Name

Allen Brain Atlas Developing Human Brain Tissue Gene Expression Profiles by RNA-seq Dataset

From Allen Brain Atlas

mRNA expression profiles for human brain tissue samples spanning 31 time points and 26 brain structures

CHEA Transcription Factor Binding Site Profiles Dataset

From ChIP-X Enrichment Analysis

transcription factor binding site profiles from published ChIP-chip, ChIP-seq, and other transcription factor functional studies

ENCODE Transcription Factor Binding Site Profiles Dataset

From Encyclopedia of DNA Elements

transcription factor binding site profiles for cell lines

LOC400026 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene

PRKRAP1 Gene

protein kinase, interferon-inducible double stranded RNA dependent activator pseudogene 1

LOC100418693 Gene

protein kinase, interferon-inducible double stranded RNA dependent activator pseudogene

LOC100418694 Gene

protein kinase, interferon-inducible double stranded RNA dependent activator pseudogene

PRKRIR Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)

PRKRA Gene

protein kinase, interferon-inducible double stranded RNA dependent activator

This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2008]

PRKRIRP8 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 8

PRKRIRP9 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 9

PRKRIRP1 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 1

PRKRIRP2 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 2

PRKRIRP3 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 3

PRKRIRP4 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 4

PRKRIRP5 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 5

PRKRIRP6 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 6

PRKRIRP7 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 7

LOC100422106 Gene

staufen double-stranded RNA binding protein 1 pseudogene

STAU1 Gene

staufen double-stranded RNA binding protein 1

Staufen is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. The human homologue of staufen encoded by STAU, in addition contains a microtubule- binding domain similar to that of microtubule-associated protein 1B, and binds tubulin. The STAU gene product has been shown to be present in the cytoplasm in association with the rough endoplasmic reticulum (RER), implicating this protein in the transport of mRNA via the microtubule network to the RER, the site of translation. Five transcript variants resulting from alternative splicing of STAU gene and encoding three isoforms have been described. Three of these variants encode the same isoform, however, differ in their 5'UTR. [provided by RefSeq, Jul 2008]

LOC100130134 Gene

staufen double-stranded RNA binding protein 2 pseudogene

STAU2 Gene

staufen double-stranded RNA binding protein 2

Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

LOC100533853 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene

PRKRIRP10 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 10

RBMS1P1 Gene

RNA binding motif, single stranded interacting protein 1 pseudogene 1

RBMS1 Gene

RNA binding motif, single stranded interacting protein 1

This gene encodes a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. Several transcript variants, resulting from alternative splicing and encoding different isoforms, have been described. A pseudogene for this locus is found on chromosome 12. [provided by RefSeq, Feb 2009]

RBMS3 Gene

RNA binding motif, single stranded interacting protein 3

This gene encodes an RNA-binding protein that belongs to the c-myc gene single-strand binding protein family. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. The encoded protein was isolated by virtue of its binding to an upstream element of the alpha2(I) collagen promoter. The observation that this protein localizes mostly in the cytoplasm suggests that it may be involved in a cytoplasmic function such as controlling RNA metabolism, rather than transcription. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

RBMS2 Gene

RNA binding motif, single stranded interacting protein 2

The protein encoded by this gene is a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. The RBMS proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. This protein was isolated by phenotypic complementation of cdc2 and cdc13 mutants of yeast and is thought to suppress cdc2 and cdc13 mutants through the induction of translation of cdc2. [provided by RefSeq, Jul 2008]

RBMS2P1 Gene

RNA binding motif, single stranded interacting protein 2 pseudogene 1

LOC100421246 Gene

D4, zinc and double PHD fingers family 2 pseudogene

DZANK1 Gene

double zinc ribbon and ankyrin repeat domains 1

This gene contains two ankyrin repeat-encoding regions. Ankyrin repeats are tandemly repeated modules of about 33 amino acids described as L-shaped structures consisting of a beta-hairpin and two alpha-helices. Ankyrin repeats occur in a large number of functionally diverse proteins, mainly from eukaryotes, and are known to function as protein-protein interaction domains. Alternative splicing has been observed for this gene but the full-length nature of additional variants has not been determined. [provided by RefSeq, Jul 2008]

DPF2 Gene

D4, zinc and double PHD fingers family 2

The protein encoded by this gene is a member of the d4 domain family, characterized by a zinc finger-like structural motif. This protein functions as a transcription factor which is necessary for the apoptotic response following deprivation of survival factors. It likely serves a regulatory role in rapid hematopoietic cell growth and turnover. This gene is considered a candidate gene for multiple endocrine neoplasia type I, an inherited cancer syndrome involving multiple parathyroid, enteropancreatic, and pituitary tumors. [provided by RefSeq, Jul 2008]

DPF3 Gene

D4, zinc and double PHD fingers, family 3

This gene encodes a member of the D4 protein family. The encoded protein is a transcription regulator that binds acetylated histones and is a component of the BAF chromatin remodeling complex. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

DPF1 Gene

D4, zinc and double PHD fingers family 1

LOC646044 Gene

single stranded DNA binding protein 4 pseudogene

SSBP4 Gene

single stranded DNA binding protein 4

LOC100132698 Gene

single stranded DNA binding protein 4 pseudogene

LOC401002 Gene

single stranded DNA binding protein 3 pseudogene

LOC646674 Gene

single stranded DNA binding protein 4 pseudogene

LOC100132723 Gene

single stranded DNA binding protein 4 pseudogene

LOC100129321 Gene

single stranded DNA binding protein 3 pseudogene

LOC100132659 Gene

single-stranded DNA binding protein 2 pseudogene

SSBP1 Gene

single-stranded DNA binding protein 1, mitochondrial

SSBP1 is a housekeeping gene involved in mitochondrial biogenesis (Tiranti et al., 1995 [PubMed 7789991]). It is also a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010]

SSBP3 Gene

single stranded DNA binding protein 3

SSBP2 Gene

single-stranded DNA binding protein 2

SSBP2 is a subunit of a single-stranded DNA (ssDNA)-binding complex involved in the maintenance of genome stability (Huang et al., 2009) [PubMed 19683501].[supplied by OMIM, Feb 2010]

