Name

SLC4A11 Gene

solute carrier family 4, sodium borate transporter, member 11

This gene encodes a voltage-regulated, electrogenic sodium-coupled borate cotransporter that is essential for borate homeostasis, cell growth and cell proliferation. Mutations in this gene have been associated with a number of endothelial corneal dystrophies including recessive corneal endothelial dystrophy 2, corneal dystrophy and perceptive deafness, and Fuchs endothelial corneal dystrophy. Multiple transcript variants encoding different isoforms have been described. [provided by RefSeq, Mar 2010]

MAGT1 Gene

magnesium transporter 1

This gene encodes a magnesium cation transporter protein that localizes to the cell membrane. This protein also associates with N-oligosaccharyl transferase and therefore may have a role in N-glycosylation. Mutations in this gene cause mental retardation X-linked type 95 (MRX95). This gene may have multiple in-frame translation initiation sites, one of which would encode a shorter protein with an N-terminus containing a signal peptide at amino acids 1-29. [provided by RefSeq, Jan 2010]

TAP1 Gene

transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is involved in the pumping of degraded cytosolic peptides across the endoplasmic reticulum into the membrane-bound compartment where class I molecules assemble. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]

TAP2 Gene

transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. [provided by RefSeq, Feb 2014]

SLC18A3 Gene

solute carrier family 18 (vesicular acetylcholine transporter), member 3

This gene is a member of the vesicular amine transporter family. The encoded transmembrane protein transports acetylcholine into secretory vesicles for release into the extracellular space. Acetylcholine transport utilizes a proton gradient established by a vacuolar ATPase. This gene is located within the first intron of the choline acetyltransferase gene. [provided by RefSeq, Jul 2008]

SLC18A2 Gene

solute carrier family 18 (vesicular monoamine transporter), member 2

The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).[supplied by OMIM, Jan 2011]

SLC18A1 Gene

solute carrier family 18 (vesicular monoamine transporter), member 1

The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).[supplied by OMIM, Mar 2008]

SLC17A9 Gene

solute carrier family 17 (vesicular nucleotide transporter), member 9

This gene encodes a member of a family of transmembrane proteins that are involved in the transport of small molecules. The encoded protein participates in the vesicular uptake, storage, and secretion of adenoside triphosphate (ATP) and other nucleotides. A mutation in this gene was found in individuals with autosomal dominant disseminated superficial actinic porokeratosis-8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

SLC17A5 Gene

solute carrier family 17 (acidic sugar transporter), member 5

This gene encodes a membrane transporter that exports free sialic acids that have been cleaved off of cell surface lipids and proteins from lysosomes. Mutations in this gene cause sialic acid storage diseases, including infantile sialic acid storage disorder and and Salla disease, an adult form. [provided by RefSeq, Jul 2008]

SLC17A6 Gene

solute carrier family 17 (vesicular glutamate transporter), member 6

SLC17A7 Gene

solute carrier family 17 (vesicular glutamate transporter), member 7

The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. [provided by RefSeq, Jul 2008]

SLC17A1 Gene

solute carrier family 17 (organic anion transporter), member 1

SLC17A3 Gene

solute carrier family 17 (organic anion transporter), member 3

The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been found for this gene. The longer isoform is a plasma membrane protein with transporter activity while the shorter isoform localizes to the endoplasmic reticulum. [provided by RefSeq, Aug 2012]

SLC22A2 Gene

solute carrier family 22 (organic cation transporter), member 2

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. It is found primarily in the kidney, where it may mediate the first step in cation reabsorption. [provided by RefSeq, Jul 2008]

SLC7A6 Gene

solute carrier family 7 (amino acid transporter light chain, y+L system), member 6

SLC7A1 Gene

solute carrier family 7 (cationic amino acid transporter, y+ system), member 1

SLC25A37 Gene

solute carrier family 25 (mitochondrial iron transporter), member 37

SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009 [PubMed 19805291]).[supplied by OMIM, Jan 2011]

OCTN3 Gene

organic cation transporter 3

SLC6A20 Gene

solute carrier family 6 (proline IMINO transporter), member 20

Transport of small hydrophilic substances across cell membranes is mediated by substrate-specific transporter proteins which have been classified into several families of related genes. The protein encoded by this gene is a member of the subgroup of transporter with unidentified substrates within the Na+ and Cl- coupled transporter family. This gene is expressed in kidney, and its alternative splicing generates 2 transcript variants. [provided by RefSeq, Jul 2008]

LOC100130121 Gene

solute carrier family 19 (thiamine transporter), member 3 pseudogene

SLC23A2 Gene

solute carrier family 23 (ascorbic acid transporter), member 2

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1. [provided by RefSeq, Jul 2008]

SLC17A8 Gene

solute carrier family 17 (vesicular glutamate transporter), member 8

This gene encodes a vesicular glutamate transporter. The encoded protein transports the neurotransmitter glutamate into synaptic vesicles before it is released into the synaptic cleft. Mutations in this gene are the cause of autosomal-dominant nonsyndromic type 25 deafness. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

SLC37A1 Gene

solute carrier family 37 (glucose-6-phosphate transporter), member 1

SLC37A1, a member of the sugar-phosphate transport family, transports glycerol-3-phosphate (G3P) between cellular compartments for its utilization in several compartment-specific biochemical pathways.[supplied by OMIM, Jul 2004]

LOC100287294 Gene

equilibrative nucleoside transporter 4-like

SLCO2B1 Gene

solute carrier organic anion transporter family, member 2B1

This locus encodes a member of the organic anion-transporting polypeptide family of membrane proteins. The protein encoded by this locus may function in regulation of placental uptake of sulfated steroids. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]

SLCO1A2 Gene

solute carrier organic anion transporter family, member 1A2

This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008]

SLC31A1 Gene

solute carrier family 31 (copper transporter), member 1

The protein encoded by this gene is a high-affinity copper transporter found in the cell membrane. The encoded protein functions as a homotrimer to effect the uptake of dietary copper. [provided by RefSeq, Aug 2011]

SLC31A2 Gene

solute carrier family 31 (copper transporter), member 2

SLC31A1P1 Gene

solute carrier family 31 (copper transporter), member 1 pseudogene 1

SLC35C2 Gene

solute carrier family 35 (GDP-fucose transporter), member C2

This gene encodes a member of the triose-phosphate transporter protein family. This gene is regulated by oxygen tension, is induced in hypoxic trophoblast cells, and is overexpressed in ovarian cancer. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Jul 2013]

SLC35C1 Gene

solute carrier family 35 (GDP-fucose transporter), member C1

This gene encodes a GDP-fucose transporter that is found in the Golgi apparatus. Mutations in this gene result in congenital disorder of glycosylation type IIc. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

LOC100422091 Gene

solute carrier family 30 (zinc transporter), member 6 pseudogene

SLC29A4 Gene

solute carrier family 29 (equilibrative nucleoside transporter), member 4

This gene encodes a member of the SLC29A/ENT transporter protein family. The encoded membrane protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

SLC29A3 Gene

solute carrier family 29 (equilibrative nucleoside transporter), member 3

This gene encodes a nucleoside transporter. The encoded protein plays a role in cellular uptake of nucleosides, nucleobases, and their related analogs. Mutations in this gene have been associated with H syndrome, which is characterized by cutaneous hyperpigmentation and hypertrichosis, hepatosplenomegaly, heart anomalies, and hypogonadism. A related disorder, PHID (pigmented hypertrichosis with insulin-dependent diabetes mellitus), has also been associated with mutations at this locus. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2010]

SLC29A2 Gene

solute carrier family 29 (equilibrative nucleoside transporter), member 2

The uptake of nucleosides by transporters, such as SLC29A2, is essential for nucleotide synthesis by salvage pathways in cells that lack de novo biosynthetic pathways. Nucleoside transport also plays a key role in the regulation of many physiologic processes through its effect on adenosine concentration at the cell surface (Griffiths et al., 1997 [PubMed 9396714]).[supplied by OMIM, Nov 2008]

SLC29A1 Gene

solute carrier family 29 (equilibrative nucleoside transporter), member 1

This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

SLC12A4 Gene

solute carrier family 12 (potassium/chloride transporter), member 4

This gene encodes a member of the SLC12A transporter family. The encoded protein mediates the coupled movement of potassium and chloride ions across the plasma membrane. This gene is expressed ubiquitously. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

SLC6A13 Gene

solute carrier family 6 (neurotransmitter transporter), member 13

SLC6A12 Gene

solute carrier family 6 (neurotransmitter transporter), member 12

SLC11A1 Gene

solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1

This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

LOC101060052 Gene

zinc transporter ZIP1-like

SLC52A1 Gene

solute carrier family 52 (riboflavin transporter), member 1

Biological redox reactions require electron donors and acceptor. Vitamin B2 is the source for the flavin in flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) which are common redox reagents. This gene encodes a member of the riboflavin (vitamin B2) transporter family. Haploinsufficiency of this protein can cause maternal riboflavin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]

SLC52A3 Gene

solute carrier family 52 (riboflavin transporter), member 3

This gene encodes a riboflavin transporter protein that is strongly expressed in the intestine and likely plays a role in intestinal absorption of riboflavin. The protein is predicted to have eleven transmembrane domains and a cell surface localization signal in the C-terminus. Mutations at this locus have been associated with Brown-Vialetto-Van Laere syndrome and Fazio-Londe disease. [provided by RefSeq, Mar 2012]

SLC52A2 Gene

solute carrier family 52 (riboflavin transporter), member 2

This gene encodes a membrane protein which belongs to the riboflavin transporter family. In humans, riboflavin must be obtained by intestinal absorption because it cannot be synthesized by the body. The water-soluble vitamin riboflavin is processed to the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) which then act as intermediaries in many cellular metabolic reactions. Paralogous members of the riboflavin transporter gene family are located on chromosomes 17 and 20. Unlike other members of this family, this gene has higher expression in brain tissue than small intestine. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. Mutations in this gene have been associated with Brown-Vialetto-Van Laere syndrome 2 - an autosomal recessive progressive neurologic disorder characterized by deafness, bulbar dysfunction, and axial and limb hypotonia. [provided by RefSeq, Jul 2012]

SLC6A11 Gene

solute carrier family 6 (neurotransmitter transporter), member 11

Gamma-aminobutyric acid (GABA) is a major inhibitory neurotransmitter. GABAergic neurotransmission is terminated by the uptake of GABA into the presynaptic terminal and the surrounding astroglial cells by sodium-dependent transporters, such as SLC6A11 (Borden et al., 1994 [PubMed 7874447]).[supplied by OMIM, Nov 2010]

SLC6A17 Gene

solute carrier family 6 (neutral amino acid transporter), member 17

The SLC6 family of proteins, which includes SLC6A17, acts as specific transporters for neurotransmitters, amino acids, and osmolytes like betaine, taurine, and creatine. SLC6 proteins are sodium cotransporters that derive the energy for solute transport from the electrochemical gradient for sodium ions (Hoglund et al., 2005 [PubMed 16125675]).[supplied by OMIM, Mar 2008]

SLC6A15 Gene

solute carrier family 6 (neutral amino acid transporter), member 15

This gene encodes a member of the solute carrier family 6 protein family which transports neutral amino acids. The encoded protein is thought to play a role in neuronal amino acid transport (PMID: 16185194) and may be associated with major depression (PMID: 21521612). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

SLC6A14 Gene

solute carrier family 6 (amino acid transporter), member 14

This gene encodes a member of the solute carrier family 6. Members of this family are sodium and chloride dependent neurotransmitter transporters. The encoded protein transports both neutral and cationic amino acids. This protein may also function as a beta-alanine carrier. Mutations in this gene may be associated with X-linked obesity. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, May 2010]

SLC6A10PB Gene

solute carrier family 6 (neurotransmitter transporter), member 8 pseudogene

SLC32A1 Gene

solute carrier family 32 (GABA vesicular transporter), member 1

The protein encoded by this gene is an integral membrane protein involved in gamma-aminobutyric acid (GABA) and glycine uptake into synaptic vesicles. The encoded protein is a member of amino acid/polyamine transporter family II. [provided by RefSeq, Jul 2008]

SLC7A9 Gene

solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9

This gene encodes a protein that belongs to a family of light subunits of amino acid transporters. This protein plays a role in the high-affinity and sodium-independent transport of cystine and neutral and dibasic amino acids, and appears to function in the reabsorption of cystine in the kidney tubule. Mutations in this gene cause non-type I cystinuria, a disease that leads to cystine stones in the urinary system due to impaired transport of cystine and dibasic amino acids. Alternate transcript variants, which encode the same protein, have been found for this gene. [provided by RefSeq, Jul 2011]

LOC105370945 Gene

probable lysosomal cobalamin transporter

SLC2AXP1 Gene

solute carrier family 2 (facilitated glucose transporter), pseudogene 1

SLCO2A1 Gene

solute carrier organic anion transporter family, member 2A1

This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues. [provided by RefSeq, Dec 2011]

SLC14A2 Gene

solute carrier family 14 (urea transporter), member 2

The protein encoded by this gene belongs to the urea transporter family. In mammalian cells, urea is the chief end product of nitrogen catabolism, and plays an important role in the urinary concentration mechanism. This protein is expressed in the inner medulla of the kidney, and mediates rapid transepithelial urea transport across the inner medullary collecting duct. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]

SLC14A1 Gene

solute carrier family 14 (urea transporter), member 1 (Kidd blood group)

The protein encoded by this gene is a membrane transporter that mediates urea transport in erythrocytes. This gene forms the basis for the Kidd blood group system. [provided by RefSeq, Mar 2009]

SLC13A2 Gene

solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2

SLC13A3 Gene

solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 3

Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet. [provided by RefSeq, Jul 2008]

SLC13A5 Gene

solute carrier family 13 (sodium-dependent citrate transporter), member 5

This gene encodes a protein belonging to the solute carrier family 13 group of proteins. This family member is a sodium-dependent citrate cotransporter that may regulate metabolic processes. Mutations in this gene cause early infantile epileptic encephalopathy 25. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

SLC40A1 Gene

solute carrier family 40 (iron-regulated transporter), member 1

The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq, Jul 2008]

CTNS Gene

cystinosin, lysosomal cystine transporter

This gene encodes a seven-transmembrane domain protein that functions to transport cystine out of lysosomes. Its activity is driven by the H+ electrochemical gradient of the lysosomal membrane. Mutations in this gene cause cystinosis, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]

