mullerian ducts which would otherwise differentiate into the uterus and fallopian tubes. Some mutations in the anti-Mullerian hormone result in persistent Mullerian duct syndrome. [provided by RefSeq, Jul 2008]

FSHB Gene

follicle stimulating hormone, beta polypeptide

The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

FSHR Gene

follicle stimulating hormone receptor

The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

PTH2R Gene

parathyroid hormone 2 receptor

The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

PMCHL2 Gene

pro-melanin-concentrating hormone-like 2, pseudogene

PMCHL1 Gene

pro-melanin-concentrating hormone-like 1, pseudogene

CRHR2 Gene

corticotropin releasing hormone receptor 2

The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]

CRHR1 Gene

corticotropin releasing hormone receptor 1

This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Readthrough transcription also exists between this gene and upstream GeneID:401884 (ADP-ribosylation factor 3 pseudogene), and the readthrough transcripts encode isoforms that share similarity with the products of this gene. [provided by RefSeq, Dec 2014]

TRIP6 Gene

thyroid hormone receptor interactor 6

This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

TSHQTL1 Gene

Thyroid-stimulating hormone level QTL 1

LHB Gene

luteinizing hormone beta polypeptide

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism. [provided by RefSeq, Jul 2008]

SHBG Gene

sex hormone-binding globulin

This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

TSHR Gene

thyroid stimulating hormone receptor

The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

PMCH Gene

pro-melanin-concentrating hormone

The melanin-concentrating hormone (MCH) is a cyclic neuropeptide isolated initially from salmon pituitary gland and later from rat hypothalamus. In mammals, MCH perikarya are confined largely to the lateral hypothalamus and zona incerta area with extensive neuronal projections throughout the brain, including the neurohypophysis. The anatomic distribution suggests a neurotransmitter or neuromodulator role for MCH in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. MCH and 2 other putative neuropeptides, NEI and NGE, are encoded by the same precursor and appear colocalized in nerve cells and in many instances within the projections. The precursor is designated pro-melanin-concentrating hormone (PMCH) (summary by Nahon et al., 1992 [PubMed 1572663]).[supplied by OMIM, Jan 2011]

MC2R Gene

melanocortin 2 receptor (adrenocorticotropic hormone)

MC2R encodes one member of the five-member G-protein associated melanocortin receptor family. Melanocortins (melanocyte-stimulating hormones and adrenocorticotropic hormone) are peptides derived from pro-opiomelanocortin (POMC). MC2R is selectively activated by adrenocorticotropic hormone, whereas the other four melanocortin receptors recognize a variety of melanocortin ligands. Mutations in MC2R can result in familial glucocorticoid deficiency. Alternate transcript variants have been found for this gene. [provided by RefSeq, May 2014]

SPX Gene

spexin hormone

GNRHR Gene

gonadotropin-releasing hormone receptor

This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008]

GNRH2 Gene

gonadotropin-releasing hormone 2

The protein encoded by this gene is a preproprotein that is cleaved to form a secreted 10 aa peptide hormone. The secreted decapeptide regulates reproduction in females by stimulating the secretion of both luteinizing- and follicle-stimulating hormones. Three transcript variants that encode unique proproteins but the same peptide hormone have been found for this gene. [provided by RefSeq, Jul 2008]

CRH Gene

corticotropin releasing hormone

Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Apr 2010]

GPHB5 Gene

glycoprotein hormone beta 5

GPHB5 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).[supplied by OMIM, Mar 2008]

PRLH Gene

prolactin releasing hormone

LOC100421169 Gene

thyroid hormone receptor interactor 11 pseudogene

THRSP Gene

thyroid hormone responsive

The protein encoded by this gene is similar to the gene product of S14, a rat gene whose expression is limited to liver and adipose tissue and is controlled by nutritional and hormonal factors. This gene has been shown to be expressed in liver and adipocytes, particularly in lipomatous modules. It is also found to be expressed in lipogenic breast cancers, which suggests a role in controlling tumor lipid metabolism. [provided by RefSeq, Jul 2008]

SLC16A2 Gene

solute carrier family 16, member 2 (thyroid hormone transporter)

This gene encodes an integral membrane protein that functions as a transporter of thyroid hormone. The encoded protein facilitates the cellular importation of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). This gene is expressed in many tissues and likely plays an important role in the development of the central nervous system. Loss of function mutations in this gene are associated with psychomotor retardation in males while females exhibit no neurological defects and more moderate thyroid-deficient phenotypes. This gene is subject to X-chromosome inactivation. Mutations in this gene are the cause of Allan-Herndon-Dudley syndrome. [provided by RefSeq, Mar 2012]

PTH2 Gene

parathyroid hormone 2

TIP39 is related to parathyroid hormone (PTH; MIM 168450) and PTH-related protein (PTHRP; MIM 168470) and is a ligand for PTH receptor-2 (PTHR2; MIM 601469) (John et al., 2002 [PubMed 11861531]).[supplied by OMIM, Mar 2008]

THRAP3 Gene

thyroid hormone receptor associated protein 3

CSH2 Gene

chorionic somatomammotropin hormone 2

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, while the ratio of 1 to 2 increases by term. Structural and expression differences provide avenues for developmental regulation and tissue specificity. [provided by RefSeq, Jul 2008]

CSH1 Gene

chorionic somatomammotropin hormone 1 (placental lactogen)

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, although the ratio of 1 to 2 increases by term. Mutations in this gene result in placental lactogen deficiency and Silver-Russell syndrome. [provided by RefSeq, Jul 2008]

LOC341378 Gene

thyroid hormone receptor interactor 11 pseudogene

TRH Gene

thyrotropin-releasing hormone

This gene encodes a member of the thyrotropin-releasing hormone family. Cleavage of the encoded proprotein releases mature thyrotropin-releasing hormone, which is a tripeptide hypothalamic regulatory hormone. The human proprotein contains six thyrotropin-releasing hormone tripeptides. Thyrotropin-releasing hormone is involved in the regulation and release of thyroid-stimulating hormone, as well as prolactin. Deficiency of this hormone has been associated with hypothalamic hypothyroidism. [provided by RefSeq, May 2013]

TRIP4 Gene

thyroid hormone receptor interactor 4

LOC100421632 Gene

thyroid hormone receptor associated protein 3 pseudogene

TSHRL1 Gene

thyroid stimulating hormone receptor-like 1

TSHB Gene

thyroid stimulating hormone, beta

The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]

LHCGR Gene

luteinizing hormone/choriogonadotropin receptor

This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq, Jul 2008]

PRLHR Gene

prolactin releasing hormone receptor

PRLHR is a 7-transmembrane domain receptor for prolactin-releasing hormone (PRLH; MIM 602663) that is highly expressed in anterior pituitary (Ozawa et al., 2002 [PubMed 11923475]).[supplied by OMIM, Mar 2008]

LIPE Gene

lipase, hormone-sensitive

The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008]

TSHRL3 Gene

thyroid stimulating hormone receptor-like 3

TSHRL2 Gene

thyroid stimulating hormone receptor-like 2

LOC100129554 Gene

thyroid hormone receptor interactor 4 pseudogene

AMHR2 Gene

anti-Mullerian hormone receptor, type II

This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2009]

TRHDE Gene

thyrotropin-releasing hormone degrading enzyme

This gene encodes a member of the peptidase M1 family. The encoded protein is an extracellular peptidase that specifically cleaves and inactivates the neuropeptide thyrotropin-releasing hormone.[provided by RefSeq, Dec 2008]

MC1R Gene

melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)

This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008]

PTH Gene

parathyroid hormone

The protein encoded by this gene is a hormone secreted by parathyroid cells. This hormone elevates blood Ca2+ level by dissolving the salts in bone and preventing their renal excretion. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH). [provided by RefSeq, Jul 2008]

TRIP10 Gene

thyroid hormone receptor interactor 10

TRIP11 Gene

thyroid hormone receptor interactor 11

This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010]

TRIP12 Gene

thyroid hormone receptor interactor 12

TRIP13 Gene

thyroid hormone receptor interactor 13

This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer. [provided by RefSeq, Oct 2009]

LOC100421173 Gene

thyroid hormone receptor interactor 11 pseudogene

LOC100421171 Gene

thyroid hormone receptor interactor 11 pseudogene

LOC100421174 Gene

thyroid hormone receptor interactor 13 pseudogene

GNRHR2 Gene

gonadotropin-releasing hormone (type 2) receptor 2, pseudogene

In non-hominoid primates and non-mammalian vertebrates, the gonadotropin releasing hormone 2 receptor gene (GnRHR2) encodes a seven-transmembrane G-protein coupled receptor. However, in human, the corresponding reading frame contains a premature stop codon, which has been suggested to encode a selenocysteine residue, but there is no solid evidence for selenocysteine incorporation (PMID: 12538601). It appears that the human GnRHR2 transcription occurs but the gene does not likely produce a functional multi-transmembrane protein. A non-transcribed pseudogene of GnRHR2 is located on chromosome 14. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2013]

MCHR2 Gene

melanin-concentrating hormone receptor 2

MCHR1 Gene

melanin-concentrating hormone receptor 1

The protein encoded by this gene, a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone. The encoded protein can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. [provided by RefSeq, Jul 2008]

PTH1R Gene

parathyroid hormone 1 receptor

The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]

SXGQTL1 Gene

Sex hormone-binding blobulin circulating level QTL 1

IGF2R Gene

insulin-like growth factor 2 receptor

This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the maternal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele. [provided by RefSeq, Apr 2013]

OGFR Gene

opioid growth factor receptor

The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq, Jul 2008]

MYDGF Gene

myeloid-derived growth factor

The protein encoded by this gene was previously thought to support proliferation of lymphoid cells and was considered an interleukin. However, this activity has not been reproducible and the function of this protein is currently unknown. [provided by RefSeq, Jul 2008]

TDGF1 Gene

teratocarcinoma-derived growth factor 1

This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

VGF Gene

VGF nerve growth factor inducible

This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008]

GAS2L1 Gene

growth arrest-specific 2 like 1

This gene encodes a member of the growth arrest-specific 2 protein family. This protein binds components of the cytoskeleton and may be involved in mediating interactions between microtubules and microfilaments. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, Jul 2013]

GAS2L3 Gene

growth arrest-specific 2 like 3

GAS2L2 Gene

growth arrest-specific 2 like 2

The protein encoded by this gene appears to crosslink microtubules and microfilaments and may be part of the cytoskeleton. This gene is mainly expressed in skeletal muscle. [provided by RefSeq, Jul 2011]

NGFRAP1 Gene

nerve growth factor receptor (TNFRSF16) associated protein 1

PDGFC Gene

platelet derived growth factor C

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

FGF1 Gene

fibroblast growth factor 1 (acidic)

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]

GADD45A Gene

growth arrest and DNA-damage-inducible, alpha

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Dec 2010]

GADD45B Gene

growth arrest and DNA-damage-inducible, beta

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]

GADD45G Gene

growth arrest and DNA-damage-inducible, gamma

This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]

LOC100113421 Gene

fibroblast growth factor 7 pseudogene

HDGF Gene

hepatoma-derived growth factor

This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. This gene was thought initially to be located on chromosome X, however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

IGF2 Gene

insulin-like growth factor 2

This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

IGF1 Gene

insulin-like growth factor 1 (somatomedin C)

The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2009]

TGFB1I1 Gene

transforming growth factor beta 1 induced transcript 1

This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GFER Gene

growth factor, augmenter of liver regeneration

The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008]

GDF5OS Gene

growth differentiation factor 5 opposite strand

NEGR1 Gene

neuronal growth regulator 1

EPS15L1 Gene

epidermal growth factor receptor pathway substrate 15-like 1

IGFALS Gene

insulin-like growth factor binding protein, acid labile subunit

The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

HDGFL1 Gene

hepatoma derived growth factor-like 1

NODAL Gene

nodal growth differentiation factor

The protein encoded by this gene is a member of the TGF-beta superfamily. Studies of the mouse counterpart suggested that this gene may be essential for mesoderm formation and subsequent organization of axial structures in early embryonic development. [provided by RefSeq, Jul 2008]

FGFR3P5 Gene

fibroblast growth factor receptor 3 pseudogene 5

GRB10 Gene

growth factor receptor-bound protein 10

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]

GRB14 Gene

growth factor receptor-bound protein 14

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. This protein likely has an inhibitory effect on receptor tyrosine kinase signaling and, in particular, on insulin receptor signaling. This gene may play a role in signaling pathways that regulate growth and metabolism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

TGFA Gene

transforming growth factor, alpha

This gene encodes a growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. This gene has been associated with many types of cancers, and it may also be involved in some cases of cleft lip/palate. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

IGFBP2 Gene

insulin-like growth factor binding protein 2, 36kDa

IGFBP3 Gene

insulin-like growth factor binding protein 3

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

IGFBP1 Gene

insulin-like growth factor binding protein 1

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]

