Name

CDC27P10 Gene

cell division cycle 27 pseudogene 10

CDC27P11 Gene

cell division cycle 27 pseudogene 11

CDC20B Gene

cell division cycle 20B

CDC20P1 Gene

cell division cycle 20 pseudogene 1

CDC27P7 Gene

cell division cycle 27 pseudogene 7

CDC25C Gene

cell division cycle 25C

This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. [provided by RefSeq, Jul 2008]

CDC25B Gene

cell division cycle 25B

CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008]

CDC25A Gene

cell division cycle 25A

CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

CDC27P2 Gene

cell division cycle 27 pseudogene 2

CDC27P3 Gene

cell division cycle 27 pseudogene 3

CDC27P1 Gene

cell division cycle 27 pseudogene 1

CDC27P6 Gene

cell division cycle 27 pseudogene 6

CDC27P4 Gene

cell division cycle 27 pseudogene 4

CDC27P5 Gene

cell division cycle 27 pseudogene 5

CDC27P8 Gene

cell division cycle 27 pseudogene 8

CDC27P9 Gene

cell division cycle 27 pseudogene 9

CDC27 Gene

cell division cycle 27

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014]

CDC26 Gene

cell division cycle 26

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008]

CDC20 Gene

cell division cycle 20

CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation. [provided by RefSeq, Jul 2008]

CDC23 Gene

cell division cycle 23

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. [provided by RefSeq, Jul 2008]

CDC26P1 Gene

cell division cycle 26 pseudogene 1

cdc2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdc2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdc25 and chk1 regulatory pathway in response to dna damage Gene Set

From Biocarta Pathways

proteins participating in the cdc25 and chk1 regulatory pathway in response to dna damage pathway from the Biocarta Pathways dataset.

CDC2-CCNB1-PTCH1 complex Gene Set

From CORUM Protein Complexes

proteins in the CDC2-CCNB1-PTCH1 complex protein complex from the CORUM Protein Complexes dataset.

CDC2-PCNA-CCNB1-GADD45A complex Gene Set

From CORUM Protein Complexes

proteins in the CDC2-PCNA-CCNB1-GADD45A complex protein complex from the CORUM Protein Complexes dataset.

Cell cycle kinase complex CDC2 Gene Set

From CORUM Protein Complexes

proteins in the Cell cycle kinase complex CDC2 protein complex from the CORUM Protein Complexes dataset.

CDC2-CCNA2-CDK2 complex Gene Set

From CORUM Protein Complexes

proteins in the CDC2-CCNA2-CDK2 complex protein complex from the CORUM Protein Complexes dataset.

Cdc2-Ccnb1 complex Gene Set

From CORUM Protein Complexes

proteins in the Cdc2-Ccnb1 complex protein complex from the CORUM Protein Complexes dataset.

RalBP1-CDC2-CCNB1 complex Gene Set

From CORUM Protein Complexes

proteins in the RalBP1-CDC2-CCNB1 complex protein complex from the CORUM Protein Complexes dataset.

Cell division cycle complex (CDC27, CDC16, ANAPC7) Gene Set

From CORUM Protein Complexes

proteins in the Cell division cycle complex (CDC27, CDC16, ANAPC7) protein complex from the CORUM Protein Complexes dataset.

MAD2-CDC20 complex Gene Set

From CORUM Protein Complexes

proteins in the MAD2-CDC20 complex protein complex from the CORUM Protein Complexes dataset.

CCNB1-CDC2 complex Gene Set

From CORUM Protein Complexes

proteins in the CCNB1-CDC2 complex protein complex from the CORUM Protein Complexes dataset.

CDC2-PCNA-CCNB1-GADD45B complex Gene Set

From CORUM Protein Complexes

proteins in the CDC2-PCNA-CCNB1-GADD45B complex protein complex from the CORUM Protein Complexes dataset.

CCNB2-CDC2 complex Gene Set

From CORUM Protein Complexes

proteins in the CCNB2-CDC2 complex protein complex from the CORUM Protein Complexes dataset.

CDC2-CCNB1-CCNF complex Gene Set

From CORUM Protein Complexes

proteins in the CDC2-CCNB1-CCNF complex protein complex from the CORUM Protein Complexes dataset.

CDC2-PCNA-CCNB1-GADD45G complex Gene Set

From CORUM Protein Complexes

proteins in the CDC2-PCNA-CCNB1-GADD45G complex protein complex from the CORUM Protein Complexes dataset.

ESPL1-CDC2 complex Gene Set

From CORUM Protein Complexes

proteins in the ESPL1-CDC2 complex protein complex from the CORUM Protein Complexes dataset.

CDC2-CCNA2 complex Gene Set

From CORUM Protein Complexes

proteins in the CDC2-CCNA2 complex protein complex from the CORUM Protein Complexes dataset.

CyclinB1-Cdc2 complex Gene Set

From CORUM Protein Complexes

proteins in the CyclinB1-Cdc2 complex protein complex from the CORUM Protein Complexes dataset.

CDC25C Gene Set

From DEPOD Substrates of Phosphatases

substrates of the phosphatase CDC25C from the curated DEPOD Substrates of Phosphatases dataset.

CDC25B Gene Set

From DEPOD Substrates of Phosphatases

substrates of the phosphatase CDC25B from the curated DEPOD Substrates of Phosphatases dataset.