LOC100422510 Gene

solute carrier family 12 (sodium/chloride transporter), member 3 pseudogene

SLC27A5 Gene

solute carrier family 27 (fatty acid transporter), member 5

The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008]

SLC27A4 Gene

solute carrier family 27 (fatty acid transporter), member 4

This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome. [provided by RefSeq, Apr 2010]

SLC27A6 Gene

solute carrier family 27 (fatty acid transporter), member 6

This gene encodes a member of the fatty acid transport protein family (FATP). FATPs are involved in the uptake of long-chain fatty acids and have unique expression patterns. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

SLC27A3 Gene

solute carrier family 27 (fatty acid transporter), member 3

SLC27A2 Gene

solute carrier family 27 (fatty acid transporter), member 2

The protein encoded by this gene is an isozyme of long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme activates long-chain, branched-chain and very-long-chain fatty acids containing 22 or more carbons to their CoA derivatives. It is expressed primarily in liver and kidney, and is present in both endoplasmic reticulum and peroxisomes, but not in mitochondria. Its decreased peroxisomal enzyme activity is in part responsible for the biochemical pathology in X-linked adrenoleukodystrophy. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]

SLC7A8 Gene

solute carrier family 7 (amino acid transporter light chain, L system), member 8

SLC7A7 Gene

solute carrier family 7 (amino acid transporter light chain, y+L system), member 7

The protein encoded by this gene is the light subunit of a cationic amino acid transporter. This sodium-independent transporter is formed when the light subunit encoded by this gene dimerizes with the heavy subunit transporter protein SLC3A2. This transporter is found in epithelial cell membranes where it transfers cationic and large neutral amino acids from the cell to the extracellular space. Defects in this gene are a cause of lysinuric protein intolerance (LPI). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]

SLC7A5 Gene

solute carrier family 7 (amino acid transporter light chain, L system), member 5

SLC7A2 Gene

solute carrier family 7 (cationic amino acid transporter, y+ system), member 2

The protein encoded by this gene is a cationic amino acid transporter and a member of the APC (amino acid-polyamine-organocation) family of transporters. The encoded membrane protein is responsible for the cellular uptake of arginine, lysine and ornithine. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

SLC7A3 Gene

solute carrier family 7 (cationic amino acid transporter, y+ system), member 3

This gene encodes a member of the solute carrier family 7. The encoded protein is a sodium-independent cationic amino acid transporter. Alternate splicing results in multiple transcripts that encoded the same protein.[provided by RefSeq, May 2010]

LOC100128093 Gene

magnesium transporter 1 pseudogene

LOC100422417 Gene

solute carrier family 6 (amino acid transporter), member 14 pseudogene

SLCO5A1 Gene

solute carrier organic anion transporter family, member 5A1

This gene encodes a 12 transmembrane domain protein that is a member of the solute carrier organic anion transporter superfamily. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

LOC105369259 Gene

putative L-type amino acid transporter 1-like protein MLAS

SLC28A1 Gene

solute carrier family 28 (concentrative nucleoside transporter), member 1

SLC22A18AS Gene

solute carrier family 22 (organic cation transporter), member 18 antisense

SLCO1C1 Gene

solute carrier organic anion transporter family, member 1C1

This gene encodes a member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of thyroid hormones in brain tissues. This protein has particularly high affinity for the thyroid hormones thyroxine, tri-iodothyronine and reverse tri-iodothyronine. Polymorphisms in the gene encoding this protein may be associated with fatigue and depression in patients suffering from hyperthyroidism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

SLC22A5 Gene

solute carrier family 22 (organic cation/carnitine transporter), member 5

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

SLC19A2 Gene

solute carrier family 19 (thiamine transporter), member 2

This gene encodes the thiamin transporter protein. Mutations in this gene cause thiamin-responsive megaloblastic anemia syndrome (TRMA), which is an autosomal recessive disorder characterized by diabetes mellitus, megaloblastic anemia and sensorineural deafness. [provided by RefSeq, Jul 2008]

SLC19A3 Gene

solute carrier family 19 (thiamine transporter), member 3

This gene encodes a ubiquitously expressed transmembrane thiamine transporter that lacks folate transport activity. Mutations in this gene cause biotin-responsive basal ganglia disease (BBGD); a recessive disorder manifested in childhood that progresses to chronic encephalopathy, dystonia, quadriparesis, and death if untreated. Patients with BBGD have bilateral necrosis in the head of the caudate nucleus and in the putamen. Administration of high doses of biotin in the early progression of the disorder eliminates pathological symptoms while delayed treatment results in residual paraparesis, mild mental retardation, or dystonia. Administration of thiamine is ineffective in the treatment of this disorder. Experiments have failed to show that this protein can transport biotin. Mutations in this gene also cause a Wernicke's-like encephalopathy.[provided by RefSeq, Jan 2010]

SLC19A1 Gene

solute carrier family 19 (folate transporter), member 1

The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

SLC25A28 Gene

solute carrier family 25 (mitochondrial iron transporter), member 28

SLC25A15P1 Gene

solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 pseudogene 1

SLC25A15P2 Gene

solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 pseudogene 2

SLC25A15P3 Gene

solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 pseudogene 3

SLC25A15P5 Gene

solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 pseudogene 5

SLCO6A1 Gene

solute carrier organic anion transporter family, member 6A1

LOC100129483 Gene

solute carrier family 35 (GDP-fucose transporter), member C2 pseudogene

SLC27A1 Gene

solute carrier family 27 (fatty acid transporter), member 1

LOC284379 Gene

solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 pseudogene

SLC2A10 Gene

solute carrier family 2 (facilitated glucose transporter), member 10

This gene encodes a member of the class III facilitative glucose transporter family. The encoded protein plays a role in regulation of glucose homeostasis. Mutations in this gene have been associated with arterial tortuosity syndrome.[provided by RefSeq, Dec 2009]

SLC22A4 Gene

solute carrier family 22 (organic cation/zwitterion transporter), member 4

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008]

SLC22A6 Gene

solute carrier family 22 (organic anion transporter), member 6

The protein encoded by this gene is involved in the sodium-dependent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and may be localized to the basolateral membrane. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

SLC22A7 Gene

solute carrier family 22 (organic anion transporter), member 7

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

SLC22A3 Gene

solute carrier family 22 (organic cation transporter), member 3

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008]

SLC22A9 Gene

solute carrier family 22 (organic anion transporter), member 9

RTP4 Gene

receptor (chemosensory) transporter protein 4

RTP5 Gene

receptor (chemosensory) transporter protein 5 (putative)

RTP2 Gene

receptor (chemosensory) transporter protein 2

RTP3 Gene

receptor (chemosensory) transporter protein 3

RTP1 Gene

receptor (chemosensory) transporter protein 1

LOC102724223 Gene

sodium- and chloride-dependent creatine transporter 1-like

SLC39A12 Gene

solute carrier family 39 (zinc transporter), member 12

Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A12 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Aug 2008]

SLC39A13 Gene

solute carrier family 39 (zinc transporter), member 13

This gene encodes a member of the LIV-1 subfamily of the ZIP transporter family. The encoded transmembrane protein functions as a zinc transporter. Mutations in this gene have been associated with the spondylocheiro dysplastic form of Ehlers-Danlos syndrome.[provided by RefSeq, Mar 2010]

SLC39A10 Gene

solute carrier family 39 (zinc transporter), member 10

Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]

SLC39A14 Gene

solute carrier family 39 (zinc transporter), member 14

Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A14 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]

SLC37A2 Gene

solute carrier family 37 (glucose-6-phosphate transporter), member 2

SLC37A4 Gene

solute carrier family 37 (glucose-6-phosphate transporter), member 4

This gene regulates glucose-6-phosphate transport from the cytoplasm to the lumen of the endoplasmic reticulum, in order to maintain glucose homeostasis. It also plays a role in ATP-mediated calcium sequestration in the lumen of the endoplasmic reticulum. Mutations in this gene have been associated with various forms of glycogen storage disease. Alternative splicing in this gene results in multiple transcript variants.[provided by RefSeq, Aug 2009]

ASNA1 Gene

arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)

This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. [provided by RefSeq, Oct 2011]

SLC43A2 Gene

solute carrier family 43 (amino acid system L transporter), member 2

System L amino acid transporters, such as SLC43A2, mediate sodium-independent transport of bulky neutral amino acids across cell membranes (Bodoy et al., 2005 [PubMed 15659399]).[supplied by OMIM, Mar 2008]

SLC43A1 Gene

solute carrier family 43 (amino acid system L transporter), member 1

SLC43A1 belongs to the system L family of plasma membrane carrier proteins that transports large neutral amino acids (Babu et al., 2003 [PubMed 12930836]).[supplied by OMIM, Mar 2008]

SLC44A1 Gene

solute carrier family 44 (choline transporter), member 1

SLC44A2 Gene

solute carrier family 44 (choline transporter), member 2

SLC35B3 Gene

solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3

This gene is a member of the solute carrier family. The encoded protein is involved in the transport of 3-prime phosphoadenosine 5-prime phosphosulfate (PAPS) from the nucleus or the cytosol to the Golgi lumen. This gene has been reported to be expressed preferentially in the human colon tissues. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

SLC35B2 Gene

solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2

Sulfotransferases (e.g., SULT4A1; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and transports PAPS from the cytosol, where it is synthesized, into the Golgi lumen (Kamiyama et al., 2003 [PubMed 12716889]).[supplied by OMIM, Mar 2008]

SLC35B4 Gene

solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4

Glycosyltransferases, such as SLC35B4, transport nucleotide sugars from the cytoplasm where they are synthesized, to the Golgi apparatus where they are utilized in the synthesis of glycoproteins, glycolipids, and proteoglycans (Ashikov et al., 2005 [PubMed 15911612]).[supplied by OMIM, Mar 2008]

ATP8B3 Gene

ATPase, aminophospholipid transporter, class I, type 8B, member 3

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to the other. This gene encodes member 3 of phospholipid-transporting ATPase 8B; other members of this protein family are located on chromosomes 1, 15 and 18. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

ATP8B2 Gene

ATPase, aminophospholipid transporter, class I, type 8B, member 2

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

ATP8B1 Gene

ATPase, aminophospholipid transporter, class I, type 8B, member 1

This gene encodes a member of the P-type cation transport ATPase family, which belongs to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Mutations in this gene may result in progressive familial intrahepatic cholestasis type 1 and in benign recurrent intrahepatic cholestasis. [provided by RefSeq, Jul 2008]

SLC25A1P4 Gene

solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 pseudogene 4

SLC25A1P5 Gene

solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 pseudogene 5

SLC25A1P1 Gene

solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 pseudogene 1

SLC25A1P2 Gene

solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 pseudogene 2

SLC25A1P3 Gene

solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1 pseudogene 3

ATP8A2P2 Gene

ATPase, aminophospholipid transporter, class I, type 8A, member 2 pseudogene 2

SLC28A2 Gene

solute carrier family 28 (concentrative nucleoside transporter), member 2

SLC28A3 Gene

solute carrier family 28 (concentrative nucleoside transporter), member 3

Nucleoside transporters, such as SLC28A3, regulate multiple cellular processes, including neurotransmission, vascular tone, adenosine concentration in the vicinity of cell surface receptors, and transport and metabolism of nucleoside drugs. SLC28A3 shows broad specificity for pyrimidine and purine nucleosides (Ritzel et al., 2001 [PubMed 11032837]).[supplied by OMIM, Mar 2008]

SLCO1B1 Gene

solute carrier organic anion transporter family, member 1B1

This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009]

SLC3A2 Gene

solute carrier family 3 (amino acid transporter heavy chain), member 2

This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. [provided by RefSeq, Nov 2010]

SLC3A1 Gene

solute carrier family 3 (amino acid transporter heavy chain), member 1

This gene encodes a type II membrane glycoprotein which is one of the components of the renal amino acid transporter which transports neutral and basic amino acids in the renal tubule and intestinal tract. Mutations and deletions in this gene are associated with cystinuria. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

SLC2A14 Gene

solute carrier family 2 (facilitated glucose transporter), member 14

Members of the glucose transporter (GLUT) family, including SLC2A14, are highly conserved integral membrane proteins that transport hexoses such as glucose and fructose into all mammalian cells. GLUTs show tissue and cell-type specific expression (Wu and Freeze, 2002 [PubMed 12504846]).[supplied by OMIM, Mar 2008]

SLC2A13 Gene

solute carrier family 2 (facilitated glucose transporter), member 13

SLC2A12 Gene

solute carrier family 2 (facilitated glucose transporter), member 12

SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Rogers et al., 2002). This family of transporters show conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008]

SLC2A11 Gene

solute carrier family 2 (facilitated glucose transporter), member 11

This gene belongs to a family of proteins that mediate the transport of sugars across the cell membrane. The encoded protein transports glucose and fructose. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

FCGRT Gene

Fc fragment of IgG, receptor, transporter, alpha

This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]

SLCO4C1 Gene

solute carrier organic anion transporter family, member 4C1

SLCO4C1 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of bile acids, conjugated steroids, thyroid hormone, eicosanoids, peptides, and numerous drugs in many tissues (Mikkaichi et al., 2004 [PubMed 14993604]).[supplied by OMIM, Mar 2008]

SLC39A8 Gene

solute carrier family 39 (zinc transporter), member 8

This gene encodes a member of the SLC39 family of solute-carrier genes, which show structural characteristics of zinc transporters. The encoded protein is glycosylated and found in the plasma membrane and mitochondria, and functions in the cellular import of zinc at the onset of inflammation. It is also thought to be the primary transporter of the toxic cation cadmium, which is found in cigarette smoke. Multiple transcript variants encoding different isoforms have been found for this gene. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Oct 2008]

SLC39A1 Gene

solute carrier family 39 (zinc transporter), member 1

This gene encodes a member of the zinc-iron permease family. The encoded protein is localized to the cell membrane and acts as a zinc uptake transporter. This gene has been linked to prostate cancer, breast cancer, and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

SLC39A2 Gene

solute carrier family 39 (zinc transporter), member 2

This gene encodes a member of the ZIP family of metal ion transporters. The encoded protein functions as a zinc transporter. Mutations in this gene may be associated with susceptibility to carotid artery disease. Multiple transcript variants have been described. [provided by RefSeq, Mar 2010]

