Name

CDK6 Gene

cyclin-dependent kinase 6

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009]

cdk6 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CDK6 Gene Set

From KEA Substrates of Kinases

substrates of the kinase CDK6 from the curated KEA Substrates of Kinases dataset.

CDK6 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDK6 from the Pathway Commons Protein-Protein Interactions dataset.

CDK6 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase CDK6 from the curated PhosphoSitePlus Substrates of Kinases dataset.

cyclin d3-cdk6 complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cyclin d3-cdk6 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

cyclin d1-cdk6 complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cyclin d1-cdk6 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

cyclin d2-cdk6 complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cyclin d2-cdk6 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

CyclinD3-CDK4-CDK6 complex Gene Set

From CORUM Protein Complexes

proteins in the CyclinD3-CDK4-CDK6 complex protein complex from the CORUM Protein Complexes dataset.

CCND2-CDK6 complex Gene Set

From CORUM Protein Complexes

proteins in the CCND2-CDK6 complex protein complex from the CORUM Protein Complexes dataset.

CyclinD3-CDK4-CDK6-p21 complex Gene Set

From CORUM Protein Complexes

proteins in the CyclinD3-CDK4-CDK6-p21 complex protein complex from the CORUM Protein Complexes dataset.

CCND3-CDK6 complex Gene Set

From CORUM Protein Complexes

proteins in the CCND3-CDK6 complex protein complex from the CORUM Protein Complexes dataset.

p19-Cdk6 complex Gene Set

From CORUM Protein Complexes

proteins in the p19-Cdk6 complex protein complex from the CORUM Protein Complexes dataset.

CyclinD1-CDK4-CDK6 complex Gene Set

From CORUM Protein Complexes

proteins in the CyclinD1-CDK4-CDK6 complex protein complex from the CORUM Protein Complexes dataset.

CCND1-CDK6 complex Gene Set

From CORUM Protein Complexes

proteins in the CCND1-CDK6 complex protein complex from the CORUM Protein Complexes dataset.

p18-Cdk6 complex Gene Set

From CORUM Protein Complexes

proteins in the p18-Cdk6 complex protein complex from the CORUM Protein Complexes dataset.

cdk6cdkn2a Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk6cdkn2a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CDK6_knockdown_93_GSE27869 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the CDK6_knockdown_93_GSE27869 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.