Name

LINCS Kinativ Kinase Inhibitor Bioactivity Profiles Dataset

From LINCS Kinativ

percent inhibition of kinases by small molecules measured in cell lysates

LINCS KinomeScan Kinase Inhibitor Targets Dataset

From LINCS KinomeScan

kinase inhibitor targets from percent inhibition of kinases by small molecules measured using purified kinases

ADCY4 Gene

adenylate cyclase 4

This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylate cyclase 4, along with adenylate cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylate cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]

ADCY5 Gene

adenylate cyclase 5

This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

ADCY6 Gene

adenylate cyclase 6

This gene encodes a member of the adenylyl cyclase family of proteins, which are required for the synthesis of cyclic AMP. All members of this family have an intracellular N-terminus, a tandem repeat of six transmembrane domains separated by a cytoplasmic loop, and a C-terminal cytoplasmic domain. The two cytoplasmic regions bind ATP and form the catalytic core of the protein. Adenylyl cyclases are important effectors of transmembrane signaling pathways and are regulated by the activity of G protein coupled receptor signaling. This protein belongs to a small subclass of adenylyl cyclase proteins that are functionally related and are inhibited by protein kinase A, calcium ions and nitric oxide. A mutation in this gene is associated with arthrogryposis multiplex congenita. [provided by RefSeq, May 2015]

ADCY1 Gene

adenylate cyclase 1 (brain)

This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

ADCY2 Gene

adenylate cyclase 2 (brain)

This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008]

ADCY3 Gene

adenylate cyclase 3

This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. [provided by RefSeq, Jul 2008]

ADCY8 Gene

adenylate cyclase 8 (brain)

Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]

ADCY9 Gene

adenylate cyclase 9

Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. It is regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The type 9 adenylyl cyclase is a widely distributed adenylyl cyclase, and it is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. [provided by RefSeq, Jul 2008]

ADCY10 Gene

adenylate cyclase 10 (soluble)

The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014]

CAP2P1 Gene

CAP, adenylate cyclase-associated protein, 2 (yeast) pseudogene 1

ADCY7 Gene

adenylate cyclase 7

This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences. Several transcript variants have been observed for this gene, but the full-length natures of only two have been determined so far. [provided by RefSeq, Oct 2013]

ADCY10P1 Gene

adenylate cyclase 10 (soluble) pseudogene 1

ADCYAP1 Gene

adenylate cyclase activating polypeptide 1 (pituitary)

This gene encodes a secreted proprotein that is further processed into multiple mature peptides. These peptides stimulate adenylate cyclase and increase cyclic adenosine monophosphate (cAMP) levels, resulting in the transcriptional activation of target genes. The products of this gene are key mediators of neuroendocrine stress responses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]

CAP1 Gene

CAP, adenylate cyclase-associated protein 1 (yeast)

The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jul 2008]

CAP2 Gene

CAP, adenylate cyclase-associated protein, 2 (yeast)

This gene was identified by its similarity to the gene for human adenylyl cyclase-associated protein. The function of the protein encoded by this gene is unknown. However, the protein appears to be able to interact with adenylyl cyclase-associated protein and actin. [provided by RefSeq, Jul 2008]

HTR7 Gene

5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled

The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]

ADCYAP1R1 Gene

adenylate cyclase activating polypeptide 1 (pituitary) receptor type I

This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Dec 2010]

SERPINE4P Gene

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 4 pseudogene

SERPINE1 Gene

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

SERPINE2 Gene

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. Thrombin, urokinase, plasmin and trypsin are among the proteases that this family member can inhibit. This gene is a susceptibility gene for chronic obstructive pulmonary disease and for emphysema. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

SERPINE3 Gene

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3

SPINK2 Gene

serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)

This gene encodes a member of the family of serine protease inhibitors of the Kazal type (SPINK). The encoded protein acts as a trypsin and acrosin inhibitor in the genital tract and is localized in the spermatozoa. The protein has been associated with the progression of lymphomas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

TFPI Gene

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

This gene encodes a protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. The encoded protein is glycosylated and predominantly found in the vascular endothelium and plasma in both free forms and complexed with plasma lipoproteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been confirmed. [provided by RefSeq, Jul 2008]

SERPING1 Gene

serpin peptidase inhibitor, clade G (C1 inhibitor), member 1

This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq, Jul 2008]

LOC100421100 Gene

RNA terminal phosphate cyclase-like 1 pseudogene

GUCY1B2 Gene

guanylate cyclase 1, soluble, beta 2 (pseudogene)

GUCY2GP Gene

guanylate cyclase 2G, pseudogene

GUCY1B3 Gene

guanylate cyclase 1, soluble, beta 3

This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

LSS Gene

lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)

The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009]

GUCD1 Gene

guanylyl cyclase domain containing 1

GUCA2A Gene

guanylate cyclase activator 2A (guanylin)

GUCA2B Gene

guanylate cyclase activator 2B (uroguanylin)

This gene encodes a member of the guanylin family, and is expressed in the stomach and intestine. This protein functions as an endogenous ligand for the guanylate cyclase-C receptor and stimulates an increase in cyclic GMP, a key component of several intracellular signal transduction pathways. It maybe involved in salt and water secretion into the intestinal lumen as well as the renal tubules, and thus regulate electrolyte homeostasis in these tissues. [provided by RefSeq, Oct 2011]

GUCY2EP Gene

guanylate cyclase 2E, pseudogene

This olfactory specific guanylyl cyclase is part of the mammalian olfactory system and and encodes a protein involved in chemosensation in rodents. The gene has become inactivated to become a pseudogene is humans and most primates. [provided by RefSeq, Oct 2008]

GUCY2C Gene

guanylate cyclase 2C

GUCY2D Gene

guanylate cyclase 2D, membrane (retina-specific)

This gene encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases. [provided by RefSeq, Dec 2008]

GUCY2F Gene

guanylate cyclase 2F, retinal

The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein. Defects in this gene may be a cause of X-linked retinitis pigmentosa. [provided by RefSeq, Dec 2008]

RCL1 Gene

RNA terminal phosphate cyclase-like 1

GUCA1A Gene

guanylate cyclase activator 1A (retina)

This gene plays a role in the recovery of retinal photoreceptors from photobleaching. In the recovery phase, the phototransduction messeneger cGMP is replenished by retinal guanylyl cyclase-1 (GC1). GC1 is activated by decreasing Ca(2+) concentrations following photobleaching. The protein encoded by this gene, guanylyl cyclase activating protein 1 (GCAP1), mediates the sensitivity of GC1 to Ca(2+) concentrations. GCAP1 promotes activity of GC1 at low Ca(2+) concentrations and inhibits GC1 activity at high Ca(2+) concentrations. Mutations in this gene cause autosomal dominant cone dystrophy (COD3); a disease characterized by reduced visual acuity associated with progressive loss of color vision. Mutations in this gene prohibit the inactivation of RetGC1 at high Ca(2+) concentrations; causing the constitutive activation of RetGC1 and, presumably, increased cell death. This gene is expressed in retina and spermatagonia. [provided by RefSeq, Feb 2009]

GUCA1C Gene

guanylate cyclase activator 1C

GUCA1B Gene

guanylate cyclase activator 1B (retina)

The protein encoded by this gene is a calcium-binding protein that activates photoreceptor guanylate cyclases. This gene may have arisen due to a gene duplication event since there is a highly similar gene clustered with it on chromosome 6. Mutations in this gene can cause a form of retinitis pigmentosa. [provided by RefSeq, Nov 2009]

RTCA Gene

RNA 3'-terminal phosphate cyclase

This gene encodes a member of the RNA 3'-phosphate cyclase family. The encoded protein plays a role in RNA metabolism by catalyzing the ATP-dependent conversion of the 3'-phosphate of RNA substrates to a 2',3'-cyclic phosphodiester. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

GUCY1A3 Gene

guanylate cyclase 1, soluble, alpha 3

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GUCY1A2 Gene

guanylate cyclase 1, soluble, alpha 2

Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

TKFC Gene

triokinase/FMN cyclase

This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been identified, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

AK2P2 Gene

adenylate kinase 2 pseudogene 2

AK9 Gene

adenylate kinase 9

AK8 Gene

adenylate kinase 8

AK3 Gene

adenylate kinase 3

The protein encoded by this gene is a GTP:ATP phosphotransferase that is found in the mitochondrial matrix. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

AK2 Gene

adenylate kinase 2

Adenylate kinases are involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. Three isozymes of adenylate kinase, namely 1, 2, and 3, have been identified in vertebrates; this gene encodes isozyme 2. Expression of these isozymes is tissue-specific and developmentally regulated. Isozyme 2 is localized in the mitochondrial intermembrane space and may play a role in apoptosis. Mutations in this gene are the cause of reticular dysgenesis. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1 and 2.[provided by RefSeq, Nov 2010]

AK1 Gene

adenylate kinase 1

Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme. [provided by RefSeq, Jul 2008]

AK4 Gene

adenylate kinase 4

This gene encodes a member of the adenylate kinase family of enzymes. The encoded protein is localized to the mitochondrial matrix. Adenylate kinases regulate the adenine and guanine nucleotide compositions within a cell by catalyzing the reversible transfer of phosphate group among these nucleotides. Five isozymes of adenylate kinase have been identified in vertebrates. Expression of these isozymes is tissue-specific and developmentally regulated. A pseudogene for this gene has been located on chromosome 17. Three transcript variants encoding the same protein have been identified for this gene. Sequence alignment suggests that the gene defined by NM_013410, NM_203464, and NM_001005353 is located on chromosome 1. [provided by RefSeq, Jul 2008]

LOC100499399 Gene

adenylate kinase 3 pseudogene

AK6P2 Gene

adenylate kinase 6 pseudogene 2

AK6P1 Gene

adenylate kinase 6 pseudogene 1

AK4P4 Gene

adenylate kinase 4 pseudogene 4

AK2P1 Gene

adenylate kinase 2 pseudogene 1

LOC390877 Gene

adenylate kinase isoenzyme 1-like

AK4P1 Gene

adenylate kinase 4 pseudogene 1

AK4P3 Gene

adenylate kinase 4 pseudogene 3

AK4P2 Gene

adenylate kinase 4 pseudogene 2

AK4P5 Gene

adenylate kinase 4 pseudogene 5

AK4P6 Gene

adenylate kinase 4 pseudogene 6

LOC101928016 Gene

adenylate kinase isoenzyme 6 pseudogene

AK3P2 Gene

adenylate kinase 3 pseudogene 2

AK7 Gene

adenylate kinase 7

AK6 Gene

adenylate kinase 6

This gene encodes a protein that belongs to the adenylate kinase family of enzymes. The protein has a nuclear localization and contains Walker A (P-loop) and Walker B motifs and a metal-coordinating residue. The protein may be involved in regulation of Cajal body formation. In human, AK6 and TAF9 (GeneID: 6880) are two distinct genes that share 5' exons. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

AK5 Gene

adenylate kinase 5

This gene encodes a member of the adenylate kinase family, which is involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate groups among adenine nucleotides. This member is related to the UMP/CMP kinase of several species. It is located in the cytosol and expressed exclusively in brain. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

AK3P6 Gene

adenylate kinase 3 pseudogene 6

AK3P4 Gene

adenylate kinase 3 pseudogene 4

AK3P5 Gene

adenylate kinase 3 pseudogene 5

AK3P3 Gene

adenylate kinase 3 pseudogene 3

PPP1R1AP2 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 1A pseudogene 2

DKK1 Gene

dickkopf WNT signaling pathway inhibitor 1

This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008]

TIMP1 Gene

TIMP metallopeptidase inhibitor 1

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq, Jul 2008]

SERPINB9 Gene

serpin peptidase inhibitor, clade B (ovalbumin), member 9

This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2012]

SERPINB8 Gene

serpin peptidase inhibitor, clade B (ovalbumin), member 8

The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by well-conserved a tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-8 (PI8; SERPINB8) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]).[supplied by OMIM, Jan 2010]

SERPINB1 Gene

serpin peptidase inhibitor, clade B (ovalbumin), member 1

The protein encoded by this gene is a member of the serpin family of proteinase inhibitors. Members of this family maintain homeostasis by neutralizing overexpressed proteinase activity through their function as suicide substrates. This protein inhibits the neutrophil-derived proteinases neutrophil elastase, cathepsin G, and proteinase-3 and thus protects tissues from damage at inflammatory sites. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