LOC400174 Gene

single stranded DNA binding protein 4 pseudogene

BDP1 Gene

B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB

The product of this gene is a subunit of the TFIIIB transcription initiation complex, which recruits RNA polymerase III to target promoters in order to initiate transcription. The encoded protein localizes to concentrated aggregates in the nucleus, and is required for transcription from all three types of polymerase III promoters. It is phosphorylated by casein kinase II during mitosis, resulting in its release from chromatin and suppression of polymerase III transcription. [provided by RefSeq, Jul 2008]

RCHY1 Gene

ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase

The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]

DUX4L7 Gene

double homeobox 4 like 7

This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length and a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. There is no evidence for transcription of the gene at this locus though RT-PCR and in vitro expression experiments indicate that a telomeric paralog of this gene is transcribed in some haplotypes. Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq, Jun 2014]

DUX4L6 Gene

double homeobox 4 like 6

This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length and a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. There is no evidence for transcription of the gene at this locus though RT-PCR and in vitro expression experiments indicate that a telomeric paralog of this gene is transcribed in some haplotypes. Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq, Jun 2014]

DUX4L5 Gene

double homeobox 4 like 5

This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length and a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. There is no evidence for transcription of the gene at this locus though RT-PCR and in vitro expression experiments indicate that a telomeric paralog of this gene is transcribed in some haplotypes. Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq, Jun 2014]

DUX4L4 Gene

double homeobox 4 like 4

This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length and a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. There is no evidence for transcription of the gene at this locus though RT-PCR and in vitro expression experiments indicate that a telomeric paralog of this gene is transcribed in some haplotypes. Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq, Jun 2014]

DUX4L3 Gene

double homeobox 4 like 3

This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length and a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. There is no evidence for transcription of the gene at this locus though RT-PCR and in vitro expression experiments indicate that a telomeric paralog of this gene is transcribed in some haplotypes. Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq, Jun 2014]

DUX4L2 Gene

double homeobox 4 like 2

This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length and a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. There is no evidence for transcription of the gene at this locus though RT-PCR and in vitro expression experiments indicate that a telomeric paralog of this gene is transcribed in some haplotypes. Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq, Jun 2014]

DUX4L9 Gene

double homeobox 4 like 9

DUX4L8 Gene

double homeobox 4 like 8

This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length and a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. There is no evidence for transcription of the gene at this locus though RT-PCR and in vitro expression experiments indicate that a telomeric paralog of this gene is transcribed in some haplotypes. Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq, Jun 2014]

LOC105369260 Gene

double homeobox protein 4-like

XRCC5 Gene

X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)

The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]

DOC2GP Gene

double C2-like domains, gamma, pseudogene

FCHSD1 Gene

FCH and double SH3 domains 1

FCHSD2 Gene

FCH and double SH3 domains 2

DUX4L1 Gene

double homeobox 4 like 1

This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length and a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. There is no evidence for transcription of the gene at this locus though RT-PCR and in vitro expression experiments indicate that a telomeric paralog of this gene is transcribed in some haplotypes. Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq, Jun 2014]

DUX4L17 Gene

double homeobox 4 like 17

DUX4L16 Gene

double homeobox 4 like 16

DUX4L15 Gene

double homeobox 4 like 15

DUX4L14 Gene

double homeobox 4 like 14

DUX4L13 Gene

double homeobox 4 like 13

DUX4L12 Gene

double homeobox 4 like 12

DUX4L11 Gene

double homeobox 4 like 11

DUX4L10 Gene

double homeobox 4 like 10

DUX4L19 Gene

double homeobox 4 like 19

DUX4L18 Gene

double homeobox 4 like 18

DUX4L31 Gene

double homeobox 4 like 31, pseudogene

LOC100287794 Gene

double homeobox protein 4-like protein 4

DUXAP10 Gene

double homeobox A pseudogene 10

Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This pseudogene is a member of the DUXA homeobox gene family. [provided by RefSeq, Jul 2008]

DOC2A Gene

double C2-like domains, alpha

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

DOC2B Gene

double C2-like domains, beta

There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2B is expressed ubiquitously and is suggested to be involved in Ca(2+)-dependent intracellular vesicle trafficking in various types of cells. [provided by RefSeq, Jul 2008]

LOC653541 Gene

double homeobox, 4-like

LOC101930078 Gene

double homeobox protein 4-like protein 4

DUX4L34 Gene

double homeobox 4 like 34, pseudogene

DUXAP8 Gene

double homeobox A pseudogene 8

Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This pseudogene is a member of the DUXA homeobox gene family. [provided by RefSeq, Jul 2008]

DUXAP6 Gene

double homeobox A pseudogene 6

Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This pseudogene is a member of the DUXA homeobox gene family. [provided by RefSeq, Jul 2008]

DUXAP4 Gene

double homeobox A pseudogene 4

Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This pseudogene is a member of the DUXA homeobox gene family. [provided by RefSeq, Jul 2008]

DUXAP2 Gene

double homeobox A pseudogene 2

Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This pseudogene is a member of the DUXA homeobox gene family. [provided by RefSeq, Jul 2008]

DUXAP3 Gene

double homeobox A pseudogene 3

Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This pseudogene is a member of the DUXA homeobox gene family. [provided by RefSeq, Jul 2008]

DUXAP9 Gene

double homeobox A pseudogene 9

Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This pseudogene is a member of the DUXA homeobox gene family. [provided by RefSeq, Jul 2008]

DUXAP1 Gene

double homeobox A pseudogene 1

Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This pseudogene is a member of the DUXA homeobox gene family. [provided by RefSeq, Jul 2008]

DUX4L45 Gene

double homeobox 4 like 45, pseudogene

DUX4L20 Gene

double homeobox 4 like 20

DUX4L27 Gene

double homeobox 4 like 27

LOC102724961 Gene

double homeobox protein 4-like protein 4

DUX5 Gene

double homeobox 5

The human genome contains hundreds of repeats of the 3.3-kb family in regions associated with heterochromatin. The DUX gene family, including DUX5, resides within these 3.3-kb repeated elements (Beckers et al., 2001 [PubMed 11245978]). See DUX4 (MIM 606009).[supplied by OMIM, Mar 2008]