SLC39A3 Gene

solute carrier family 39 (zinc transporter), member 3

SLC39A4 Gene

solute carrier family 39 (zinc transporter), member 4

This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The encoded protein localizes to cell membranes and is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

SLC39A5 Gene

solute carrier family 39 (zinc transporter), member 5

The protein encoded by this gene belongs to the ZIP family of zinc transporters that transport zinc into cells from outside, and play a crucial role in controlling intracellular zinc levels. Zinc is an essential cofactor for many enzymes and proteins involved in gene transcription, growth, development and differentiation. Mutations in this gene have been associated with autosomal dominant high myopia (MYP24). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

SLC39A6 Gene

solute carrier family 39 (zinc transporter), member 6

Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]

SLC39A7 Gene

solute carrier family 39 (zinc transporter), member 7

The protein encoded by this gene transports zinc from the Golgi and endoplasmic reticulum to the cytoplasm. This transport may be important for activation of tyrosine kinases, some of which could be involved in cancer progression. Therefore, modulation of the encoded protein could be useful as a therapeutic agent against cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

SLC23A1 Gene

solute carrier family 23 (ascorbic acid transporter), member 1

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two transporters. The encoded protein is active in bulk vitamin C transport involving epithelial surfaces. Previously, this gene had an official symbol of SLC23A2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

SLC20A2 Gene

solute carrier family 20 (phosphate transporter), member 2

This gene encodes a member of the inorganic phosphate transporter family. The encoded protein is a type 3 sodium-dependent phosphate symporter that plays an important role in phosphate homeostasis by mediating cellular phosphate uptake. The encoded protein also confers susceptibility to viral infection as a gamma-retroviral receptor. Mutations in this gene may play a role in familial idiopathic basal ganglia calcification. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

SLC20A1 Gene

solute carrier family 20 (phosphate transporter), member 1

The protein encoded by this gene is a sodium-phosphate symporter that absorbs phosphate from interstitial fluid for use in cellular functions such as metabolism, signal transduction, and nucleic acid and lipid synthesis. The encoded protein is also a retroviral receptor, causing human cells to be susceptible to infection by gibbon ape leukemia virus, simian sarcoma-associated virus, feline leukemia virus subgroup B, and 10A1 murine leukemia virus.[provided by RefSeq, Mar 2011]

SLC30A9 Gene

solute carrier family 30 (zinc transporter), member 9

SLC30A8 Gene

solute carrier family 30 (zinc transporter), member 8

The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

SLC30A5 Gene

solute carrier family 30 (zinc transporter), member 5

This gene encodes a member of the SLC30A/ZnT family of zinc transporter proteins. ZnT proteins mediate both cellular zinc efflux and zinc sequestration into membrane-bound organelles. The encoded protein plays a role in the early secretory pathway as a heterodimer with zinc transporter 6, and may also regulate zinc sequestration into secretory granules of pancreatic beta cells. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 19. [provided by RefSeq, Oct 2011]

SLC30A4 Gene

solute carrier family 30 (zinc transporter), member 4

Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]).[supplied by OMIM, Mar 2008]

SLC30A7 Gene

solute carrier family 30 (zinc transporter), member 7

Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A7, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).[supplied by OMIM, Mar 2008]

SLC30A6 Gene

solute carrier family 30 (zinc transporter), member 6

Zinc functions as a cofactor for numerous enzymes, nuclear factors, and hormones and as an intra- and intercellular signal ion. Members of the zinc transporter (ZNT)/SLC30 subfamily of the cation diffusion facilitator family, such as SLC30A6, permit cellular efflux of zinc (Seve et al., 2004 [PubMed 15154973]).[supplied by OMIM, Mar 2008]

SLC30A1 Gene

solute carrier family 30 (zinc transporter), member 1

SLC30A3 Gene

solute carrier family 30 (zinc transporter), member 3

SLC30A2 Gene

solute carrier family 30 (zinc transporter), member 2

LOC100422432 Gene

solute carrier family 6 (amino acid transporter), member 14 pseudogene

SLC16A8 Gene

solute carrier family 16 (monocarboxylate transporter), member 8

SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010]

SLC16A1 Gene

solute carrier family 16 (monocarboxylate transporter), member 1

The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]

SLC16A3 Gene

solute carrier family 16 (monocarboxylate transporter), member 3

Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008]

SLC16A2 Gene

solute carrier family 16, member 2 (thyroid hormone transporter)

This gene encodes an integral membrane protein that functions as a transporter of thyroid hormone. The encoded protein facilitates the cellular importation of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). This gene is expressed in many tissues and likely plays an important role in the development of the central nervous system. Loss of function mutations in this gene are associated with psychomotor retardation in males while females exhibit no neurological defects and more moderate thyroid-deficient phenotypes. This gene is subject to X-chromosome inactivation. Mutations in this gene are the cause of Allan-Herndon-Dudley syndrome. [provided by RefSeq, Mar 2012]

SLC16A7 Gene

solute carrier family 16 (monocarboxylate transporter), member 7

This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

SLC15A2 Gene

solute carrier family 15 (oligopeptide transporter), member 2

The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of small peptides, as well as beta-lactam antibiotics and other peptide-like drugs, from the tubular filtrate. This transporter, SLC15A2, belongs to the same gene family as SLC15A1 (MIM 600544), the proton-coupled peptide transporter found in the small intestine (Liu et al, 1995 [PubMed 7756356]).[supplied by OMIM, Feb 2011]

SLC15A3 Gene

solute carrier family 15 (oligopeptide transporter), member 3

SLC15A1 Gene

solute carrier family 15 (oligopeptide transporter), member 1

This gene encodes an intestinal hydrogen peptide cotransporter that is a member of the solute carrier family 15. The encoded protein is localized to the brush border membrane of the intestinal epithelium and mediates the uptake of di- and tripeptides from the lumen into the enterocytes. This protein plays an important role in the uptake and digestion of dietary proteins. This protein also facilitates the absorption of numerous peptidomimetic drugs. [provided by RefSeq, Apr 2010]

SLC15A4 Gene

solute carrier family 15 (oligopeptide transporter), member 4

SLC22A13 Gene

solute carrier family 22 (organic anion/urate transporter), member 13

This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 4. The encoded protein is a transmembrane protein involved in the transport of small molecules. This protein can function to mediate urate uptake and is a high affinity nicotinate exchanger in the kidneys and the intestine. [provided by RefSeq, Sep 2008]

SLC20A1P1 Gene

solute carrier family 20 (phosphate transporter), member 1 pseudogene 1

SLC20A1P3 Gene

solute carrier family 20 (phosphate transporter), member 1 pseudogene 3

SLC20A1P2 Gene

solute carrier family 20 (phosphate transporter), member 1 pseudogene 2

ATP8A2 Gene

ATPase, aminophospholipid transporter, class I, type 8A, member 2

ATP8A1 Gene

ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1

The P-type adenosinetriphosphatases (P-type ATPases) are a family of proteins which use the free energy of ATP hydrolysis to drive uphill transport of ions across membranes. Several subfamilies of P-type ATPases have been identified. One subfamily catalyzes transport of heavy metal ions. Another subfamily transports non-heavy metal ions (NMHI). The protein encoded by this gene is a member of the third subfamily of P-type ATPases and acts to transport amphipaths, such as phosphatidylserine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

SLC16A10 Gene

solute carrier family 16 (aromatic amino acid transporter), member 10

SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic amino acids across the plasma membrane.[supplied by OMIM, Apr 2004]

SLC46A1 Gene

solute carrier family 46 (folate transporter), member 1

This gene encodes a transmembrane proton-coupled folate transporter protein that facilitates the movement of folate and antifolate substrates across cell membranes, optimally in acidic pH environments. This protein is also expressed in the brain and choroid plexus where it transports folates into the central nervous system. This protein further functions as a heme transporter in duodenal enterocytes, and potentially in other tissues like liver and kidney. Its localization to the apical membrane or cytoplasm of intestinal cells is modulated by dietary iron levels. Mutations in this gene are associated with autosomal recessive hereditary folate malabsorption disease. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]

CUTC Gene

cutC copper transporter

Members of the CUT family of copper transporters are associated with copper homeostasis and are involved in the uptake, storage, delivery, and efflux of copper (Gupta et al., 1995 [PubMed 7635807]; Li et al., 2005 [PubMed 16182249]).[supplied by OMIM, Mar 2008]

SLC6A3 Gene

solute carrier family 6 (neurotransmitter transporter), member 3

This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.[provided by RefSeq, Nov 2009]

SLC6A2 Gene

solute carrier family 6 (neurotransmitter transporter), member 2

This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

SLC6A1 Gene

solute carrier family 6 (neurotransmitter transporter), member 1

The SLC6A1 gene encodes a gamma-aminobutyric acid (GABA) transporter, which removes GABA from the synaptic cleft (Hirunsatit et al., 2009 [PubMed 19077666]).[supplied by OMIM, Jul 2009]

SLC6A7 Gene

solute carrier family 6 (neurotransmitter transporter), member 7

This gene is a member of the gamma-aminobutyric acid (GABA) neurotransmitter gene family and encodes a high-affinity mammalian brain L-proline transporter protein. This transporter protein differs from other sodium-dependent plasma membrane carriers by its pharmacological specificity, kinetic properties, and ionic requirements. [provided by RefSeq, Jul 2008]

SLC6A6 Gene

solute carrier family 6 (neurotransmitter transporter), member 6

This gene encodes a multi-pass membrane protein that is a member of a family of sodium and chloride-ion dependent transporters. The encoded protein transports taurine and beta-alanine. There is a pseudogene for this gene on chromosome 21. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

SLC6A5 Gene

solute carrier family 6 (neurotransmitter transporter), member 5

This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic synapses. Mutations in this gene cause hyperekplexia; a heterogenous neurological disorder characterized by exaggerated startle responses and neonatal apnea. [provided by RefSeq, Oct 2009]

SLC6A4 Gene

solute carrier family 6 (neurotransmitter transporter), member 4

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]

SLC6A9 Gene

solute carrier family 6 (neurotransmitter transporter, glycine), member 9

SLC6A8 Gene

solute carrier family 6 (neurotransmitter transporter), member 8

The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

SLC7A5P1 Gene

solute carrier family 7 (amino acid transporter light chain, L system), member 5 pseudogene 1

This locus represents a transcribed pseudogene of the L-type amino acid transporter 1. [provided by RefSeq, Jul 2008]

SLC7A5P2 Gene

solute carrier family 7 (amino acid transporter light chain, L system), member 5 pseudogene 2

SLC25A15P4 Gene

solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 pseudogene 4

SLCO3A1 Gene

solute carrier organic anion transporter family, member 3A1

LOC100422614 Gene

solute carrier family 7 (anionic amino acid transporter), member 13 pseudogene

LOC100422610 Gene

solute carrier family 7 (cationic amino acid transporter, y+ system), member 3 pseudogene

SLC6A19 Gene

solute carrier family 6 (neutral amino acid transporter), member 19

This gene encodes a system B(0) transmembrane protein that actively transports most neutral amino acids across the apical membrane of epithelial cells. Mutations in this gene result in Hartnup disorder. [provided by RefSeq, Jul 2008]

SLC6A18 Gene

solute carrier family 6 (neutral amino acid transporter), member 18

The SLC6 family of proteins, which includes SLC6A18, act as specific transporters for neurotransmitters, amino acids, and osmolytes like betaine, taurine, and creatine. SLC6 proteins are sodium cotransporters that derive the energy for solute transport from the electrochemical gradient for sodium ions (Hoglund et al., 2005 [PubMed 16125675]).[supplied by OMIM, Apr 2010]

SLC33A1 Gene

solute carrier family 33 (acetyl-CoA transporter), member 1

The protein encoded by this gene is required for the formation of O-acetylated (Ac) gangliosides. The encoded protein is predicted to contain 6 to 10 transmembrane domains, and a leucine zipper motif in transmembrane domain III. Defects in this gene have been reported to cause spastic paraplegia autosomal dominant type 42 (SPG42) in one Chinese family, but not in similar patients of European descent. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]

LOC101060604 Gene

putative L-type amino acid transporter 1-like protein IMAA

SLCO1B3 Gene

solute carrier organic anion transporter family, member 1B3

This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. [provided by RefSeq, Feb 2012]

SLCO1B7 Gene

solute carrier organic anion transporter family, member 1B7 (non-functional)

SLC22A16 Gene

solute carrier family 22 (organic cation/carnitine transporter), member 16

This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The encoded protein has also been shown to transport anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells. [provided by RefSeq, Dec 2011]

SLC22A12 Gene

solute carrier family 22 (organic anion/urate transporter), member 12

The protein encoded by this gene is a member of the organic anion transporter (OAT) family, and it acts as a urate transporter to regulate urate levels in blood. This protein is an integral membrane protein primarily found in epithelial cells of the proximal tubule of the kidney. An elevated level of serum urate, hyperuricemia, is associated with increased incidences of gout, and mutations in this gene cause renal hypouricemia type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

SLC22A11 Gene

solute carrier family 22 (organic anion/urate transporter), member 11

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

SLC4A10 Gene

solute carrier family 4, sodium bicarbonate transporter, member 10

This gene belongs to a small family of sodium-coupled bicarbonate transporters (NCBTs) that regulate the intracellular pH of neurons, the secretion of bicarbonate ions across the choroid plexus, and the pH of the brain extracellular fluid. The protein encoded by this gene was initially identified as a sodium-driven chloride bicarbonate exchanger (NCBE) though there is now evidence that its sodium/bicarbonate cotransport activity is independent of any chloride ion countertransport under physiological conditions. This gene is now classified as a member A10 of the SLC4 family of transmembrane solute carriers. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]

LOC100462652 Gene

solute carrier family 6 (amino acid transporter), member 14 pseudogene

SLC35D2 Gene

solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2

Nucleotide sugars, which are synthesized in the cytosol or the nucleus, are high-energy donor substrates for glycosyltransferases located in the lumen of the endoplasmic reticulum and Golgi apparatus. Translocation of nucleotide sugars from the cytosol into the lumen compartment is mediated by specific nucleotide sugar transporters, such as SLC35D2 (Suda et al., 2004 [PubMed 15082721]).[supplied by OMIM, Mar 2008]