SERPINB3 Gene

serpin peptidase inhibitor, clade B (ovalbumin), member 3

SERPINB2 Gene

serpin peptidase inhibitor, clade B (ovalbumin), member 2

SERPINB5 Gene

serpin peptidase inhibitor, clade B (ovalbumin), member 5

SERPINB4 Gene

serpin peptidase inhibitor, clade B (ovalbumin), member 4

SERPINB7 Gene

serpin peptidase inhibitor, clade B (ovalbumin), member 7

This gene encodes a member of a family of proteins which function as protease inhibitors. Expression of this gene is upregulated in IgA nephropathy and mutations have been found to cause palmoplantar keratoderma, Nagashima type. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

SERPINB6 Gene

serpin peptidase inhibitor, clade B (ovalbumin), member 6

The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

SRCIN1 Gene

SRC kinase signaling inhibitor 1

GDI2 Gene

GDP dissociation inhibitor 2

GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GDI1 Gene

GDP dissociation inhibitor 1

GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific mental retardation. [provided by RefSeq, Jul 2008]

AZIN1 Gene

antizyme inhibitor 1

The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]

SERPINB8P1 Gene

serpin peptidase inhibitor, clade B8 (ovalbumin) pseudogene 1

NKIRAS2 Gene

NFKB inhibitor interacting Ras-like 2

NKIRAS1 Gene

NFKB inhibitor interacting Ras-like 1

DND1 Gene

DND microRNA-mediated repression inhibitor 1

This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17. [provided by RefSeq, Dec 2010]

INCA1 Gene

inhibitor of CDK, cyclin A1 interacting protein 1

SERPINH1P1 Gene

serpin peptidase inhibitor, clade H1, pseudogene 1

NFKBIB Gene

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta

The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]

NFKBID Gene

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta

NFKBIE Gene

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon

The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus. [provided by RefSeq, Sep 2011]

NFKBIZ Gene

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta

This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

DRAIC Gene

downregulated RNA in cancer, inhibitor of cell invasion and migration

PI3 Gene

peptidase inhibitor 3, skin-derived

This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014]

SERPINI1 Gene

serpin peptidase inhibitor, clade I (neuroserpin), member 1

This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The protein is primarily secreted by axons in the brain, and preferentially reacts with and inhibits tissue-type plasminogen activator. It is thought to play a role in the regulation of axonal growth and the development of synaptic plasticity. Mutations in this gene result in familial encephalopathy with neuroserpin inclusion bodies (FENIB), which is a dominantly inherited form of familial encephalopathy and epilepsy characterized by the accumulation of mutant neuroserpin polymers. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

SERPINI2 Gene

serpin peptidase inhibitor, clade I (pancpin), member 2

The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

PPP1R14D Gene

protein phosphatase 1, regulatory (inhibitor) subunit 14D

Protein phosphatase-1 (PP1; see MIM 176875) is a major cellular phosphatase that reverses serine/threonine protein phosphorylation. PPP1R14D is a PP1 inhibitor that itself is regulated by phosphorylation (Liu et al., 2004 [PubMed 12974676]).[supplied by OMIM, Feb 2010]

PPP1R14B Gene

protein phosphatase 1, regulatory (inhibitor) subunit 14B

PPP1R14C Gene

protein phosphatase 1, regulatory (inhibitor) subunit 14C

The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM, Feb 2010]

PPP1R14A Gene

protein phosphatase 1, regulatory (inhibitor) subunit 14A

The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011]

PINX1 Gene

PIN2/TERF1 interacting, telomerase inhibitor 1

PKIG Gene

protein kinase (cAMP-dependent, catalytic) inhibitor gamma

This gene encodes a member of the protein kinase inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive cAMP-dependent protein kinase inhibitor, and is a predominant form of inhibitor in various tissues. The encoded protein may be involved in osteogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

PKIA Gene

protein kinase (cAMP-dependent, catalytic) inhibitor alpha

The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

PKIB Gene

protein kinase (cAMP-dependent, catalytic) inhibitor beta

This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

SERPINA2 Gene

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene)

This gene encodes a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. The encoded intracellular glycoprotein is localized at the endoplasmic reticulum. This gene is a polymorphic pseudogene, with the non-functional allele being predominant in some populations. Some individuals, as represented by the reference genome allele, contain a 2kb coding region deletion and a start code mutation. [provided by RefSeq, Feb 2014]

SERPINA3 Gene

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3

The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008]

SERPINA4 Gene

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4

SERPINA5 Gene

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5

The protein encoded by this gene is a member of the serpin family of proteins, a group of proteins that inhibit serine proteases. This gene is one in a cluster of serpin genes located on the q arm of chromosome 14. This family member is a glycoprotein that can inhibit several serine proteases, including protein C and various plasminogen activators and kallikreins, and it thus plays diverse roles in hemostasis and thrombosis in multiple organs. [provided by RefSeq, Aug 2012]

SERPINA6 Gene

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6

This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]

SERPINA9 Gene

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9

TMBIM6 Gene

transmembrane BAX inhibitor motif containing 6

TMBIM4 Gene

transmembrane BAX inhibitor motif containing 4

TMBIM1 Gene

transmembrane BAX inhibitor motif containing 1

CDKN3 Gene

cyclin-dependent kinase inhibitor 3

The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

ERICD Gene

E2F1-regulated inhibitor of cell death (non-protein coding)

SPINK9 Gene

serine peptidase inhibitor, Kazal type 9

SPINK8 Gene

serine peptidase inhibitor, Kazal type 8 (putative)

LOC400026 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene

KAZALD1 Gene

Kazal-type serine peptidase inhibitor domain 1

This gene encodes a secreted member of the insulin growth factor-binding protein (IGFBP) superfamily. It contains an N-terminal insulin growth factor-binding domain, a central Kazal-type serine protease inhibitor and follistatin-like domain, and a C-terminal immunoglobulin-like domain. Studies of the mouse ortholog suggest that this gene product may have a function in bone development and bone regeneration. [provided by RefSeq, Feb 2009]

IKBKAP Gene

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein

The protein encoded by this gene is a scaffold protein and a regulator for 3 different kinases involved in proinflammatory signaling. This encoded protein can bind NF-kappa-B-inducing kinase (NIK) and IKKs through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. [provided by RefSeq, Jul 2008]

SERPINB11 Gene

serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene)

SERPINB10 Gene

serpin peptidase inhibitor, clade B (ovalbumin), member 10

The superfamily of high molecular weight serine proteinase inhibitors (serpins) regulate a diverse set of intracellular and extracellular processes such as complement activation, fibrinolysis, coagulation, cellular differentiation, tumor suppression, apoptosis, and cell migration. Serpins are characterized by a well-conserved tertiary structure that consists of 3 beta sheets and 8 or 9 alpha helices (Huber and Carrell, 1989 [PubMed 2690952]). A critical portion of the molecule, the reactive center loop connects beta sheets A and C. Protease inhibitor-10 (PI10; SERPINB10) is a member of the ov-serpin subfamily, which, relative to the archetypal serpin PI1 (MIM 107400), is characterized by a high degree of homology to chicken ovalbumin, lack of N- and C-terminal extensions, absence of a signal peptide, and a serine rather than an asparagine residue at the penultimate position (summary by Bartuski et al., 1997 [PubMed 9268635]).[supplied by OMIM, Jan 2010]

SERPINB13 Gene

serpin peptidase inhibitor, clade B (ovalbumin), member 13

SERPINB12 Gene

serpin peptidase inhibitor, clade B (ovalbumin), member 12

DKK4 Gene

dickkopf WNT signaling pathway inhibitor 4

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. Activity of this protein is modulated by binding to the Wnt co-receptor and the co-factor kremen 2. [provided by RefSeq, Jul 2008]

DKK3 Gene

dickkopf WNT signaling pathway inhibitor 3

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. The expression of this gene is decreased in a variety of cancer cell lines and it may function as a tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

IKBKG Gene

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma

This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Aug 2011]

DBIL5P Gene

diazepam binding inhibitor-like 5, pseudogene

SERPINA7P1 Gene

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 pseudogene 1

PRKRIR Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)

EID2B Gene

EP300 interacting inhibitor of differentiation 2B

CIAPIN1P Gene

cytokine induced apoptosis inhibitor 1 pseudogene

SERPIND1 Gene

serpin peptidase inhibitor, clade D (heparin cofactor), member 1

The product encoded by this gene is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. The gene contains five exons and four introns. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2008]

PDCD4 Gene

programmed cell death 4 (neoplastic transformation inhibitor)

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

SERPINB9P1 Gene

serpin peptidase inhibitor, clade B (ovalbumin), member 9, pseudogene 1

GDI2P2 Gene

GDP dissociation inhibitor 2 pseudogene 2

GDI2P1 Gene

GDP dissociation inhibitor 2 pseudogene 1

AZIN2 Gene

antizyme inhibitor 2

The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion. Accumulation of antizyme inhibitor 2 has also been observed in brains of patients with Alzheimer's disease. There has been confusion in literature and databases over the nomenclature of this gene, stemming from an earlier report that a human cDNA clone (identical to ODCp/AZIN2) had arginine decarboxylase (ADC) activity (PMID:14738999). Subsequent studies in human and mouse showed that antizyme inhibitor 2 was devoid of arginine decarboxylase activity (PMID:19956990). Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]

TIMP4 Gene

TIMP metallopeptidase inhibitor 4

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008]

TIMP3 Gene

TIMP metallopeptidase inhibitor 3

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq, Jul 2008]

TIMP2 Gene

TIMP metallopeptidase inhibitor 2

This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]

VTCN1 Gene

V-set domain containing T cell activation inhibitor 1

This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

ID2B Gene

inhibitor of DNA binding 2B, dominant negative helix-loop-helix protein (pseudogene)

XIAP Gene

X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase

This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]

LOC100131680 Gene

52 kDa repressor of the inhibitor of the protein kinase-like

PPP1R14BP5 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 14B pseudogene 5

LOC390760 Gene

protein phosphatase inhibitor 2-like

PIAS2 Gene

protein inhibitor of activated STAT, 2

This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1. [provided by RefSeq, Aug 2011]

PIAS3 Gene

protein inhibitor of activated STAT, 3

This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

PIAS1 Gene

protein inhibitor of activated STAT, 1

This gene encodes a member of the mammalian PIAS [protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1)] family. This member contains a putative zinc-binding motif and a highly acidic region. It inhibits STAT1-mediated gene activation and the DNA binding activity, binds to Gu protein/RNA helicase II/DEAD box polypeptide 21, and interacts with androgen receptor (AR). It functions in testis as a nuclear receptor transcriptional coregulator and may have a role in AR initiation and maintenance of spermatogenesis. [provided by RefSeq, Jul 2008]

PIAS4 Gene

protein inhibitor of activated STAT, 4

PPP1R14BP4 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 14B pseudogene 4

PPP1R14BP2 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 14B pseudogene 2

PPP1R14BP3 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 14B pseudogene 3

PPP1R14BP1 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 14B pseudogene 1

BAMBI Gene

BMP and activin membrane-bound inhibitor

This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF-beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis. [provided by RefSeq, Jul 2008]

CAMK2N2 Gene

calcium/calmodulin-dependent protein kinase II inhibitor 2

This gene encodes a protein that is highly similar to the rat CaM-KII inhibitory protein, an inhibitor of calcium/calmodulin-dependent protein kinase II (CAMKII). CAMKII regulates numerous physiological functions, including neuronal synaptic plasticity through the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate (AMPA) receptors. Studies of the similar protein in rat suggest that this protein may function as a negative regulator of CaM-KII and may act to inhibit the phosphorylation of AMPA receptors. [provided by RefSeq, Jul 2008]

CAMK2N1 Gene

calcium/calmodulin-dependent protein kinase II inhibitor 1

SERPINC1 Gene

serpin peptidase inhibitor, clade C (antithrombin), member 1

The protein encoded by this gene is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency. [provided by RefSeq, Jul 2009]

LOC391239 Gene

V-set domain containing T cell activation inhibitor 1 pseudogene

DKK2 Gene

dickkopf WNT signaling pathway inhibitor 2

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6). [provided by RefSeq, Jul 2008]

SPINT2 Gene

serine peptidase inhibitor, Kunitz type, 2

This gene encodes a transmembrane protein with two extracellular Kunitz domains that inhibits a variety of serine proteases. The protein inhibits HGF activator which prevents the formation of active hepatocyte growth factor. This gene is a putative tumor suppressor, and mutations in this gene result in congenital sodium diarrhea. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