DUX4 Gene

double homeobox 4

This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

DUX1 Gene

double homeobox 1

The human genome contains hundreds of repeats of the 3.3-kb family in regions associated with heterochromatin. The DUX gene family, including DUX1, resides within these 3.3-kb repeated elements (Beckers et al., 2001 [PubMed 11245978]). See DUX4 (MIM 606009).[supplied by OMIM, Mar 2008]

DUX3 Gene

double homeobox 3

The human genome contains hundreds of repeats of the 3.3-kb family in regions associated with heterochromatin. The DUX gene family, including DUX3, resides within these 3.3-kb repeated elements (Beckers et al., 2001 [PubMed 11245978]). See DUX4 (MIM 606009).[supplied by OMIM, Mar 2008]

DUXA Gene

double homeobox A

Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This gene is a member of the DUXA homeobox gene family. Evidence of mRNA expression has not yet been found for this gene. Multiple, related processed pseudogenes have been found which are thought to reflect expression of this gene in the germ line or embryonic cells. [provided by RefSeq, Jul 2008]

DUXB Gene

double homeobox B

BDP1P Gene

B double prime 1 pseudogene

LOC100287954 Gene

double homeobox protein 4-like protein 4

LOC100419081 Gene

double homeobox A pseudogene

LOC100287823 Gene

double homeobox protein 4-like protein 4

DUXAP7 Gene

double homeobox A pseudogene 7

Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This pseudogene is a member of the DUXA homeobox gene family. [provided by RefSeq, Jul 2008]

DUXAP5 Gene

double homeobox A pseudogene 5

Homeobox genes encode DNA-binding proteins, many of which are thought to be involved in early embryonic development. Homeobox genes encode a DNA-binding domain of 60 to 63 amino acids referred to as the homeodomain. This pseudogene is a member of the DUXA homeobox gene family. [provided by RefSeq, Jul 2008]

DUX4L26 Gene

double homeobox 4 like 26

DUX4L24 Gene

double homeobox 4 like 24

DUX4L25 Gene

double homeobox 4 like 25

DUX4L22 Gene

double homeobox 4 like 22

DUX4L23 Gene

double homeobox 4 like 23

DUX4L21 Gene

double homeobox 4 like 21

ZFR2 Gene

zinc finger RNA binding protein 2

LOC100129391 Gene

zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 pseudogene

ZFRP1 Gene

zinc finger RNA binding protein pseudogene 1

LOC100421641 Gene

zinc finger CCHC-type and RNA binding motif 1 pseudogene

ZFR Gene

zinc finger RNA binding protein

ZRSR1 Gene

zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 1

ZRSR2 Gene

zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2

This gene encodes an essential splicing factor. The encoded protein associates with the U2 auxiliary factor heterodimer, which is required for the recognition of a functional 3' splice site in pre-mRNA splicing, and may play a role in network interactions during spliceosome assembly. [provided by RefSeq, Jul 2008]

LOC100289238 Gene

zinc finger RNA binding protein pseudogene

LOC100131556 Gene

zinc finger CCHC-type and RNA binding motif 1 pseudogene

ZCRB1 Gene

zinc finger CCHC-type and RNA binding motif 1

Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron. The protein encoded by this gene contains a RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and many other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing. [provided by RefSeq, Jul 2008]

LOC105379427 Gene

zinc finger protein 717-like

LOC442041 Gene

zinc finger protein 532 pseudogene

ZNF117 Gene

zinc finger protein 117

ZNF114 Gene

zinc finger protein 114

ZNF112 Gene

zinc finger protein 112

ZNF736P3Y Gene

zinc finger protein 736 pseudogene 3, Y-linked

LOC100419801 Gene

zinc finger protein 532 pseudogene

LOC100419803 Gene

zinc finger protein 510 pseudogene

LOC100419802 Gene

zinc finger protein 184 pseudogene

LOC100419806 Gene

zinc finger protein 519 pseudogene

ZNF831 Gene

zinc finger protein 831

ZNF830 Gene

zinc finger protein 830

ZNF835 Gene

zinc finger protein 835

ZNF837 Gene

zinc finger protein 837

ZNF836 Gene

zinc finger protein 836

ZNF839 Gene

zinc finger protein 839

ZNF304 Gene

zinc finger protein 304

ZNF302 Gene

zinc finger protein 302

This gene encodes a member of the zinc-finger protein family. The encoded protein contains seven C2H2-type zinc fingers and a KRAB domain, but its function has yet to be determined. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2014]

ZNF300 Gene

zinc finger protein 300

The protein encoded by this gene is a C2H2-type zinc finger DNA binding protein and likely transcriptional regulator. The function of this protein is not yet known. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

LOC100419755 Gene

zinc finger protein 426 pseudogene

ZSCAN5CP Gene

zinc finger and SCAN domain containing 5C, pseudogene

ZSWIM5P3 Gene

zinc finger, SWIM-type containing 5 pseudogene 3

ZSWIM5P2 Gene

zinc finger, SWIM-type containing 5 pseudogene 2

ZSWIM5P1 Gene

zinc finger, SWIM-type containing 5 pseudogene 1

ZNF848P Gene

zinc finger protein 848, pseudogene

ZBTB7A Gene

zinc finger and BTB domain containing 7A

ZBTB7C Gene

zinc finger and BTB domain containing 7C

ZBTB7B Gene

zinc finger and BTB domain containing 7B

This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

ZNF605 Gene

zinc finger protein 605

ZCCHC23 Gene

zinc finger, CCHC domain containing 23

ZCCHC24 Gene

zinc finger, CCHC domain containing 24

LOC100421259 Gene

zinc finger and BTB domain containing 14 pseudogene

UNKL Gene

unkempt family zinc finger-like

This gene encodes a RING finger protein that may function in Rac signaling. It can bind to Brg/Brm-associated factor 60b and can promote its ubiquitination. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jun 2013]