SLC35D1 Gene

solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1

Glycosylation of cellular glycoconjugates occurs in the endoplasmic reticulum (ER) and Golgi compartment, and requires transport of nucleotide sugars from the cytosol into the lumen of the ER and Golgi by specific transporters. The protein encoded by this gene resides in the ER, and transports both UDP-glucuronic acid (UDP-GlcA) and UDP-N-acetylgalactosamine (UDP-GalNAc) from the cytoplasm to the ER lumen. It may participate in glucuronidation and/or chondroitin sulfate biosynthesis. Mutations in this gene are associated with Schneckenbecken dysplasia.[provided by RefSeq, Sep 2009]

SLC16A5 Gene

solute carrier family 16 (monocarboxylate transporter), member 5

This gene encodes a member of the monocarboxylate transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

SLC25A15 Gene

solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15

This gene is a member of the mitochondrial carrier family. The encoded protein transports ornithine across the inner mitochondrial membrane from the cytosol to the mitochondrial matrix. The protein is an essential component of the urea cycle, and functions in ammonium detoxification and biosynthesis of the amino acid arginine. Mutations in this gene result in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome. There is a pseudogene of this locus on the Y chromosome.[provided by RefSeq, May 2009]

SLC25A10 Gene

solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10

This gene encodes a member of a family of proteins that translocate small metabolites across the mitochondrial membrane. The encoded protein exchanges dicarboxylates, such as malate and succinate, for phosphate, sulfate, and other small molecules, thereby providing substrates for metabolic processes including the Krebs cycle and fatty acid synthesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

SLC50A1 Gene

solute carrier family 50 (sugar efflux transporter), member 1

MMGT1 Gene

membrane magnesium transporter 1

LOC100131725 Gene

solute carrier family 39 (zinc transporter), member 14 pseudogene

LOC100533846 Gene

solute carrier family 30 (zinc transporter), member 5 pseudogene

SLCO4A1 Gene

solute carrier organic anion transporter family, member 4A1

MRS2 Gene

MRS2 magnesium transporter

SLC12A5 Gene

solute carrier family 12 (potassium/chloride transporter), member 5

K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Sep 2008]

SLC12A7 Gene

solute carrier family 12 (potassium/chloride transporter), member 7

SLC12A6 Gene

solute carrier family 12 (potassium/chloride transporter), member 6

This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy. [provided by RefSeq, Jul 2008]

SLC12A1 Gene

solute carrier family 12 (sodium/potassium/chloride transporter), member 1

This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010]

SLC12A3 Gene

solute carrier family 12 (sodium/chloride transporter), member 3

This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

SLC12A2 Gene

solute carrier family 12 (sodium/potassium/chloride transporter), member 2

The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

SLC11A2 Gene

solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2

This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]

LOC402269 Gene

equilibrative nucleoside transporter 4-like

SLC35A1 Gene

solute carrier family 35 (CMP-sialic acid transporter), member A1

The protein encoded by this gene is found in the membrane of the Golgi apparatus, where it transports nucleotide sugars into the Golgi. One such nucleotide sugar is CMP-sialic acid, which is imported into the Golgi by the encoded protein and subsequently glycosylated. Defects in this gene are a cause of congenital disorder of glycosylation type 2F (CDG2F). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]

SLC35A2 Gene

solute carrier family 35 (UDP-galactose transporter), member A2

This gene encodes a member of the nucleotide-sugar transporter family. The encoded protein is a multi-pass membrane protein. It transports UDP-galactose from the cytosol into Golgi vesicles, where it serves as a glycosyl donor for the generation of glycans. Mutations in this gene cause congenital disorder of glycosylation type IIm (CDG2M). Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

SLC35A3 Gene

solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3

This gene encodes a UDP-N-acetylglucosamine transporter found in the golgi apparatus membrane. In cattle, a missense mutation in this gene causes complex vertebral malformation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

SLC41A1 Gene

solute carrier family 41 (magnesium transporter), member 1

SLC41A2 Gene

solute carrier family 41 (magnesium transporter), member 2

SLC22A1 Gene

solute carrier family 22 (organic cation transporter), member 1

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter. [provided by RefSeq, Jul 2008]

SLC22A8 Gene

solute carrier family 22 (organic anion transporter), member 8

This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, May 2010]

ATP8A2P3 Gene

ATPase, aminophospholipid transporter, class I, type 8A, member 2 pseudogene 3

ATP8A2P1 Gene

ATPase, aminophospholipid transporter, class I, type 8A, member 2 pseudogene 1

SLC2A3P2 Gene

solute carrier family 2 (facilitated glucose transporter), member 3 pseudogene 2

SLC2A3P1 Gene

solute carrier family 2 (facilitated glucose transporter), member 3 pseudogene 1

SLC2A3P4 Gene

solute carrier family 2 (facilitated glucose transporter), member 3 pseudogene 4

SLC48A1 Gene

solute carrier family 48 (heme transporter), member 1

SLC25A2 Gene

solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2

This intronless gene encodes a protein that localizes to the mitochondrial inner membrane and likely functions as a transporter of small molecules such as ornithine. This gene is located between the protocadherin beta and gamma gene clusters on chromosome 5. [provided by RefSeq, Dec 2014]

SLC25A1 Gene

solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1

This gene encodes a member of the mitochondrial carrier subfamily of solute carrier proteins. Members of this family include nuclear-encoded transporters that translocate small metabolites across the mitochondrial membrane. This protein regulates the movement of citrate across the inner membranes of the mitochondria. Mutations in this gene have been associated with combined D-2- and L-2-hydroxyglutaric aciduria. Pseudogenes of this gene have been identified on chromosomes 7, 11, 16, and 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

SLC1A4 Gene

solute carrier family 1 (glutamate/neutral amino acid transporter), member 4

SLC1A5 Gene

solute carrier family 1 (neutral amino acid transporter), member 5

The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by OMIM, Jan 2011]

SLC1A6 Gene

solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6

SLC1A7 Gene

solute carrier family 1 (glutamate transporter), member 7

SLC1A1 Gene

solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1

This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010]

SLC1A2 Gene

solute carrier family 1 (glial high affinity glutamate transporter), member 2

This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010]

SLC1A3 Gene

solute carrier family 1 (glial high affinity glutamate transporter), member 3

This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2014]

SLC2A9 Gene

solute carrier family 2 (facilitated glucose transporter), member 9

This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

SLC2A8 Gene

solute carrier family 2 (facilitated glucose transporter), member 8

This gene belongs to the solute carrier 2A family, which includes intracellular glucose transporters. Based on sequence comparison, the glucose transporters are grouped into three classes and this gene is a member of class II. The encoded protein, like other members of the family, contains several conserved residues and motifs and 12 transmembrane domains with both amino and carboxyl ends being on the cytosolic side of the membrane. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]

SLC2A7 Gene

solute carrier family 2 (facilitated glucose transporter), member 7

SLC2A7 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion (Li et al., 2004). This family of transporters shows conservation of 12 transmembrane helices as well as functionally significant amino acid residues (Joost and Thorens, 2001 [PubMed 11780753]).[supplied by OMIM, Mar 2008]

SLC2A6 Gene

solute carrier family 2 (facilitated glucose transporter), member 6

Hexose transport into mammalian cells is catalyzed by a family of membrane proteins, including SLC2A6, that contain 12 transmembrane domains and a number of critical conserved residues.[supplied by OMIM, Jul 2002]

SLC2A5 Gene

solute carrier family 2 (facilitated glucose/fructose transporter), member 5

SLC2A4 Gene

solute carrier family 2 (facilitated glucose transporter), member 4

This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008]

SLC2A3 Gene

solute carrier family 2 (facilitated glucose transporter), member 3

SLC2A2 Gene

solute carrier family 2 (facilitated glucose transporter), member 2

This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

SLC2A1 Gene

solute carrier family 2 (facilitated glucose transporter), member 1

This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. Mutations in this gene have been found in a family with paroxysmal exertion-induced dyskinesia. [provided by RefSeq, Apr 2013]

LOC100130329 Gene

solute carrier family 41 (magnesium transporter), member 2 pseudogene

SLC6A10P Gene

solute carrier family 6 (neurotransmitter transporter), member 10, pseudogene

LOC100420667 Gene

solute carrier family 19 (thiamine transporter), member 3 pseudogene

SLC7A10 Gene

solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10

SLC7A10, in association with 4F2HC (SLC3A2; MIM 158070), mediates high-affinity transport of D-serine and several other neutral amino acids (Nakauchi et al., 2000 [PubMed 10863037]).[supplied by OMIM, Mar 2008]

SLC7A11 Gene

solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]

SLC7A13 Gene

solute carrier family 7 (anionic amino acid transporter), member 13

SIDT1 Gene

SID1 transmembrane family, member 1

SIDT2 Gene

SID1 transmembrane family, member 2

LOC391600 Gene

transmembrane epididymal protein 1 pseudogene

TMEM200B Gene

transmembrane protein 200B

TMEM160 Gene

transmembrane protein 160

TMEM163 Gene

transmembrane protein 163

TMEM165 Gene

transmembrane protein 165

This gene encodes a predicted transmembrane protein with a perinuclear Golgi-like distribution in fibroblasts. Mutations in this gene are associated with the autosomal recessive disorder congenital disorder of glycosylation, type IIk. Knockdown of this gene's expression causes decreased sialylation in HEK cells and suggests this gene plays a role in terminal Golgi glycosylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

TMEM164 Gene

transmembrane protein 164

TMEM168 Gene

transmembrane protein 168

TMEM255B Gene

transmembrane protein 255B

TMEM255A Gene

transmembrane protein 255A

TMEM167AP1 Gene

transmembrane protein 167A pseudogene 1

LOC100313942 Gene

transmembrane protein 92 pseudogene

LOC440181 Gene

transmembrane protein 98 pseudogene

GHITM Gene

growth hormone inducible transmembrane protein

TMC5 Gene

transmembrane channel-like 5

TM4SF18 Gene

transmembrane 4 L six family member 18

TM4SF19 Gene

transmembrane 4 L six family member 19

LOC391020 Gene

interferon induced transmembrane protein 3 pseudogene

CLMN Gene

calmin (calponin-like, transmembrane)

LOC100419882 Gene

transmembrane protein 98 pseudogene

FAM205CP Gene

transmembrane protein C9orf144B pseudogene

TMEM258 Gene

transmembrane protein 258

TMEM257 Gene

transmembrane protein 257

This intronless gene is expressed in the hippocampus and maps close to a candidate region for several X-linked mental retardation (XLMR) syndromes. It is conserved in primates, cow, and horse, but not found in mouse and rat. The exact function of this gene is not known, but on the basis of its physical location and expression pattern, it is proposed to have an important function in the brain. [provided by RefSeq, Jan 2010]

TMEM256 Gene

transmembrane protein 256

TMEM254 Gene

transmembrane protein 254

TMEM253 Gene

transmembrane protein 253

TMEM252 Gene

transmembrane protein 252

TMEM251 Gene

transmembrane protein 251

TMUB1 Gene

transmembrane and ubiquitin-like domain containing 1

TMUB2 Gene

transmembrane and ubiquitin-like domain containing 2

FLRT1 Gene

fibronectin leucine rich transmembrane protein 1

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain. [provided by RefSeq, Jul 2008]

FLRT3 Gene

fibronectin leucine rich transmembrane protein 3

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRTs may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. This gene is expressed in many tissues. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2010]

FLRT2 Gene

fibronectin leucine rich transmembrane protein 2

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRT family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. [provided by RefSeq, Jul 2008]

IFITM8P Gene

interferon induced transmembrane protein 8 pseudogene

TMPPE Gene

transmembrane protein with metallophosphoesterase domain

LOC100419975 Gene

transmembrane protein 192 pseudogene

TMEM247 Gene

transmembrane protein 247

TMEM241 Gene

transmembrane protein 241

TMEM242 Gene

transmembrane protein 242

POM121L4P Gene

POM121 transmembrane nucleoporin-like 4 pseudogene

TMEM185B Gene

transmembrane protein 185B

TMEM185A Gene

transmembrane protein 185A

The protein encoded by this gene is predicted to be a transmembrane protein. This gene is best known for localizing to the CpG island of the fragile site FRAXF. The 5' untranslated region of this gene contains a CGG trinucleotide repeat sequence that normally consists of 7-40 tandem CGG repeats but which can expand to greater than 300 repeats. Methylation of the CpG island leads to transcriptional silencing of this gene, but neither the silencing nor an expanded repeat region appear to manifest itself in a clear phenotypic manner. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Aug 2013]

OSTM1 Gene

osteopetrosis associated transmembrane protein 1

This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis. [provided by RefSeq, Jul 2008]

TMEM37 Gene

transmembrane protein 37

TMEM31 Gene

transmembrane protein 31

TMEM33 Gene

transmembrane protein 33

TMEM169 Gene

transmembrane protein 169

TPTE2 Gene

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2

TPIP is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol phospholipids.[supplied by OMIM, Jul 2002]

TMCC1P1 Gene

transmembrane and coiled-coil domain family 1 pseudogene 1

TMTC2 Gene

transmembrane and tetratricopeptide repeat containing 2

TAPT1 Gene

transmembrane anterior posterior transformation 1

This gene encodes a highly conserved, putative transmembrane protein. A mutation in the mouse ortholog of this gene results in homeotic, posterior-to-anterior transformations of the axial skeleton which are similar to the phenotype of mouse homeobox C8 gene mutants. This gene is proposed to function downstream of homeobox C8 to transduce extracellular patterning information during axial skeleton development. An alternatively spliced transcript variant encoding a substantially different isoform has been described, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]

GS1-259H13.2 Gene

transmembrane protein 225-like

AMN Gene

amnion associated transmembrane protein

The protein encoded by this gene is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila. [provided by RefSeq, Jul 2008]

LOC100420252 Gene

transmembrane channel-like 6 pseudogene

TMEM178B Gene

transmembrane protein 178B

LOC100131216 Gene

transmembrane protein 38B pseudogene

VSTM5 Gene

V-set and transmembrane domain containing 5

VSTM4 Gene

V-set and transmembrane domain containing 4

VSTM1 Gene

V-set and transmembrane domain containing 1

LOC642515 Gene

proline-rich transmembrane protein 1-like

LOC100422352 Gene

transmembrane and tetratricopeptide repeat containing 1 pseudogene

LIME1 Gene

Lck interacting transmembrane adaptor 1

This gene encodes a transmembrane adaptor protein that links the T and B-cell receptor stimulation to downstream signaling pathways via its association with the Src family kinases Lck and Lyn, respectively. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2015]