SPINT1 Gene

serine peptidase inhibitor, Kunitz type 1

The protein encoded by this gene is a member of the Kunitz family of serine protease inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]

SPINT4 Gene

serine peptidase inhibitor, Kunitz type 4

DBI Gene

diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)

This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

LOC105372412 Gene

phospholipase A2 inhibitor and Ly6/PLAUR domain-containing protein-like

MDFI Gene

MyoD family inhibitor

This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures. [provided by RefSeq, Jul 2008]

PRKRIRP8 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 8

PRKRIRP9 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 9

PRKRIRP1 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 1

PRKRIRP2 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 2

PRKRIRP3 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 3

PRKRIRP4 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 4

PRKRIRP5 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 5

PRKRIRP6 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 6

PRKRIRP7 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 7

IBTK Gene

inhibitor of Bruton agammaglobulinemia tyrosine kinase

Bruton tyrosine kinase (BTK) is a protein tyrosine kinase that is expressed in B cells, macrophages, and neutrophils. The protein encoded by this gene binds to BTK and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription. This gene has a pseudogene on chromosome 18. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

ITIH1 Gene

inter-alpha-trypsin inhibitor heavy chain 1

The protein encoded by this gene is the heavy chain of a serine protease inhibitor that may serve to carry hyaluronan in plasma. This gene is part of a cluster of similar genes on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

ITIH3 Gene

inter-alpha-trypsin inhibitor heavy chain 3

The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009]

ITIH2 Gene

inter-alpha-trypsin inhibitor heavy chain 2

The inter-alpha-trypsin inhibitors (ITI) are a family of structurally related plasma serine protease inhibitors involved in extracellular matrix stabilization and in prevention of tumor metastasis. The ITI family contains multiple proteins made up of a light chain (see MIM 176870) and a variable number of heavy chains (Salier et al., 1987 [PubMed 2446322]; Himmelfarb et al., 2004 [PubMed 14744536]).[supplied by OMIM, Nov 2009]

ITIH5 Gene

inter-alpha-trypsin inhibitor heavy chain family, member 5

This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasma serine protease inhibitors and are composed of a light chain and varying numbers of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

ITIH4 Gene

inter-alpha-trypsin inhibitor heavy chain family, member 4

The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

ITIH6 Gene

inter-alpha-trypsin inhibitor heavy chain family, member 6

The protein encoded by this gene belongs to the interalpha trypsin inhibitor heavy chain (ITIH) family. Interalpha trypsin inhibitor (ITI) is composed of two heavy chains (containing VWA domain) and one light chain. The light chain confers the protease-inhibitor function, while the heavy chains are involved in mediating protein-protein interactions with the components of the extracellular matrix. [provided by RefSeq, Sep 2009]

PSMF1 Gene

proteasome (prosome, macropain) inhibitor subunit 1 (PI31)

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

KLLN Gene

killin, p53-regulated DNA replication inhibitor

The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53. [provided by RefSeq, Dec 2012]

PPP1R1AP1 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 1A pseudogene 1

TRIAP1P1 Gene

TP53 regulated inhibitor of apoptosis 1 pseudogene 1

API5 Gene

apoptosis inhibitor 5

This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

PPP1R2 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2

TCAIM Gene

T cell activation inhibitor, mitochondrial

SPINK14 Gene

serine peptidase inhibitor, Kazal type 14 (putative)

SPINK13 Gene

serine peptidase inhibitor, Kazal type 13 (putative)

LOC100420509 Gene

X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase pseudogene

CDKN1C Gene

cyclin-dependent kinase inhibitor 1C (p57, Kip2)

This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

CDKN1B Gene

cyclin-dependent kinase inhibitor 1B (p27, Kip1)

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]

CDKN1A Gene

cyclin-dependent kinase inhibitor 1A (p21, Cip1)

This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010]

GMNN Gene

geminin, DNA replication inhibitor

This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011]

SERPINA13P Gene

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 13, pseudogene

CAAP1 Gene

caspase activity and apoptosis inhibitor 1

IBTKP1 Gene

inhibitor of Bruton agammaglobulinemia tyrosine kinase pseudogene 1

SERPINF1 Gene

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

The protein encoded by this gene is a member of the serpin family, although it does not display the serine protease inhibitory activity shown by many of the other serpin family members. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells.[provided by RefSeq, Mar 2011]

SERPINF2 Gene

serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2

This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

MDFIC Gene

MyoD family inhibitor domain containing

This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

NFKBIL1 Gene

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1

This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

ARPIN Gene

actin-related protein 2/3 complex inhibitor

SPINT3 Gene

serine peptidase inhibitor, Kunitz type, 3

TFPI2 Gene

tissue factor pathway inhibitor 2

This gene encodes a member of the Kunitz-type serine proteinase inhibitor family. The protein can inhibit a variety of serine proteases including factor VIIa/tissue factor, factor Xa, plasmin, trypsin, chymotryspin and plasma kallikrein. This gene has been identified as a tumor suppressor gene in several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

MEI1 Gene

meiosis inhibitor 1

LOC100418682 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene

LOC100418683 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene

LOC100418684 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene

AVEN Gene

apoptosis, caspase activation inhibitor

CDKN2B Gene

cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]

CDKN2D Gene

cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

PPP1R1A Gene

protein phosphatase 1, regulatory (inhibitor) subunit 1A

PPP1R1C Gene

protein phosphatase 1, regulatory (inhibitor) subunit 1C

Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that regulates a variety of cellular functions. PP1 consists of a catalytic subunit (see PPP1CA; MIM 176875) and regulatory subunits that determine the subcellular localization of PP1 or regulate its function. PPP1R1C belongs to a group of PP1 inhibitory subunits that are themselves regulated by phosphorylation (Wang et al., 2008 [PubMed 18310074]).[supplied by OMIM, Feb 2010]

PPP1R1B Gene

protein phosphatase 1, regulatory (inhibitor) subunit 1B

This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

PPP1R11 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 11

This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]

API5P1 Gene

apoptosis inhibitor 5 pseudogene 1

OSGIN2 Gene

oxidative stress induced growth inhibitor family member 2

OSGIN1 Gene

oxidative stress induced growth inhibitor 1

This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011]

EPPIN Gene

epididymal peptidase inhibitor

This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. The protein can inhibit human sperm motility and exhibits antimicrobial activity against E. coli, and polymorphisms in this gene are associated with male infertility. Read-through transcription also exists between this gene and the downstream WFDC6 (WAP four-disulfide core domain 6) gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

PPP1R2P3 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 3

ISM1 Gene

isthmin 1, angiogenesis inhibitor

SPINK7 Gene

serine peptidase inhibitor, Kazal type 7 (putative)

SPINK6 Gene

serine peptidase inhibitor, Kazal type 6

The protein encoded by this gene is a Kazal-type serine protease inhibitor that acts on kallikrein-related peptidases in the skin. Two transcript variants the same protein have been found for this gene. [provided by RefSeq, Aug 2010]

SPINK5 Gene

serine peptidase inhibitor, Kazal type 5

This gene encodes a multidomain serine protease inhibitor that contains 15 potential inhibitory domains. The inhibitor may play a role in skin and hair morphogenesis and anti-inflammatory and/or antimicrobial protection of mucous epithelia. Mutations may result in Netherton syndrome, a disorder characterized by ichthyosis, defective cornification, and atopy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

SPINK4 Gene

serine peptidase inhibitor, Kazal type 4

SPINK1 Gene

serine peptidase inhibitor, Kazal type 1

The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. [provided by RefSeq, Oct 2008]

LOC100133127 Gene

geminin, DNA replication inhibitor pseudogene 1

IKBKB Gene

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta

The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]

IKBKE Gene

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]

SERPINA12 Gene

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12

SERPINA10 Gene

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10

The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2010]

SERPINA11 Gene

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 11

PI16 Gene

peptidase inhibitor 16

PI15 Gene

peptidase inhibitor 15

This gene encodes a trypsin inhibitor. The protein shares similarity to insect venom allergens, mammalian testis-specific proteins and plant pathogenesis-related proteins. It is frequently expressed in human neuroblastoma and glioblastoma cell lines, and thus may play a role in the central nervous system. [provided by RefSeq, Jul 2008]

RNH1 Gene

ribonuclease/angiogenin inhibitor 1

Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]

DBIP2 Gene

diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) pseudogene 2

DBIP3 Gene

diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) pseudogene 3

DBIP1 Gene

diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) pseudogene 1

TRIAP1 Gene

TP53 regulated inhibitor of apoptosis 1

LOC100128413 Gene

X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase pseudogene

SERPINH1 Gene

serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)

This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]

ARHGDIG Gene

Rho GDP dissociation inhibitor (GDI) gamma

The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010]

ARHGDIB Gene

Rho GDP dissociation inhibitor (GDI) beta

Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]

ARHGDIA Gene

Rho GDP dissociation inhibitor (GDI) alpha

This gene encodes a protein that plays a key role in the regulation of signaling through Rho GTPases. The encoded protein inhibits the disassociation of Rho family members from GDP (guanine diphosphate), thereby maintaining these factors in an inactive state. Activity of this protein is important in a variety of cellular processes, and expression of this gene may be altered in tumors. Mutations in this gene have been found in individuals with nephrotic syndrome, type 8. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

PPP1R2P1 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 1

PPP1R2P2 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 2

PPP1R2P5 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 5

PPP1R2P4 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 4

PPP1R2P6 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 6

PPP1R2P9 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9

PPP1R2P8 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 8

PTGFRN Gene

prostaglandin F2 receptor inhibitor

AGT Gene

angiotensinogen (serpin peptidase inhibitor, clade A, member 8)

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Jul 2008]

LOC390600 Gene

cytokine induced apoptosis inhibitor 1 pseudogene

SPINT5P Gene

serine peptidase inhibitor, Kunitz type 5, pseudogene

SLPI Gene

secretory leukocyte peptidase inhibitor

This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. This antimicrobial protein has antibacterial, antifungal and antiviral activity. [provided by RefSeq, Nov 2014]

CIAPIN1 Gene

cytokine induced apoptosis inhibitor 1

CIAPIN1 is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 (MIM 151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is dependent on growth factor stimulation (Shibayama et al., 2004 [PubMed 14970183]).[supplied by OMIM, Mar 2008]

INGX Gene

inhibitor of growth family, X-linked, pseudogene

ING4 Gene

inhibitor of growth family, member 4

This gene encodes a tumor suppressor protein that contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in the TP53-dependent regulatory pathway. Multiple alternatively spliced transcript variants have been observed that encode distinct proteins. [provided by RefSeq, Jul 2008]

ING5 Gene

inhibitor of growth family, member 5

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This protein can bind TP53 and EP300/p300, a component of the histone acetyl transferase complex, suggesting its involvement in TP53-dependent regulatory pathway. [provided by RefSeq, Jul 2008]

ING1 Gene

inhibitor of growth family, member 1

This gene encodes a tumor suppressor protein that can induce cell growth arrest and apoptosis. The encoded protein is a nuclear protein that physically interacts with the tumor suppressor protein TP53 and is a component of the p53 signaling pathway. Reduced expression and rearrangement of this gene have been detected in various cancers. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

ING2 Gene

inhibitor of growth family, member 2

This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

ING3 Gene

inhibitor of growth family, member 3

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]

RERG Gene

RAS-like, estrogen-regulated, growth inhibitor

RERG, a member of the RAS superfamily of GTPases, inhibits cell proliferation and tumor formation (Finlin et al., 2001 [PubMed 11533059]).[supplied by OMIM, Mar 2009]

SYVN1 Gene

synovial apoptosis inhibitor 1, synoviolin

This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms. [provided by RefSeq, May 2011]

ERRFI1 Gene

ERBB receptor feedback inhibitor 1

ERRFI1 is a cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995 [PubMed 7641805]). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000 [PubMed 10749885]; Fiorentino et al., 2000 [PubMed 11003669]).[supplied by OMIM, Mar 2008]

PPP1R11P2 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 11 pseudogene 2

PPP1R11P1 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 11 pseudogene 1

EID2 Gene

EP300 interacting inhibitor of differentiation 2

EID3 Gene

EP300 interacting inhibitor of differentiation 3

EID1 Gene

EP300 interacting inhibitor of differentiation 1

LOC100533853 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene

CDKN2C Gene

cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

CDKN2A Gene

cyclin-dependent kinase inhibitor 2A

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]