ZNF733P Gene

zinc finger protein 733, pseudogene

ZDHHC3 Gene

zinc finger, DHHC-type containing 3

LOC100419888 Gene

zinc finger protein 331 pseudogene

ZNF213 Gene

zinc finger protein 213

C2H2 zinc finger proteins, such as ZNF213, have bipartite structures in which one domain binds DNA or RNA and the other modulates target gene expression.[supplied by OMIM, Apr 2004]

ZNF419 Gene

zinc finger protein 419

ZNF418 Gene

zinc finger protein 418

ZNF417 Gene

zinc finger protein 417

ZNF416 Gene

zinc finger protein 416

ZNF415 Gene

zinc finger protein 415

ZNF414 Gene

zinc finger protein 414

ZNF410 Gene

zinc finger protein 410

ZNF726P1 Gene

zinc finger protein 726 pseudogene 1

LOC100130632 Gene

zinc finger protein 530-like

ZNF658 Gene

zinc finger protein 658

ZNF655 Gene

zinc finger protein 655

This gene encodes a zinc finger protein. The zinc finger proteins are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ZNF653 Gene

zinc finger protein 653

ZNF652 Gene

zinc finger protein 652

ZNF384 Gene

zinc finger protein 384

This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Apr 2011]

ZNF383 Gene

zinc finger protein 383

ZFP41 Gene

ZFP41 zinc finger protein

ZFP42 Gene

ZFP42 zinc finger protein

LOC100419762 Gene

zinc finger protein 773 pseudogene

ZMYND19P1 Gene

zinc finger, MYND-type containing 19 pseudogene 1

ZFHX4 Gene

zinc finger homeobox 4

LOC100130861 Gene

zinc finger protein 736 pseudogene

ZFHX3 Gene

zinc finger homeobox 3

This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

ZNF192P2 Gene

zinc finger protein 192 pseudogene 2

ZNF192P1 Gene

zinc finger protein 192 pseudogene 1

LOC730076 Gene

zinc finger domain containing pseudogene

ZNF497 Gene

zinc finger protein 497

ZNF496 Gene

zinc finger protein 496

ZNF493 Gene

zinc finger protein 493

ZNF490 Gene

zinc finger protein 490

LOC646629 Gene

zinc finger protein 470 pseudogene

ZNF826P Gene

zinc finger protein 826, pseudogene

ZNF519P3 Gene

zinc finger protein 519 pseudogene 3

ZIM2 Gene

zinc finger, imprinted 2

In human, ZIM2 and PEG3 (GeneID:5178) are two distinct genes that share a set of 5' exons and have a common promoter, and both genes are paternally expressed. Alternative splicing events connect the shared exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. This is in contrast to mouse and cow, where ZIM2 and PEG3 genes do not share exons in common, and the imprinting status of ZIM2 is also not conserved amongst mammals. Additional 5' alternatively spliced transcripts encoding the same protein have been found for the human ZIM2 gene. [provided by RefSeq, Oct 2010]

ZIM3 Gene

zinc finger, imprinted 3

GATAD1 Gene

GATA zinc finger domain containing 1

The protein encoded by this gene contains a zinc finger at the N-terminus, and is thought to bind to a histone modification site that regulates gene expression. Mutations in this gene have been associated with autosomal recessive dilated cardiomyopathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

ZNF519 Gene

zinc finger protein 519

ZNF512 Gene

zinc finger protein 512

This gene encodes a protein containing four putative zinc finger motifs. Zinc finger motifs may bind to proteins or nucleic acids. Zinc finger-containing proteins are involved in a variety of processes, including regulation of transcription. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Sep 2012]

ZNF513 Gene

zinc finger protein 513

The protein encoded by this gene is a possible transcriptional regulator involved in retinal development. Defects in this gene can be a cause of autosomal-recessive retinitis pigmentosa. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

ZNF510 Gene

zinc finger protein 510

ZNF511 Gene

zinc finger protein 511

ZNF516 Gene

zinc finger protein 516

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc-finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. [provided by RefSeq, Sep 2012]

ZNF514 Gene

zinc finger protein 514

CNBP Gene

CCHC-type zinc finger, nucleic acid binding protein

This gene encodes a nucleic-acid binding protein with seven zinc-finger domains. The protein has a preference for binding single stranded DNA and RNA. The protein functions in cap-independent translation of ornithine decarboxylase mRNA, and may also function in sterol-mediated transcriptional regulation. A CCTG expansion in the first intron of this gene results in myotonic dystrophy type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

LOC100421122 Gene

zinc finger protein 106 homolog (mouse) pseudogene

ZNF75D Gene

zinc finger protein 75D

This gene encodes a protein that likely functions as a transcription factor. The protein, which belongs to the ZNF75 family, includes an N-terminal SCAN domain, a KRAB box, and five C2H2-type zinc finger motifs. Another functional gene belonging to this family is located on chromosome 16, while pseudogenes have been identified on chromosomes 11 and 12. Alternative splicing results in multiple transcripts variants. [provided by RefSeq, Jun 2010]

LOC100533635 Gene

zinc finger protein 384 pseudogene

ZNF750 Gene

zinc finger protein 750

This gene encodes a protein with a nuclear localization site and a C2H2 zinc finger domain. Mutations in this gene have been associated with seborrhea-like dermatitis with psoriasiform elements. [provided by RefSeq, Jul 2008]

LOC100533638 Gene

zinc finger protein 85 pseudogene

LOC728376 Gene

zinc finger protein 430 pseudogene

ZGLP1 Gene

zinc finger, GATA-like protein 1

ZC3H12A Gene

zinc finger CCCH-type containing 12A

ZC3H12A is an MCP1 (CCL2; MIM 158105)-induced protein that acts as a transcriptional activator and causes cell death of cardiomyocytes, possibly via induction of genes associated with apoptosis.[supplied by OMIM, Mar 2008]

ZC3H12B Gene

zinc finger CCCH-type containing 12B

The protein encoded by this gene belongs to a family of CCCH-type zinc finger proteins that are involved in the proinflammatory activation of macrophages. The exact function of this family member is unknown, but it is thought to function as a ribonuclease. [provided by RefSeq, May 2010]