IGFBP7 Gene

insulin-like growth factor binding protein 7

This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]

IGFBP4 Gene

insulin-like growth factor binding protein 4

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]

IGFBP5 Gene

insulin-like growth factor binding protein 5

LOC105369252 Gene

hepatocyte growth factor-like protein

OGFRL1 Gene

opioid growth factor receptor-like 1

GFI1B Gene

growth factor independent 1B transcription repressor

This gene encodes a zinc-finger containing transcriptional regulator that is primarily expressed in cells of hematopoietic lineage. The encoded protein complexes with numerous other transcriptional regulatory proteins including GATA-1, runt-related transcription factor 1 and histone deacetylases to control expression of genes involved in the development and maturation of erythrocytes and megakaryocytes. Mutations in this gene are the cause of the autosomal dominant platelet disorder, platelet-type bleeding disorder-17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

CGRRF1 Gene

cell growth regulator with ring finger domain 1

LOC100420339 Gene

opioid growth factor receptor pseudogene

NGF Gene

nerve growth factor (beta polypeptide)

This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]

LOC728433 Gene

fibroblast growth factor 7 pseudogene

KGFLP1 Gene

fibroblast growth factor 7 pseudogene

NGFG Gene

Nerve growth factor, gamma subunit

NGFR Gene

nerve growth factor receptor

Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. [provided by RefSeq, Jul 2008]

MST1P2 Gene

macrophage stimulating 1 (hepatocyte growth factor-like) pseudogene 2

FRS3 Gene

fibroblast growth factor receptor substrate 3

This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013]

FRS2 Gene

fibroblast growth factor receptor substrate 2

PDGFRB Gene

platelet-derived growth factor receptor, beta polypeptide

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008]

PDGFRA Gene

platelet-derived growth factor receptor, alpha polypeptide

This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]

PDGFRL Gene

platelet-derived growth factor receptor-like

This gene encodes a protein with significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. [provided by RefSeq, Jul 2008]

GREB1L Gene

growth regulation by estrogen in breast cancer-like

FGF19 Gene

fibroblast growth factor 19

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008]

FGF18 Gene

fibroblast growth factor 18

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]

FGF13 Gene

fibroblast growth factor 13

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked mental retardation mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini. [provided by RefSeq, Nov 2008]

FGF12 Gene

fibroblast growth factor 12

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

FGF11 Gene

fibroblast growth factor 11

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this gene has not yet been determined. The expression pattern of the mouse homolog implies a role in nervous system development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

FGF10 Gene

fibroblast growth factor 10

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008]

FGF17 Gene

fibroblast growth factor 17

This gene encodes a member of the fibroblast growth factor (FGF) family. Member of the FGF family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is expressed during embryogenesis and in the adult cerebellum and cortex and may be essential for vascular growth and normal brain development. Mutations in this gene are the cause of hypogonadotropic hypogonadism 20 with or without anosmia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

FGF16 Gene

fibroblast growth factor 16

This gene encodes a member of a family of proteins that are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene is expressed in cardiac cells and is required for proper heart development. Mutation in this gene was also observed in individuals with metacarpal 4-5 fusion. [provided by RefSeq, Mar 2014]

FGF14 Gene

fibroblast growth factor 14

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. A mutation in this gene is associated with autosomal dominant cerebral ataxia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

GAS2L1P1 Gene

growth arrest-specific 2 like 1 pseudogene 1

PDGFA Gene

platelet-derived growth factor alpha polypeptide

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer or as a heterodimer with the platelet-derived growth factor beta polypeptide, where the dimers are connected by disulfide bonds. Studies using knockout mice have shown cellular defects in oligodendrocytes, alveolar smooth muscle cells, and Leydig cells in the testis; knockout mice die either as embryos or shortly after birth. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]

PDGFB Gene

platelet-derived growth factor beta polypeptide

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a motif of eight cysteines. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans resulting from unregulated expression of growth factor. Two alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2013]

PDGFD Gene

platelet derived growth factor D

The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-terminal domain, the CUB domain. Two splice variants have been identified for this gene. [provided by RefSeq, Jul 2008]

NAMA Gene

non-protein coding RNA, associated with MAP kinase pathway and growth arrest

LOC100421483 Gene

transforming growth factor, beta receptor 1 pseudogene

EPS15 Gene

epidermal growth factor receptor pathway substrate 15

This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009]

IGF2BP1 Gene

insulin-like growth factor 2 mRNA binding protein 1

This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

IGF2BP2 Gene

insulin-like growth factor 2 mRNA binding protein 2

This gene encodes a member of the IGF-II mRNA-binding protein (IMP) family. The protein encoded by this gene contains four KH domains and two RRM domains. It functions by binding to the 5' UTR of the insulin-like growth factor 2 (IGF2) mRNA and regulating IGF2 translation. Alternative promoter usage and alternate splicing result in multiple variants encoding different isoforms. [provided by RefSeq, May 2014]

LOC100421364 Gene

fibroblast growth factor binding protein 1 pseudogene

FGF9 Gene

fibroblast growth factor 9

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein was isolated as a secreted factor that exhibits a growth-stimulating effect on cultured glial cells. In nervous system, this protein is produced mainly by neurons and may be important for glial cell development. Expression of the mouse homolog of this gene was found to be dependent on Sonic hedgehog (Shh) signaling. Mice lacking the homolog gene displayed a male-to-female sex reversal phenotype, which suggested a role in testicular embryogenesis. [provided by RefSeq, Jul 2008]

FGF8 Gene

fibroblast growth factor 8 (androgen-induced)

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]

FGF7 Gene

fibroblast growth factor 7

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008]

FGF6 Gene

fibroblast growth factor 6

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene displayed oncogenic transforming activity when transfected into mammalian cells. The mouse homolog of this gene exhibits a restricted expression profile predominantly in the myogenic lineage, which suggested a role in muscle regeneration or differentiation. [provided by RefSeq, Jul 2008]

FGF5 Gene

fibroblast growth factor 5

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified as an oncogene, which confers transforming potential when transfected into mammalian cells. Targeted disruption of the homolog of this gene in mouse resulted in the phenotype of abnormally long hair, which suggested a function as an inhibitor of hair elongation. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

FGF4 Gene

fibroblast growth factor 4

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008]

FGF3 Gene

fibroblast growth factor 3

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008]

FGF2 Gene

fibroblast growth factor 2 (basic)

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008]

GADD45GIP1 Gene

growth arrest and DNA-damage-inducible, gamma interacting protein 1

This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. The encoded protein may interact with other cell cycle regulators. [provided by RefSeq, Aug 2012]

VEGFA Gene

vascular endothelial growth factor A

This gene is a member of the PDGF/VEGF growth factor family and encodes a protein that is often found as a disulfide linked homodimer. This protein is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis and endothelial cell growth, promoting cell migration, and inhibiting apoptosis. Elevated levels of this protein is linked to POEMS syndrome, also known as Crow-Fukase syndrome. Mutations in this gene have been associated with proliferative and nonproliferative diabetic retinopathy. Alternatively spliced transcript variants, encoding either freely secreted or cell-associated isoforms, have been characterized. There is also evidence for the use of non-AUG (CUG) translation initiation sites upstream of, and in-frame with the first AUG, leading to additional isoforms. [provided by RefSeq, Jul 2008]

VEGFC Gene

vascular endothelial growth factor C

The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family. The encoded protein promotes angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels. The proprotein is further cleaved into a fully processed form that can bind and activate VEGFR-2 and VEGFR-3 receptors. [provided by RefSeq, Apr 2014]

VEGFB Gene

vascular endothelial growth factor B

This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]

HBEGF Gene

heparin-binding EGF-like growth factor

GAP43 Gene

growth associated protein 43

The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

LOC346296 Gene

insulin-like growth factor 2 mRNA binding protein 3 pseudogene

IGFBP6 Gene

insulin-like growth factor binding protein 6

GADD45AP1 Gene

growth arrest and DNA-damage-inducible, alpha pseudogene 1

TGFBR2 Gene

transforming growth factor, beta receptor II (70/80kDa)

This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

TGFBR1 Gene

transforming growth factor, beta receptor 1

The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

IGF2BP3 Gene

insulin-like growth factor 2 mRNA binding protein 3

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]

TGFBRAP1 Gene

transforming growth factor, beta receptor associated protein 1

EPS8 Gene

epidermal growth factor receptor pathway substrate 8

This gene encodes a member of the EPS8 family. This protein contains one PH domain and one SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

FGFR4 Gene

fibroblast growth factor receptor 4

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis. [provided by RefSeq, Jul 2008]

FGFR2 Gene

fibroblast growth factor receptor 2

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]

FGFR3 Gene

fibroblast growth factor receptor 3

This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Jul 2009]

FGFR1 Gene

fibroblast growth factor receptor 1

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

CXCL1 Gene

chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)

This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]

FGF7P2 Gene

fibroblast growth factor 7 pseudogene 2

FGF7P1 Gene

fibroblast growth factor 7 pseudogene 1

GFI1 Gene

growth factor independent 1 transcription repressor

This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

TGFB1 Gene

transforming growth factor, beta 1

This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. Many cells have TGFB receptors, and the protein positively and negatively regulates many other growth factors. The secreted protein is cleaved into a latency-associated peptide (LAP) and a mature TGFB1 peptide, and is found in either a latent form composed of a TGFB1 homodimer, a LAP homodimer, and a latent TGFB1-binding protein, or in an active form composed of a TGFB1 homodimer. The mature peptide may also form heterodimers with other TGFB family members. This gene is frequently upregulated in tumor cells, and mutations in this gene result in Camurati-Engelmann disease.[provided by RefSeq, Oct 2009]

TGFB2 Gene

transforming growth factor, beta 2

This gene encodes a member of the transforming growth factor beta (TGFB) family of cytokines, which are multifunctional peptides that regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types by transducing their signal through combinations of transmembrane type I and type II receptors (TGFBR1 and TGFBR2) and their downstream effectors, the SMAD proteins. Disruption of the TGFB/SMAD pathway has been implicated in a variety of human cancers. The encoded protein is secreted and has suppressive effects of interleukin-2 dependent T-cell growth. Translocation t(1;7)(q41;p21) between this gene and HDAC9 is associated with Peters' anomaly, a congenital defect of the anterior chamber of the eye. The knockout mice lacking this gene show perinatal mortality and a wide range of developmental, including cardiac, defects. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]

TGFB3 Gene

transforming growth factor, beta 3

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009]

TGFBI Gene

transforming growth factor, beta-induced, 68kDa

This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]

LOC727884 Gene

insulin-like growth factor 2 mRNA binding protein 2 pseudogene

LOC653453 Gene

fibroblast growth factor 7 pseudogene

LOC105373985 Gene

multiple epidermal growth factor-like domains protein 6

TBRG1 Gene

transforming growth factor beta regulator 1

TBRG4 Gene

transforming growth factor beta regulator 4

USMG5 Gene

up-regulated during skeletal muscle growth 5 homolog (mouse)

CTGF Gene

connective tissue growth factor

The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]

OSGIN2 Gene

oxidative stress induced growth inhibitor family member 2

OSGIN1 Gene

oxidative stress induced growth inhibitor 1

This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011]

HGS Gene

hepatocyte growth factor-regulated tyrosine kinase substrate

The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010]

HGF Gene

hepatocyte growth factor (hepapoietin A; scatter factor)

Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

HDGFP1 Gene

hepatoma-derived growth factor pseudogene 1

LOC102724562 Gene

hepatocyte growth factor-like protein

FGFR3P6 Gene

fibroblast growth factor receptor 3 pseudogene 6

FGFR3P4 Gene

fibroblast growth factor receptor 3 pseudogene 4

FGFR3P3 Gene

fibroblast growth factor receptor 3 pseudogene 3

FGFR3P2 Gene

fibroblast growth factor receptor 3 pseudogene 2

FGFR3P1 Gene

fibroblast growth factor receptor 3 pseudogene 1

HAGLR Gene

HOXD antisense growth-associated long non-coding RNA

EGFR Gene

epidermal growth factor receptor

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

FGF22 Gene

fibroblast growth factor 22

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The mouse homolog of this gene was found to be preferentially expressed in the inner root sheath of the hair follicle, which suggested a role in hair development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

FGF23 Gene

fibroblast growth factor 23

This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC). [provided by RefSeq, Feb 2013]

FGF20 Gene

fibroblast growth factor 20

The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009]

FGF21 Gene

fibroblast growth factor 21

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. [provided by RefSeq, Jul 2008]

LOC645468 Gene

insulin-like growth factor 2 mRNA binding protein 3 pseudogene

TGFBR3 Gene

transforming growth factor, beta receptor III

This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]