CDC25A Gene Set

From DEPOD Substrates of Phosphatases

substrates of the phosphatase CDC25A from the curated DEPOD Substrates of Phosphatases dataset.

cdc20mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdc20mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdc20enabling Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdc20enabling in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdc27 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdc27 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdc25 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdc25 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdc20 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdc20 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdc2dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdc2dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdc20dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdc20dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdc2cyclin Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdc2cyclin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdc2like Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdc2like in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdc20independent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdc20independent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdc25acdk2independent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdc25acdk2independent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdc2mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdc2mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdc2l5 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdc2l5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdc2cdk1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdc2cdk1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdc25c Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdc25c in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdc25b Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdc25b in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdc25a Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdc25a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdc2p34 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdc2p34 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

inhibition of apc-cdc20 complex activity Gene Set

From GO Biological Process Annotations

genes participating in the inhibition of apc-cdc20 complex activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of apc-cdc20 complex activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of apc-cdc20 complex activity biological process from the curated GO Biological Process Annotations dataset.

activation of apc-cdc20 complex activity Gene Set

From GO Biological Process Annotations

genes participating in the activation of apc-cdc20 complex activity biological process from the curated GO Biological Process Annotations dataset.

Anaphase-promoting complex, subunit CDC26 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Anaphase-promoting complex, subunit CDC26 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Cdc23 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Cdc23 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Guanine-nucleotide dissociation stimulator, CDC24, conserved site Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Guanine-nucleotide dissociation stimulator, CDC24, conserved site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Mad1/Cdc20-bound-Mad2 binding protein Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Mad1/Cdc20-bound-Mad2 binding protein protein domain from the InterPro Predicted Protein Domain Annotations dataset.

DNA polymerase subunit Cdc27 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the DNA polymerase subunit Cdc27 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine/threonine-protein kinase, Cdc2 inhibitor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine/threonine-protein kinase, Cdc2 inhibitor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

CDC27 Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for CDC27 from the MSigDB Cancer Gene Co-expression Modules dataset.

CDC20 Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for CDC20 from the MSigDB Cancer Gene Co-expression Modules dataset.

BL1574 (CDC2L6) Gene Set

From NURSA Protein Complexes

proteins in the BL1574 (CDC2L6) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

BL4893 (CDC20) Gene Set

From NURSA Protein Complexes

proteins in the BL4893 (CDC20) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

BL4891 (CDC20) Gene Set

From NURSA Protein Complexes

proteins in the BL4891 (CDC20) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

BL330 (CDC25A) Gene Set

From NURSA Protein Complexes

proteins in the BL330 (CDC25A) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

SC-954 (CDC2) Gene Set

From NURSA Protein Complexes

proteins in the SC-954 (CDC2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

BL1573 (CDC2L6) Gene Set

From NURSA Protein Complexes

proteins in the BL1573 (CDC2L6) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

EPI-1490-1 (CDC25C) Gene Set

From NURSA Protein Complexes

proteins in the EPI-1490-1 (CDC25C) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

SC-97 (CDC25A) Gene Set

From NURSA Protein Complexes

proteins in the SC-97 (CDC25A) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

BL1575 (CDC2L6) Gene Set

From NURSA Protein Complexes

proteins in the BL1575 (CDC2L6) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

SC-12340R (CDC2) Gene Set

From NURSA Protein Complexes

proteins in the SC-12340R (CDC2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

CDC27 Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for CDC27 from the NURSA Protein-Protein Interactions dataset.

CDC23 Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for CDC23 from the NURSA Protein-Protein Interactions dataset.

CDC23 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDC23 from the Pathway Commons Protein-Protein Interactions dataset.

CDC25B Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDC25B from the Pathway Commons Protein-Protein Interactions dataset.

CDC25A Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDC25A from the Pathway Commons Protein-Protein Interactions dataset.

CDC27 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDC27 from the Pathway Commons Protein-Protein Interactions dataset.

CDC26 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDC26 from the Pathway Commons Protein-Protein Interactions dataset.

CDC25C Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDC25C from the Pathway Commons Protein-Protein Interactions dataset.

CDC20 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDC20 from the Pathway Commons Protein-Protein Interactions dataset.

cdc2-protein-kinase Gene Set

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term cdc2-protein-kinase in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Gene Set

From Reactome Pathways

proteins participating in the Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway from the Reactome Pathways dataset.

APC/C:Cdc20 mediated degradation of mitotic proteins Gene Set

From Reactome Pathways

proteins participating in the APC/C:Cdc20 mediated degradation of mitotic proteins pathway from the Reactome Pathways dataset.

APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint Gene Set

From Reactome Pathways

proteins participating in the APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint pathway from the Reactome Pathways dataset.

Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins Gene Set

From Reactome Pathways

proteins participating in the Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway from the Reactome Pathways dataset.

Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes Gene Set

From Reactome Pathways

proteins participating in the Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes pathway from the Reactome Pathways dataset.

APC-Cdc20 mediated degradation of Nek2A Gene Set

From Reactome Pathways

proteins participating in the APC-Cdc20 mediated degradation of Nek2A pathway from the Reactome Pathways dataset.

APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Gene Set

From Reactome Pathways

proteins participating in the APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway from the Reactome Pathways dataset.

APC/C:Cdc20 mediated degradation of Securin Gene Set

From Reactome Pathways

proteins participating in the APC/C:Cdc20 mediated degradation of Securin pathway from the Reactome Pathways dataset.

APC/C:Cdc20 mediated degradation of Cyclin B Gene Set

From Reactome Pathways

proteins participating in the APC/C:Cdc20 mediated degradation of Cyclin B pathway from the Reactome Pathways dataset.

Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Gene Set

From Reactome Pathways

proteins participating in the Ubiquitin Mediated Degradation of Phosphorylated Cdc25A pathway from the Reactome Pathways dataset.

Cdc20:Phospho-APC/C mediated degradation of Cyclin A Gene Set

From Reactome Pathways

proteins participating in the Cdc20:Phospho-APC/C mediated degradation of Cyclin A pathway from the Reactome Pathways dataset.