LOC442017 Gene

interferon induced transmembrane protein 3 pseudogene

IFITM5 Gene

interferon induced transmembrane protein 5

This gene encodes a membrane protein thought to play a role in bone mineralization. This gene is located on chromosome 11 in a cluster of related genes which are induced by interferon, however, this gene has not been shown to be interferon inducible. A similar gene, located in a gene cluster on mouse chromosome 7, is a member of the interferon-inducible fragilis gene family. The mouse gene encodes a transmembrane protein described as participating in germ cell competence. A mutation in the 5' UTR of this gene has been associated with osteogenesis imperfecta type V (PMID: 22863190, 22863195). [provided by RefSeq, Aug 2012]

TMEM133 Gene

transmembrane protein 133

There is evidence that this intronless gene is transcribed but the protein is predicted. The gene function is unknown. [provided by RefSeq, Jul 2008]

TMEM130 Gene

transmembrane protein 130

TMEM131 Gene

transmembrane protein 131

TMEM136 Gene

transmembrane protein 136

TMEM134 Gene

transmembrane protein 134

TMEM135 Gene

transmembrane protein 135

TMEM138 Gene

transmembrane protein 138

This gene encodes a multi-pass transmembrane protein. Reduced expression of this gene in mouse fibroblasts causes short cilia and failure of ciliogenesis. Expression of this gene is tightly coordinated with expression of the neighboring gene TMEM216. Mutations in this gene are associated with the autosomal recessive neurodevelopmental disorder Joubert Syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

TMEM139 Gene

transmembrane protein 139

LOC100286958 Gene

transmembrane protein 183A pseudogene

TMBIM6 Gene

transmembrane BAX inhibitor motif containing 6

TMBIM4 Gene

transmembrane BAX inhibitor motif containing 4

TMBIM1 Gene

transmembrane BAX inhibitor motif containing 1

TMEFF1 Gene

transmembrane protein with EGF-like and two follistatin-like domains 1

TMEFF2 Gene

transmembrane protein with EGF-like and two follistatin-like domains 2

This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

LOC100419853 Gene

transmembrane protein 69 pseudogene

TMEM50B Gene

transmembrane protein 50B

TMEM50A Gene

transmembrane protein 50A

This gene is located in the RH gene locus, between the RHD and RHCE genes. The function of its protein product is unknown; however, its sequence has potential transmembrane domains suggesting that it may be an integral membrane protein. Its position between the RH genes suggests that polymorphisms in this gene may be tightly linked to RH haplotypes and may contribute to selective pressure for or against certain RH haplotypes. [provided by RefSeq, Jul 2008]

TMED7 Gene

transmembrane emp24 protein transport domain containing 7

TMED6 Gene

transmembrane emp24 protein transport domain containing 6

TMED5 Gene

transmembrane emp24 protein transport domain containing 5

TMED4 Gene

transmembrane emp24 protein transport domain containing 4

TMED3 Gene

transmembrane emp24 protein transport domain containing 3

TMED2 Gene

transmembrane emp24 domain trafficking protein 2

TMED1 Gene

transmembrane emp24 protein transport domain containing 1

This gene belongs to the TMED (transmembrane emp24 domain-containing) protein family, which is involved in the vesicular trafficking of proteins. The protein encoded by this gene was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1) and may play a role in innate immunity. This protein lacks any similarity to other interleukin 1 ligands. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

TMED9 Gene

transmembrane emp24 protein transport domain containing 9

TMED8 Gene

transmembrane emp24 protein transport domain containing 8

PLGRKT Gene

plasminogen receptor, C-terminal lysine transmembrane protein

LOC100420062 Gene

transmembrane protein 160 pseudogene

POM121L9P Gene

POM121 transmembrane nucleoporin-like 9, pseudogene

This locus is inferred to be a transcribed pseudogene based on the observation that protein homology is limited to the first of seven exons (indicated by alignment of AL117401.1 to the assembled human genome). This pattern suggests rapid turnover by the nonsense-mediated decay pathway. [provided by RefSeq, Jul 2008]

TMED10P1 Gene

transmembrane emp24-like trafficking protein 10 (yeast) pseudogene 1

TMED10P2 Gene

transmembrane emp24-like trafficking protein 10 (yeast) pseudogene 2

TMEM201 Gene

transmembrane protein 201

TMEM202 Gene

transmembrane protein 202

TMEM203 Gene

transmembrane protein 203

TMEM204 Gene

transmembrane protein 204

C16ORF30 plays a role in cell adhesion and cellular permeability at adherens junctions (Kearsey et al., 2004 [PubMed 15206924]).[supplied by OMIM, Mar 2008]

TMEM205 Gene

transmembrane protein 205

TMEM206 Gene

transmembrane protein 206

TMEM207 Gene

transmembrane protein 207

TMEM208 Gene

transmembrane protein 208

TMEM209 Gene

transmembrane protein 209

TMEM65 Gene

transmembrane protein 65

TMEM64 Gene

transmembrane protein 64

TMEM62 Gene

transmembrane protein 62

TMEM61 Gene

transmembrane protein 61

TMEM60 Gene

transmembrane protein 60

TMEM69 Gene

transmembrane protein 69

TMEM68 Gene

transmembrane protein 68

LOC100288935 Gene

transmembrane protein 258 pseudogene

TMEM67 Gene

transmembrane protein 67

The protein encoded by this gene localizes to the primary cilium and to the plasma membrane. The gene functions in centriole migration to the apical membrane and formation of the primary cilium. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6). [provided by RefSeq, Nov 2008]

TMEM161BP1 Gene

transmembrane protein 161B pseudogene 1

RNFT1 Gene

ring finger protein, transmembrane 1

TMEM183AP1 Gene

transmembrane protein 183A pseudogene 1

LAPTM4A Gene

lysosomal protein transmembrane 4 alpha

This gene encodes a protein that has four predicted transmembrane domains. The function of this gene has not yet been determined; however, studies in the mouse homolog suggest a role in the transport of small molecules across endosomal and lysosomal membranes. [provided by RefSeq, Jul 2008]

LAPTM4B Gene

lysosomal protein transmembrane 4 beta

POM121L1P Gene

POM121 transmembrane nucleoporin-like 1, pseudogene

This locus appears to be a pseudogene related to DKFZp434K191, which is of unknown function. This pseudogene lies in the immunoglobulin lambda gene cluster on chromosome 22q11.21. [provided by RefSeq, Jul 2008]

POM121L11P Gene

POM121 transmembrane nucleoporin-like 11, pseudogene

POM121L12 Gene

POM121 transmembrane nucleoporin-like 12

TMPRSS11GP Gene

transmembrane protease, serine 11G, pseudogene

POM121 Gene

POM121 transmembrane nucleoporin

This gene encodes a transmembrane protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex, which mediates transport to and from the nucleus. The encoded protein may anchor this complex to the nuclear envelope. There are multiple related genes and pseudogenes for this gene on chromosomes 5, 7, 15, and 22. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]

LOC100132025 Gene

transmembrane domain-containing protein ENSP00000320207-like

LOC100420074 Gene

transmembrane protein 183A pseudogene

LETM2 Gene

leucine zipper-EF-hand containing transmembrane protein 2

SIT1 Gene

signaling threshold regulating transmembrane adaptor 1

TMEM161A Gene

transmembrane protein 161A

TMEM161B Gene

transmembrane protein 161B

TM7SF3 Gene

transmembrane 7 superfamily member 3

TM7SF2 Gene

transmembrane 7 superfamily member 2

LRTM2 Gene

leucine-rich repeats and transmembrane domains 2

LOC100421730 Gene

transmembrane emp24 domain trafficking protein 2 pseudogene

TMEM179B Gene

transmembrane protein 179B

TMEM132E Gene

transmembrane protein 132E

TMEM132D Gene

transmembrane protein 132D

TMEM132A Gene

transmembrane protein 132A

This gene encodes a protein that is highly similar to the rat Grp78-binding protein (GBP). Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

TMEM132B Gene

transmembrane protein 132B

LOC645900 Gene

lysosomal protein transmembrane 4 beta pseudogene

LOC100130437 Gene

transmembrane protein 126A pseudogene

TMEM109 Gene

transmembrane protein 109

TMEM108 Gene

transmembrane protein 108

TMEM102 Gene

transmembrane protein 102

TMEM101 Gene

transmembrane protein 101

TMEM107 Gene

transmembrane protein 107

TMEM105 Gene

transmembrane protein 105

TMEM104 Gene

transmembrane protein 104

LOC650293 Gene

seven transmembrane helix receptor

TMCC1 Gene

transmembrane and coiled-coil domain family 1

TMCC2 Gene

transmembrane and coiled-coil domain family 2

TMCC3 Gene

transmembrane and coiled-coil domain family 3

LOC100113397 Gene

vezatin, adherens junctions transmembrane protein pseudogene

TMEM74B Gene

transmembrane protein 74B

POM121B Gene

POM121 transmembrane nucleoporin B (pseudogene)

RNFT2 Gene

ring finger protein, transmembrane 2

LETM1P2 Gene

leucine zipper-EF-hand containing transmembrane protein 1, pseudogene 2

LETM1P3 Gene

leucine zipper-EF-hand containing transmembrane protein 1, pseudogene 3

TMEM259 Gene

transmembrane protein 259

TM9SF4 Gene

transmembrane 9 superfamily protein member 4

TM9SF1 Gene

transmembrane 9 superfamily member 1

TM9SF3 Gene

transmembrane 9 superfamily member 3

TM9SF2 Gene

transmembrane 9 superfamily member 2

This gene encodes a member of the transmembrane 9 superfamily. The encoded 76 kDa protein localizes to early endosomes in human cells. The encoded protein possesses a conserved and highly hydrophobic C-terminal domain which contains nine transmembrane domains. The protein may play a role in small molecule transport or act as an ion channel. A pseudogene associated with this gene is located on the X chromosome. [provided by RefSeq, Oct 2012]

CMTM8 Gene

CKLF-like MARVEL transmembrane domain containing 8

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]

CMTM2 Gene

CKLF-like MARVEL transmembrane domain containing 2

This gene belongs to the chemokine-like factor gene superfamily, a novel family that links the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role in testicular development. [provided by RefSeq, Jul 2008]

CMTM3 Gene

CKLF-like MARVEL transmembrane domain containing 3

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants containing different 5' UTRs, but encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

CMTM1 Gene

CKLF-like MARVEL transmembrane domain containing 1

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. The protein encoded by this gene may play an important role in testicular development. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CKLF (chemokine-like factor).[provided by RefSeq, Feb 2011]

CMTM6 Gene

CKLF-like MARVEL transmembrane domain containing 6

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]

CMTM4 Gene

CKLF-like MARVEL transmembrane domain containing 4

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

CMTM5 Gene

CKLF-like MARVEL transmembrane domain containing 5

This gene encodes a member of the chemokine-like factor superfamily. This family of genes encodes multi-pass membrane proteins that are similar to both the chemokine and the transmembrane 4 superfamilies of signaling molecules. The encoded protein may exhibit tumor suppressor activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

TMEM150A Gene

transmembrane protein 150A

TMEM150C Gene

transmembrane protein 150C

TMEM150B Gene

transmembrane protein 150B

This gene encodes a protein that belongs to the DRAM (damage-regulated autophagy modulator) family of membrane-spanning proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

FAM205BP Gene

transmembrane protein C9orf144B pseudogene

LOC100996337 Gene

transmembrane protein 191B-like

TMEM182 Gene

transmembrane protein 182

TMEM181 Gene

transmembrane protein 181

The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009 [PubMed 19965467]; Wollscheid et al., 2009 [PubMed 19349973]).[supplied by OMIM, Jan 2010]

TMEM180 Gene

transmembrane protein 180

TMEM187 Gene

transmembrane protein 187

This gene consists of two exons and encodes a multi-pass membrane protein. An alternatively spliced transcript variant encoding the same protein has been found, but its biological validity is not determined. [provided by RefSeq, May 2010]

TMEM186 Gene

transmembrane protein 186

This gene encodes a potential transmembrane protein. [provided by RefSeq, Dec 2012]

TMEM189 Gene

transmembrane protein 189

Co-transcription of this gene and the neighboring downstream gene (ubiquitin-conjugating enzyme E2 variant 1) generates a rare read-through transcript, which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. The protein encoded by this individual gene lacks a UEV1 domain but includes three transmembrane regions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

TMEM59 Gene

transmembrane protein 59

This gene encodes a protein shown to regulate autophagy in response to bacterial infection. This protein may also regulate the retention of amyloid precursor protein (APP) in the Golgi apparatus through its control of APP glycosylation. Overexpression of this protein has been found to promote apoptosis in a glioma cell line. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

TMEM57 Gene

transmembrane protein 57

TMEM54 Gene

transmembrane protein 54

TMEM52 Gene

transmembrane protein 52

TMEM53 Gene

transmembrane protein 53

TMEM51 Gene

transmembrane protein 51

TMEM198B Gene

transmembrane protein 198B, pseudogene

TMEM154 Gene

transmembrane protein 154

PMEPA1 Gene

prostate transmembrane protein, androgen induced 1

This gene encodes a transmembrane protein that contains a Smad interacting motif (SIM). Expression of this gene is induced by androgens and transforming growth factor beta, and the encoded protein suppresses the androgen receptor and transforming growth factor beta signaling pathways though interactions with Smad proteins. Overexpression of this gene may play a role in multiple types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

MCTP1 Gene

multiple C2 domains, transmembrane 1

MCTP2 Gene

multiple C2 domains, transmembrane 2

LOC100287335 Gene

transmembrane protein 183A pseudogene

NDC1 Gene

NDC1 transmembrane nucleoporin

RNFT1P1 Gene

ring finger protein, transmembrane 1 pseudogene 1

RNFT1P2 Gene

ring finger protein, transmembrane 1 pseudogene 2

TMIGD3 Gene

transmembrane and immunoglobulin domain containing 3

This gene encodes a transmembrane and immunoglobulin domain-containing protein. Alternative splicing results in multiple transcript variants, one of which shares its 5' terminal exon with that of the overlapping adenosine A3 receptor gene (GeneID:140), thus resulting in a fusion product. [provided by RefSeq, Nov 2014]

TMIGD2 Gene

transmembrane and immunoglobulin domain containing 2

TMEM55A Gene

transmembrane protein 55A

TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]

TMEM55B Gene

transmembrane protein 55B

TMEM55B catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]).[supplied by OMIM, Mar 2008]