LOC105378979 Gene

growth/differentiation factor 3-like

KGFLP2 Gene

keratinocyte growth factor-like protein 2

IGFBPL1 Gene

insulin-like growth factor binding protein-like 1

LTBP4 Gene

latent transforming growth factor beta binding protein 4

The protein encoded by this gene binds transforming growth factor beta (TGFB) as it is secreted and targeted to the extracellular matrix. TGFB is biologically latent after secretion and insertion into the extracellular matrix, and sheds TGFB and other proteins upon activation. Defects in this gene may be a cause of cutis laxa and severe pulmonary, gastrointestinal, and urinary abnormalities. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010]

LTBP3 Gene

latent transforming growth factor beta binding protein 3

The protein encoded by this gene forms a complex with transforming growth factor beta (TGF-beta) proteins and may be involved in their subcellular localization. Activation of this complex requires removal of the encoded binding protein. This protein also may play a structural role in the extracellular matrix. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]

LTBP2 Gene

latent transforming growth factor beta binding protein 2

The protein encoded by this gene belongs to the family of latent transforming growth factor (TGF)-beta binding proteins (LTBP), which are extracellular matrix proteins with multi-domain structure. This protein is the largest member of the LTBP family possessing unique regions and with most similarity to the fibrillins. It has thus been suggested that it may have multiple functions: as a member of the TGF-beta latent complex, as a structural component of microfibrils, and a role in cell adhesion. [provided by RefSeq, Jul 2008]

LTBP1 Gene

latent transforming growth factor beta binding protein 1

The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

FGFRL1 Gene

fibroblast growth factor receptor-like 1

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008]

EPS15P1 Gene

epidermal growth factor receptor pathway substrate 15 pseudogene 1

GAS8 Gene

growth arrest-specific 8

This gene includes 11 exons spanning 25 kb and maps to a region of chromosome 16 that is sometimes deleted in breast and prostrate cancer. The second intron contains an apparently intronless gene, C16orf3, that is transcribed in the opposite orientation. This gene is a putative tumor suppressor gene. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

GAS1 Gene

growth arrest-specific 1

Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. [provided by RefSeq, Jul 2008]

GAS2 Gene

growth arrest-specific 2

The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009]

GAS5 Gene

growth arrest-specific 5 (non-protein coding)

This gene produces a spliced long non-coding RNA and is a member of the 5' terminal oligo-pyrimidine class of genes. It is a small nucleolar RNA host gene, containing multiple C/D box snoRNA genes in its introns. Part of the secondary RNA structure of the encoded transcript mimics glucocorticoid response element (GRE) which means it can bind to the DNA binding domain of the glucocorticoid receptor (nuclear receptor subfamily 3, group C, member 1). This action blocks the glucocorticoid receptor from being activated and thereby stops it from regulating the transcription of its target genes. This transcript is also thought to regulate the transcriptional activity of other receptors, such as androgen, progesterone and mineralocorticoid receptors, that can bind to its GRE mimic region. Multiple functions have been associated with this transcript, including cellular growth arrest and apoptosis. It has also been identified as a potential tumor suppressor, with its down-regulation associated with cancer in multiple different tissues. [provided by RefSeq, Mar 2015]

GAS7 Gene

growth arrest-specific 7

Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described. [provided by RefSeq, Jul 2008]

GAS6 Gene

growth arrest-specific 6

This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]

LOC728195 Gene

fibroblast growth factor 7 pseudogene

GRB2 Gene

growth factor receptor-bound protein 2

The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GRB7 Gene

growth factor receptor-bound protein 7

The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

INGX Gene

inhibitor of growth family, X-linked, pseudogene

ING4 Gene

inhibitor of growth family, member 4

This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008]

ING5 Gene

inhibitor of growth family, member 5

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway. [provided by RefSeq, Jul 2008]

ING1 Gene

inhibitor of growth family, member 1

This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

ING2 Gene

inhibitor of growth family, member 2

This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

ING3 Gene

inhibitor of growth family, member 3

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]

TGFBR3L Gene

transforming growth factor, beta receptor III-like

GAS2L1P2 Gene

growth arrest-specific 2 like 1 pseudogene 2

RERG Gene

RAS-like, estrogen-regulated, growth inhibitor

RERG, a member of the RAS superfamily of GTPases, inhibits cell proliferation and tumor formation (Finlin et al., 2001 [PubMed 11533059]).[supplied by OMIM, Mar 2009]

CGREF1 Gene

cell growth regulator with EF-hand domain 1

GDF15 Gene

growth differentiation factor 15

Bone morphogenetic proteins (e.g., BMP9; MIM 605120) are members of the transforming growth factor-beta (see TGFB1; MIM 190180) superfamily and regulate tissue differentiation and maintenance. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein.[supplied by OMIM, Oct 2009]

GDF11 Gene

growth differentiation factor 11

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. [provided by RefSeq, Jul 2008]

GDF10 Gene

growth differentiation factor 10

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that the protein encoded by this gene plays a role in skeletal morphogenesis. [provided by RefSeq, Jul 2008]

PGF Gene

placental growth factor

This gene encodes a growth factor found in placenta which is homologous to vascular endothelial growth factor. Alternatively spliced transcripts encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2011]

GREB1 Gene

growth regulation by estrogen in breast cancer 1

This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

HDGFRP2 Gene

hepatoma-derived growth factor-related protein 2

This gene encodes a member of the hepatoma-derived growth factor (HDGF) family. The protein includes an N-terminal PWWP domain that binds to methyl-lysine-containing histones, with specific binding of this protein to tri-methylated lysines 36 and 79 of histone H3, and di- and tri-methylated lysine 20 of histone H4. The protein functions in LEDGF/p75-independent HIV-1 replication by determining HIV-1 integration site selection. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

HDGFRP3 Gene

hepatoma-derived growth factor, related protein 3

EGF Gene

epidermal growth factor

This gene encodes a member of the epidermal growth factor superfamily. The encoded protein is synthesized as a large precursor molecule that is proteolytically cleaved to generate the 53-amino acid epidermal growth factor peptide. This protein acts a potent mitogenic factor that plays an important role in the growth, proliferation and differentiation of numerous cell types. This protein acts by binding the high affinity cell surface receptor, epidermal growth factor receptor. Defects in this gene are the cause of hypomagnesemia type 4. Dysregulation of this gene has been associated with the growth and progression of certain cancers. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

LOC100421893 Gene

insulin-like growth factor 2 mRNA binding protein 2 pseudogene

OGFRP1 Gene

opioid growth factor receptor pseudogene 1

IGF1R Gene

insulin-like growth factor 1 receptor

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

TDGF1P7 Gene

teratocarcinoma-derived growth factor 1 pseudogene 7

TDGF1P6 Gene

teratocarcinoma-derived growth factor 1 pseudogene 6

TDGF1P5 Gene

teratocarcinoma-derived growth factor 1 pseudogene 5

TDGF1P4 Gene

teratocarcinoma-derived growth factor 1 pseudogene 4

TDGF1P3 Gene

teratocarcinoma-derived growth factor 1 pseudogene 3

The TDGF3 locus has characteristics of a retrotransposon, including lack of introns and a poly(A) sequence. [provided by RefSeq, Jul 2008]

TDGF1P2 Gene

teratocarcinoma-derived growth factor 1 pseudogene 2

TDGF1P1 Gene

teratocarcinoma-derived growth factor 1 pseudogene 1

FGFBP3 Gene

fibroblast growth factor binding protein 3

FGFBP2 Gene

fibroblast growth factor binding protein 2

This gene encodes a member of the fibroblast growth factor binding protein family. The encoded protein is a serum protein that is selectively secreted by cytotoxic lymphocytes and may be involved in cytotoxic lymphocyte-mediated immunity. An increase in the amount of gene product may be associated with atopic asthma and mild extrinsic asthma.[provided by RefSeq Staff, Oct 2008]

FGFBP1 Gene

fibroblast growth factor binding protein 1

This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]

GDF9 Gene

growth differentiation factor 9

This gene encodes a member of the transforming growth factor-beta superfamily. The encoded preproprotein is processed into a secreted factor that is required for ovarian folliculogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GDF3 Gene

growth differentiation factor 3

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. [provided by RefSeq, Jul 2008]

GDF2 Gene

growth differentiation factor 2

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein plays a role in the adult liver and in differentiation of cholinergic central nervous system neurons. Mutations in this gene are associated with hereditary hemorrhagic telangiectasia. [provided by RefSeq, Jan 2014]

GDF1 Gene

growth differentiation factor 1

This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site that is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in rodents suggest that this protein is involved in the establishment of left-right asymmetry in early embryogenesis and in neural development in later embryogenesis. This protein is transcribed from a bicistronic mRNA that also encodes the longevity assurance gene. Mutations in this gene are associated with several congenital cardiovascular malformations. [provided by RefSeq, Mar 2014]

GDF7 Gene

growth differentiation factor 7

This gene encodes a member of the bone morphogenetic protein (BMP) family. BMPs belong to the transforming growth factor-beta superfamily of secreted signalling molecules that regulate diverse processes in growth, repair and embryonic development. In mouse, this gene functions as an inductive signal from the roof plate required for the specification of neuronal identity in the dorsal spinal cord. [provided by RefSeq, Jul 2008]

GDF6 Gene

growth differentiation factor 6

This gene encodes a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily of secreted signaling molecules. It is required for normal formation of some bones and joints in the limbs, skull, and axial skeleton. Mutations in this gene result in colobomata, which are congenital abnormalities in ocular development, and in Klippel-Feil syndrome (KFS), which is a congenital disorder of spinal segmentation. [provided by RefSeq, Jul 2008]

GDF5 Gene

growth differentiation factor 5

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development. [provided by RefSeq, Jul 2008]

FIBP Gene

fibroblast growth factor (acidic) intracellular binding protein

Acidic fibroblast growth factor is mitogenic for a variety of different cell types and acts by stimulating mitogenesis or inducing morphological changes and differentiation. The FIBP protein is an intracellular protein that binds selectively to acidic fibroblast growth factor (aFGF). It is postulated that FIBP may be involved in the mitogenic action of aFGF. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

MDK Gene

midkine (neurite growth-promoting factor 2)

This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

GCY Gene

growth control, Y chromosome influenced

HR Gene

hair growth associated

This gene encodes a protein that is involved in hair growth. This protein functions as a transcriptional corepressor of multiple nuclear receptors, including thyroid hormone receptor, the retinoic acid receptor-related orphan receptors and the vitamin D receptors, and it interacts with histone deacetylases. The translation of this protein is modulated by a regulatory open reading frame (ORF) that exists upstream of the primary ORF. Mutations in this upstream ORF cause Marie Unna hereditary hypotrichosis (MUHH), an autosomal dominant form of genetic hair loss. Mutations in this gene also cause autosomal recessive congenital alopecia and atrichia with papular lesions, other diseases resulting in hair loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

UCMA Gene

upper zone of growth plate and cartilage matrix associated

cellular response to growth hormone stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to growth hormone stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to hormone stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to hormone stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to corticotropin-releasing hormone stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to corticotropin-releasing hormone stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to steroid hormone stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to steroid hormone stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to luteinizing hormone stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to luteinizing hormone stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to follicle-stimulating hormone stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to follicle-stimulating hormone stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to thyroid hormone stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to thyroid hormone stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to peptide hormone stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to peptide hormone stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to parathyroid hormone stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to parathyroid hormone stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to hepatocyte growth factor stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to hepatocyte growth factor stimulus biological process from the curated GO Biological Process Annotations dataset.

regulation of cellular response to growth factor stimulus Gene Set

From GO Biological Process Annotations

genes participating in the regulation of cellular response to growth factor stimulus biological process from the curated GO Biological Process Annotations dataset.

negative regulation of cellular response to growth factor stimulus Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of cellular response to growth factor stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to growth factor stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to growth factor stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to fibroblast growth factor stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to fibroblast growth factor stimulus biological process from the curated GO Biological Process Annotations dataset.

regulation of cellular response to hepatocyte growth factor stimulus Gene Set

From GO Biological Process Annotations

genes participating in the regulation of cellular response to hepatocyte growth factor stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to nerve growth factor stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to nerve growth factor stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to transforming growth factor beta stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to transforming growth factor beta stimulus biological process from the curated GO Biological Process Annotations dataset.

negative regulation of cellular response to hepatocyte growth factor stimulus Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of cellular response to hepatocyte growth factor stimulus biological process from the curated GO Biological Process Annotations dataset.

negative regulation of cellular response to vascular endothelial growth factor stimulus Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of cellular response to vascular endothelial growth factor stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to platelet-derived growth factor stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to platelet-derived growth factor stimulus biological process from the curated GO Biological Process Annotations dataset.

negative regulation of cellular response to transforming growth factor beta stimulus Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of cellular response to transforming growth factor beta stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to vascular endothelial growth factor stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to vascular endothelial growth factor stimulus biological process from the curated GO Biological Process Annotations dataset.

regulation of cellular response to transforming growth factor beta stimulus Gene Set

From GO Biological Process Annotations

genes participating in the regulation of cellular response to transforming growth factor beta stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to epidermal growth factor stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to epidermal growth factor stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to insulin-like growth factor stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to insulin-like growth factor stimulus biological process from the curated GO Biological Process Annotations dataset.

regulation of cellular response to vascular endothelial growth factor stimulus Gene Set

From GO Biological Process Annotations

genes participating in the regulation of cellular response to vascular endothelial growth factor stimulus biological process from the curated GO Biological Process Annotations dataset.

positive regulation of cellular response to transforming growth factor beta stimulus Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of cellular response to transforming growth factor beta stimulus biological process from the curated GO Biological Process Annotations dataset.

growth hormone-releasing hormone receptor activity Gene Set

From GO Molecular Function Annotations

genes performing the growth hormone-releasing hormone receptor activity molecular function from the curated GO Molecular Function Annotations dataset.

growth hormone-releasing hormone receptor binding Gene Set

From GO Molecular Function Annotations

genes performing the growth hormone-releasing hormone receptor binding molecular function from the curated GO Molecular Function Annotations dataset.

growth hormone-releasing hormone activity Gene Set

From GO Molecular Function Annotations

genes performing the growth hormone-releasing hormone activity molecular function from the curated GO Molecular Function Annotations dataset.