ZC3H12C Gene

zinc finger CCCH-type containing 12C

ZC3H12D Gene

zinc finger CCCH-type containing 12D

TSRM Gene

zinc finger domain-related protein TSRM

ZFYVE21 Gene

zinc finger, FYVE domain containing 21

LOC100419752 Gene

zinc finger protein 251 pseudogene

DNLZ Gene

DNL-type zinc finger

ZNF273 Gene

zinc finger protein 273

This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with 13 C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in transcriptional regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

ZNF277 Gene

zinc finger protein 277

ZNF276 Gene

zinc finger protein 276

ZNF275 Gene

zinc finger protein 275

This gene encodes a zinc finger protein that appears to be conserved in eutheria. Its function has not yet been established. [provided by RefSeq, Jul 2010]

ZNF274 Gene

zinc finger protein 274

This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals. [provided by RefSeq, Jul 2008]

ZBTB45P2 Gene

zinc finger and BTB domain containing 45 pseudogene 2

ZBTB45P1 Gene

zinc finger and BTB domain containing 45 pseudogene 1

LOC100652813 Gene

zinc finger protein 138 pseudogene

LOC100419830 Gene

zinc finger protein 337 pseudogene

LOC100419834 Gene

zinc finger protein 134 pseudogene

LOC100419836 Gene

zinc finger protein 347 pseudogene

LOC100419838 Gene

zinc finger protein 860 pseudogene

LOC100419839 Gene

zinc finger protein 300 pseudogene

ZNF815P Gene

zinc finger protein 815, pseudogene

LOC100131479 Gene

zinc finger protein 430 pseudogene

ZNF841 Gene

zinc finger protein 841

ZNF843 Gene

zinc finger protein 843

ZNF844 Gene

zinc finger protein 844

ZNF846 Gene

zinc finger protein 846

ZNF592 Gene

zinc finger protein 592

This gene is thought to play a role in a complex developmental pathway and the regulation of genes involved in cerebellar development. Mutations in this gene have been associated with autosomal recessive spinocerebellar ataxia. [provided by RefSeq, Jan 2011]

ZNF593 Gene

zinc finger protein 593

ZNF596 Gene

zinc finger protein 596

ZNF595 Gene

zinc finger protein 595

This gene encodes a protein belonging to the Cys2His2 zinc finger protein family, whose members function as transcription factors that can regulate a broad variety of developmental and cellular processes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Oct 2013]

ZNF598 Gene

zinc finger protein 598

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This protein and Grb10-interacting GYF protein 2 have been identified as a components of the mammalian 4EHP (m4EHP) complex. The complex is thought to function as a translation repressor in embryonic development. [provided by RefSeq, Oct 2012]

ZNF599 Gene

zinc finger protein 599

ZNF337 Gene

zinc finger protein 337

This gene encodes a zinc finger domain containing protein. The function of this protein has yet to be determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

ZNF334 Gene

zinc finger protein 334

This gene encodes a member of the C2H2 zinc finger family. The encoded protein contains a Krueppel-associated box, fourteen C2H2 zinc finger domains, and four C2H2-type/integrase DNA-binding domains. Decreased expression of this gene may be a marker for rheumatoid arthritis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

ZNF335 Gene

zinc finger protein 335

The protein encoded by this gene enhances transcriptional activation by ligand-bound nuclear hormone receptors. However, it does this not by direct interaction with the receptor, but by direct interaction with the nuclear hormone receptor transcriptional coactivator NRC. The encoded protein may function by altering local chromatin structure. [provided by RefSeq, Jul 2008]

ZNF333 Gene

zinc finger protein 333

ZNF330 Gene

zinc finger protein 330

ZNF331 Gene

zinc finger protein 331

This gene encodes a zinc finger protein containing a KRAB (Kruppel-associated box) domain found in transcriptional repressors. A pseudogene of this gene is located on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

LOC100419761 Gene

zinc finger protein 654 pseudogene

LOC100419763 Gene

zinc finger with KRAB and SCAN domains 8 pseudogene

ZNF33B Gene

zinc finger protein 33B

This gene encodes a member of the zinc finger family of proteins. This gene shows decreased expression in cumulus cells derived from patients undergoing controlled ovarian stimulation. This gene is present in a gene cluster with several related zinc finger genes in the pericentromeric region of chromosome 10. Pseudogenes have been identified on chromosomes 7 and 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

ZNF33A Gene

zinc finger protein 33A

ZFP92 Gene

ZFP92 zinc finger protein

ZFP90 Gene

ZFP90 zinc finger protein

This gene encodes a member of the zinc finger protein family that modulates gene expression. The encoded protein derepresses the transcription of certain fetal cardiac genes and may contribute to the genetic reprogramming that occurs during the development of heart failure. Genome wide association studies have identified this gene among ulcerative colitis risk loci. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Mar 2015]

ZFP91 Gene

ZFP91 zinc finger protein

The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010]

ZEB1 Gene

zinc finger E-box binding homeobox 1

This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010]

LOC101929991 Gene

zinc finger protein 93-like

LOC100505841 Gene

zinc finger protein 474-like

ZCCHC12 Gene

zinc finger, CCHC domain containing 12

ZCCHC11 Gene

zinc finger, CCHC domain containing 11

ZCCHC11 is an RNA uridyltransferase (EC 2.7.7.52) that uses UTP to add uridines to the 3-prime end of substrate RNA molecules (Jones et al., 2009 [PubMed 19701194]).[supplied by OMIM, Jan 2011]

ZCCHC10 Gene

zinc finger, CCHC domain containing 10

ZCCHC17 Gene

zinc finger, CCHC domain containing 17

ZCCHC16 Gene

zinc finger, CCHC domain containing 16

ZCCHC14 Gene

zinc finger, CCHC domain containing 14

ZCCHC18 Gene

zinc finger, CCHC domain containing 18

ZNF83 Gene

zinc finger protein 83

ZNF81 Gene

zinc finger protein 81

This gene encodes a protein that likely functions as a transcription factor. The protein contains an N-terminal KRAB domain and several C2H2-type zinc finger motifs. Mutations in this gene cause mental retardation X-linked type 45 (MRX45). [provided by RefSeq, May 2010]