LOC440683 Gene

seven transmembrane helix receptor

TMEM30B Gene

transmembrane protein 30B

FITM2 Gene

fat storage-inducing transmembrane protein 2

FIT2 belongs to an evolutionarily conserved family of proteins involved in fat storage (Kadereit et al., 2008 [PubMed 18160536]).[supplied by OMIM, May 2008]

FITM1 Gene

fat storage-inducing transmembrane protein 1

FIT1 belongs to an evolutionarily conserved family of proteins involved in fat storage (Kadereit et al., 2008 [PubMed 18160536]).[supplied by OMIM, May 2008]

LOC100420020 Gene

transmembrane protein 55B pseudogene

DCSTAMP Gene

dendrocyte expressed seven transmembrane protein

This gene encodes a seven-pass transmembrane protein that is primarily expressed in dendritic cells. The encoded protein is involved in a range of immunological functions carried out by dendritic cells. This protein plays a role in osteoclastogenesis and myeloid differentiation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]

LOC101929203 Gene

RING finger and transmembrane domain-containing protein 1-like

TMX4 Gene

thioredoxin-related transmembrane protein 4

TMX1 Gene

thioredoxin-related transmembrane protein 1

TXNDC1 is a thioredoxin (TXN; see MIM 187700)-related protein with disulfide reductase activity (Matsuo et al., 2001 [PubMed 11152479]).[supplied by OMIM, Mar 2008]

TMX3 Gene

thioredoxin-related transmembrane protein 3

TMX2 Gene

thioredoxin-related transmembrane protein 2

LOC100130176 Gene

transmembrane protein 188 pseudogene

TMEM86A Gene

transmembrane protein 86A

TMEM86B Gene

transmembrane protein 86B

TMEM45A Gene

transmembrane protein 45A

TMEM45B Gene

transmembrane protein 45B

GPNMB Gene

glycoprotein (transmembrane) nmb

The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

TMEM155 Gene

transmembrane protein 155

TMEM156 Gene

transmembrane protein 156

TMEM158 Gene

transmembrane protein 158 (gene/pseudogene)

Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under other conditions that induce senescence. The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway. [provided by RefSeq, Jul 2008]

TMEM159 Gene

transmembrane protein 159

TMPRSS12 Gene

transmembrane (C-terminal) protease, serine 12

TMPRSS13 Gene

transmembrane protease, serine 13

This gene encodes a member of the type II transmembrane serine protease family. Transmembrane serine proteases are regulated by protease inhibitors and known to function in development, homeostasis, infection, and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

TMPRSS15 Gene

transmembrane protease, serine 15

This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq, Jul 2008]

LOC100101247 Gene

interferon induced transmembrane protein pseudogene

LOC100101246 Gene

interferon induced transmembrane protein 3 pseudogene

TEDDM2P Gene

transmembrane epididymal protein 2, pseudogene

IFITM10 Gene

interferon induced transmembrane protein 10

TMPRSS11CP Gene

transmembrane protease, serine 11C, pseudogene

TMEM213 Gene

transmembrane protein 213

TMEM210 Gene

transmembrane protein 210

TMEM215 Gene

transmembrane protein 215

LOC442389 Gene

interferon induced transmembrane protein pseudogene

LETM1 Gene

leucine zipper-EF-hand containing transmembrane protein 1

This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause Wolf-Hirschhorn syndrome, a complex malformation syndrome caused by the deletion of parts of the distal short arm of chromosome 4. Related pseudogenes have been identified on chromosomes 8, 15 and 19. [provided by RefSeq, Oct 2009]

LOC101930080 Gene

GPS, PLAT and transmembrane domain-containing protein FLJ00285-like

TMEM88 Gene

transmembrane protein 88

TMEM81 Gene

transmembrane protein 81

TMEM80 Gene

transmembrane protein 80

TMEM8A Gene

transmembrane protein 8A

TMEM8C Gene

transmembrane protein 8C

TMEM8B Gene

transmembrane protein 8B

TMEM87B Gene

transmembrane protein 87B

TMEM87A Gene

transmembrane protein 87A

IFITM9P Gene

interferon induced transmembrane protein 9 pseudogene

TMEM52B Gene

transmembrane protein 52B

LOC442309 Gene

interferon induced transmembrane protein 3 pseudogene

TMEM97P1 Gene

transmembrane protein 97 pseudogene 1

TMEM184A Gene

transmembrane protein 184A

TMEM184B Gene

transmembrane protein 184B

TMEM184C Gene

transmembrane protein 184C

TMEM222 Gene

transmembrane protein 222

TMEM223 Gene

transmembrane protein 223

TMEM220 Gene

transmembrane protein 220

TMEM221 Gene

transmembrane protein 221

LOC646616 Gene

transmembrane protein 183A pseudogene

LRTM1 Gene

leucine-rich repeats and transmembrane domains 1

TMED10 Gene

transmembrane emp24-like trafficking protein 10 (yeast)

This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]

LOC728048 Gene

interferon induced transmembrane protein pseudogene

TMEM167B Gene

transmembrane protein 167B

TMEM167A Gene

transmembrane protein 167A

LOC729707 Gene

transmembrane and tetratricopeptide repeat containing 4 pseudogene

GPA33 Gene

glycoprotein A33 (transmembrane)

The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily. [provided by RefSeq, Jul 2008]

TMEM132C Gene

transmembrane protein 132C

TENM3 Gene

teneurin transmembrane protein 3

TENM2 Gene

teneurin transmembrane protein 2

TENM1 Gene

teneurin transmembrane protein 1

The protein encoded by this gene belongs to the tenascin family and teneurin subfamily. It is expressed in the neurons and may function as a cellular signal transducer. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

TENM4 Gene

teneurin transmembrane protein 4

STEAP1 Gene

six transmembrane epithelial antigen of the prostate 1

This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [provided by RefSeq, Jul 2008]

P4HTM Gene

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

TMEM39B Gene

transmembrane protein 39B

TMEM39A Gene

transmembrane protein 39A

POM121L13P Gene

POM121 transmembrane nucleoporin-like 13, pseudogene

SERTM1 Gene

serine-rich and transmembrane domain containing 1

LOC100420053 Gene

transmembrane protein 126A pseudogene

TMC4 Gene

transmembrane channel-like 4

TMC6 Gene

transmembrane channel-like 6

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 10 transmembrane domains and 2 leucine zipper motifs. [provided by RefSeq, Jul 2008]

TMC7 Gene

transmembrane channel-like 7

TMC1 Gene

transmembrane channel-like 1

This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, it is known to be required for normal function of cochlear hair cells. Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual deafness. [provided by RefSeq, Jul 2008]

TMC2 Gene

transmembrane channel-like 2

This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, expression in the inner ear suggests that it may be crucial for normal auditory function. Mutations in this gene may underlie hereditary disorders of balance and hearing. [provided by RefSeq, Jul 2008]

TMC3 Gene

transmembrane channel-like 3

TMC8 Gene

transmembrane channel-like 8

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008]

CYSTM1 Gene

cysteine-rich transmembrane module containing 1

IFITM4P Gene

interferon induced transmembrane protein 4 pseudogene

LOC100420119 Gene

transmembrane protein 132B pseudogene

TMCO5B Gene

transmembrane and coiled-coil domains 5B, pseudogene

TMCO5A Gene

transmembrane and coiled-coil domains 5A

TMEM200C Gene

transmembrane protein 200C

LOC724105 Gene

cysteine-rich transmembrane module containing 1 pseudogene

TMEM125 Gene

transmembrane protein 125

TMEM127 Gene

transmembrane protein 127

This gene encodes a transmembrane protein with 3 predicted transmembrane domains. The protein is associated with a subpopulation of vesicular organelles corresponding to early endosomal structures, with the Golgi, and with lysosomes, and may participate in protein trafficking between these structures. Mutations in this gene and several other genes cause pheochromocytomas. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2010]

TMEM121 Gene

transmembrane protein 121

TMEM123 Gene

transmembrane protein 123

This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. [provided by RefSeq, Jul 2008]

TMEM129 Gene

transmembrane protein 129, E3 ubiquitin protein ligase

TMEM128 Gene

transmembrane protein 128

TMEM35 Gene

transmembrane protein 35

TMEM14E Gene

transmembrane protein 14E

TMEM143 Gene

transmembrane protein 143

TMEM140 Gene

transmembrane protein 140

TMEM89 Gene

transmembrane protein 89

TMEM82 Gene

transmembrane protein 82

OCSTAMP Gene

osteoclast stimulatory transmembrane protein

TPTEP1 Gene

transmembrane phosphatase with tensin homology pseudogene 1

POM121L8P Gene

POM121 transmembrane nucleoporin-like 8 pseudogene

LOC100420118 Gene

transmembrane protein 132C pseudogene

TMEM211 Gene

transmembrane protein 211

TMEM217 Gene

transmembrane protein 217

TMEM216 Gene

transmembrane protein 216

This locus encodes a transmembrane domain-containing protein. Mutations at this locus have been associated with Meckel-Gruber Syndrome Type 2, and Joubert Syndrome 2, also known as Cerebello-oculorenal Syndrome 2. [provided by RefSeq, Aug 2010]

TMEM214 Gene

transmembrane protein 214

TMEM219 Gene

transmembrane protein 219

TMEM218 Gene

transmembrane protein 218

TMEM78 Gene

transmembrane protein 78

TMEM79 Gene

transmembrane protein 79

TMEM70 Gene

transmembrane protein 70

This gene likely encodes a mitochondrial membrane protein. The encoded protein may play a role in biogenesis of mitochondrial ATP synthase. Mutations in this gene have been associated with neonatal mitochondrial encephalocardiomyopathy due to ATP synthase deficiency. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]

TMEM71 Gene

transmembrane protein 71

TMEM72 Gene

transmembrane protein 72

TMEM74 Gene

transmembrane protein 74

TMEM75 Gene

transmembrane protein 75

LOC121296 Gene

transmembrane protein 132B pseudogene

LOC100129118 Gene

transmembrane protein 167A pseudogene

CRIM1 Gene

cysteine rich transmembrane BMP regulator 1 (chordin-like)

This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins. [provided by RefSeq, Nov 2010]

TRAT1 Gene

T cell receptor associated transmembrane adaptor 1

TMEM63A Gene

transmembrane protein 63A

TMEM63C Gene

transmembrane protein 63C

TMEM63B Gene

transmembrane protein 63B

LOC100996401 Gene

transmembrane protein 191B

SEMA5B Gene

sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B

This gene encodes a member of the semaphorin protein family which regulates axon growth during development of the nervous system. The encoded protein has a characteristic Sema domain near the N-terminus, through which semaphorins bind to plexin, and five thrombospondin type 1 repeats in the C-terminal region of the protein. The protein product may be cleaved and exist as a secreted molecule (PMID: 19463192). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

SEMA5A Gene

sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A

This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.[provided by RefSeq, Jan 2010]

TMX2P1 Gene

thioredoxin-related transmembrane protein 2 pseudogene 1

LOC100420008 Gene

transmembrane protein 126B pseudogene

DSPA2D Gene

interferon induced transmembrane protein 3 pseudogene

LOC100420909 Gene

transmembrane protein 251 pseudogene

KREMEN1 Gene

kringle containing transmembrane protein 1

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein is a component of a membrane complex that modulates canonical WNT signaling through lipoprotein receptor-related protein 6 (LRP6). It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Jul 2008]

CLPTM1 Gene

cleft lip and palate associated transmembrane protein 1

TMEM262 Gene

transmembrane protein 262

TMEM198 Gene

transmembrane protein 198

TMEM177 Gene

transmembrane protein 177

TMEM174 Gene

transmembrane protein 174

TMEM175 Gene

transmembrane protein 175

TMEM171 Gene

transmembrane protein 171

TMEM100 Gene

transmembrane protein 100

TMEM191B Gene

transmembrane protein 191B

TMEM191C Gene

transmembrane protein 191C

TMEM191A Gene

transmembrane protein 191A (pseudogene)

VSTM2L Gene

V-set and transmembrane domain containing 2 like

VSTM2A Gene

V-set and transmembrane domain containing 2A

VSTM2B Gene

V-set and transmembrane domain containing 2B

LETM1P1 Gene

leucine zipper-EF-hand containing transmembrane protein 1, pseudogene 1

TM4SF20 Gene

transmembrane 4 L six family member 20

LOC100506400 Gene

transmembrane protein 258 pseudogene

LOC388104 Gene

transmembrane protein 183A pseudogene

TMEM151B Gene

transmembrane protein 151B

TMEM151A Gene

transmembrane protein 151A

TM4SF1 Gene

transmembrane 4 L six family member 1

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008]

TM4SF4 Gene

transmembrane 4 L six family member 4

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that can regulate cell proliferation.[provided by RefSeq, Mar 2011]

TM4SF5 Gene

transmembrane 4 L six family member 5

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells. [provided by RefSeq, Jul 2008]

TMEM248 Gene

transmembrane protein 248

TMEM249 Gene

transmembrane protein 249

TMEM244 Gene

transmembrane protein 244

TMEM245 Gene

transmembrane protein 245

TMEM246 Gene

transmembrane protein 246

TMEM240 Gene

transmembrane protein 240

This gene encodes a transmembrane-domain containing protein found in the brain and cerebellum. Mutations in this gene result in spinocerebellar ataxia 21. [provided by RefSeq, Dec 2014]

TMEM243 Gene

transmembrane protein 243, mitochondrial

LRTOMT Gene

leucine rich transmembrane and O-methyltransferase domain containing

This gene includes two transcript forms. The short form has one open reading frame (ORF), which encodes the leucine-rich repeats (LRR)-containing protein of unknown function. This protein is called LRTOMT1 or LRRC51. The long form has two alternative ORFs; the upstream ORF has the same translation start codon as used in the short form and the resulting transcript is a candidate for nonsense-mediated decay, and the downstream ORF encodes a different protein, which is a transmembrane catechol-O-methyltransferase and is called LRTOMT2, TOMT or COMT2. The COMT2 is essential for auditory and vestibular function. Defects in the COMT2 can cause nonsyndromic deafness. Alternatively spliced transcript variants from each transcript form have been found for this gene. [provided by RefSeq, Sep 2012]

TMTC4 Gene

transmembrane and tetratricopeptide repeat containing 4

TMTC3 Gene

transmembrane and tetratricopeptide repeat containing 3

This gene encodes a protein that belongs to the transmembrane and tetratricopeptide repeat-containing protein family. [provided by RefSeq, May 2010]