GPCR, family 2, growth hormone-releasing hormone receptor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the GPCR, family 2, growth hormone-releasing hormone receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

cellular response to cortisol stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to cortisol stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to glucagon stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to glucagon stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to extracellular stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to extracellular stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to macrophage colony-stimulating factor stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to macrophage colony-stimulating factor stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to carbohydrate stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to carbohydrate stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to estradiol stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to estradiol stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to temperature stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to temperature stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to jasmonic acid stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to jasmonic acid stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to cytokine stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to cytokine stimulus biological process from the curated GO Biological Process Annotations dataset.

regulation of insulin secretion involved in cellular response to glucose stimulus Gene Set

From GO Biological Process Annotations

genes participating in the regulation of insulin secretion involved in cellular response to glucose stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to leptin stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to leptin stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to insulin stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to insulin stimulus biological process from the curated GO Biological Process Annotations dataset.

insulin secretion involved in cellular response to glucose stimulus Gene Set

From GO Biological Process Annotations

genes participating in the insulin secretion involved in cellular response to glucose stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to biotic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to biotic stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to glucocorticoid stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to glucocorticoid stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to prostaglandin d stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to prostaglandin d stimulus biological process from the curated GO Biological Process Annotations dataset.

negative regulation of cellular response to testosterone stimulus Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of cellular response to testosterone stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to dna damage stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to dna damage stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to estrogen stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to estrogen stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to amine stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to amine stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to glucose stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to glucose stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to high density lipoprotein particle stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to high density lipoprotein particle stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to mineralocorticoid stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to mineralocorticoid stimulus biological process from the curated GO Biological Process Annotations dataset.

negative regulation of insulin secretion involved in cellular response to glucose stimulus Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of insulin secretion involved in cellular response to glucose stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to fructose stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to fructose stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to amino acid stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to amino acid stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to stimulus biological process from the curated GO Biological Process Annotations dataset.

positive regulation of cellular response to insulin stimulus Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of cellular response to insulin stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to bmp stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to bmp stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to gonadotropin stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to gonadotropin stimulus biological process from the curated GO Biological Process Annotations dataset.

regulation of cellular response to insulin stimulus Gene Set

From GO Biological Process Annotations

genes participating in the regulation of cellular response to insulin stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to chemical stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to chemical stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to epinephrine stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to epinephrine stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to prostaglandin stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to prostaglandin stimulus biological process from the curated GO Biological Process Annotations dataset.

positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to monoamine stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to monoamine stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to progesterone stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to progesterone stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to corticosteroid stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to corticosteroid stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to norepinephrine stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to norepinephrine stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to catecholamine stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to catecholamine stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to low-density lipoprotein particle stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to low-density lipoprotein particle stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to abiotic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to abiotic stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to water stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to water stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to testosterone stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to testosterone stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to monosaccharide stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to monosaccharide stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to prostaglandin e stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to prostaglandin e stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to external stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to external stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to mechanical stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to mechanical stimulus biological process from the curated GO Biological Process Annotations dataset.

positive regulation of insulin secretion involved in cellular response to glucose stimulus Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of insulin secretion involved in cellular response to glucose stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to granulocyte macrophage colony-stimulating factor stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to granulocyte macrophage colony-stimulating factor stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to hexose stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to hexose stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to electrical stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to electrical stimulus biological process from the curated GO Biological Process Annotations dataset.

regulation of cellular response to testosterone stimulus Gene Set

From GO Biological Process Annotations

genes participating in the regulation of cellular response to testosterone stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to dexamethasone stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to dexamethasone stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to disaccharide stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to disaccharide stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to sucrose stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to sucrose stimulus biological process from the curated GO Biological Process Annotations dataset.

negative regulation of cellular response to insulin stimulus Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of cellular response to insulin stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to light stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to light stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to lipoprotein particle stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to lipoprotein particle stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to endogenous stimulus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to endogenous stimulus biological process from the curated GO Biological Process Annotations dataset.

response to insulin-like growth factor stimulus Gene Set

From GO Biological Process Annotations

genes participating in the response to insulin-like growth factor stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular response to gonadotropin-releasing hormone Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to gonadotropin-releasing hormone biological process from the curated GO Biological Process Annotations dataset.

response to growth hormone Gene Set

From GO Biological Process Annotations

genes participating in the response to growth hormone biological process from the curated GO Biological Process Annotations dataset.

detection of hormone stimulus Gene Set

From GO Biological Process Annotations

genes participating in the detection of hormone stimulus biological process from the curated GO Biological Process Annotations dataset.

regulation of cell growth by extracellular stimulus Gene Set

From GO Biological Process Annotations

genes participating in the regulation of cell growth by extracellular stimulus biological process from the curated GO Biological Process Annotations dataset.

gonadotropin hormone-releasing hormone activity Gene Set

From GO Molecular Function Annotations

genes performing the gonadotropin hormone-releasing hormone activity molecular function from the curated GO Molecular Function Annotations dataset.

Parathyroid hormone/parathyroid hormone-related protein Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Parathyroid hormone/parathyroid hormone-related protein protein domain from the InterPro Predicted Protein Domain Annotations dataset.

regulation of inflammatory response to antigenic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the regulation of inflammatory response to antigenic stimulus biological process from the curated GO Biological Process Annotations dataset.

negative regulation of response to extracellular stimulus Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of response to extracellular stimulus biological process from the curated GO Biological Process Annotations dataset.

positive regulation of response to stimulus Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of response to stimulus biological process from the curated GO Biological Process Annotations dataset.

regulation of chronic inflammatory response to non-antigenic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the regulation of chronic inflammatory response to non-antigenic stimulus biological process from the curated GO Biological Process Annotations dataset.

response to temperature stimulus Gene Set

From GO Biological Process Annotations

genes participating in the response to temperature stimulus biological process from the curated GO Biological Process Annotations dataset.

response to extracellular stimulus Gene Set

From GO Biological Process Annotations

genes participating in the response to extracellular stimulus biological process from the curated GO Biological Process Annotations dataset.

response to endogenous stimulus Gene Set

From GO Biological Process Annotations

genes participating in the response to endogenous stimulus biological process from the curated GO Biological Process Annotations dataset.

negative regulation of response to stimulus Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of response to stimulus biological process from the curated GO Biological Process Annotations dataset.

response to low light intensity stimulus Gene Set

From GO Biological Process Annotations

genes participating in the response to low light intensity stimulus biological process from the curated GO Biological Process Annotations dataset.

negative regulation of acute inflammatory response to non-antigenic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of acute inflammatory response to non-antigenic stimulus biological process from the curated GO Biological Process Annotations dataset.

response to xenobiotic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the response to xenobiotic stimulus biological process from the curated GO Biological Process Annotations dataset.

response to stimulus Gene Set

From GO Biological Process Annotations

genes participating in the response to stimulus biological process from the curated GO Biological Process Annotations dataset.

negative regulation of response to cytokine stimulus Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of response to cytokine stimulus biological process from the curated GO Biological Process Annotations dataset.

regulation of response to extracellular stimulus Gene Set

From GO Biological Process Annotations

genes participating in the regulation of response to extracellular stimulus biological process from the curated GO Biological Process Annotations dataset.

regulation of acute inflammatory response to antigenic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the regulation of acute inflammatory response to antigenic stimulus biological process from the curated GO Biological Process Annotations dataset.

response to abiotic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the response to abiotic stimulus biological process from the curated GO Biological Process Annotations dataset.

negative regulation of response to biotic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of response to biotic stimulus biological process from the curated GO Biological Process Annotations dataset.

acute inflammatory response to antigenic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the acute inflammatory response to antigenic stimulus biological process from the curated GO Biological Process Annotations dataset.

positive regulation of glucose import in response to insulin stimulus Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of glucose import in response to insulin stimulus biological process from the curated GO Biological Process Annotations dataset.

negative regulation of acute inflammatory response to antigenic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of acute inflammatory response to antigenic stimulus biological process from the curated GO Biological Process Annotations dataset.

response to electrical stimulus Gene Set

From GO Biological Process Annotations

genes participating in the response to electrical stimulus biological process from the curated GO Biological Process Annotations dataset.

negative regulation of response to dna damage stimulus Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of response to dna damage stimulus biological process from the curated GO Biological Process Annotations dataset.

positive regulation of response to cytokine stimulus Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of response to cytokine stimulus biological process from the curated GO Biological Process Annotations dataset.

positive regulation of chronic inflammatory response to antigenic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of chronic inflammatory response to antigenic stimulus biological process from the curated GO Biological Process Annotations dataset.

positive regulation of response to dna damage stimulus Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of response to dna damage stimulus biological process from the curated GO Biological Process Annotations dataset.

regulation of chronic inflammatory response to antigenic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the regulation of chronic inflammatory response to antigenic stimulus biological process from the curated GO Biological Process Annotations dataset.

chronic inflammatory response to antigenic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the chronic inflammatory response to antigenic stimulus biological process from the curated GO Biological Process Annotations dataset.

negative regulation of response to external stimulus Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of response to external stimulus biological process from the curated GO Biological Process Annotations dataset.

positive regulation of chronic inflammatory response to non-antigenic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of chronic inflammatory response to non-antigenic stimulus biological process from the curated GO Biological Process Annotations dataset.

negative regulation of glucose import in response to insulin stimulus Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of glucose import in response to insulin stimulus biological process from the curated GO Biological Process Annotations dataset.

positive regulation of response to biotic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of response to biotic stimulus biological process from the curated GO Biological Process Annotations dataset.

negative regulation of inflammatory response to antigenic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of inflammatory response to antigenic stimulus biological process from the curated GO Biological Process Annotations dataset.

response to external stimulus Gene Set

From GO Biological Process Annotations

genes participating in the response to external stimulus biological process from the curated GO Biological Process Annotations dataset.

response to biotic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the response to biotic stimulus biological process from the curated GO Biological Process Annotations dataset.

regulation of response to external stimulus Gene Set

From GO Biological Process Annotations

genes participating in the regulation of response to external stimulus biological process from the curated GO Biological Process Annotations dataset.

response to light stimulus Gene Set

From GO Biological Process Annotations

genes participating in the response to light stimulus biological process from the curated GO Biological Process Annotations dataset.

regulation of acute inflammatory response to non-antigenic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the regulation of acute inflammatory response to non-antigenic stimulus biological process from the curated GO Biological Process Annotations dataset.

negative regulation of chronic inflammatory response to antigenic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of chronic inflammatory response to antigenic stimulus biological process from the curated GO Biological Process Annotations dataset.

regulation of response to stimulus Gene Set

From GO Biological Process Annotations

genes participating in the regulation of response to stimulus biological process from the curated GO Biological Process Annotations dataset.

response to stimulus involved in regulation of muscle adaptation Gene Set

From GO Biological Process Annotations

genes participating in the response to stimulus involved in regulation of muscle adaptation biological process from the curated GO Biological Process Annotations dataset.

response to electrical stimulus involved in regulation of muscle adaptation Gene Set

From GO Biological Process Annotations

genes participating in the response to electrical stimulus involved in regulation of muscle adaptation biological process from the curated GO Biological Process Annotations dataset.

positive regulation of response to extracellular stimulus Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of response to extracellular stimulus biological process from the curated GO Biological Process Annotations dataset.

response to external biotic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the response to external biotic stimulus biological process from the curated GO Biological Process Annotations dataset.

regulation of glucose import in response to insulin stimulus Gene Set

From GO Biological Process Annotations

genes participating in the regulation of glucose import in response to insulin stimulus biological process from the curated GO Biological Process Annotations dataset.

positive regulation of acute inflammatory response to non-antigenic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of acute inflammatory response to non-antigenic stimulus biological process from the curated GO Biological Process Annotations dataset.

regulation of response to dna damage stimulus Gene Set

From GO Biological Process Annotations

genes participating in the regulation of response to dna damage stimulus biological process from the curated GO Biological Process Annotations dataset.

inflammatory response to antigenic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the inflammatory response to antigenic stimulus biological process from the curated GO Biological Process Annotations dataset.

response to auditory stimulus Gene Set

From GO Biological Process Annotations

genes participating in the response to auditory stimulus biological process from the curated GO Biological Process Annotations dataset.

regulation of response to cytokine stimulus Gene Set

From GO Biological Process Annotations

genes participating in the regulation of response to cytokine stimulus biological process from the curated GO Biological Process Annotations dataset.

positive regulation of inflammatory response to antigenic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of inflammatory response to antigenic stimulus biological process from the curated GO Biological Process Annotations dataset.

positive regulation of acute inflammatory response to antigenic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of acute inflammatory response to antigenic stimulus biological process from the curated GO Biological Process Annotations dataset.

positive regulation of response to external stimulus Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of response to external stimulus biological process from the curated GO Biological Process Annotations dataset.

response to mechanical stimulus Gene Set

From GO Biological Process Annotations

genes participating in the response to mechanical stimulus biological process from the curated GO Biological Process Annotations dataset.

regulation of response to biotic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the regulation of response to biotic stimulus biological process from the curated GO Biological Process Annotations dataset.

cellular hormone metabolic process Gene Set

From GO Biological Process Annotations

genes participating in the cellular hormone metabolic process biological process from the curated GO Biological Process Annotations dataset.

growth hormone signaling pathway Gene Set

From Biocarta Pathways

proteins participating in the growth hormone signaling pathway pathway from the Biocarta Pathways dataset.