CRIPAK Gene

cysteine-rich PAK1 inhibitor

CRIPAK is a negative regulator of PAK1 (MIM 602590) that is upregulated by estrogen (Talukder et al., 2006 [PubMed 16278681]).[supplied by OMIM, Mar 2008]

ID4 Gene

inhibitor of DNA binding 4, dominant negative helix-loop-helix protein

This gene encodes a member of the inhibitor of DNA binding (ID) protein family. These proteins are basic helix-loop-helix transcription factors which can act as tumor suppressors but lack DNA binding activity. Consequently, the activity of the encoded protein depends on the protein binding partner. [provided by RefSeq, Dec 2011]

ID2 Gene

inhibitor of DNA binding 2, dominant negative helix-loop-helix protein

The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]

ID3 Gene

inhibitor of DNA binding 3, dominant negative helix-loop-helix protein

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011]

ID1 Gene

inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

LOC100128588 Gene

PIN2/TERF1 interacting, telomerase inhibitor 1 pseudogene

LOC105375396 Gene

bax inhibitor 1-like

SERPINA15P Gene

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 15, pseudogene

NFKBIA Gene

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. [provided by RefSeq, Aug 2011]

HIF1AN Gene

hypoxia inducible factor 1, alpha subunit inhibitor

PINLYP Gene

phospholipase A2 inhibitor and LY6/PLAUR domain containing

PCSK1N Gene

proprotein convertase subtilisin/kexin type 1 inhibitor

The protein encoded by this gene functions as an inhibitor of prohormone convertase 1, which regulates the proteolytic cleavage of neuroendocrine peptide precursors. The proprotein is further processed into multiple short peptides. A polymorphism within this gene may be associated with obesity. [provided by RefSeq, Aug 2013]

LOC100133137 Gene

geminin, DNA replication inhibitor pseudogene 2

SERPINA1 Gene

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1

The protein encoded by this gene is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

SERPINA7 Gene

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7

There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]

PPP1R2P10 Gene

protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 10

LOC100533708 Gene

protein inhibitor of activated STAT, 2 pseudogene

LOC100132831 Gene

A20-binding inhibitor of NF-kappaB activation 2 pseudogene

DBIL5P2 Gene

diazepam binding inhibitor-like 5 pseudogene 2

PRKRIRP10 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 10

IKBKGP1 Gene

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma pseudogene 1

API5P2 Gene

apoptosis inhibitor 5 pseudogene 2

adenylate cyclase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the adenylate cyclase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

positive regulation of adenylate cyclase activity involved in g-protein coupled receptor signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of adenylate cyclase activity involved in g-protein coupled receptor signaling pathway biological process from the curated GO Biological Process Annotations dataset.

negative regulation of adenylate cyclase activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of adenylate cyclase activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of adenylate cyclase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of adenylate cyclase activity biological process from the curated GO Biological Process Annotations dataset.

activation of adenylate cyclase activity Gene Set

From GO Biological Process Annotations

genes participating in the activation of adenylate cyclase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of adenylate cyclase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of adenylate cyclase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of adenylate cyclase activity involved in g-protein coupled receptor signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the regulation of adenylate cyclase activity involved in g-protein coupled receptor signaling pathway biological process from the curated GO Biological Process Annotations dataset.

adenylate cyclase activity Gene Set

From GO Molecular Function Annotations

genes performing the adenylate cyclase activity molecular function from the curated GO Molecular Function Annotations dataset.

pituitary adenylate cyclase activating polypeptide activity Gene Set

From GO Molecular Function Annotations

genes performing the pituitary adenylate cyclase activating polypeptide activity molecular function from the curated GO Molecular Function Annotations dataset.

adenylate cyclase inhibiting g-protein coupled glutamate receptor activity Gene Set

From GO Molecular Function Annotations

genes performing the adenylate cyclase inhibiting g-protein coupled glutamate receptor activity molecular function from the curated GO Molecular Function Annotations dataset.

adenylate cyclase regulator activity Gene Set

From GO Molecular Function Annotations

genes performing the adenylate cyclase regulator activity molecular function from the curated GO Molecular Function Annotations dataset.

calcium- and calmodulin-responsive adenylate cyclase activity Gene Set

From GO Molecular Function Annotations

genes performing the calcium- and calmodulin-responsive adenylate cyclase activity molecular function from the curated GO Molecular Function Annotations dataset.

Adenylate Cyclase Toxin Gene Set

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical Adenylate Cyclase Toxin from the curated CTD Gene-Chemical Interactions dataset.

adenylate cyclase-inhibiting opioid receptor signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the adenylate cyclase-inhibiting opioid receptor signaling pathway biological process from the curated GO Biological Process Annotations dataset.

adenylate cyclase-inhibiting serotonin receptor signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the adenylate cyclase-inhibiting serotonin receptor signaling pathway biological process from the curated GO Biological Process Annotations dataset.

adenylate cyclase-inhibiting adrenergic receptor signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the adenylate cyclase-inhibiting adrenergic receptor signaling pathway biological process from the curated GO Biological Process Annotations dataset.

adenylate cyclase-inhibiting g-protein coupled glutamate receptor signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the adenylate cyclase-inhibiting g-protein coupled glutamate receptor signaling pathway biological process from the curated GO Biological Process Annotations dataset.

adenylate cyclase-activating dopamine receptor signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the adenylate cyclase-activating dopamine receptor signaling pathway biological process from the curated GO Biological Process Annotations dataset.

adenylate cyclase-inhibiting g-protein coupled acetylcholine receptor signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the adenylate cyclase-inhibiting g-protein coupled acetylcholine receptor signaling pathway biological process from the curated GO Biological Process Annotations dataset.

adenylate cyclase-inhibiting dopamine receptor signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the adenylate cyclase-inhibiting dopamine receptor signaling pathway biological process from the curated GO Biological Process Annotations dataset.

adenylate cyclase-modulating g-protein coupled receptor signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the adenylate cyclase-modulating g-protein coupled receptor signaling pathway biological process from the curated GO Biological Process Annotations dataset.

adenylate cyclase-inhibiting g-protein coupled receptor signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the adenylate cyclase-inhibiting g-protein coupled receptor signaling pathway biological process from the curated GO Biological Process Annotations dataset.

adenylate cyclase-activating adrenergic receptor signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the adenylate cyclase-activating adrenergic receptor signaling pathway biological process from the curated GO Biological Process Annotations dataset.

adenylate cyclase-activating g-protein coupled receptor signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the adenylate cyclase-activating g-protein coupled receptor signaling pathway biological process from the curated GO Biological Process Annotations dataset.

pituitary adenylate cyclase-activating polypeptide receptor binding Gene Set

From GO Molecular Function Annotations

genes performing the pituitary adenylate cyclase-activating polypeptide receptor binding molecular function from the curated GO Molecular Function Annotations dataset.

adenylate cyclase binding Gene Set

From GO Molecular Function Annotations

genes performing the adenylate cyclase binding molecular function from the curated GO Molecular Function Annotations dataset.

Adenylate cyclase-associated CAP, N-terminal Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Adenylate cyclase-associated CAP, N-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Adenylate cyclase-associated CAP Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Adenylate cyclase-associated CAP protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Adenylate cyclase, conserved domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Adenylate cyclase, conserved domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Adenylate cyclase-associated CAP, C-terminal Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Adenylate cyclase-associated CAP, C-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

GPCR, family 2, pituitary adenylate cyclase activating polypeptide type 1 receptor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the GPCR, family 2, pituitary adenylate cyclase activating polypeptide type 1 receptor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Inhibition of adenylate cyclase pathway Gene Set

From Reactome Pathways

proteins participating in the Inhibition of adenylate cyclase pathway pathway from the Reactome Pathways dataset.

CREB phosphorylation through the activation of Adenylate Cyclase Gene Set

From Reactome Pathways

proteins participating in the CREB phosphorylation through the activation of Adenylate Cyclase pathway from the Reactome Pathways dataset.

Adenylate cyclase inhibitory pathway Gene Set

From Reactome Pathways

proteins participating in the Adenylate cyclase inhibitory pathway pathway from the Reactome Pathways dataset.

Adenylate cyclase activating pathway Gene Set

From Reactome Pathways

proteins participating in the Adenylate cyclase activating pathway pathway from the Reactome Pathways dataset.

Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Adenylyl cyclase class-3/4/guanylyl cyclase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Adenylyl cyclase class-3/4/guanylyl cyclase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

cyclase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the cyclase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

guanylate cyclase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the guanylate cyclase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

nucleoside triphosphate adenylate kinase activity Gene Set

From GO Molecular Function Annotations

genes performing the nucleoside triphosphate adenylate kinase activity molecular function from the curated GO Molecular Function Annotations dataset.

adenylate kinase activity Gene Set

From GO Molecular Function Annotations

genes performing the adenylate kinase activity molecular function from the curated GO Molecular Function Annotations dataset.

negative regulation of guanylate cyclase activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of guanylate cyclase activity biological process from the curated GO Biological Process Annotations dataset.

negative regulation of cyclase activity Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of cyclase activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of cyclase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of cyclase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of cyclase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of cyclase activity biological process from the curated GO Biological Process Annotations dataset.

positive regulation of guanylate cyclase activity Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of guanylate cyclase activity biological process from the curated GO Biological Process Annotations dataset.

regulation of guanylate cyclase activity Gene Set

From GO Biological Process Annotations

genes participating in the regulation of guanylate cyclase activity biological process from the curated GO Biological Process Annotations dataset.

cyclase regulator activity Gene Set

From GO Molecular Function Annotations

genes performing the cyclase regulator activity molecular function from the curated GO Molecular Function Annotations dataset.

oxidosqualene cyclase activity Gene Set

From GO Molecular Function Annotations

genes performing the oxidosqualene cyclase activity molecular function from the curated GO Molecular Function Annotations dataset.

cyclase activator activity Gene Set

From GO Molecular Function Annotations

genes performing the cyclase activator activity molecular function from the curated GO Molecular Function Annotations dataset.

guanylate cyclase activator activity Gene Set

From GO Molecular Function Annotations

genes performing the guanylate cyclase activator activity molecular function from the curated GO Molecular Function Annotations dataset.

cyclase activity Gene Set

From GO Molecular Function Annotations

genes performing the cyclase activity molecular function from the curated GO Molecular Function Annotations dataset.

calcium sensitive guanylate cyclase activator activity Gene Set

From GO Molecular Function Annotations

genes performing the calcium sensitive guanylate cyclase activator activity molecular function from the curated GO Molecular Function Annotations dataset.

guanylate cyclase activity Gene Set

From GO Molecular Function Annotations

genes performing the guanylate cyclase activity molecular function from the curated GO Molecular Function Annotations dataset.

rna-3'-phosphate cyclase activity Gene Set

From GO Molecular Function Annotations

genes performing the rna-3'-phosphate cyclase activity molecular function from the curated GO Molecular Function Annotations dataset.

guanylate cyclase regulator activity Gene Set

From GO Molecular Function Annotations

genes performing the guanylate cyclase regulator activity molecular function from the curated GO Molecular Function Annotations dataset.

MyoD family inhibitor/MyoD family inhibitor domain-containing protein Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the MyoD family inhibitor/MyoD family inhibitor domain-containing protein protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Proteinase inhibitor I35, tissue inhibitor of metalloproteinase, C-terminal domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Proteinase inhibitor I35, tissue inhibitor of metalloproteinase, C-terminal domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Proteinase inhibitor I35, tissue inhibitor of metalloproteinase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Proteinase inhibitor I35, tissue inhibitor of metalloproteinase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Adenylate kinase deficiency, hemolytic anemia due to Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Adenylate kinase deficiency, hemolytic anemia due to phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Adenylate Kinase Deficiency, Hemolytic Anemia Due To Gene Set

From CTD Gene-Disease Associations

genes/proteins associated with the disease Adenylate Kinase Deficiency, Hemolytic Anemia Due To from the curated CTD Gene-Disease Associations dataset.

Phosphothiophosphoric Acid-Adenylate Ester Gene Set

From DrugBank Drug Targets

interacting proteins for the Phosphothiophosphoric Acid-Adenylate Ester drug from the curated DrugBank Drug Targets dataset.