TMTC1 Gene

transmembrane and tetratricopeptide repeat containing 1

TMEM97P2 Gene

transmembrane protein 97 pseudogene 2

CFTRP1 Gene

cystic fibrosis transmembrane conductance regulator pseudogene 1

TMEM176A Gene

transmembrane protein 176A

TMEM176B Gene

transmembrane protein 176B

VEZT Gene

vezatin, adherens junctions transmembrane protein

This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]

TMEM120B Gene

transmembrane protein 120B

TMEM120A Gene

transmembrane protein 120A

KREMEN2 Gene

kringle containing transmembrane protein 2

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

TMEM248P1 Gene

transmembrane protein 248 pseudogene 1

LRRTM4 Gene

leucine rich repeat transmembrane neuronal 4

LRRTM1 Gene

leucine rich repeat transmembrane neuronal 1

LRRTM3 Gene

leucine rich repeat transmembrane neuronal 3

LRRTM2 Gene

leucine rich repeat transmembrane neuronal 2

TMEM173 Gene

transmembrane protein 173

This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

SEMA6D Gene

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D

Semaphorins are a large family, including both secreted and membrane associated proteins, many of which have been implicated as inhibitors or chemorepellents in axon pathfinding, fasciculation and branching, and target selection. All semaphorins possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Additional sequence motifs C-terminal to the semaphorin domain allow classification into distinct subfamilies. Results demonstrate that transmembrane semaphorins, like the secreted ones, can act as repulsive axon guidance cues. This gene encodes a class 6 vertebrate transmembrane semaphorin that demonstrates alternative splicing. Several transcript variants have been identified and expression of the distinct encoded isoforms is thought to be regulated in a tissue- and development-dependent manner. [provided by RefSeq, Nov 2010]

SEMA6B Gene

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B

This gene encodes a member of the semaphorin family, a group of proteins characterized by the presence of a conserved semaphorin (sema) domain. Whereas some semaphorins are transmembrane proteins, others are secreted. Semaphorins play a major role in axon guidance. The protein encoded by this gene may be involved in both peripheral and central nervous system development. [provided by RefSeq, Jul 2008]

SEMA6C Gene

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C

This gene encodes a member of the semaphorin family. Semaphorins represent important molecular signals controlling multiple aspects of the cellular response that follows CNS injury, and thus may play an important role in neural regeneration. [provided by RefSeq, May 2010]

SEMA6A Gene

sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

The transmembrane semaphorin SEMA6A is expressed in developing neural tissue and is required for proper development of the thalamocortical projection (Leighton et al., 2001 [PubMed 11242070]).[supplied by OMIM, Feb 2011]

IFITM3 Gene

interferon induced transmembrane protein 3

The protein encoded by this gene is an interferon-induced membrane protein that helps confer immunity to influenza A H1N1 virus, West Nile virus, and dengue virus. Two transcript variants, only one of them protein-coding, have been found for this gene. Another variant encoding an N-terminally truncated isoform has been reported, but the full-length nature of this variant has not been determined. [provided by RefSeq, May 2012]

IFITM1 Gene

interferon induced transmembrane protein 1

LOC100127982 Gene

transmembrane protein 69 pseudogene

POM121C Gene

POM121 transmembrane nucleoporin C

TMEM27 Gene

transmembrane protein 27

This gene encodes a type 1 transmembrane protein that is important for trafficking amino acid transporters to the apical brush border of proximal tubules. The encoded protein binds to amino acid transporters and regulates their expression on the plasma membrane. It also plays a role in controlling insulin exocytosis by regulating formation of the SNARE (soluble N-ethylmaleimide-sensitive-factor attachment protein receptor) complex in pancreatic beta cells. The extracellular domain of the encoded protein may be cleaved and shed from the plasma membrane specifically in pancreatic beta cells. [provided by RefSeq, Jun 2013]

TMEM26 Gene

transmembrane protein 26

TMEM25 Gene

transmembrane protein 25

LOC100287541 Gene

POM121 transmembrane nucleoporin pseudogene

LAX1 Gene

lymphocyte transmembrane adaptor 1

TMEM225 Gene

transmembrane protein 225

TMEM256P1 Gene

transmembrane protein 256 pseudogene 1

LAPTM5 Gene

lysosomal protein transmembrane 5

This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as E3 protein, may play a role in hematopoiesis. [provided by RefSeq, Feb 2009]

TMPRSS11A Gene

transmembrane protease, serine 11A

TMPRSS11B Gene

transmembrane protease, serine 11B

TMPRSS11D Gene

transmembrane protease, serine 11D

This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. [provided by RefSeq, Jul 2008]

TMPRSS11E Gene

transmembrane protease, serine 11E

TMPRSS11F Gene

transmembrane protease, serine 11F

TMEM212 Gene

transmembrane protein 212

TMEM14D Gene

transmembrane protein 14D (pseudogene)

TMEM14C Gene

transmembrane protein 14C

TMEM14B Gene

transmembrane protein 14B

TMEM14A Gene

transmembrane protein 14A

TMEM147 Gene

transmembrane protein 147

TMEM145 Gene

transmembrane protein 145

TMEM144 Gene

transmembrane protein 144

TMEM141 Gene

transmembrane protein 141

LOC123862 Gene

interferon induced transmembrane protein pseudogene

TMEM194A Gene

transmembrane protein 194A

LOC100420958 Gene

transmembrane 9 superfamily member 2 pseudogene

TMEM59L Gene

transmembrane protein 59-like

This gene encodes a predicted type-I membrane glycoprotein. The encoded protein may play a role in functioning of the central nervous system. [provided by RefSeq, Jul 2008]

IFITM2 Gene

interferon induced transmembrane protein 2

TMEM229A Gene

transmembrane protein 229A

TMEM229B Gene

transmembrane protein 229B

TM6SF1 Gene

transmembrane 6 superfamily member 1

TM6SF2 Gene

transmembrane 6 superfamily member 2

SECTM1 Gene

secreted and transmembrane 1

This gene encodes a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein. It is found in a perinuclear Golgi-like pattern and thought to be involved in hematopoietic and/or immune system processes. [provided by RefSeq, Jul 2008]

TMEM98 Gene

transmembrane protein 98

This gene encodes a transmembrane protein. A missense mutation in this gene result in Nanophthalmos 4 (NNO4). Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2014]

TMEM99 Gene

transmembrane protein 99

TMEM92 Gene

transmembrane protein 92

TMEM91 Gene

transmembrane protein 91

TMEM97 Gene

transmembrane protein 97

TMEM97 is a conserved integral membrane protein that plays a role in controlling cellular cholesterol levels (Bartz et al., 2009 [PubMed 19583955]).[supplied by OMIM, Aug 2009]

TMEM95 Gene

transmembrane protein 95

TMIE Gene

transmembrane inner ear

This gene encodes a transmembrane inner ear protein. Studies in mouse suggest that this gene is required for normal postnatal maturation of sensory hair cells in the cochlea, including correct development of stereocilia bundles. This gene is one of multiple genes responsible for recessive non-syndromic deafness (DFNB), also known as autosomal recessive nonsyndromic hearing loss (ARNSHL), the most common form of congenitally acquired inherited hearing impairment. [provided by RefSeq, Mar 2009]

TMEM88B Gene

transmembrane protein 88B

CMTM7 Gene

CKLF-like MARVEL transmembrane domain containing 7

This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. The protein encoded by this gene is highly expressed in leukocytes, but its exact function is unknown. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

TPTE2P5 Gene

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 5

LOC105369277 Gene

transmembrane protein C16orf54

PRRG4 Gene

proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)

PRRG3 Gene

proline rich Gla (G-carboxyglutamic acid) 3 (transmembrane)

This gene encodes a protein which contains a vitamin K-dependent carboxylation/gamma-carboxyglutamic domain. The encoded protein is a member of a family of vitamin K-dependent transmembrane proteins which contain a glutamate-rich extracellular domain. [provided by RefSeq, Aug 2011]

TMEM261P1 Gene

transmembrane protein 261 pseudogene 1

POM121L6P Gene

POM121 transmembrane nucleoporin-like 6 pseudogene

LOC100101126 Gene

thioredoxin-related transmembrane protein 1 pseudogene

LOC100101127 Gene

thioredoxin-related transmembrane protein 1 pseudogene

TMEM239 Gene

transmembrane protein 239

TMEM238 Gene

transmembrane protein 238

TMEM235 Gene

transmembrane protein 235

TMEM234 Gene

transmembrane protein 234

TMEM237 Gene

transmembrane protein 237

The protein encoded by this gene is a tetraspanin protein that is thought to be involved in WNT signaling. Defects in this gene are a cause of Joubert syndrome-14. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

TMEM236 Gene

transmembrane protein 236

TMEM231 Gene

transmembrane protein 231

This gene encodes a transmembrane protein, which is a component of the B9 complex involved in the formation of the diffusion barrier between the cilia and plasma membrane. Mutations in this gene cause Joubert syndrome (JBTS). Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]

TMEM230 Gene

transmembrane protein 230

TMEM233 Gene

transmembrane protein 233

TMEM232 Gene

transmembrane protein 232

TMCO1 Gene

transmembrane and coiled-coil domains 1

This locus encodes a transmembrane protein. Mutations at this locus have been associated with craniofacial dysmorphism, skeletal anomalies, and mental retardation. Mutations at this locus have also been associated with open angle glaucoma blindness. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

TMCO2 Gene

transmembrane and coiled-coil domains 2

TMCO4 Gene

transmembrane and coiled-coil domains 4

TMCO6 Gene

transmembrane and coiled-coil domains 6

LRIT2 Gene

leucine-rich repeat, immunoglobulin-like and transmembrane domains 2

LRIT3 Gene

leucine-rich repeat, immunoglobulin-like and transmembrane domains 3

This gene encodes a protein that has a fibronectin type III domain and a C-terminal transmembrane domain, as well as a leucine-rich repeat domain and immunoglobulin-like domain near the N-terminus. The encoded protein may regulate fibroblast growth factor receptors and affect the modification of these receptors, which are glycosylated differently in the Golgi and endoplasmic reticulum. Mutations in this gene are associated with congenital stationary night blindness, type 1F. [provided by RefSeq, May 2013]

LRIT1 Gene

leucine-rich repeat, immunoglobulin-like and transmembrane domains 1

TMEM11 Gene

transmembrane protein 11

TMEM17 Gene

transmembrane protein 17

TMEM18 Gene

transmembrane protein 18

TMEM19 Gene

transmembrane protein 19

TMEM194B Gene

transmembrane protein 194B

TMEM200A Gene

transmembrane protein 200A

LOC643058 Gene

interferon induced transmembrane protein 3 pseudogene

TPTE Gene

transmembrane phosphatase with tensin homology

This gene encodes a PTEN-related tyrosine phosphatase which may play a role in the signal transduction pathways of the endocrine or spermatogenic function of the testis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

LOC100129133 Gene

transmembrane protein 184C pseudogene

TMEM9 Gene

transmembrane protein 9

TMEM2 Gene

transmembrane protein 2

TMEM5 Gene

transmembrane protein 5

This gene encodes a type II transmembrane protein that is thought to have glycosyltransferase function. Mutations in this gene result in cobblestone lissencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

TMEM38A Gene

transmembrane protein 38A

TMEM38B Gene

transmembrane protein 38B

This gene encodes an intracellular monovalent cation channel that functions in maintenance of intracellular calcium release. Mutations in this gene may be associated with autosomal recessive osteogenesis. [provided by RefSeq, Oct 2012]

PRRT4 Gene

proline-rich transmembrane protein 4

PRRT1 Gene

proline-rich transmembrane protein 1

PRRT3 Gene

proline-rich transmembrane protein 3

PRRT2 Gene

proline-rich transmembrane protein 2

This gene encodes a transmembrane protein containing a proline-rich domain in its N-terminal half. Studies in mice suggest that it is predominantly expressed in brain and spinal cord in embryonic and postnatal stages. Mutations in this gene are associated with episodic kinesigenic dyskinesia-1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

CFTR Gene

cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)

This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene. [provided by RefSeq, Jul 2008]

POM121L10P Gene

POM121 transmembrane nucleoporin-like 10, pseudogene

TMEM183A Gene

transmembrane protein 183A

TMEM183B Gene

transmembrane protein 183B

This locus was thought to represent a pseudogene of chromosome 1 open reading frame 37 because it is intronless and retains a polyA tail at the 3' end. It does however contain a complete open reading frame that subsequent research has demonstrated to be transcribed in a limited number of human tissues. The encoded protein may represent a transmembrane protein associated with cell membranes and be involved in cell-cell or cell-environment interactions. [provided by RefSeq, Jul 2010]

TMEM41A Gene

transmembrane protein 41A

TMEM41B Gene

transmembrane protein 41B

LOC100420067 Gene

transmembrane protein 231 pseudogene

LOC100420066 Gene

transmembrane protein 111 pseudogene

TMEM179 Gene

transmembrane protein 179

TMEM56 Gene

transmembrane protein 56

TMEM178A Gene

transmembrane protein 178A

TMEM30A Gene

transmembrane protein 30A

TMEM30C Gene

transmembrane protein 30C

LOC100379290 Gene

transmembrane and coiled-coil domain family 1 pseudogene

TMEM119 Gene

transmembrane protein 119

TMEM110 Gene

transmembrane protein 110

TMEM114 Gene

transmembrane protein 114

This gene encodes a glycosylated transmembrane protein that plays a role in lens and eye development. Mutations in this gene, including a t(16;22)(p13.3;q11.2) translocation, are associated with congenital and juvenile cataract disorders. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

TMEM115 Gene

transmembrane protein 115

TMEM116 Gene

transmembrane protein 116

TMEM117 Gene

transmembrane protein 117

TMEM170B Gene

transmembrane protein 170B

TMEM170A Gene

transmembrane protein 170A

POM121L14P Gene

POM121 transmembrane nucleoporin-like 14, pseudogene

LOC642975 Gene

transmembrane protein 230 pseudogene

LOC100420116 Gene

transmembrane protein 132B pseudogene

LOC100996634 Gene

transmembrane protein FLJ37396

GAPT Gene

GRB2-binding adaptor protein, transmembrane

LOC100132789 Gene

transmembrane protein 126A pseudogene

TMEM265 Gene

transmembrane protein 265

TMEM263 Gene

transmembrane protein 263

TMEM260 Gene

transmembrane protein 260

TMEM261 Gene

transmembrane protein 261

TMEM190 Gene

transmembrane protein 190

TMEM192 Gene

transmembrane protein 192

TMEM196 Gene

transmembrane protein 196

TMEM199 Gene

transmembrane protein 199

TMEM44 Gene

transmembrane protein 44

TMEM47 Gene

transmembrane protein 47

This gene encodes a member of the PMP22/EMP/claudin protein family. The encoded protein is localized to the ER and the plasma membrane. In dogs, transcripts of this gene exist at high levels in the brain. [provided by RefSeq, Jul 2008]