Isolated growth hormone deficiency type 1B Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Isolated growth hormone deficiency type 1B phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Growth hormone deficiency with pituitary anomalies Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Growth hormone deficiency with pituitary anomalies phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Growth hormone insensitivity with immunodeficiency Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Growth hormone insensitivity with immunodeficiency phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

X-linked agammaglobulinemia with growth hormone deficiency Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the X-linked agammaglobulinemia with growth hormone deficiency phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Pituitary adenoma, growth hormone-secreting, 2 Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Pituitary adenoma, growth hormone-secreting, 2 phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

growth hormone receptor complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the growth hormone receptor complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

growth hormone receptor complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the growth hormone receptor complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Isolated Growth Hormone Deficiency, Type II Gene Set

From CTD Gene-Disease Associations

genes/proteins associated with the disease Isolated Growth Hormone Deficiency, Type II from the curated CTD Gene-Disease Associations dataset.

Isolated Growth Hormone Deficiency, Type IB Gene Set

From CTD Gene-Disease Associations

genes/proteins associated with the disease Isolated Growth Hormone Deficiency, Type IB from the curated CTD Gene-Disease Associations dataset.

Growth Hormone-Secreting Pituitary Adenoma Gene Set

From CTD Gene-Disease Associations

genes/proteins associated with the disease Growth Hormone-Secreting Pituitary Adenoma from the curated CTD Gene-Disease Associations dataset.

Hypogammaglobulinemia and Isolated growth hormone deficiency, X-linked Gene Set

From CTD Gene-Disease Associations

genes/proteins associated with the disease Hypogammaglobulinemia and Isolated growth hormone deficiency, X-linked from the curated CTD Gene-Disease Associations dataset.

growth hormone secreting pituitary adenoma Gene Set

From DISEASES Text-mining Gene-Disease Assocation Evidence Scores

genes co-occuring with the disease growth hormone secreting pituitary adenoma in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

growth hormone secretion and height Gene Set

From GAD Gene-Disease Associations

genes associated with the disease growth hormone secretion and height in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

growth hormone-deficient Gene Set

From GAD Gene-Disease Associations

genes associated with the disease growth hormone-deficient in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

growth hormone responsiveness Gene Set

From GAD Gene-Disease Associations

genes associated with the disease growth hormone responsiveness in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

growth hormone deficiency Gene Set

From GAD Gene-Disease Associations

genes associated with the disease growth hormone deficiency in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

growth hormone-deficiency Gene Set

From GAD Gene-Disease Associations

genes associated with the disease growth hormone-deficiency in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

regulation of growth hormone secretion Gene Set

From GO Biological Process Annotations

genes participating in the regulation of growth hormone secretion biological process from the curated GO Biological Process Annotations dataset.

negative regulation of growth hormone receptor signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of growth hormone receptor signaling pathway biological process from the curated GO Biological Process Annotations dataset.

positive regulation of growth hormone receptor signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of growth hormone receptor signaling pathway biological process from the curated GO Biological Process Annotations dataset.

growth hormone receptor signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the growth hormone receptor signaling pathway biological process from the curated GO Biological Process Annotations dataset.

regulation of growth hormone receptor signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the regulation of growth hormone receptor signaling pathway biological process from the curated GO Biological Process Annotations dataset.

negative regulation of growth hormone secretion Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of growth hormone secretion biological process from the curated GO Biological Process Annotations dataset.

growth hormone secretion Gene Set

From GO Biological Process Annotations

genes participating in the growth hormone secretion biological process from the curated GO Biological Process Annotations dataset.

positive regulation of growth hormone secretion Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of growth hormone secretion biological process from the curated GO Biological Process Annotations dataset.

jak-stat cascade involved in growth hormone signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the jak-stat cascade involved in growth hormone signaling pathway biological process from the curated GO Biological Process Annotations dataset.

growth hormone receptor complex Gene Set

From GO Cellular Component Annotations

proteins localized to the growth hormone receptor complex cellular component from the curated GO Cellular Component Annotations dataset.

growth hormone receptor binding Gene Set

From GO Molecular Function Annotations

genes performing the growth hormone receptor binding molecular function from the curated GO Molecular Function Annotations dataset.

growth hormone secretagogue receptor activity Gene Set

From GO Molecular Function Annotations

genes performing the growth hormone secretagogue receptor activity molecular function from the curated GO Molecular Function Annotations dataset.

growth hormone deficiency Gene Set

From HPO Gene-Disease Associations

genes associated with the growth hormone deficiency phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

secondary growth hormone deficiency Gene Set

From HPO Gene-Disease Associations

genes associated with the secondary growth hormone deficiency phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

growth hormone excess Gene Set

From HPO Gene-Disease Associations

genes associated with the growth hormone excess phenotype by mapping known disease genes to disease phenotypes from the HPO Gene-Disease Associations dataset.

Growth Hormone-Secreting Pituitary Adenoma Gene Set

From HuGE Navigator Gene-Phenotype Associations

genes associated with the Growth Hormone-Secreting Pituitary Adenoma phenotype by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.

Growth hormone secretagogue receptor type 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Growth hormone secretagogue receptor type 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

FMRFamide-related peptide/Growth hormone-releasing peptide Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the FMRFamide-related peptide/Growth hormone-releasing peptide protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Growth hormone/erythropoietin receptor, ligand binding Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Growth hormone/erythropoietin receptor, ligand binding protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Growth hormone-binding protein Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Growth hormone-binding protein protein domain from the InterPro Predicted Protein Domain Annotations dataset.

decreased circulating growth hormone level Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the decreased circulating growth hormone level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

increased growth hormone level Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the increased growth hormone level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

insensitivity to growth hormone Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the insensitivity to growth hormone phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

abnormal growth hormone level Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the abnormal growth hormone level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

increased circulating growth hormone level Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the increased circulating growth hormone level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

decreased growth hormone level Gene Set

From MPO Gene-Phenotype Associations

gene mutations causing the decreased growth hormone level phenotype in transgenic mice from the MPO Gene-Phenotype Associations dataset.

?isolated growth hormone deficiency due to defect in ghrf Gene Set

From OMIM Gene-Disease Associations

genes associated with the ?isolated growth hormone deficiency due to defect in ghrf phenotype from the curated OMIM Gene-Disease Associations dataset.

mental retardation, x-linked, with isolated growth hormone deficiency Gene Set

From OMIM Gene-Disease Associations

genes associated with the mental retardation, x-linked, with isolated growth hormone deficiency phenotype from the curated OMIM Gene-Disease Associations dataset.

growth hormone insensitivity with immunodeficiency Gene Set

From OMIM Gene-Disease Associations

genes associated with the growth hormone insensitivity with immunodeficiency phenotype from the curated OMIM Gene-Disease Associations dataset.

increased responsiveness to growth hormone Gene Set

From OMIM Gene-Disease Associations

genes associated with the increased responsiveness to growth hormone phenotype from the curated OMIM Gene-Disease Associations dataset.

growth hormone deficiency, isolated, type ii Gene Set

From OMIM Gene-Disease Associations

genes associated with the growth hormone deficiency, isolated, type ii phenotype from the curated OMIM Gene-Disease Associations dataset.

growth hormone deficiency, isolated, type ia Gene Set

From OMIM Gene-Disease Associations

genes associated with the growth hormone deficiency, isolated, type ia phenotype from the curated OMIM Gene-Disease Associations dataset.

growth hormone deficiency, isolated, type ib Gene Set

From OMIM Gene-Disease Associations

genes associated with the growth hormone deficiency, isolated, type ib phenotype from the curated OMIM Gene-Disease Associations dataset.

?cataracts, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, and skeletal dysplasia Gene Set

From OMIM Gene-Disease Associations

genes associated with the ?cataracts, growth hormone deficiency, sensory neuropathy, sensorineural hearing loss, and skeletal dysplasia phenotype from the curated OMIM Gene-Disease Associations dataset.

pituitary adenoma, growth hormone-secreting Gene Set

From OMIM Gene-Disease Associations

genes associated with the pituitary adenoma, growth hormone-secreting phenotype from the curated OMIM Gene-Disease Associations dataset.

growth hormone deficiency with pituitary anomalies Gene Set

From OMIM Gene-Disease Associations

genes associated with the growth hormone deficiency with pituitary anomalies phenotype from the curated OMIM Gene-Disease Associations dataset.

Growth hormone receptor signaling Gene Set

From Reactome Pathways

proteins participating in the Growth hormone receptor signaling pathway from the Reactome Pathways dataset.

birth weight; fetal growth retardation; intrauterine growth retardation; vitamin d deficiency Gene Set

From GAD Gene-Disease Associations

genes associated with the disease birth weight; fetal growth retardation; intrauterine growth retardation; vitamin d deficiency in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

insulin-like growth factor-1; insulin-like growth factor-3 Gene Set

From GAD Gene-Disease Associations

genes associated with the disease insulin-like growth factor-1; insulin-like growth factor-3 in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

abruptio placentae; fetal death; fetal growth retardation; intrauterine growth retardation; placenta abruptio; placenta diseases; thrombophilia Gene Set

From GAD Gene-Disease Associations

genes associated with the disease abruptio placentae; fetal death; fetal growth retardation; intrauterine growth retardation; placenta abruptio; placenta diseases; thrombophilia in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

abruptio placentae; congenital abnormalities; fetal growth retardation; intrauterine growth retardation; placenta abruptio; pregnancy complications Gene Set

From GAD Gene-Disease Associations

genes associated with the disease abruptio placentae; congenital abnormalities; fetal growth retardation; intrauterine growth retardation; placenta abruptio; pregnancy complications in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

abortion, habitual; activated protein c resistance; fetal growth retardation; hypertension; intrauterine growth retardation; pre-eclampsia; pregnancy complications, hematologic; thrombophilia Gene Set

From GAD Gene-Disease Associations

genes associated with the disease abortion, habitual; activated protein c resistance; fetal growth retardation; hypertension; intrauterine growth retardation; pre-eclampsia; pregnancy complications, hematologic; thrombophilia in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

birth weight; fetal growth retardation; intrauterine growth retardation; pre-eclampsia; recurrence Gene Set

From GAD Gene-Disease Associations

genes associated with the disease birth weight; fetal growth retardation; intrauterine growth retardation; pre-eclampsia; recurrence in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

abruptio placentae; fetal growth retardation; intrauterine growth retardation; placenta abruptio; pre-eclampsia; pregnancy complications Gene Set

From GAD Gene-Disease Associations

genes associated with the disease abruptio placentae; fetal growth retardation; intrauterine growth retardation; placenta abruptio; pre-eclampsia; pregnancy complications in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

fetal growth retardation; hellp syndrome; intrauterine growth retardation; pregnancy complications, hematologic; thrombosis Gene Set

From GAD Gene-Disease Associations

genes associated with the disease fetal growth retardation; hellp syndrome; intrauterine growth retardation; pregnancy complications, hematologic; thrombosis in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

fetal growth retardation; intrauterine growth retardation; pregnancy complications, hematologic; thrombophilia Gene Set