Phosphoaminophosphonic Acid-Adenylate Ester Gene Set

From DrugBank Drug Targets

interacting proteins for the Phosphoaminophosphonic Acid-Adenylate Ester drug from the curated DrugBank Drug Targets dataset.

adenylate Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term adenylate in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Propinol adenylate Gene Set

From HMDB Metabolites of Enzymes

interacting proteins for the Propinol adenylate metabolite from the curated HMDB Metabolites of Enzymes dataset.

L-2-Aminoadipate adenylate Gene Set

From HMDB Metabolites of Enzymes

interacting proteins for the L-2-Aminoadipate adenylate metabolite from the curated HMDB Metabolites of Enzymes dataset.

Acetyl adenylate Gene Set

From HMDB Metabolites of Enzymes

interacting proteins for the Acetyl adenylate metabolite from the curated HMDB Metabolites of Enzymes dataset.

Adenylate kinase 4, mitochondrial Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Adenylate kinase 4, mitochondrial protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Adenylate kinase 2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Adenylate kinase 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Adenylate kinase, isozyme 1/5 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Adenylate kinase, isozyme 1/5 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Adenylate kinase/UMP-CMP kinase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Adenylate kinase/UMP-CMP kinase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Adenylate kinase 3/4, mitochondrial Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Adenylate kinase 3/4, mitochondrial protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Adenylate kinase subfamily Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Adenylate kinase subfamily protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Adenylate cylcase, type 10 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Adenylate cylcase, type 10 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Adenylate kinase, active site lid domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Adenylate kinase, active site lid domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Adenylate kinase isoenzyme 6 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Adenylate kinase isoenzyme 6 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Adenylate kinase isoenzyme 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Adenylate kinase isoenzyme 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

hemolytic anemia due to adenylate kinase deficiency Gene Set

From OMIM Gene-Disease Associations

genes associated with the hemolytic anemia due to adenylate kinase deficiency phenotype from the curated OMIM Gene-Disease Associations dataset.

guanylate cyclase complex, soluble Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the guanylate cyclase complex, soluble cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

guanylate cyclase complex, soluble Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the guanylate cyclase complex, soluble cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Guanylyl cyclase, soluble (GUCY1A3, GUCY1B3) Gene Set

From CORUM Protein Complexes

proteins in the Guanylyl cyclase, soluble (GUCY1A3, GUCY1B3) protein complex from the CORUM Protein Complexes dataset.

Guanylyl cyclase, soluble (GUCY1A2, GUCY1B3) Gene Set

From CORUM Protein Complexes

proteins in the Guanylyl cyclase, soluble (GUCY1A2, GUCY1B3) protein complex from the CORUM Protein Complexes dataset.

cyclase Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cyclase in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

receptor guanylyl cyclase signaling pathway Gene Set

From GO Biological Process Annotations

genes participating in the receptor guanylyl cyclase signaling pathway biological process from the curated GO Biological Process Annotations dataset.

guanylate cyclase complex, soluble Gene Set

From GO Cellular Component Annotations

proteins localized to the guanylate cyclase complex, soluble cellular component from the curated GO Cellular Component Annotations dataset.

RNA 3'-terminal phosphate cyclase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the RNA 3'-terminal phosphate cyclase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Adenylyl cyclase-associated protein CAP2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Adenylyl cyclase-associated protein CAP2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Adenylyl cyclase-associated protein CAP1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Adenylyl cyclase-associated protein CAP1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

RNA 3'-terminal phosphate cyclase, insert domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the RNA 3'-terminal phosphate cyclase, insert domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Guanylyl cyclase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Guanylyl cyclase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

RNA 3'-terminal phosphate cyclase type 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the RNA 3'-terminal phosphate cyclase type 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Squalene cyclase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Squalene cyclase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Guanylate cyclase activating protein 2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Guanylate cyclase activating protein 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Streptomyces cyclase/dehydrase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Streptomyces cyclase/dehydrase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

RNA 3'-terminal phosphate cyclase-like, conserved site Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the RNA 3'-terminal phosphate cyclase-like, conserved site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

RNA 3'-terminal phosphate cyclase type 2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the RNA 3'-terminal phosphate cyclase type 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

ADP-ribosyl cyclase (CD38/157) Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the ADP-ribosyl cyclase (CD38/157) protein domain from the InterPro Predicted Protein Domain Annotations dataset.

RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Nucleotide cyclase Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Nucleotide cyclase protein domain from the InterPro Predicted Protein Domain Annotations dataset.

RNA 3'-terminal phosphate cyclase domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the RNA 3'-terminal phosphate cyclase domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

cyclase Gene Set

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term cyclase in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

Nitric oxide stimulates guanylate cyclase Gene Set

From Reactome Pathways

proteins participating in the Nitric oxide stimulates guanylate cyclase pathway from the Reactome Pathways dataset.

aspartic-type endopeptidase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the aspartic-type endopeptidase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

ornithine decarboxylase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the ornithine decarboxylase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

ligase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the ligase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

nitric-oxide synthase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the nitric-oxide synthase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

phospholipase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the phospholipase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

protein kinase c inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the protein kinase c inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

protein serine/threonine kinase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the protein serine/threonine kinase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

gdp-dissociation inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the gdp-dissociation inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

rho gdp-dissociation inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the rho gdp-dissociation inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

protein serine/threonine phosphatase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the protein serine/threonine phosphatase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

phospholipase a2 inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the phospholipase a2 inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

endopeptidase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the endopeptidase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

metalloendopeptidase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the metalloendopeptidase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

ion channel inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the ion channel inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

potassium channel inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the potassium channel inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

peroxidase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the peroxidase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

peptidyl-dipeptidase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the peptidyl-dipeptidase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

histone deacetylase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the histone deacetylase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

cyclin-dependent protein serine/threonine kinase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the cyclin-dependent protein serine/threonine kinase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

lipase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the lipase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

serine-type endopeptidase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the serine-type endopeptidase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

protein kinase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the protein kinase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

receptor signaling protein tyrosine kinase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the receptor signaling protein tyrosine kinase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

calcium-dependent protein kinase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the calcium-dependent protein kinase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

phospholipase d inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the phospholipase d inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

channel inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the channel inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

chloride channel inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the chloride channel inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

peptidase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the peptidase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

rab gdp-dissociation inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the rab gdp-dissociation inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

protein phosphatase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the protein phosphatase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

sodium channel inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the sodium channel inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

cysteine-type endopeptidase inhibitor activity involved in apoptotic process Gene Set

From GO Molecular Function Annotations

genes performing the cysteine-type endopeptidase inhibitor activity involved in apoptotic process molecular function from the curated GO Molecular Function Annotations dataset.

camp-dependent protein kinase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the camp-dependent protein kinase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

calcium channel inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the calcium channel inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

gtpase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the gtpase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

kinase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the kinase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

atpase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the atpase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

inward rectifier potassium channel inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the inward rectifier potassium channel inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

ribonuclease inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the ribonuclease inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

protein tyrosine kinase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the protein tyrosine kinase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

endoribonuclease inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the endoribonuclease inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

ubiquitin-protein transferase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the ubiquitin-protein transferase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

cysteine-type endopeptidase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the cysteine-type endopeptidase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

telomerase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the telomerase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

metalloenzyme inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the metalloenzyme inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

phosphatase inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the phosphatase inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

enzyme inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the enzyme inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

receptor inhibitor activity Gene Set

From GO Molecular Function Annotations

genes performing the receptor inhibitor activity molecular function from the curated GO Molecular Function Annotations dataset.

Hereditary C1 esterase inhibitor deficiency - dysfunctional factor Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Hereditary C1 esterase inhibitor deficiency - dysfunctional factor phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Plasminogen activator inhibitor type 1 deficiency Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Plasminogen activator inhibitor type 1 deficiency phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Complement component 4, partial deficiency of, due to dysfunctional c1 inhibitor Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Complement component 4, partial deficiency of, due to dysfunctional c1 inhibitor phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

BLOOD GROUP--LUTHERAN INHIBITOR Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the BLOOD GROUP--LUTHERAN INHIBITOR phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

protein c inhibitor-coagulation factor xa complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the protein c inhibitor-coagulation factor xa complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

protein c inhibitor-tmprss7 complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the protein c inhibitor-tmprss7 complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

protein c inhibitor-plasma kallikrein complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the protein c inhibitor-plasma kallikrein complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

serine protease inhibitor complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the serine protease inhibitor complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

protein c inhibitor-klk3 complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the protein c inhibitor-klk3 complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

protein c inhibitor-tmprss11e complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the protein c inhibitor-tmprss11e complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

protein c inhibitor-thrombin complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the protein c inhibitor-thrombin complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

protein c inhibitor-plau complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the protein c inhibitor-plau complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

protein c inhibitor-plat complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the protein c inhibitor-plat complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

protein c inhibitor-coagulation factor xi complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the protein c inhibitor-coagulation factor xi complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

protease inhibitor complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the protease inhibitor complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

protein c inhibitor-coagulation factor v complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the protein c inhibitor-coagulation factor v complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

serine protease inhibitor complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the serine protease inhibitor complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

protein c inhibitor-thrombin complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the protein c inhibitor-thrombin complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

protease inhibitor complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the protease inhibitor complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

EGFR tyrosine kinase inhibitor 324674 Gene Set

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical EGFR tyrosine kinase inhibitor 324674 from the curated CTD Gene-Chemical Interactions dataset.

p38alpha inhibitor CMPD1 Gene Set

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical p38alpha inhibitor CMPD1 from the curated CTD Gene-Chemical Interactions dataset.

protein kinase inhibitor peptide Gene Set

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical protein kinase inhibitor peptide from the curated CTD Gene-Chemical Interactions dataset.

calpain inhibitor III Gene Set

From CTD Gene-Chemical Interactions

genes/proteins interacting with the chemical calpain inhibitor III from the curated CTD Gene-Chemical Interactions dataset.

Plasminogen Activator Inhibitor-1 Deficiency Gene Set

From CTD Gene-Disease Associations

genes/proteins associated with the disease Plasminogen Activator Inhibitor-1 Deficiency from the curated CTD Gene-Disease Associations dataset.

c1 inhibitor deficiency Gene Set

From DISEASES Text-mining Gene-Disease Assocation Evidence Scores

genes co-occuring with the disease c1 inhibitor deficiency in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Alpha-1-proteinase inhibitor Gene Set

From DrugBank Drug Targets

interacting proteins for the Alpha-1-proteinase inhibitor drug from the curated DrugBank Drug Targets dataset.

Beta-Dadf, Msa, Multisubstrate Adduct Inhibitor Gene Set

From DrugBank Drug Targets

interacting proteins for the Beta-Dadf, Msa, Multisubstrate Adduct Inhibitor drug from the curated DrugBank Drug Targets dataset.

Naphthyridine Inhibitor Gene Set

From DrugBank Drug Targets

interacting proteins for the Naphthyridine Inhibitor drug from the curated DrugBank Drug Targets dataset.

Inhibitor Idd 384 Gene Set

From DrugBank Drug Targets

interacting proteins for the Inhibitor Idd 384 drug from the curated DrugBank Drug Targets dataset.

Rbt205 Inhibitor Gene Set

From DrugBank Drug Targets

interacting proteins for the Rbt205 Inhibitor drug from the curated DrugBank Drug Targets dataset.