ZNF80 Gene

zinc finger protein 80

ZNF85 Gene

zinc finger protein 85

ZNF84 Gene

zinc finger protein 84

LOC440180 Gene

zinc finger, CCHC domain containing 7 pseudogene

ZNF736P7Y Gene

zinc finger protein 736 pseudogene 7, Y-linked

ZNF863P Gene

zinc finger protein 863, pseudogene

WIZP1 Gene

widely interspaced zinc finger motifs pseudogene 1

HELZ Gene

helicase with zinc finger

HELZ is a member of the superfamily I class of RNA helicases. RNA helicases alter the conformation of RNA by unwinding double-stranded regions, thereby altering the biologic activity of the RNA molecule and regulating access to other proteins (Wagner et al., 1999 [PubMed 10471385]).[supplied by OMIM, Mar 2008]

RBAK Gene

RB-associated KRAB zinc finger

This gene encodes a nuclear protein which interacts with the tumor suppressor retinoblastoma 1. The two interacting proteins are thought to act as a transcriptional repressor for promoters which are activated by the E2F1 transcription factor. This protein contains a Kruppel-associated box (KRAB), which is a transcriptional repressor motif. Read-through transcripts that include exons from the downstream gene LOC389458 are expressed from this locus. [provided by RefSeq, Mar 2011]

ZNF619P1 Gene

zinc finger protein 619 pseudogene 1

ZNF33BP1 Gene

zinc finger protein 33B pseudogene 1

VEZF1P1 Gene

vascular endothelial zinc finger 1 pseudogene 1

ZDHHC20 Gene

zinc finger, DHHC-type containing 20

ZDHHC21 Gene

zinc finger, DHHC-type containing 21

ZDHHC22 Gene

zinc finger, DHHC-type containing 22

ZDHHC23 Gene

zinc finger, DHHC-type containing 23

ZDHHC24 Gene

zinc finger, DHHC-type containing 24

ZNF141 Gene

zinc finger protein 141

ZNF140 Gene

zinc finger protein 140

ZNF143 Gene

zinc finger protein 143

ZNF142 Gene

zinc finger protein 142

The protein encoded by this gene belongs to the Kruppel family of C2H2-type zinc finger proteins. It contains 31 C2H2-type zinc fingers and may be involved in transcriptional regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]

ZNF146 Gene

zinc finger protein 146

ZNF148 Gene

zinc finger protein 148

ZNF736P4Y Gene

zinc finger protein 736 pseudogene 4, Y-linked

ZNF736P12Y Gene

zinc finger protein 736 pseudogene 12, Y-linked

ZC3HC1 Gene

zinc finger, C3HC-type containing 1

This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis. [provided by RefSeq, Aug 2013]

ZNF968P Gene

zinc finger protein 968, pseudogene

CTCF Gene

CCCTC-binding factor (zinc finger protein)

This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

ZNF426 Gene

zinc finger protein 426

ZNF425 Gene

zinc finger protein 425

ZNF423 Gene

zinc finger protein 423

The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development. Mutations in this gene are associated with nephronophthisis-14 and Joubert syndrome-19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2012]

ZNF420 Gene

zinc finger protein 420

ZNF428 Gene

zinc finger protein 428

ZNF429 Gene

zinc finger protein 429

ZNF969P Gene

zinc finger protein 969, pseudogene

ZNF884P Gene

zinc finger protein 884, pseudogene

LOC100421197 Gene

zinc finger and BTB domain containing 10 pseudogene

ZC3H6 Gene

zinc finger CCCH-type containing 6

ZFP14 Gene

ZFP14 zinc finger protein

LOC728743 Gene

zinc finger protein pseudogene

LOC100128713 Gene

zinc finger protein 816A pseudogene

ZNF735 Gene

zinc finger protein 735

ZNF92P2 Gene

zinc finger protein 92 pseudogene 2

ZNF92P3 Gene

zinc finger protein 92 pseudogene 3

ZNF219 Gene

zinc finger protein 219

LOC100419859 Gene

zinc finger, MYM-type 1 pseudogene

LOC100419678 Gene

zinc finger, MYM-type 1 pseudogene

ZFHX2 Gene

zinc finger homeobox 2

HKR1 Gene

HKR1, GLI-Kruppel zinc finger family member

LOC100130854 Gene

zinc finger protein 562 pseudogene

LOC100419686 Gene

zinc finger protein 256 pseudogene

LOC100419685 Gene

zinc finger protein 555 pseudogene

LOC100419684 Gene

zinc finger protein 114 pseudogene

LOC100419680 Gene

zinc finger protein 430 pseudogene

ZFPM2 Gene

zinc finger protein, FOG family member 2

The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression of GATA-target genes, suggesting different modulation in different promoter contexts. A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. [provided by RefSeq, Jul 2008]

ZNF271P Gene

zinc finger protein 271, pseudogene

Zinc finger proteins interact with nucleic acids and have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on zinc finger proteins.[supplied by OMIM, Apr 2004]

ZNF519P1 Gene

zinc finger protein 519 pseudogene 1

ZNF519P2 Gene

zinc finger protein 519 pseudogene 2

ZDHHC20P3 Gene

zinc finger, DHHC-type containing 20 pseudogene 3

ZNF355P Gene

zinc finger protein 355, pseudogene

ZNF603P Gene

zinc finger protein 603, pseudogene

ZNF663P Gene

zinc finger protein 663, pseudogene

ZNF252P Gene

zinc finger protein 252, pseudogene

ZNF877P Gene

zinc finger protein 877, pseudogene

RBCK1 Gene

RanBP-type and C3HC4-type zinc finger containing 1

The protein encoded by this gene is similar to mouse UIP28/UbcM4 interacting protein. Alternative splicing has been observed at this locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]