From GAD Gene-Disease Associations

genes associated with the disease fetal growth retardation; intrauterine growth retardation; pregnancy complications, hematologic; thrombophilia in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

abortion, spontaneous; abruptio placentae; fetal death; fetal growth retardation; intrauterine growth retardation; placenta abruptio Gene Set

From GAD Gene-Disease Associations

genes associated with the disease abortion, spontaneous; abruptio placentae; fetal death; fetal growth retardation; intrauterine growth retardation; placenta abruptio in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

fetal growth retardation; infant, premature, diseases; intrauterine growth retardation; sepsis; systemic infection Gene Set

From GAD Gene-Disease Associations

genes associated with the disease fetal growth retardation; infant, premature, diseases; intrauterine growth retardation; sepsis; systemic infection in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

fetal diseases; fetal growth retardation; hypertension induced by pregnancy; hypertension, pregnancy-induced; intrauterine growth retardation; pre-eclampsia; pregnancy complications, hematologic; thrombophilia Gene Set

From GAD Gene-Disease Associations

genes associated with the disease fetal diseases; fetal growth retardation; hypertension induced by pregnancy; hypertension, pregnancy-induced; intrauterine growth retardation; pre-eclampsia; pregnancy complications, hematologic; thrombophilia in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

abortion, spontaneous; activated protein c resistance; fetal growth retardation; intrauterine growth retardation; pre-eclampsia; pregnancy complications, hematologic Gene Set

From GAD Gene-Disease Associations

genes associated with the disease abortion, spontaneous; activated protein c resistance; fetal growth retardation; intrauterine growth retardation; pre-eclampsia; pregnancy complications, hematologic in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

birth weight; fetal alcohol syndrome; fetal growth retardation; intrauterine growth retardation; syndrome; fetal, alcohol (dysmorphic) Gene Set

From GAD Gene-Disease Associations

genes associated with the disease birth weight; fetal alcohol syndrome; fetal growth retardation; intrauterine growth retardation; syndrome; fetal, alcohol (dysmorphic) in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

abruptio placentae; fetal death; fetal growth retardation; intrauterine growth retardation; placenta abruptio; pre-eclampsia; pregnancy complications, hematologic; thrombophilia Gene Set

From GAD Gene-Disease Associations

genes associated with the disease abruptio placentae; fetal death; fetal growth retardation; intrauterine growth retardation; placenta abruptio; pre-eclampsia; pregnancy complications, hematologic; thrombophilia in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

fetal growth retardation; hellp syndrome; intrauterine growth retardation; pre-eclampsia Gene Set

From GAD Gene-Disease Associations

genes associated with the disease fetal growth retardation; hellp syndrome; intrauterine growth retardation; pre-eclampsia in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

fetal growth retardation; intrauterine growth retardation; pre-eclampsia Gene Set

From GAD Gene-Disease Associations

genes associated with the disease fetal growth retardation; intrauterine growth retardation; pre-eclampsia in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

fetal growth retardation; intrauterine growth retardation; pregnancy complications Gene Set

From GAD Gene-Disease Associations

genes associated with the disease fetal growth retardation; intrauterine growth retardation; pregnancy complications in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

fetal growth retardation; intrauterine growth retardation Gene Set

From GAD Gene-Disease Associations

genes associated with the disease fetal growth retardation; intrauterine growth retardation in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

birth weight; fetal growth retardation; intrauterine growth retardation Gene Set

From GAD Gene-Disease Associations

genes associated with the disease birth weight; fetal growth retardation; intrauterine growth retardation in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

growth plate cartilage chondrocyte growth Gene Set

From GO Biological Process Annotations

genes participating in the growth plate cartilage chondrocyte growth biological process from the curated GO Biological Process Annotations dataset.

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Gene Set

From Reactome Pathways

proteins participating in the Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) pathway from the Reactome Pathways dataset.

response to luteinizing hormone Gene Set

From GO Biological Process Annotations

genes participating in the response to luteinizing hormone biological process from the curated GO Biological Process Annotations dataset.

response to parathyroid hormone Gene Set

From GO Biological Process Annotations

genes participating in the response to parathyroid hormone biological process from the curated GO Biological Process Annotations dataset.

response to hormone Gene Set

From GO Biological Process Annotations

genes participating in the response to hormone biological process from the curated GO Biological Process Annotations dataset.

response to corticotropin-releasing hormone Gene Set

From GO Biological Process Annotations

genes participating in the response to corticotropin-releasing hormone biological process from the curated GO Biological Process Annotations dataset.

response to steroid hormone Gene Set

From GO Biological Process Annotations

genes participating in the response to steroid hormone biological process from the curated GO Biological Process Annotations dataset.

response to thyroid hormone Gene Set

From GO Biological Process Annotations

genes participating in the response to thyroid hormone biological process from the curated GO Biological Process Annotations dataset.

response to gonadotropin-releasing hormone Gene Set

From GO Biological Process Annotations

genes participating in the response to gonadotropin-releasing hormone biological process from the curated GO Biological Process Annotations dataset.

response to peptide hormone Gene Set

From GO Biological Process Annotations

genes participating in the response to peptide hormone biological process from the curated GO Biological Process Annotations dataset.

response to follicle-stimulating hormone Gene Set

From GO Biological Process Annotations

genes participating in the response to follicle-stimulating hormone biological process from the curated GO Biological Process Annotations dataset.

{hdl response to hormone replacement, augmented} Gene Set

From OMIM Gene-Disease Associations

genes associated with the {hdl response to hormone replacement, augmented} phenotype from the curated OMIM Gene-Disease Associations dataset.

cellular response to glyoxal Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to glyoxal biological process from the curated GO Biological Process Annotations dataset.

cellular response to reactive nitrogen species Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to reactive nitrogen species biological process from the curated GO Biological Process Annotations dataset.

cellular response to lipopolysaccharide Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to lipopolysaccharide biological process from the curated GO Biological Process Annotations dataset.

cellular response to caffeine Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to caffeine biological process from the curated GO Biological Process Annotations dataset.

cellular response to ammonium ion Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to ammonium ion biological process from the curated GO Biological Process Annotations dataset.

cellular response to potassium ion starvation Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to potassium ion starvation biological process from the curated GO Biological Process Annotations dataset.

negative regulation of cellular response to hypoxia Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of cellular response to hypoxia biological process from the curated GO Biological Process Annotations dataset.

cellular response to hydrogen peroxide Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to hydrogen peroxide biological process from the curated GO Biological Process Annotations dataset.

cellular response to hyperoxia Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to hyperoxia biological process from the curated GO Biological Process Annotations dataset.

cellular response to hypoxia Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to hypoxia biological process from the curated GO Biological Process Annotations dataset.

cellular response to oxidative stress Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to oxidative stress biological process from the curated GO Biological Process Annotations dataset.

cellular response to mycophenolic acid Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to mycophenolic acid biological process from the curated GO Biological Process Annotations dataset.

cellular response to blue light Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to blue light biological process from the curated GO Biological Process Annotations dataset.

cellular response to gamma radiation Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to gamma radiation biological process from the curated GO Biological Process Annotations dataset.

cellular response to caloric restriction Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to caloric restriction biological process from the curated GO Biological Process Annotations dataset.

cellular response to acid chemical Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to acid chemical biological process from the curated GO Biological Process Annotations dataset.

cellular response to osmotic stress Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to osmotic stress biological process from the curated GO Biological Process Annotations dataset.

cellular response to leucine Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to leucine biological process from the curated GO Biological Process Annotations dataset.

cellular response to nitrogen compound Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to nitrogen compound biological process from the curated GO Biological Process Annotations dataset.

cellular response to nitric oxide Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to nitric oxide biological process from the curated GO Biological Process Annotations dataset.

cellular response to nitrogen dioxide Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to nitrogen dioxide biological process from the curated GO Biological Process Annotations dataset.

cellular response to genistein Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to genistein biological process from the curated GO Biological Process Annotations dataset.

cellular response to oleic acid Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to oleic acid biological process from the curated GO Biological Process Annotations dataset.

negative regulation of cellular response to oxidative stress Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of cellular response to oxidative stress biological process from the curated GO Biological Process Annotations dataset.

cellular response to reactive oxygen species Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to reactive oxygen species biological process from the curated GO Biological Process Annotations dataset.

cellular hyperosmotic salinity response Gene Set

From GO Biological Process Annotations

genes participating in the cellular hyperosmotic salinity response biological process from the curated GO Biological Process Annotations dataset.

cellular response to vitamin Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to vitamin biological process from the curated GO Biological Process Annotations dataset.

cellular response to molecule of bacterial origin Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to molecule of bacterial origin biological process from the curated GO Biological Process Annotations dataset.

cellular response to unfolded protein Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to unfolded protein biological process from the curated GO Biological Process Annotations dataset.

cellular response to magnetism Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to magnetism biological process from the curated GO Biological Process Annotations dataset.

cellular response to cell-matrix adhesion Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to cell-matrix adhesion biological process from the curated GO Biological Process Annotations dataset.

cellular response to cycloheximide Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to cycloheximide biological process from the curated GO Biological Process Annotations dataset.

cellular process regulating host cell cycle in response to virus Gene Set

From GO Biological Process Annotations

genes participating in the cellular process regulating host cell cycle in response to virus biological process from the curated GO Biological Process Annotations dataset.

cellular response to iron ion starvation Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to iron ion starvation biological process from the curated GO Biological Process Annotations dataset.

cellular response to organonitrogen compound Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to organonitrogen compound biological process from the curated GO Biological Process Annotations dataset.

cellular response to staurosporine Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to staurosporine biological process from the curated GO Biological Process Annotations dataset.

cellular response to oxygen-containing compound Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to oxygen-containing compound biological process from the curated GO Biological Process Annotations dataset.

cellular response to mycotoxin Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to mycotoxin biological process from the curated GO Biological Process Annotations dataset.

cellular response to fluoride Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to fluoride biological process from the curated GO Biological Process Annotations dataset.

cellular response to hydrostatic pressure Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to hydrostatic pressure biological process from the curated GO Biological Process Annotations dataset.

cellular response to bile acid Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to bile acid biological process from the curated GO Biological Process Annotations dataset.

cellular response to heat Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to heat biological process from the curated GO Biological Process Annotations dataset.

cellular response to aluminum ion Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to aluminum ion biological process from the curated GO Biological Process Annotations dataset.

cellular response to hydroxyisoflavone Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to hydroxyisoflavone biological process from the curated GO Biological Process Annotations dataset.

cellular response to purine-containing compound Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to purine-containing compound biological process from the curated GO Biological Process Annotations dataset.

cellular response to nutrient Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to nutrient biological process from the curated GO Biological Process Annotations dataset.

cellular response to l-ascorbic acid Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to l-ascorbic acid biological process from the curated GO Biological Process Annotations dataset.

cellular response to azide Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to azide biological process from the curated GO Biological Process Annotations dataset.

cellular response to superoxide Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to superoxide biological process from the curated GO Biological Process Annotations dataset.

cellular response to lipid Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to lipid biological process from the curated GO Biological Process Annotations dataset.

positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia biological process from the curated GO Biological Process Annotations dataset.

cellular response to redox state Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to redox state biological process from the curated GO Biological Process Annotations dataset.

cellular response to exogenous dsrna Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to exogenous dsrna biological process from the curated GO Biological Process Annotations dataset.

cellular response to morphine Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to morphine biological process from the curated GO Biological Process Annotations dataset.

cellular response to organic substance Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to organic substance biological process from the curated GO Biological Process Annotations dataset.

positive regulation of cellular response to hypoxia Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of cellular response to hypoxia biological process from the curated GO Biological Process Annotations dataset.

regulation of cellular response to drug Gene Set

From GO Biological Process Annotations

genes participating in the regulation of cellular response to drug biological process from the curated GO Biological Process Annotations dataset.

cellular response to alkaloid Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to alkaloid biological process from the curated GO Biological Process Annotations dataset.

positive regulation of cellular response to oxidative stress Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of cellular response to oxidative stress biological process from the curated GO Biological Process Annotations dataset.

cellular response to cholesterol Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to cholesterol biological process from the curated GO Biological Process Annotations dataset.

cellular response to dsrna Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to dsrna biological process from the curated GO Biological Process Annotations dataset.

cellular response to ergosterol Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to ergosterol biological process from the curated GO Biological Process Annotations dataset.

cellular response to interferon-beta Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to interferon-beta biological process from the curated GO Biological Process Annotations dataset.

cellular response to dopamine Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to dopamine biological process from the curated GO Biological Process Annotations dataset.

cellular hypotonic response Gene Set

From GO Biological Process Annotations

genes participating in the cellular hypotonic response biological process from the curated GO Biological Process Annotations dataset.

regulation of cellular response to heat Gene Set

From GO Biological Process Annotations

genes participating in the regulation of cellular response to heat biological process from the curated GO Biological Process Annotations dataset.

cellular response to methyl methanesulfonate Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to methyl methanesulfonate biological process from the curated GO Biological Process Annotations dataset.