Inhibitor of P38 Kinase Gene Set

From DrugBank Drug Targets

interacting proteins for the Inhibitor of P38 Kinase drug from the curated DrugBank Drug Targets dataset.

fibrinogen; factor vii; plasminogen activator inhibitor-1 Gene Set

From GAD Gene-Disease Associations

genes associated with the disease fibrinogen; factor vii; plasminogen activator inhibitor-1 in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

angiotensin-converting enzyme inhibitor-related cough Gene Set

From GAD Gene-Disease Associations

genes associated with the disease angiotensin-converting enzyme inhibitor-related cough in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

cough, angiotensin-converting enzyme; inhibitor-related Gene Set

From GAD Gene-Disease Associations

genes associated with the disease cough, angiotensin-converting enzyme; inhibitor-related in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

thrombin-activatable fibrinolysis inhibitor levels Gene Set

From GAD Gene-Disease Associations

genes associated with the disease thrombin-activatable fibrinolysis inhibitor levels in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

hdac inhibitor-induced growth arrest. Gene Set

From GAD Gene-Disease Associations

genes associated with the disease hdac inhibitor-induced growth arrest. in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

thrombin acthrombin activatable fibrinolysis; inhibitor level Gene Set

From GAD Gene-Disease Associations

genes associated with the disease thrombin acthrombin activatable fibrinolysis; inhibitor level in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

plasminogen activator inhibitor-1; tissue-type plasminogen activator Gene Set

From GAD Gene-Disease Associations

genes associated with the disease plasminogen activator inhibitor-1; tissue-type plasminogen activator in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

plasminogen activator inhibitor-1 concentrations Gene Set

From GAD Gene-Disease Associations

genes associated with the disease plasminogen activator inhibitor-1 concentrations in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

thrombin activatable fibrinolysis inhibitor Gene Set

From GAD Gene-Disease Associations

genes associated with the disease thrombin activatable fibrinolysis inhibitor in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

plasminogen activator; plasminogen activator inhibitor-type 1 Gene Set

From GAD Gene-Disease Associations

genes associated with the disease plasminogen activator; plasminogen activator inhibitor-type 1 in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

plasminogen activator inhibitor-1 Gene Set

From GAD Gene-Disease Associations

genes associated with the disease plasminogen activator inhibitor-1 in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

circulating levels of plasminogen activator inhibitor-1 Gene Set

From GAD Gene-Disease Associations

genes associated with the disease circulating levels of plasminogen activator inhibitor-1 in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

plasma antigen levels of plasminogen activator inhibitor-1 Gene Set

From GAD Gene-Disease Associations

genes associated with the disease plasma antigen levels of plasminogen activator inhibitor-1 in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

inhibitor Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term inhibitor in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

protein c inhibitor-plasma kallikrein complex Gene Set

From GO Cellular Component Annotations

proteins localized to the protein c inhibitor-plasma kallikrein complex cellular component from the curated GO Cellular Component Annotations dataset.

protein c inhibitor-coagulation factor xa complex Gene Set

From GO Cellular Component Annotations

proteins localized to the protein c inhibitor-coagulation factor xa complex cellular component from the curated GO Cellular Component Annotations dataset.

protein c inhibitor-tmprss7 complex Gene Set

From GO Cellular Component Annotations

proteins localized to the protein c inhibitor-tmprss7 complex cellular component from the curated GO Cellular Component Annotations dataset.

serine protease inhibitor complex Gene Set

From GO Cellular Component Annotations

proteins localized to the serine protease inhibitor complex cellular component from the curated GO Cellular Component Annotations dataset.

protein c inhibitor-klk3 complex Gene Set

From GO Cellular Component Annotations

proteins localized to the protein c inhibitor-klk3 complex cellular component from the curated GO Cellular Component Annotations dataset.

protein c inhibitor-tmprss11e complex Gene Set

From GO Cellular Component Annotations

proteins localized to the protein c inhibitor-tmprss11e complex cellular component from the curated GO Cellular Component Annotations dataset.

protein c inhibitor-plau complex Gene Set

From GO Cellular Component Annotations

proteins localized to the protein c inhibitor-plau complex cellular component from the curated GO Cellular Component Annotations dataset.

protein c inhibitor-plat complex Gene Set

From GO Cellular Component Annotations

proteins localized to the protein c inhibitor-plat complex cellular component from the curated GO Cellular Component Annotations dataset.

protein c inhibitor-thrombin complex Gene Set

From GO Cellular Component Annotations

proteins localized to the protein c inhibitor-thrombin complex cellular component from the curated GO Cellular Component Annotations dataset.

protein c inhibitor-coagulation factor xi complex Gene Set

From GO Cellular Component Annotations

proteins localized to the protein c inhibitor-coagulation factor xi complex cellular component from the curated GO Cellular Component Annotations dataset.

protease inhibitor complex Gene Set

From GO Cellular Component Annotations

proteins localized to the protease inhibitor complex cellular component from the curated GO Cellular Component Annotations dataset.

protein c inhibitor-coagulation factor v complex Gene Set

From GO Cellular Component Annotations

proteins localized to the protein c inhibitor-coagulation factor v complex cellular component from the curated GO Cellular Component Annotations dataset.

gdp-dissociation inhibitor binding Gene Set

From GO Molecular Function Annotations

genes performing the gdp-dissociation inhibitor binding molecular function from the curated GO Molecular Function Annotations dataset.

rho gdp-dissociation inhibitor binding Gene Set

From GO Molecular Function Annotations

genes performing the rho gdp-dissociation inhibitor binding molecular function from the curated GO Molecular Function Annotations dataset.

FPRL1-inhibitor protein Gene Set

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the FPRL1-inhibitor protein ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

BMS pyrazole inhibitor 7f Gene Set

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the BMS pyrazole inhibitor 7f ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

sphingosine kinase inhibitor Gene Set

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the sphingosine kinase inhibitor ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

alpha1-proteinase inhibitor Gene Set

From Guide to Pharmacology Chemical Ligands of Receptors

receptors of the alpha1-proteinase inhibitor ligand (chemical) from the curated Guide to Pharmacology Chemical Ligands of Receptors dataset.

Plasminogen activator inhibitor type 1 levels (PAI-1) Gene Set

From GWAS Catalog SNP-Phenotype Associations

genes associated with the Plasminogen activator inhibitor type 1 levels (PAI-1) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.

Response to mTOR inhibitor (rapamycin) Gene Set

From GWAS Catalog SNP-Phenotype Associations

genes associated with the Response to mTOR inhibitor (rapamycin) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.

Response to protease inhibitor treatment in hepatitis c (peak serum total bilirubin levels) Gene Set

From GWAS Catalog SNP-Phenotype Associations

genes associated with the Response to protease inhibitor treatment in hepatitis c (peak serum total bilirubin levels) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.

Response to mTOR inhibitor (everolimus) Gene Set

From GWAS Catalog SNP-Phenotype Associations

genes associated with the Response to mTOR inhibitor (everolimus) phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.

RelA-associated inhibitor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the RelA-associated inhibitor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Proteinase inhibitor I19, pacifastin Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Proteinase inhibitor I19, pacifastin protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Proteinase inhibitor I25A, stefin A Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Proteinase inhibitor I25A, stefin A protein domain from the InterPro Predicted Protein Domain Annotations dataset.

RNase L inhibitor RLI, possible metal-binding domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the RNase L inhibitor RLI, possible metal-binding domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Proteinase inhibitor I25, cystatin Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Proteinase inhibitor I25, cystatin protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Proteinase inhibitor I47, latexin Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Proteinase inhibitor I47, latexin protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Leucine-rich repeat, ribonuclease inhibitor subtype Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Leucine-rich repeat, ribonuclease inhibitor subtype protein domain from the InterPro Predicted Protein Domain Annotations dataset.

GPCR, family 2, brain-specific angiogenesis inhibitor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the GPCR, family 2, brain-specific angiogenesis inhibitor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Hypoxia-inducible factor 1-alpha inhibitor, domain II Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Hypoxia-inducible factor 1-alpha inhibitor, domain II protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Rho GDP-dissociation inhibitor domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Rho GDP-dissociation inhibitor domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Peptidase S8 propeptide/proteinase inhibitor I9 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Peptidase S8 propeptide/proteinase inhibitor I9 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Leukocyte elastase inhibitor (serpin B1) Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Leukocyte elastase inhibitor (serpin B1) protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Plasminogen activator inhibitor 1 RNA-binding protein Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Plasminogen activator inhibitor 1 RNA-binding protein protein domain from the InterPro Predicted Protein Domain Annotations dataset.

RHO protein GDP dissociation inhibitor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the RHO protein GDP dissociation inhibitor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Proteinase inhibitor I25, cystatin, conserved site Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Proteinase inhibitor I25, cystatin, conserved site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Metalloproteinase inhibitor 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Metalloproteinase inhibitor 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Membrane-associated diazepam binding inhibitor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Membrane-associated diazepam binding inhibitor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tissue inhibitor of metalloprotease 2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tissue inhibitor of metalloprotease 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tissue inhibitor of metalloprotease 3 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tissue inhibitor of metalloprotease 3 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tissue inhibitor of metalloprotease 4 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tissue inhibitor of metalloprotease 4 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Proteinase inhibitor I2, Kunitz metazoa Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Proteinase inhibitor I2, Kunitz metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Calcium/calmodulin-dependent protein kinase II inhibitor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Calcium/calmodulin-dependent protein kinase II inhibitor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Bax inhibitor-1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Bax inhibitor-1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Proteinase inhibitor I25C, fetuin, conserved site Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Proteinase inhibitor I25C, fetuin, conserved site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Proteinase inhibitor I1, Kazal metazoa Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Proteinase inhibitor I1, Kazal metazoa protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Trypsin Inhibitor-like, cysteine rich domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Trypsin Inhibitor-like, cysteine rich domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Phospholipase A2 inhibitor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Phospholipase A2 inhibitor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Cyclin-dependent kinase inhibitor 2A Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Cyclin-dependent kinase inhibitor 2A protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Cyclin-dependent kinase inhibitor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Cyclin-dependent kinase inhibitor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

GDP dissociation inhibitor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the GDP dissociation inhibitor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

T-cell activation inhibitor, mitochondrial Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the T-cell activation inhibitor, mitochondrial protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Proteinase inhibitor I29, cathepsin propeptide Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Proteinase inhibitor I29, cathepsin propeptide protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Plasminogen activator inhibitor-2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Plasminogen activator inhibitor-2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

ATPase inhibitor, IATP, mitochondria Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the ATPase inhibitor, IATP, mitochondria protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Inhibitor of growth protein, N-terminal Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Inhibitor of growth protein, N-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Securin sister-chromatid separation inhibitor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Securin sister-chromatid separation inhibitor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Inhibitor of CDK interacting with cyclin A1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Inhibitor of CDK interacting with cyclin A1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

PKC-activated phosphatase-1 inhibitor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the PKC-activated phosphatase-1 inhibitor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

SRC kinase signalling inhibitor 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the SRC kinase signalling inhibitor 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Cyclin-dependent kinase inhibitor 1, vertebrate Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Cyclin-dependent kinase inhibitor 1, vertebrate protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Hypoxia-inducible factor 1-alpha inhibitor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Hypoxia-inducible factor 1-alpha inhibitor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Securin sister-chromatid separation inhibitor, metazoan Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Securin sister-chromatid separation inhibitor, metazoan protein domain from the InterPro Predicted Protein Domain Annotations dataset.

DNA-binding protein inhibitor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the DNA-binding protein inhibitor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein phosphatase inhibitor 2 (IPP-2) Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein phosphatase inhibitor 2 (IPP-2) protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tissue inhibitor of metalloproteinases-like, OB-fold Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tissue inhibitor of metalloproteinases-like, OB-fold protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Inter-alpha-trypsin inhibitor heavy chain, C-terminal Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Inter-alpha-trypsin inhibitor heavy chain, C-terminal protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Oxidative stress-induced growth inhibitor 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Oxidative stress-induced growth inhibitor 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tyrosine/threonine-protein kinase, Cdc2 inhibitor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tyrosine/threonine-protein kinase, Cdc2 inhibitor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Proteinase inhibitor, propeptide Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Proteinase inhibitor, propeptide protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Oxidative stress-induced growth inhibitor 2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Oxidative stress-induced growth inhibitor 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Bax inhibitor 1-related Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Bax inhibitor 1-related protein domain from the InterPro Predicted Protein Domain Annotations dataset.