ZNF722P Gene

zinc finger protein 722, pseudogene

ZNF628 Gene

zinc finger protein 628

Zinc finger proteins (ZNFs), which bind nucleic acids, perform many key functions, the most important of which is regulating transcription. See ZNF91 (MIM 603971) for general information on ZNFs.[supplied by OMIM, Mar 2008]

ZNF629 Gene

zinc finger protein 629

ZNF624 Gene

zinc finger protein 624

ZNF625 Gene

zinc finger protein 625

ZNF626 Gene

zinc finger protein 626

ZNF627 Gene

zinc finger protein 627

ZNF620 Gene

zinc finger protein 620

ZNF621 Gene

zinc finger protein 621

ZNF622 Gene

zinc finger protein 622

ZNF623 Gene

zinc finger protein 623

SWSAP1 Gene

SWIM-type zinc finger 7 associated protein 1

ZSCAN18 Gene

zinc finger and SCAN domain containing 18

ZSCAN10 Gene

zinc finger and SCAN domain containing 10

ZSCAN12 Gene

zinc finger and SCAN domain containing 12

ZSCAN16 Gene

zinc finger and SCAN domain containing 16

LOC100533643 Gene

zinc finger protein 91 pseudogene

LOC100533644 Gene

zinc finger protein 628 pseudogene

LOC100533646 Gene

zinc finger protein 135 pseudogene

ZNF544 Gene

zinc finger protein 544

ZNF547 Gene

zinc finger protein 547

ZNF540 Gene

zinc finger protein 540

ZNF543 Gene

zinc finger protein 543

ZNF549 Gene

zinc finger protein 549

ZNF548 Gene

zinc finger protein 548

ZBTB8A Gene

zinc finger and BTB domain containing 8A

ZBTB8B Gene

zinc finger and BTB domain containing 8B

ZFPM1 Gene

zinc finger protein, FOG family member 1

ZFAND6P1 Gene

zinc finger, AN1-type domain 6 pseudogene 1

ZMIZ2 Gene

zinc finger, MIZ-type containing 2

ZMIZ2 and ZMIZ1 (MIM 607159) are members of a PIAS (see MIM 603566)-like family of proteins that interact with nuclear hormone receptors. ZMIZ2 interacts with androgen receptor (AR; MIM 313700) and enhances AR-mediated transcription (Huang et al., 2005 [PubMed 16051670]).[supplied by OMIM, May 2010]

ZMIZ1 Gene

zinc finger, MIZ-type containing 1

This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Mar 2010]

ZNF70P1 Gene

zinc finger protein 70 pseudogene 1

ZNF783 Gene

zinc finger family member 783

ZNF782 Gene

zinc finger protein 782

ZNF781 Gene

zinc finger protein 781

ZNF787 Gene

zinc finger protein 787

ZNF786 Gene

zinc finger protein 786

ZNF785 Gene

zinc finger protein 785

ZNF784 Gene

zinc finger protein 784

ZNF789 Gene

zinc finger protein 789

ZNF788 Gene

zinc finger family member 788

LOC100289416 Gene

zinc finger protein 793

ZEB2P1 Gene

zinc finger E-box binding homeobox 2 pseudogene 1

ZBED4 Gene

zinc finger, BED-type containing 4

LOC100533641 Gene

zinc finger protein 100 pseudogene

ZNF248 Gene

zinc finger protein 248

GATAD2A Gene

GATA zinc finger domain containing 2A

LOC105378242 Gene

zinc finger protein 705A-like

ZDHHC11B Gene

zinc finger, DHHC-type containing 11B

LOC100419863 Gene

zinc finger protein 705A pseudogene

ZFPL1 Gene

zinc finger protein-like 1

LOC101060391 Gene

zinc finger CCCH domain-containing protein 18-like

ZNRF4 Gene

zinc and ring finger 4

ZNRF1 Gene

zinc and ring finger 1, E3 ubiquitin protein ligase

This gene encodes an E3 ubiquitin-protein ligase that plays a role in neural-cell differentiation. Overexpression of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification, and in synaptic vessicle membranes in neurons. [provided by RefSeq, Feb 2012]

ZNRF3 Gene

zinc and ring finger 3

ZNRF2 Gene

zinc and ring finger 2, E3 ubiquitin protein ligase

ZNF646P1 Gene

zinc finger protein 646 pseudogene 1

ZNF546 Gene

zinc finger protein 546

ZNF541 Gene

zinc finger protein 541

ZFAND2B Gene

zinc finger, AN1-type domain 2B

This gene encodes a protein containing AN1-type zinc-fingers and ubiquitin-interacting motifs. The encoded protein likely associates with the proteosome to stimulate the degradation of toxic or misfolded proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]

ZFAND2A Gene

zinc finger, AN1-type domain 2A

LOC101930552 Gene

zinc finger protein 717-like

ZNF709 Gene

zinc finger protein 709

ZNF708 Gene

zinc finger protein 708

ZNF703 Gene

zinc finger protein 703

ZNF701 Gene

zinc finger protein 701

ZNF700 Gene

zinc finger protein 700

ZNF707 Gene

zinc finger protein 707

ZNF706 Gene

zinc finger protein 706

ZNF704 Gene

zinc finger protein 704

ZC3H10 Gene

zinc finger CCCH-type containing 10

ZC3H13 Gene

zinc finger CCCH-type containing 13

ZC3H14 Gene

zinc finger CCCH-type containing 14

ZC3H14 belongs to a family of poly(A)-binding proteins that influence gene expression by regulating mRNA stability, nuclear export, and translation (Kelly et al., 2007 [PubMed 17630287]).[supplied by OMIM, Mar 2010]

ZC3H18 Gene

zinc finger CCCH-type containing 18

ZNF56 Gene

zinc finger protein 56

ZNF57 Gene

zinc finger protein 57

ZNF7 Gene

zinc finger protein 7

ZNF4 Gene

zinc finger protein-4

ZNF5 Gene

zinc finger protein-5

ZNF2 Gene

zinc finger protein 2

The protein encoded by this gene belongs to the C2H2-type zinc-finger protein family. The exact function of this gene is not known, however, zinc-finger proteins are known to interact with DNA and function as transcription regulators. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