cellular response to tumor necrosis factor Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to tumor necrosis factor biological process from the curated GO Biological Process Annotations dataset.

cellular response to hydroperoxide Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to hydroperoxide biological process from the curated GO Biological Process Annotations dataset.

cellular response to nitrogen starvation Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to nitrogen starvation biological process from the curated GO Biological Process Annotations dataset.

cellular response to ionizing radiation Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to ionizing radiation biological process from the curated GO Biological Process Annotations dataset.

cellular response to sterol depletion Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to sterol depletion biological process from the curated GO Biological Process Annotations dataset.

cellular response to ph Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to ph biological process from the curated GO Biological Process Annotations dataset.

cellular response to potassium ion Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to potassium ion biological process from the curated GO Biological Process Annotations dataset.

cellular response to diacyl bacterial lipopeptide Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to diacyl bacterial lipopeptide biological process from the curated GO Biological Process Annotations dataset.

cellular response to nitrite Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to nitrite biological process from the curated GO Biological Process Annotations dataset.

cellular response to cisplatin Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to cisplatin biological process from the curated GO Biological Process Annotations dataset.

cellular response to cadmium ion Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to cadmium ion biological process from the curated GO Biological Process Annotations dataset.

cellular response to brefeldin a Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to brefeldin a biological process from the curated GO Biological Process Annotations dataset.

cellular response to toxic substance Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to toxic substance biological process from the curated GO Biological Process Annotations dataset.

cellular response to nutrient levels Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to nutrient levels biological process from the curated GO Biological Process Annotations dataset.

regulation of cellular response to x-ray Gene Set

From GO Biological Process Annotations

genes participating in the regulation of cellular response to x-ray biological process from the curated GO Biological Process Annotations dataset.

cellular response to nitrogen levels Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to nitrogen levels biological process from the curated GO Biological Process Annotations dataset.

cellular response to trichostatin a Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to trichostatin a biological process from the curated GO Biological Process Annotations dataset.

cellular response to salt stress Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to salt stress biological process from the curated GO Biological Process Annotations dataset.

cellular response to fatty acid Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to fatty acid biological process from the curated GO Biological Process Annotations dataset.

cellular response to mercury ion Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to mercury ion biological process from the curated GO Biological Process Annotations dataset.

cellular response to interleukin-18 Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to interleukin-18 biological process from the curated GO Biological Process Annotations dataset.

cellular response to interleukin-13 Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to interleukin-13 biological process from the curated GO Biological Process Annotations dataset.

cellular response to radiation Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to radiation biological process from the curated GO Biological Process Annotations dataset.

cellular response to atp Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to atp biological process from the curated GO Biological Process Annotations dataset.

cellular response to manganese ion Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to manganese ion biological process from the curated GO Biological Process Annotations dataset.

cellular response to lithium ion Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to lithium ion biological process from the curated GO Biological Process Annotations dataset.

cellular response to menadione Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to menadione biological process from the curated GO Biological Process Annotations dataset.

cellular response to increased oxygen levels Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to increased oxygen levels biological process from the curated GO Biological Process Annotations dataset.

cellular response to histamine Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to histamine biological process from the curated GO Biological Process Annotations dataset.

cellular response to organic cyclic compound Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to organic cyclic compound biological process from the curated GO Biological Process Annotations dataset.

cellular response to indole-3-methanol Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to indole-3-methanol biological process from the curated GO Biological Process Annotations dataset.

cellular response to fluid shear stress Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to fluid shear stress biological process from the curated GO Biological Process Annotations dataset.

cellular response to muramyl dipeptide Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to muramyl dipeptide biological process from the curated GO Biological Process Annotations dataset.

positive regulation of cellular response to x-ray Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of cellular response to x-ray biological process from the curated GO Biological Process Annotations dataset.

cellular response to bacterial lipopeptide Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to bacterial lipopeptide biological process from the curated GO Biological Process Annotations dataset.

cellular response to zinc ion starvation Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to zinc ion starvation biological process from the curated GO Biological Process Annotations dataset.

cellular response to decreased oxygen levels Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to decreased oxygen levels biological process from the curated GO Biological Process Annotations dataset.

cellular response to lipoteichoic acid Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to lipoteichoic acid biological process from the curated GO Biological Process Annotations dataset.

cellular response to misfolded protein Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to misfolded protein biological process from the curated GO Biological Process Annotations dataset.

cellular response to water deprivation Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to water deprivation biological process from the curated GO Biological Process Annotations dataset.

cellular response to glucose starvation Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to glucose starvation biological process from the curated GO Biological Process Annotations dataset.

cellular response to sterol Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to sterol biological process from the curated GO Biological Process Annotations dataset.

cellular response to x-ray Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to x-ray biological process from the curated GO Biological Process Annotations dataset.

cellular hyperosmotic response Gene Set

From GO Biological Process Annotations

genes participating in the cellular hyperosmotic response biological process from the curated GO Biological Process Annotations dataset.

cellular response to alkaline ph Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to alkaline ph biological process from the curated GO Biological Process Annotations dataset.

cellular response to nicotine Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to nicotine biological process from the curated GO Biological Process Annotations dataset.

cellular response to heparin Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to heparin biological process from the curated GO Biological Process Annotations dataset.

cellular response to cold Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to cold biological process from the curated GO Biological Process Annotations dataset.

cellular response to acidic ph Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to acidic ph biological process from the curated GO Biological Process Annotations dataset.

cellular response to magnesium ion Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to magnesium ion biological process from the curated GO Biological Process Annotations dataset.

cellular response to arsenic-containing substance Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to arsenic-containing substance biological process from the curated GO Biological Process Annotations dataset.

cellular response to ketone Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to ketone biological process from the curated GO Biological Process Annotations dataset.

cellular response to bacterial lipoprotein Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to bacterial lipoprotein biological process from the curated GO Biological Process Annotations dataset.

cellular response to triacyl bacterial lipopeptide Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to triacyl bacterial lipopeptide biological process from the curated GO Biological Process Annotations dataset.

cellular response to hydroxyurea Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to hydroxyurea biological process from the curated GO Biological Process Annotations dataset.

cellular response to cgmp Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to cgmp biological process from the curated GO Biological Process Annotations dataset.

cellular response to oxygen radical Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to oxygen radical biological process from the curated GO Biological Process Annotations dataset.

cellular response to retinoic acid Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to retinoic acid biological process from the curated GO Biological Process Annotations dataset.

cellular response to antibiotic Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to antibiotic biological process from the curated GO Biological Process Annotations dataset.

cellular response to virus Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to virus biological process from the curated GO Biological Process Annotations dataset.

cellular stress response to acidic ph Gene Set

From GO Biological Process Annotations

genes participating in the cellular stress response to acidic ph biological process from the curated GO Biological Process Annotations dataset.

cellular response to interleukin-4 Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to interleukin-4 biological process from the curated GO Biological Process Annotations dataset.

cellular response to interleukin-6 Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to interleukin-6 biological process from the curated GO Biological Process Annotations dataset.

cellular response to interleukin-1 Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to interleukin-1 biological process from the curated GO Biological Process Annotations dataset.

cellular response to interleukin-3 Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to interleukin-3 biological process from the curated GO Biological Process Annotations dataset.

cellular response to cobalt ion Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to cobalt ion biological process from the curated GO Biological Process Annotations dataset.

cellular response to cocaine Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to cocaine biological process from the curated GO Biological Process Annotations dataset.

cellular response to type i interferon Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to type i interferon biological process from the curated GO Biological Process Annotations dataset.

cellular hypotonic salinity response Gene Set

From GO Biological Process Annotations

genes participating in the cellular hypotonic salinity response biological process from the curated GO Biological Process Annotations dataset.

cellular response to peptidoglycan Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to peptidoglycan biological process from the curated GO Biological Process Annotations dataset.

cellular response to molecule of fungal origin Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to molecule of fungal origin biological process from the curated GO Biological Process Annotations dataset.

positive regulation of cellular response to drug Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of cellular response to drug biological process from the curated GO Biological Process Annotations dataset.

cellular response to oxygen levels Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to oxygen levels biological process from the curated GO Biological Process Annotations dataset.

cellular response to iron ion Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to iron ion biological process from the curated GO Biological Process Annotations dataset.

cellular response to peptide Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to peptide biological process from the curated GO Biological Process Annotations dataset.

cellular response to ethanol Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to ethanol biological process from the curated GO Biological Process Annotations dataset.

cellular response to copper ion Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to copper ion biological process from the curated GO Biological Process Annotations dataset.

cellular response to triglyceride Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to triglyceride biological process from the curated GO Biological Process Annotations dataset.

cellular response to sodium dodecyl sulfate Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to sodium dodecyl sulfate biological process from the curated GO Biological Process Annotations dataset.

cellular response to uv-a Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to uv-a biological process from the curated GO Biological Process Annotations dataset.

cellular response to uv-c Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to uv-c biological process from the curated GO Biological Process Annotations dataset.

cellular response to uv-b Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to uv-b biological process from the curated GO Biological Process Annotations dataset.

cellular response to phosphate starvation Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to phosphate starvation biological process from the curated GO Biological Process Annotations dataset.

cellular response to calcium ion Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to calcium ion biological process from the curated GO Biological Process Annotations dataset.

cellular response to copper ion starvation Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to copper ion starvation biological process from the curated GO Biological Process Annotations dataset.

cellular response to stress Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to stress biological process from the curated GO Biological Process Annotations dataset.

cellular response to lipid hydroperoxide Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to lipid hydroperoxide biological process from the curated GO Biological Process Annotations dataset.

cellular response to metal ion Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to metal ion biological process from the curated GO Biological Process Annotations dataset.

cellular response to iron(iii) ion Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to iron(iii) ion biological process from the curated GO Biological Process Annotations dataset.

cellular response to starvation Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to starvation biological process from the curated GO Biological Process Annotations dataset.

cellular response to inorganic substance Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to inorganic substance biological process from the curated GO Biological Process Annotations dataset.

cellular response to drug Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to drug biological process from the curated GO Biological Process Annotations dataset.

cellular response to amino acid starvation Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to amino acid starvation biological process from the curated GO Biological Process Annotations dataset.

cellular response to vitamin d Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to vitamin d biological process from the curated GO Biological Process Annotations dataset.

cellular response to vitamin e Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to vitamin e biological process from the curated GO Biological Process Annotations dataset.

cellular response to vitamin k Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to vitamin k biological process from the curated GO Biological Process Annotations dataset.

cellular response to alcohol Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to alcohol biological process from the curated GO Biological Process Annotations dataset.

cellular response to erythropoietin Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to erythropoietin biological process from the curated GO Biological Process Annotations dataset.

negative regulation of cellular response to heat Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of cellular response to heat biological process from the curated GO Biological Process Annotations dataset.

cellular response to freezing Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to freezing biological process from the curated GO Biological Process Annotations dataset.

regulation of cellular response to oxidative stress Gene Set

From GO Biological Process Annotations

genes participating in the regulation of cellular response to oxidative stress biological process from the curated GO Biological Process Annotations dataset.

cellular response to laminar fluid shear stress Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to laminar fluid shear stress biological process from the curated GO Biological Process Annotations dataset.

cellular response to dithiothreitol Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to dithiothreitol biological process from the curated GO Biological Process Annotations dataset.

cellular response to topologically incorrect protein Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to topologically incorrect protein biological process from the curated GO Biological Process Annotations dataset.

cellular response to tumor cell Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to tumor cell biological process from the curated GO Biological Process Annotations dataset.

cellular response to interferon-alpha Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to interferon-alpha biological process from the curated GO Biological Process Annotations dataset.

cellular response to vitamin b1 Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to vitamin b1 biological process from the curated GO Biological Process Annotations dataset.

regulation of cellular response to hypoxia Gene Set

From GO Biological Process Annotations

genes participating in the regulation of cellular response to hypoxia biological process from the curated GO Biological Process Annotations dataset.

cellular response to uv Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to uv biological process from the curated GO Biological Process Annotations dataset.

cellular response to isoquinoline alkaloid Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to isoquinoline alkaloid biological process from the curated GO Biological Process Annotations dataset.

cellular response to camp Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to camp biological process from the curated GO Biological Process Annotations dataset.

cellular response to sorbitol Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to sorbitol biological process from the curated GO Biological Process Annotations dataset.

cellular defense response Gene Set

From GO Biological Process Annotations

genes participating in the cellular defense response biological process from the curated GO Biological Process Annotations dataset.

cellular response to chromate Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to chromate biological process from the curated GO Biological Process Annotations dataset.

cellular response to zinc ion Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to zinc ion biological process from the curated GO Biological Process Annotations dataset.

cellular response to interferon-gamma Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to interferon-gamma biological process from the curated GO Biological Process Annotations dataset.

cellular response to camptothecin Gene Set

From GO Biological Process Annotations

genes participating in the cellular response to camptothecin biological process from the curated GO Biological Process Annotations dataset.

regulation of cellular response to stress Gene Set

From GO Biological Process Annotations

genes participating in the regulation of cellular response to stress biological process from the curated GO Biological Process Annotations dataset.