BMP and activin membrane-bound inhibitor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the BMP and activin membrane-bound inhibitor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Plasma protease C1 inhibitor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Plasma protease C1 inhibitor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Inhibitor of nuclear factor kappa-B kinase-interacting protein Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Inhibitor of nuclear factor kappa-B kinase-interacting protein protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Inhibitor of growth protein 2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Inhibitor of growth protein 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Inhibitor of growth protein 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Inhibitor of growth protein 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Inhibitor of growth protein 4 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Inhibitor of growth protein 4 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Inhibitor of growth protein 5 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Inhibitor of growth protein 5 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tissue factor pathway inhibitor 2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tissue factor pathway inhibitor 2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Tissue factor pathway inhibitor 1 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Tissue factor pathway inhibitor 1 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Blood coagulation inhibitor, Disintegrin Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Blood coagulation inhibitor, Disintegrin protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein phosphatase inhibitor, 1DARPP-32 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein phosphatase inhibitor, 1DARPP-32 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Proteinase inhibitor I27, calpastatin Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Proteinase inhibitor I27, calpastatin protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Cyclin-dependent kinase inhibitor 3 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Cyclin-dependent kinase inhibitor 3 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Protein phosphatase inhibitor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Protein phosphatase inhibitor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Proteinase inhibitor, carboxypeptidase propeptide Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Proteinase inhibitor, carboxypeptidase propeptide protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Cyclin-dependent kinase inhibitor 1B Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Cyclin-dependent kinase inhibitor 1B protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Cyclin-dependent kinase inhibitor 1C Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Cyclin-dependent kinase inhibitor 1C protein domain from the InterPro Predicted Protein Domain Annotations dataset.

cAMP-dependent protein kinase inhibitor Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the cAMP-dependent protein kinase inhibitor protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Bax inhibitor 1, conserved site Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Bax inhibitor 1, conserved site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Proteinase inhibitor I2, Kunitz, conserved site Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Proteinase inhibitor I2, Kunitz, conserved site protein domain from the InterPro Predicted Protein Domain Annotations dataset.

BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_HCC515_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K97330509_Src Kinase Inhibitor II_HA1E_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K97330509_Src Kinase Inhibitor II_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K07859598_Raf1 Kinase Inhibitor I_MCF7_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K07859598_Raf1 Kinase Inhibitor I_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_HT29_24_h_3.33_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_DV90_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_DV90_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K07859598_Raf1 Kinase Inhibitor I_HCC515_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K07859598_Raf1 Kinase Inhibitor I_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_HT115_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_HT115_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_A375_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K72541103_JAK3 Inhibitor I_HA1E_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K72541103_JAK3 Inhibitor I_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_NCIH508_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_NCIH508_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K52850071_JAK3 Inhibitor II_HCC515_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K52850071_JAK3 Inhibitor II_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_NCIH1694_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_NCIH1694_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K95655893_VEGF Receptor 3 Kinase Inhibitor, MAZ51_PC3_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K95655893_VEGF Receptor 3 Kinase Inhibitor, MAZ51_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K95655893_VEGF Receptor 3 Kinase Inhibitor, MAZ51_MCF7_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K95655893_VEGF Receptor 3 Kinase Inhibitor, MAZ51_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_SW480_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_SW480_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_PC3_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_OV7_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_OV7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_SKBR3_24_h_0.12_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_SKBR3_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_RMGI_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_RMGI_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04546108_JAK3 Inhibitor VI_HCC515_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04546108_JAK3 Inhibitor VI_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_SKM1_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_SKM1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_SKBR3_24_h_1.11_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_SKBR3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K70792160_Akt inhibitor X_SW948_6.0_h_24.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K70792160_Akt inhibitor X_SW948_6.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K93023739_IKK Inhibitor X_VCAP_6.0_h_6.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K93023739_IKK Inhibitor X_VCAP_6.0_h_6.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K09907482_PRL-3 Inhibitor I_HT29_24.0_h_40.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K09907482_PRL-3 Inhibitor I_HT29_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_HCT116_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_HCT116_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_HEPG2_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_SNGM_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_SNGM_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K83354763_NF-kB Activation Inhibitor II, JSH-23_RMUGS_6.0_h_6.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K83354763_NF-kB Activation Inhibitor II, JSH-23_RMUGS_6.0_h_6.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K70792160_Akt inhibitor X_VCAP_6.0_h_24.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K70792160_Akt inhibitor X_VCAP_6.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_SW480_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_SW480_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K46678324_Rho-Kinase Inhibitor II_A375_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K46678324_Rho-Kinase Inhibitor II_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_MCF7_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K70792160_Akt inhibitor X_HEPG2_6.0_h_24.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K70792160_Akt inhibitor X_HEPG2_6.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_THP1_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_THP1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K51781482_IKK-3 Inhibitor IX_SW620_6.0_h_6.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K51781482_IKK-3 Inhibitor IX_SW620_6.0_h_6.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K93725829_ERK inhibitor 11e_A375_24.0_h_0.5_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K93725829_ERK inhibitor 11e_A375_24.0_h_0.5_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K23875128_Rho kinase inhibitor III [rockout]_A549_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K23875128_Rho kinase inhibitor III [rockout]_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K51781482_IKK-3 Inhibitor IX_HA1E_6.0_h_6.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K51781482_IKK-3 Inhibitor IX_HA1E_6.0_h_6.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K09991945_GSK-3-inhibitor-II_HT29_24_h_0.12_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K09991945_GSK-3-inhibitor-II_HT29_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K83354763_NF-kB Activation Inhibitor II, JSH-23_PC3_6.0_h_6.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K83354763_NF-kB Activation Inhibitor II, JSH-23_PC3_6.0_h_6.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K67860401_GSK-3b Inhibitor VIII_HA1E_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K67860401_GSK-3b Inhibitor VIII_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_CL34_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_CL34_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K70792160_Akt inhibitor X_HA1E_6.0_h_24.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K70792160_Akt inhibitor X_HA1E_6.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_MDST8_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_MDST8_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K09991945_GSK-3-inhibitor-II_HEPG2_24_h_10_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K09991945_GSK-3-inhibitor-II_HEPG2_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K93725829_ERK inhibitor 11e_HT29_24.0_h_0.5_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K93725829_ERK inhibitor 11e_HT29_24.0_h_0.5_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_A549_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_HEPG2_24_h_10_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_HEPG2_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K23875128_Rho kinase inhibitor III [rockout]_H1299_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K23875128_Rho kinase inhibitor III [rockout]_H1299_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_BT20_3_h_1.11_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_BT20_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04546108_JAK3 Inhibitor VI_HA1E_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04546108_JAK3 Inhibitor VI_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_HCT116_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_HCT116_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K23875128_Rho kinase inhibitor III [rockout]_NCIH2073_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K23875128_Rho kinase inhibitor III [rockout]_NCIH2073_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_H1299_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_H1299_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K09991945_GSK-3 Inhibitor II_HA1E_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K09991945_GSK-3 Inhibitor II_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K09991945_GSK-3 Inhibitor II_A549_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K09991945_GSK-3 Inhibitor II_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_A673_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_A673_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K23875128_Rho kinase inhibitor III [rockout]_SW620_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K23875128_Rho kinase inhibitor III [rockout]_SW620_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_NCIH596_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_NCIH596_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_SKBR3_3_h_10_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_SKBR3_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_PC3_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_NOMO1_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_NOMO1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K09991945_GSK-3 Inhibitor II_A375_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K09991945_GSK-3 Inhibitor II_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_HEC108_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_HEC108_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_SKLU1_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_SKLU1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K83354763_NF-kB Activation Inhibitor II, JSH-23_SKM1_6.0_h_6.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K83354763_NF-kB Activation Inhibitor II, JSH-23_SKM1_6.0_h_6.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_H1299_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_H1299_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_LOVO_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_LOVO_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K83354763_NF-kB Activation Inhibitor II, JSH-23_VCAP_6.0_h_6.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K83354763_NF-kB Activation Inhibitor II, JSH-23_VCAP_6.0_h_6.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K52850071_JAK3 Inhibitor II_HA1E_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K52850071_JAK3 Inhibitor II_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_WSUDLCL2_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_WSUDLCL2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K68873215_Phosphodiesterase V Inhibitor II_PC3_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K68873215_Phosphodiesterase V Inhibitor II_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_AGS_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_AGS_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_BT20_3_h_3.33_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_BT20_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_MCF7_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K52850071_JAK3 Inhibitor II_HA1E_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K52850071_JAK3 Inhibitor II_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04546108_JAK3 Inhibitor VI_PC3_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04546108_JAK3 Inhibitor VI_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_HA1E_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K09991945_GSK-3-inhibitor-II_HA1E_24_h_0.37_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K09991945_GSK-3-inhibitor-II_HA1E_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K09907482_PRL-3 Inhibitor I_HT29_6.0_h_40.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K09907482_PRL-3 Inhibitor I_HT29_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_SKLU1_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_SKLU1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_SNUC5_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_SNUC5_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K83354763_NF-kB Activation Inhibitor II, JSH-23_HA1E_6.0_h_6.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K83354763_NF-kB Activation Inhibitor II, JSH-23_HA1E_6.0_h_6.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K23875128_Rho kinase inhibitor III [rockout]_HCC515_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K23875128_Rho kinase inhibitor III [rockout]_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K70792160_Akt inhibitor X_A673_6.0_h_24.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K70792160_Akt inhibitor X_A673_6.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_MCF10A_24_h_10_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_MCF10A_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_VCAP_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_OV7_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_OV7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_HT29_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_VCAP_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_HA1E_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K09991945_GSK-3 Inhibitor II_MCF7_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K09991945_GSK-3 Inhibitor II_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K09907482_PRL-3 Inhibitor I_PC3_6.0_h_40.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K09907482_PRL-3 Inhibitor I_PC3_6.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K93725829_ERK inhibitor 11e_HCT116_6.0_h_0.5_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K93725829_ERK inhibitor 11e_HCT116_6.0_h_0.5_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_HCC515_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_A375_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_NCIH2073_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_NCIH2073_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_PC3_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_VCAP_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_AGS_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_AGS_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_MCF7_3_h_10_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_MCF7_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K70792160_Akt inhibitor X_MCF7_6.0_h_24.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K70792160_Akt inhibitor X_MCF7_6.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K70792160_Akt inhibitor X_HCC515_24.0_h_24.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K70792160_Akt inhibitor X_HCC515_24.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K52850071_JAK3 Inhibitor II_VCAP_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K52850071_JAK3 Inhibitor II_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K70792160_Akt inhibitor X_HT29_24.0_h_24.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K70792160_Akt inhibitor X_HT29_24.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_BT20_3_h_10_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_BT20_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_HA1E_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K72541103_JAK3 Inhibitor I_PC3_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K72541103_JAK3 Inhibitor I_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K09991945_GSK-3 Inhibitor II_MCF7_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K09991945_GSK-3 Inhibitor II_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_SW948_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_SW948_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K72541103_JAK3 Inhibitor I_HCC515_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K72541103_JAK3 Inhibitor I_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_PL21_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_PL21_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K61737877_VEGF Receptor 2 Kinase Inhibitor IV_VCAP_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K61737877_VEGF Receptor 2 Kinase Inhibitor IV_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_MDST8_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_MDST8_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K70792160_Akt inhibitor X_HCC515_6.0_h_24.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K70792160_Akt inhibitor X_HCC515_6.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_SNUC4_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_SNUC4_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_HS578T_3_h_3.33_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_HS578T_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_SKMEL28_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_SKMEL28_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_EFO27_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_EFO27_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K70792160_Akt inhibitor X_MCF7_24.0_h_24.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K70792160_Akt inhibitor X_MCF7_24.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_PC3_24_h_1.11_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_EFO27_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_EFO27_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_BT20_24_h_10_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_BT20_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_PC3_24_h_10_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_PC3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04546108_JAK3 Inhibitor VI_HA1E_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04546108_JAK3 Inhibitor VI_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K95655893_VEGF Receptor 3 Kinase Inhibitor, MAZ51_A549_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K95655893_VEGF Receptor 3 Kinase Inhibitor, MAZ51_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_HT29_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_HT29_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_TYKNU_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_TYKNU_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_MDAMB231_3_h_10_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_MDAMB231_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_PC3_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K72541103_JAK3 Inhibitor I_PC3_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K72541103_JAK3 Inhibitor I_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K51781482_IKK-3 Inhibitor IX_VCAP_6.0_h_6.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K51781482_IKK-3 Inhibitor IX_VCAP_6.0_h_6.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K23875128_Rho kinase inhibitor III [rockout]_SKLU1_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K23875128_Rho kinase inhibitor III [rockout]_SKLU1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_HCC515_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_RMUGS_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_RMUGS_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K70792160_Akt inhibitor X_A549_6.0_h_24.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K70792160_Akt inhibitor X_A549_6.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_HEPG2_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K70792160_Akt inhibitor X_SW620_6.0_h_24.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K70792160_Akt inhibitor X_SW620_6.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K95655893_VEGF Receptor 3 Kinase Inhibitor, MAZ51_A375_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K95655893_VEGF Receptor 3 Kinase Inhibitor, MAZ51_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_A549_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_RMGI_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_RMGI_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_PC3_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_HCC515_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_MCF7_24_h_10_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_MCF7_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_THP1_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_THP1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K09991945_GSK-3 Inhibitor II_PC3_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K09991945_GSK-3 Inhibitor II_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K07859598_Raf1 Kinase Inhibitor I_HCC515_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K07859598_Raf1 Kinase Inhibitor I_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K09991945_GSK-3 Inhibitor II_PC3_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K09991945_GSK-3 Inhibitor II_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_HA1E_24_h_10_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_HA1E_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K40853697_STAT3 Inhibitor VI, S31-201_CL34_6.0_h_160.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K40853697_STAT3 Inhibitor VI, S31-201_CL34_6.0_h_160.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_HA1E_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_SW620_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_SW620_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_NCIH596_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_NCIH596_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K67860401_GSK-3b Inhibitor VIII_PC3_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K67860401_GSK-3b Inhibitor VIII_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K67860401_GSK-3b Inhibitor VIII_PC3_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K67860401_GSK-3b Inhibitor VIII_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_RKO_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_RKO_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_HS578T_3_h_10_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_HS578T_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_PC3_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K52850071_JAK3 Inhibitor II_PC3_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K52850071_JAK3 Inhibitor II_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K93725829_ERK inhibitor 11e_SW620_6.0_h_0.5_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K93725829_ERK inhibitor 11e_SW620_6.0_h_0.5_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_A673_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_A673_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K23875128_Rho kinase inhibitor III [rockout]_HA1E_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K23875128_Rho kinase inhibitor III [rockout]_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K70792160_Akt inhibitor X_HA1E_24.0_h_24.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K70792160_Akt inhibitor X_HA1E_24.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K83354763_NF-kB Activation Inhibitor II, JSH-23_HA1E_24.0_h_6.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K83354763_NF-kB Activation Inhibitor II, JSH-23_HA1E_24.0_h_6.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_HT29_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_SKBR3_24_h_10_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_SKBR3_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K23875128_Rho kinase inhibitor III [rockout]_HA1E_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K23875128_Rho kinase inhibitor III [rockout]_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_MCF10A_3_h_10_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_MCF10A_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K09991945_GSK-3-inhibitor-II_MCF7_24_h_10_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K09991945_GSK-3-inhibitor-II_MCF7_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K93725829_ERK inhibitor 11e_U937_6.0_h_0.5_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K93725829_ERK inhibitor 11e_U937_6.0_h_0.5_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K23875128_Rho kinase inhibitor III [rockout]_A375_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K23875128_Rho kinase inhibitor III [rockout]_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_HCC15_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_HCC15_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_VCAP_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K09907482_PRL-3 Inhibitor I_PC3_24.0_h_40.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K09907482_PRL-3 Inhibitor I_PC3_24.0_h_40.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K95655893_VEGF Receptor 3 Kinase Inhibitor, MAZ51_HT29_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K95655893_VEGF Receptor 3 Kinase Inhibitor, MAZ51_HT29_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K70792160_Akt inhibitor X_SKM1_6.0_h_24.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K70792160_Akt inhibitor X_SKM1_6.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_PC3_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K95655893_VEGF Receptor 3 Kinase Inhibitor, MAZ51_A375_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K95655893_VEGF Receptor 3 Kinase Inhibitor, MAZ51_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_SW948_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_SW948_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K23875128_Rho kinase inhibitor III [rockout]_HCC515_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K23875128_Rho kinase inhibitor III [rockout]_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_MCF7_24_h_3.33_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_HT29_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_HT29_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K83354763_NF-kB Activation Inhibitor II, JSH-23_RMGI_6.0_h_6.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K83354763_NF-kB Activation Inhibitor II, JSH-23_RMGI_6.0_h_6.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K67860401_GSK-3b Inhibitor VIII_HCC515_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K67860401_GSK-3b Inhibitor VIII_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_HA1E_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_VCAP_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K27665173_PDGF Receptor Tyrosine Kinase Inhibitor I_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_SKMEL28_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_SKMEL28_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_HCC515_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_A549_24_h_10_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_A549_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_VCAP_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K93023739_IKK Inhibitor X_NCIH508_6.0_h_6.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K93023739_IKK Inhibitor X_NCIH508_6.0_h_6.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_HCC15_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_HCC15_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_CL34_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_CL34_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K09991945_GSK-3 Inhibitor II_A375_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K09991945_GSK-3 Inhibitor II_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K67860401_GSK-3b Inhibitor VIII_HA1E_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K67860401_GSK-3b Inhibitor VIII_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K95655893_VEGF Receptor 3 Kinase Inhibitor, MAZ51_VCAP_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K95655893_VEGF Receptor 3 Kinase Inhibitor, MAZ51_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K70792160_Akt inhibitor X_A375_24.0_h_24.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K70792160_Akt inhibitor X_A375_24.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_HCC515_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_A375_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_JHUEM2_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_JHUEM2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_MCF7_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K93725829_ERK inhibitor 11e_HT29_6.0_h_0.5_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K93725829_ERK inhibitor 11e_HT29_6.0_h_0.5_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_MCF7_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K61737877_VEGF Receptor 2 Kinase Inhibitor IV_HA1E_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K61737877_VEGF Receptor 2 Kinase Inhibitor IV_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K07859598_Raf1 Kinase Inhibitor I_HA1E_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K07859598_Raf1 Kinase Inhibitor I_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K23875128_Rho kinase inhibitor III [rockout]_OV7_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K23875128_Rho kinase inhibitor III [rockout]_OV7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K52850071_JAK3 Inhibitor II_PC3_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K52850071_JAK3 Inhibitor II_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_SKBR3_24_h_3.33_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_SKBR3_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K09991945_GSK-3 Inhibitor II_VCAP_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K09991945_GSK-3 Inhibitor II_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_A549_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_VCAP_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04546108_JAK3 Inhibitor VI_HCC515_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04546108_JAK3 Inhibitor VI_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_NCIH2073_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_NCIH2073_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04546108_JAK3 Inhibitor VI_PC3_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04546108_JAK3 Inhibitor VI_PC3_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_HS578T_24_h_10_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_HS578T_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K70792160_Akt inhibitor X_HT29_6.0_h_24.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K70792160_Akt inhibitor X_HT29_6.0_h_24.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04546108_JAK3 Inhibitor VI_VCAP_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04546108_JAK3 Inhibitor VI_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_SW620_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_SW620_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K28296557_Akt inhibitor IV_RMUGS_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K28296557_Akt inhibitor IV_RMUGS_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K72541103_JAK3 Inhibitor I_HCC515_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K72541103_JAK3 Inhibitor I_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04546108_JAK3 Inhibitor VI_VCAP_24.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04546108_JAK3 Inhibitor VI_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_MDAMB231_24_h_10_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_MDAMB231_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K69840642_HDAC6 inhibitor ISOX_U937_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K69840642_HDAC6 inhibitor ISOX_U937_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K09991945_GSK-3 Inhibitor II_HA1E_6.0_h_10.0_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K09991945_GSK-3 Inhibitor II_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