TMEM40 Gene

transmembrane protein 40

TMEM43 Gene

transmembrane protein 43

This gene belongs to the TMEM43 family. Defects in this gene are the cause of familial arrhythmogenic right ventricular dysplasia type 5 (ARVD5), also known as arrhythmogenic right ventricular cardiomyopathy type 5 (ARVC5). Arrhythmogenic right ventricular dysplasia is an inherited disorder, often involving both ventricles, and is characterized by ventricular tachycardia, heart failure, sudden cardiac death, and fibrofatty replacement of cardiomyocytes. This gene contains a response element for PPAR gamma (an adipogenic transcription factor), which may explain the fibrofatty replacement of the myocardium, a characteristic pathological finding in ARVC. [provided by RefSeq, Oct 2008]

TMEM42 Gene

transmembrane protein 42

TEDDM1 Gene

transmembrane epididymal protein 1

TMPRSS9 Gene

transmembrane protease, serine 9

TMPRSS2 Gene

transmembrane protease, serine 2

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

TMPRSS3 Gene

transmembrane protease, serine 3

This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a serine protease domain, a transmembrane domain, an LDL receptor-like domain, and a scavenger receptor cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset autosomal recessive deafness. This gene is expressed in fetal cochlea and many other tissues, and is thought to be involved in the development and maintenance of the inner ear or the contents of the perilymph and endolymph. This gene was also identified as a tumor-associated gene that is overexpressed in ovarian tumors. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]

TMPRSS4 Gene

transmembrane protease, serine 4

This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

TMPRSS5 Gene

transmembrane protease, serine 5

This gene encodes a protein that belongs to the serine protease family. Serine proteases are known to be involved in many physiological and pathological processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

TMPRSS6 Gene

transmembrane protease, serine 6

The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

TMPRSS7 Gene

transmembrane protease, serine 7

LOC100422730 Gene

sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A pseudogene

TMEM126A Gene

transmembrane protein 126A

The protein encoded by this gene is a mitochondrial membrane protein of unknown function. Defects in this gene are a cause of optic atrophy type 7 (OPA7). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

TMEM126B Gene

transmembrane protein 126B

TMIGD1 Gene

transmembrane and immunoglobulin domain containing 1

POM121L7 Gene

POM121 transmembrane nucleoporin-like 7

POM121L2 Gene

POM121 transmembrane nucleoporin-like 2

TPTE2P2 Gene

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 2

TPTE2P3 Gene

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 3

TPTE2P1 Gene

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 1

TPTE2P6 Gene

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 6

TPTE2P4 Gene

transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 pseudogene 4

POM121L3P Gene

POM121 transmembrane nucleoporin-like 3, pseudogene

TMEM106B Gene

transmembrane protein 106B

TMEM106C Gene

transmembrane protein 106C

TMEM106A Gene

transmembrane protein 106A

SEMA4A Gene

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A

This gene encodes a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. The encoded protein is a single-pass type I membrane protein containing an immunoglobulin-like C2-type domain, a PSI domain and a sema domain. It inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons. It is an activator of T-cell-mediated immunity and suppresses vascular endothelial growth factor (VEGF)-mediated endothelial cell migration and proliferation in vitro and angiogenesis in vivo. Mutations in this gene are associated with retinal degenerative diseases including retinitis pigmentosa type 35 (RP35) and cone-rod dystrophy type 10 (CORD10). Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]

SEMA4B Gene

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B

SEMA4C Gene

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C

SEMA4D Gene

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D

SEMA4F Gene

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4F

This gene encodes a transmembrane class IV semaphorin family protein, which plays a role in neural development. This gene may be involved in neurogenesis in prostate cancer, the development of neurofibromas, and breast cancer tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

SEMA4G Gene

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G

Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

TMCO3 Gene

transmembrane and coiled-coil domains 3

LOC100420011 Gene

transmembrane protein 38A pseudogene

LOC100130326 Gene

transmembrane protein 183A pseudogene

TPRA1 Gene

transmembrane protein, adipocyte asscociated 1

TMEM185AP1 Gene

transmembrane protein 185A pseudogene 1

TMED11P Gene

transmembrane emp24 protein transport domain containing 11, pseudogene

borate transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the borate transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

borate transmembrane transport Gene Set

From GO Biological Process Annotations

genes participating in the borate transmembrane transport biological process from the curated GO Biological Process Annotations dataset.

2-aminoethoxydiphenyl borate Gene Set

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical 2-aminoethoxydiphenyl borate from the curated CTD Gene-Chemical Interactions dataset.

sodium borate Gene Set

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical sodium borate from the curated CTD Gene-Chemical Interactions dataset.

borate Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term borate in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

borate transport Gene Set

From GO Biological Process Annotations

genes participating in the borate transport biological process from the curated GO Biological Process Annotations dataset.

regulation of transmembrane transporter activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of transmembrane transporter activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of sodium ion transmembrane transporter activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of sodium ion transmembrane transporter activity biological process from the curated GO Biological Process Annotations dataset.

regulation of calcium ion transmembrane transporter activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of calcium ion transmembrane transporter activity biological process from the curated GO Biological Process Annotations dataset.

regulation of potassium ion transmembrane transporter activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of potassium ion transmembrane transporter activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of sodium ion transmembrane transporter activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of sodium ion transmembrane transporter activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of calcium ion transmembrane transporter activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of calcium ion transmembrane transporter activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of potassium ion transmembrane transporter activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of potassium ion transmembrane transporter activity biological process from the curated GO Biological Process Annotations dataset.

regulation of sodium ion transmembrane transporter activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of sodium ion transmembrane transporter activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of rubidium ion transmembrane transporter activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of rubidium ion transmembrane transporter activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of calcium ion transmembrane transporter activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of calcium ion transmembrane transporter activity biological process from the curated GO Biological Process Annotations dataset.

regulation of rubidium ion transmembrane transporter activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of rubidium ion transmembrane transporter activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of ion transmembrane transporter activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of ion transmembrane transporter activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of potassium ion transmembrane transporter activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of potassium ion transmembrane transporter activity biological process from the curated GO Biological Process Annotations dataset.

regulation of ion transmembrane transporter activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of ion transmembrane transporter activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of ion transmembrane transporter activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of ion transmembrane transporter activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of rubidium ion transmembrane transporter activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of rubidium ion transmembrane transporter activity biological process from the curated GO Biological Process Annotations dataset.

sulfur amino acid transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the sulfur amino acid transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphate ion transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphate ion transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

formate uptake transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the formate uptake transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

iodide transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the iodide transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

glycine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the glycine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

udp-xylose transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the udp-xylose transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

monosaccharide transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the monosaccharide transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

l-proline transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the l-proline transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

protein transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the protein transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

putrescine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the putrescine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

nitrate transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the nitrate transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

mannose transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the mannose transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

hexose transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the hexose transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

high-affinity l-ornithine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the high-affinity l-ornithine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

glucoside transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the glucoside transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

secondary active monocarboxylate transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the secondary active monocarboxylate transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

branched-chain amino acid transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the branched-chain amino acid transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

pyrimidine nucleotide-sugar transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the pyrimidine nucleotide-sugar transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

high-affinity lysine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the high-affinity lysine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

sulfur compound transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the sulfur compound transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

l-asparagine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the l-asparagine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

l-tyrosine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the l-tyrosine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

l-alanine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the l-alanine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

amino acid transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the amino acid transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

prostaglandin transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the prostaglandin transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

cysteine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the cysteine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

deoxynucleotide transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the deoxynucleotide transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

fructose transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the fructose transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

alanine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the alanine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

macromolecule transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the macromolecule transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

l-glutamate transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the l-glutamate transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

l-lysine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the l-lysine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

quaternary ammonium group transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the quaternary ammonium group transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

c4-dicarboxylate transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the c4-dicarboxylate transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

amine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the amine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

secondary active transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the secondary active transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

copper ion transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the copper ion transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

glucose transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the glucose transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

oxalate transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the oxalate transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

l-histidine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the l-histidine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

bile acid transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the bile acid transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

alcohol transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the alcohol transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

nucleotide transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the nucleotide transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

l-glutamine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the l-glutamine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

p-p-bond-hydrolysis-driven transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the p-p-bond-hydrolysis-driven transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

amide transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the amide transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

l-threonine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the l-threonine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

l-leucine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the l-leucine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

udp-glucuronic acid transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the udp-glucuronic acid transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

aromatic amino acid transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the aromatic amino acid transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

drug transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the drug transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

cadmium ion transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the cadmium ion transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

water transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the water transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

choline transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the choline transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

proton-dependent peptide secondary active transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the proton-dependent peptide secondary active transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

thyroid hormone transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the thyroid hormone transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

primary active transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the primary active transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

sugar transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the sugar transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

l-hydroxyproline transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the l-hydroxyproline transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

anion transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the anion transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

sodium-dependent phosphate transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the sodium-dependent phosphate transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

ferrous iron uptake transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the ferrous iron uptake transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

high-affinity basic amino acid transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the high-affinity basic amino acid transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

cation transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the cation transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

basic amino acid transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the basic amino acid transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

l-ornithine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the l-ornithine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

nucleic acid transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the nucleic acid transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

nickel cation transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the nickel cation transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

adenine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the adenine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

glycerol transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the glycerol transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

coenzyme a transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the coenzyme a transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

taurine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the taurine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

organic anion transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the organic anion transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

creatine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the creatine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

nitric oxide transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the nitric oxide transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

magnesium ion transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the magnesium ion transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

glucose-6-phosphate transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the glucose-6-phosphate transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

d-glucose transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the d-glucose transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

vitamin transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the vitamin transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

carboxylic acid transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the carboxylic acid transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

inorganic cation transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the inorganic cation transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

chloride transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the chloride transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

organic cation transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the organic cation transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

organic hydroxy compound transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the organic hydroxy compound transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

sulfur-containing amino acid secondary active transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the sulfur-containing amino acid secondary active transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

neutral amino acid transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the neutral amino acid transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

inorganic diphosphate transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the inorganic diphosphate transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

pyruvate transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the pyruvate transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

l-amino acid transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the l-amino acid transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

copper uptake transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the copper uptake transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

organophosphate ester transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the organophosphate ester transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

formate transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the formate transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

nucleobase transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the nucleobase transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

inorganic phosphate transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the inorganic phosphate transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

sulfate transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the sulfate transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

potassium ion transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the potassium ion transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

iron ion transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the iron ion transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

substrate-specific transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the substrate-specific transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

zinc ion transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the zinc ion transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

oligopeptide transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the oligopeptide transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

pyrimidine nucleobase transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the pyrimidine nucleobase transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

canalicular bile acid transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the canalicular bile acid transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

sodium-dependent l-ascorbate transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the sodium-dependent l-ascorbate transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

hexose phosphate transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the hexose phosphate transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

tricarboxylic acid transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the tricarboxylic acid transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

polyamine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the polyamine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

thiamine uptake transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the thiamine uptake transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

purine nucleotide transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the purine nucleotide transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

urate transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the urate transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

carbon dioxide transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the carbon dioxide transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

s-adenosyl-l-methionine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the s-adenosyl-l-methionine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

proton-dependent oligopeptide secondary active transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the proton-dependent oligopeptide secondary active transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

inorganic anion transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the inorganic anion transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

succinate transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the succinate transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

organic acid transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the organic acid transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

modified amino acid transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the modified amino acid transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

low-affinity phosphate transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the low-affinity phosphate transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

fad transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the fad transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

l-cystine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the l-cystine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

polyol transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the polyol transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

hydrogen ion transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the hydrogen ion transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

dopamine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the dopamine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

efflux transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the efflux transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

malate transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the malate transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

cobalt ion transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the cobalt ion transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

adenine nucleotide transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the adenine nucleotide transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

acidic amino acid transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the acidic amino acid transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

acyl carnitine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the acyl carnitine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

monocarboxylic acid transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the monocarboxylic acid transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

rna transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the rna transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

divalent inorganic cation transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the divalent inorganic cation transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

serotonin transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the serotonin transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

purine ribonucleotide transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the purine ribonucleotide transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

udp-n-acetylglucosamine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the udp-n-acetylglucosamine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

lactate transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the lactate transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

secondary active sulfate transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the secondary active sulfate transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

cystine secondary active transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the cystine secondary active transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

l-serine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the l-serine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

metal ion transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the metal ion transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

atp transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the atp transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

sodium-dependent multivitamin transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the sodium-dependent multivitamin transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

p-p-bond-hydrolysis-driven protein transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the p-p-bond-hydrolysis-driven protein transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

gamma-aminobutyric acid transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the gamma-aminobutyric acid transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

dicarboxylic acid transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the dicarboxylic acid transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

sodium-independent organic anion transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the sodium-independent organic anion transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

udp-galactose transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the udp-galactose transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

nucleotide-sugar transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the nucleotide-sugar transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

secondary active organic cation transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the secondary active organic cation transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

l-methionine transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the l-methionine transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphate transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphate transmembrane transporter activity molecular function from the curated GO Molecular Function Annotations dataset.

molybdate ion transmembrane transporter activity Gene Set

From GO Molecular Function Annotations

genes performing the