Cellular response to hypoxia Gene Set

From Reactome Pathways

proteins participating in the Cellular response to hypoxia pathway from the Reactome Pathways dataset.

Cellular response to heat stress Gene Set

From Reactome Pathways

proteins participating in the Cellular response to heat stress pathway from the Reactome Pathways dataset.

response to epidermal growth factor Gene Set

From GO Biological Process Annotations

genes participating in the response to epidermal growth factor biological process from the curated GO Biological Process Annotations dataset.

response to hepatocyte growth factor Gene Set

From GO Biological Process Annotations

genes participating in the response to hepatocyte growth factor biological process from the curated GO Biological Process Annotations dataset.

response to platelet-derived growth factor Gene Set

From GO Biological Process Annotations

genes participating in the response to platelet-derived growth factor biological process from the curated GO Biological Process Annotations dataset.

response to fibroblast growth factor Gene Set

From GO Biological Process Annotations

genes participating in the response to fibroblast growth factor biological process from the curated GO Biological Process Annotations dataset.

response to transforming growth factor beta Gene Set

From GO Biological Process Annotations

genes participating in the response to transforming growth factor beta biological process from the curated GO Biological Process Annotations dataset.

response to growth factor Gene Set

From GO Biological Process Annotations

genes participating in the response to growth factor biological process from the curated GO Biological Process Annotations dataset.

response to nerve growth factor Gene Set

From GO Biological Process Annotations

genes participating in the response to nerve growth factor biological process from the curated GO Biological Process Annotations dataset.

critical illness; multiple organ failure; systemic inflam response synd; systemic inflammatory response syndrome Gene Set

From GAD Gene-Disease Associations

genes associated with the disease critical illness; multiple organ failure; systemic inflam response synd; systemic inflammatory response syndrome in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

postoperative complications; systemic inflam response synd; systemic inflammatory response syndrome Gene Set

From GAD Gene-Disease Associations

genes associated with the disease postoperative complications; systemic inflam response synd; systemic inflammatory response syndrome in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

multiple organ failure; systemic inflam response synd; systemic inflammatory response syndrome Gene Set

From GAD Gene-Disease Associations

genes associated with the disease multiple organ failure; systemic inflam response synd; systemic inflammatory response syndrome in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

critical illness; sepsis; systemic infection; systemic inflam response synd; systemic inflammatory response syndrome Gene Set

From GAD Gene-Disease Associations

genes associated with the disease critical illness; sepsis; systemic infection; systemic inflam response synd; systemic inflammatory response syndrome in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

critical illness; systemic inflam response synd; systemic inflammatory response syndrome Gene Set

From GAD Gene-Disease Associations

genes associated with the disease critical illness; systemic inflam response synd; systemic inflammatory response syndrome in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

cholesterol, response to; dietary fat, response to Gene Set

From GAD Gene-Disease Associations

genes associated with the disease cholesterol, response to; dietary fat, response to in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

systemic inflam response synd; systemic inflammatory response syndrome Gene Set

From GAD Gene-Disease Associations

genes associated with the disease systemic inflam response synd; systemic inflammatory response syndrome in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

response to host immune response Gene Set

From GO Biological Process Annotations

genes participating in the response to host immune response biological process from the curated GO Biological Process Annotations dataset.

response to immune response of other organism involved in symbiotic interaction Gene Set

From GO Biological Process Annotations

genes participating in the response to immune response of other organism involved in symbiotic interaction biological process from the curated GO Biological Process Annotations dataset.

Response to alcohol consumption (flushing response) Gene Set

From GWAS Catalog SNP-Phenotype Associations

genes associated with the Response to alcohol consumption (flushing response) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.

stimulus Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stimulus in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stimulusdependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stimulusdependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stimulusresponsive Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stimulusresponsive in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stimulusresponse Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stimulusresponse in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stimulusspecific Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stimulusspecific in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stimulusinduced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stimulusinduced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

detection of biotic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the detection of biotic stimulus biological process from the curated GO Biological Process Annotations dataset.

detection of light stimulus involved in sensory perception Gene Set

From GO Biological Process Annotations

genes participating in the detection of light stimulus involved in sensory perception biological process from the curated GO Biological Process Annotations dataset.

sensory perception of chemical stimulus Gene Set

From GO Biological Process Annotations

genes participating in the sensory perception of chemical stimulus biological process from the curated GO Biological Process Annotations dataset.

detection of mechanical stimulus involved in sensory perception of sound Gene Set

From GO Biological Process Annotations

genes participating in the detection of mechanical stimulus involved in sensory perception of sound biological process from the curated GO Biological Process Annotations dataset.

detection of carbohydrate stimulus Gene Set

From GO Biological Process Annotations

genes participating in the detection of carbohydrate stimulus biological process from the curated GO Biological Process Annotations dataset.

detection of endogenous stimulus Gene Set

From GO Biological Process Annotations

genes participating in the detection of endogenous stimulus biological process from the curated GO Biological Process Annotations dataset.

detection of cell density by contact stimulus involved in contact inhibition Gene Set

From GO Biological Process Annotations

genes participating in the detection of cell density by contact stimulus involved in contact inhibition biological process from the curated GO Biological Process Annotations dataset.

sensory perception of temperature stimulus Gene Set

From GO Biological Process Annotations

genes participating in the sensory perception of temperature stimulus biological process from the curated GO Biological Process Annotations dataset.

detection of monosaccharide stimulus Gene Set

From GO Biological Process Annotations

genes participating in the detection of monosaccharide stimulus biological process from the curated GO Biological Process Annotations dataset.

detection of chemical stimulus Gene Set

From GO Biological Process Annotations

genes participating in the detection of chemical stimulus biological process from the curated GO Biological Process Annotations dataset.

detection of temperature stimulus involved in sensory perception Gene Set

From GO Biological Process Annotations

genes participating in the detection of temperature stimulus involved in sensory perception biological process from the curated GO Biological Process Annotations dataset.

detection of mechanical stimulus involved in equilibrioception Gene Set

From GO Biological Process Annotations

genes participating in the detection of mechanical stimulus involved in equilibrioception biological process from the curated GO Biological Process Annotations dataset.

detection of chemical stimulus involved in sensory perception of sweet taste Gene Set

From GO Biological Process Annotations

genes participating in the detection of chemical stimulus involved in sensory perception of sweet taste biological process from the curated GO Biological Process Annotations dataset.

detection of mechanical stimulus involved in sensory perception of touch Gene Set

From GO Biological Process Annotations

genes participating in the detection of mechanical stimulus involved in sensory perception of touch biological process from the curated GO Biological Process Annotations dataset.

detection of chemical stimulus involved in sensory perception of sour taste Gene Set

From GO Biological Process Annotations

genes participating in the detection of chemical stimulus involved in sensory perception of sour taste biological process from the curated GO Biological Process Annotations dataset.

detection of external stimulus Gene Set

From GO Biological Process Annotations

genes participating in the detection of external stimulus biological process from the curated GO Biological Process Annotations dataset.

detection of chemical stimulus involved in sensory perception Gene Set

From GO Biological Process Annotations

genes participating in the detection of chemical stimulus involved in sensory perception biological process from the curated GO Biological Process Annotations dataset.

detection of chemical stimulus involved in sensory perception of pain Gene Set

From GO Biological Process Annotations

genes participating in the detection of chemical stimulus involved in sensory perception of pain biological process from the curated GO Biological Process Annotations dataset.

detection of stimulus Gene Set

From GO Biological Process Annotations

genes participating in the detection of stimulus biological process from the curated GO Biological Process Annotations dataset.

detection of stimulus involved in sensory perception Gene Set

From GO Biological Process Annotations

genes participating in the detection of stimulus involved in sensory perception biological process from the curated GO Biological Process Annotations dataset.

sensory perception of mechanical stimulus Gene Set

From GO Biological Process Annotations

genes participating in the sensory perception of mechanical stimulus biological process from the curated GO Biological Process Annotations dataset.

detection of light stimulus Gene Set

From GO Biological Process Annotations

genes participating in the detection of light stimulus biological process from the curated GO Biological Process Annotations dataset.

detection of mechanical stimulus involved in sensory perception Gene Set

From GO Biological Process Annotations

genes participating in the detection of mechanical stimulus involved in sensory perception biological process from the curated GO Biological Process Annotations dataset.

detection of mechanical stimulus involved in sensory perception of pain Gene Set

From GO Biological Process Annotations

genes participating in the detection of mechanical stimulus involved in sensory perception of pain biological process from the curated GO Biological Process Annotations dataset.

detection of chemical stimulus involved in sensory perception of bitter taste Gene Set

From GO Biological Process Annotations

genes participating in the detection of chemical stimulus involved in sensory perception of bitter taste biological process from the curated GO Biological Process Annotations dataset.

detection of abiotic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the detection of abiotic stimulus biological process from the curated GO Biological Process Annotations dataset.

detection of external biotic stimulus Gene Set

From GO Biological Process Annotations

genes participating in the detection of external biotic stimulus biological process from the curated GO Biological Process Annotations dataset.

sensory perception of light stimulus Gene Set

From GO Biological Process Annotations

genes participating in the sensory perception of light stimulus biological process from the curated GO Biological Process Annotations dataset.

detection of chemical stimulus involved in sensory perception of taste Gene Set

From GO Biological Process Annotations

genes participating in the detection of chemical stimulus involved in sensory perception of taste biological process from the curated GO Biological Process Annotations dataset.

detection of temperature stimulus Gene Set

From GO Biological Process Annotations

genes participating in the detection of temperature stimulus biological process from the curated GO Biological Process Annotations dataset.

detection of temperature stimulus involved in sensory perception of pain Gene Set

From GO Biological Process Annotations

genes participating in the detection of temperature stimulus involved in sensory perception of pain biological process from the curated GO Biological Process Annotations dataset.

detection of hexose stimulus Gene Set

From GO Biological Process Annotations

genes participating in the detection of hexose stimulus biological process from the curated GO Biological Process Annotations dataset.

detection of mechanical stimulus Gene Set

From GO Biological Process Annotations

genes participating in the detection of mechanical stimulus biological process from the curated GO Biological Process Annotations dataset.

detection of cell density by contact stimulus Gene Set

From GO Biological Process Annotations

genes participating in the detection of cell density by contact stimulus biological process from the curated GO Biological Process Annotations dataset.

detection of chemical stimulus involved in sensory perception of smell Gene Set

From GO Biological Process Annotations

genes participating in the detection of chemical stimulus involved in sensory perception of smell biological process from the curated GO Biological Process Annotations dataset.

detection of light stimulus involved in visual perception Gene Set

From GO Biological Process Annotations

genes participating in the detection of light stimulus involved in visual perception biological process from the curated GO Biological Process Annotations dataset.

Thyroid hormone metabolism, abnormal Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Thyroid hormone metabolism, abnormal phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Thyrotropin-releasing hormone resistance, generalized Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Thyrotropin-releasing hormone resistance, generalized phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Thyroid hormone resistance, generalized, autosomal recessive Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Thyroid hormone resistance, generalized, autosomal recessive phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Pituitary hormone deficiency, combined Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Pituitary hormone deficiency, combined phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Thyroid hormone resistance, generalized, autosomal dominant Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Thyroid hormone resistance, generalized, autosomal dominant phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Follicle-stimulating hormone deficiency, isolated Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Follicle-stimulating hormone deficiency, isolated phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Acrodysostosis 2, with or without hormone resistance Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Acrodysostosis 2, with or without hormone resistance phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Pituitary hormone deficiency, combined 4 Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Pituitary hormone deficiency, combined 4 phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Pituitary hormone deficiency, combined 3 Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Pituitary hormone deficiency, combined 3 phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Pituitary hormone deficiency, combined 2 Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Pituitary hormone deficiency, combined 2 phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Pituitary hormone deficiency, combined 1 Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Pituitary hormone deficiency, combined 1 phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Pituitary hormone deficiency, combined, 5 Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Pituitary hormone deficiency, combined, 5 phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Pituitary hormone deficiency, combined, 6 Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Pituitary hormone deficiency, combined, 6 phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Thyroid hormone resistance, selective pituitary Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Thyroid hormone resistance, selective pituitary phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

follicle-stimulating hormone complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the follicle-stimulating hormone complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

alpha helical corticotropin-releasing hormone Gene Set

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical alpha helical corticotropin-releasing hormone from the curated CTD Gene-Chemical Interactions dataset.

Adrenocorticotropic Hormone Gene Set

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Adrenocorticotropic Hormone from the curated CTD Gene-Chemical Interactions dataset.

Gonadotropin-Releasing Hormone Gene Set

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Gonadotropin-Releasing Hormone from the curated CTD Gene-Chemical Interactions dataset.

corticotropin releasing hormone (9-41) Gene Set

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical corticotropin releasing hormone (9-41) from the curated CTD Gene-Chemical Interactions dataset.

juvenile hormone III Gene Set