BRD-K04887706_AKT-inhibitor-1-2_HT29_24_h_10_um Gene Set

From LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules

genes differentially expressed following the BRD-K04887706_AKT-inhibitor-1-2_HT29_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

adenocarcinoma of lung, response to tyrosine kinase inhibitor in Gene Set

From OMIM Gene-Disease Associations

genes associated with the adenocarcinoma of lung, response to tyrosine kinase inhibitor in phenotype from the curated OMIM Gene-Disease Associations dataset.

{transcription of plasminogen activator inhibitor, modulator of} Gene Set

From OMIM Gene-Disease Associations

genes associated with the {transcription of plasminogen activator inhibitor, modulator of} phenotype from the curated OMIM Gene-Disease Associations dataset.

alpha-2-plasmin inhibitor deficiency Gene Set

From OMIM Gene-Disease Associations

genes associated with the alpha-2-plasmin inhibitor deficiency phenotype from the curated OMIM Gene-Disease Associations dataset.

blood group--lutheran inhibitor Gene Set

From OMIM Gene-Disease Associations

genes associated with the blood group--lutheran inhibitor phenotype from the curated OMIM Gene-Disease Associations dataset.

nonsmall cell lung cancer, response to tyrosine kinase inhibitor in Gene Set

From OMIM Gene-Disease Associations

genes associated with the nonsmall cell lung cancer, response to tyrosine kinase inhibitor in phenotype from the curated OMIM Gene-Disease Associations dataset.

plasminogen activator inhibitor-1 deficiency Gene Set

From OMIM Gene-Disease Associations

genes associated with the plasminogen activator inhibitor-1 deficiency phenotype from the curated OMIM Gene-Disease Associations dataset.

WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Gene Set

From Reactome Pathways

proteins participating in the WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 pathway from the Reactome Pathways dataset.

Transcriptional activation of cell cycle inhibitor p21 Gene Set

From Reactome Pathways

proteins participating in the Transcriptional activation of cell cycle inhibitor p21 pathway from the Reactome Pathways dataset.

ACE Inhibitor Pathway(Mus musculus) Gene Set

From Wikipathways Pathways

proteins participating in the ACE Inhibitor Pathway(Mus musculus) pathway from the Wikipathways Pathways dataset.

ACE Inhibitor Pathway(Homo sapiens) Gene Set

From Wikipathways Pathways

proteins participating in the ACE Inhibitor Pathway(Homo sapiens) pathway from the Wikipathways Pathways dataset.

brca1 dependent ub ligase activity Gene Set

From Biocarta Pathways

proteins participating in the brca1 dependent ub ligase activity pathway from the Biocarta Pathways dataset.

mechanism of acetaminophen activity and toxicity Gene Set

From Biocarta Pathways

proteins participating in the mechanism of acetaminophen activity and toxicity pathway from the Biocarta Pathways dataset.

pelp1 modulation of estrogen receptor activity Gene Set

From Biocarta Pathways

proteins participating in the pelp1 modulation of estrogen receptor activity pathway from the Biocarta Pathways dataset.

regulation of transcriptional activity by pml Gene Set

From Biocarta Pathways

proteins participating in the regulation of transcriptional activity by pml pathway from the Biocarta Pathways dataset.

Impdh2 enzyme activity, variation in Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Impdh2 enzyme activity, variation in phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

Kallikrein, decreased urinary activity of Gene Set

From ClinVar Gene-Phenotype Associations

genes associated with the Kallikrein, decreased urinary activity of phenotype from the curated ClinVar Gene-Phenotype Associations dataset.

GPI-GnT activity complex Gene Set

From CORUM Protein Complexes

proteins in the GPI-GnT activity complex protein complex from the CORUM Protein Complexes dataset.

factor 13 activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease factor 13 activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

neutral endopeptidase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease neutral endopeptidase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

tpmt activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease tpmt activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

substrate activity of udp-glucuronosyltransferase Gene Set

From GAD Gene-Disease Associations

genes associated with the disease substrate activity of udp-glucuronosyltransferase in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

temperature-sensitive enzymatic activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease temperature-sensitive enzymatic activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

triglycerides; blood pressure, arterial; antioxidant activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease triglycerides; blood pressure, arterial; antioxidant activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

erythrocyte histamine n-methyltransferase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease erythrocyte histamine n-methyltransferase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

histamine n-methyltransferase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease histamine n-methyltransferase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

autonomic nervous system activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease autonomic nervous system activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

diazonase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease diazonase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

event-related prefrontal activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease event-related prefrontal activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

erythrocyte catalase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease erythrocyte catalase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

enzyme activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease enzyme activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

brain activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease brain activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

endothelial nitric oxide activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease endothelial nitric oxide activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

11beta-hydroxylase activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease 11beta-hydroxylase activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

high plasma cetp activity. Gene Set

From GAD Gene-Disease Associations

genes associated with the disease high plasma cetp activity. in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

decreases transcriptional activity and responsiveness to interleukin-6 Gene Set

From GAD Gene-Disease Associations

genes associated with the disease decreases transcriptional activity and responsiveness to interleukin-6 in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

paraoxonase1 activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease paraoxonase1 activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

inflammatory bowel disease; colorectal cancer; ace activity; coronary atherosclerosis Gene Set

From GAD Gene-Disease Associations

genes associated with the disease inflammatory bowel disease; colorectal cancer; ace activity; coronary atherosclerosis in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

cyp2c9 activity Gene Set

From GAD Gene-Disease Associations

genes associated with the disease cyp2c9 activity in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.