ZNF3 Gene

zinc finger protein 3

CTCFL Gene

CCCTC-binding factor (zinc finger protein)-like

CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. This gene is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and the protein encoded by this gene are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

ZNF8 Gene

zinc finger protein 8

ZKSCAN7P1 Gene

zinc finger with KRAB and SCAN domains 7 pseudogene 1

LOC643381 Gene

zinc finger protein 614 pseudogene

ZSCAN9 Gene

zinc finger and SCAN domain containing 9

ZSCAN4 Gene

zinc finger and SCAN domain containing 4

The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem (ES) cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture (Zalzman et al., 2010 [PubMed 20336070]).[supplied by OMIM, May 2010]

ZSCAN1 Gene

zinc finger and SCAN domain containing 1

ZSCAN2 Gene

zinc finger and SCAN domain containing 2

The protein encoded by this gene contains several copies of zinc finger motif, which is commonly found in transcriptional regulatory proteins. Studies in mice show that this gene is expressed during embryonic development, and specifically in the testis in adult mice, suggesting that it may play a role in regulating genes in germ cells. Alternative splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

LOC646388 Gene

zinc finger, CCHC domain containing 9 pseudogene

LOC100533636 Gene

zinc finger protein 519 pseudogene

ZNF138 Gene

zinc finger protein 138

ZNF131 Gene

zinc finger protein 131

ZNF132 Gene

zinc finger protein 132

ZNF133 Gene

zinc finger protein 133

ZNF134 Gene

zinc finger protein 134

ZNF135 Gene

zinc finger protein 135

ZNF136 Gene

zinc finger protein 136

ZNF736P1Y Gene

zinc finger protein 736 pseudogene 1, Y-linked

ZNF736P11Y Gene

zinc finger protein 736 pseudogene 11, Y-linked

ZNF813 Gene

zinc finger protein 813

ZNF812 Gene

zinc finger protein 812

LOC100287523 Gene

zinc finger protein 2-like

ZNF362 Gene

zinc finger protein 362

ZNF365 Gene

zinc finger protein 365

This gene encodes several isoforms which have different expression patterns and functions. Mutation in this gene is associated with uric acid nephrolithiasis (UAN). Alternatively spliced variants, encoding distinct proteins, have been identified. [provided by RefSeq, May 2010]

ZNF367 Gene

zinc finger protein 367

ZNF366 Gene

zinc finger protein 366

LOC100419739 Gene

zinc finger protein 341 pseudogene

ZGPAT Gene

zinc finger, CCCH-type with G patch domain

MORC2 Gene

MORC family CW-type zinc finger 2

MORC3 Gene

MORC family CW-type zinc finger 3

This gene encodes a protein that localizes to the nuclear matrix. The protein also has RNA binding activity, and has a predicted coiled-coil domain. [provided by RefSeq, Jul 2008]

MORC1 Gene

MORC family CW-type zinc finger 1

This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells. [provided by RefSeq, Jan 2009]

MORC4 Gene

MORC family CW-type zinc finger 4

In human, the four current members of the microrchidia (morc) gene family share an N-terminal ATPase-like ATP-binding region and a CW four-cysteine zinc-finger motif. The protein encoded by this gene also has a nuclear matrix binding domain and a two-stranded coiled-coil motif near its C-terminus. This gene is widely expressed at low levels in normal tissues and has elevated expression in placenta and testis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jan 2010]

ZNFX1 Gene

zinc finger, NFX1-type containing 1

LOC105379522 Gene

zinc finger protein 717-like

ZNHIT3 Gene

zinc finger, HIT-type containing 3

ZNHIT2 Gene

zinc finger, HIT-type containing 2

ZNHIT1 Gene

zinc finger, HIT-type containing 1

ZNHIT6 Gene

zinc finger, HIT-type containing 6

FEZF1 Gene

FEZ family zinc finger 1

This gene encodes a transcriptional repressor that belongs to the zinc finger double domain protein family. The encoded protein is thought to play a role in the embryonic migration of gonadotropin-releasing hormone neurons into the brain. Mutations in this gene are associated with hypogonadotropic hypogonadism-22 with anosmia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

FEZF2 Gene

FEZ family zinc finger 2

ZFP69B Gene

ZFP69 zinc finger protein B

LOC101928508 Gene

zinc finger Ran-binding domain-containing protein 2 pseudogene

LOC105369285 Gene

zinc finger protein 813-like

ZNF479 Gene

zinc finger protein 479

ZNF471 Gene

zinc finger protein 471

ZNF470 Gene

zinc finger protein 470

ZNF473 Gene

zinc finger protein 473

ZNF474 Gene

zinc finger protein 474

LOC100418554 Gene

zinc finger protein 93 pseudogene

LOC100418556 Gene

zinc finger protein 70 pseudogene

LOC100418550 Gene

zinc finger protein 93 pseudogene

LOC100418551 Gene

zinc finger protein 70 pseudogene

LOC100418552 Gene

zinc finger protein 93 pseudogene

LOC100418553 Gene

zinc finger protein 70 pseudogene

ZMYND15 Gene

zinc finger, MYND-type containing 15

This gene encodes a MYND-containing zinc-binding protein with a nuclear localization sequence. A similar gene in mice has been shown to act as a testis-specific transcriptional repressor by recruiting histone deacetylase enzymes to regulate spatiotemporal expression of many haploid genes. This protein may play an important role in spermatogenesis. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]

ZMYND12 Gene

zinc finger, MYND-type containing 12

ZMYND10 Gene

zinc finger, MYND-type containing 10

ZMYND11 Gene

zinc finger, MYND-type containing 11

The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

ZMYND19 Gene

zinc finger, MYND-type containing 19

ZMYND19 is a MYND zinc finger domain-containing protein that binds to the C terminus of melanin-concentrating hormone receptor-1 (MCHR1; MIM 601751) (Bachner et al., 2002 [PubMed 12208518]), and to the N termini of alpha-tubulin (TUBA1; MIM 191110), and beta-tubulin (TUBB; MIM 191130) (Francke et al., 2005 [PubMed 16039987]).[supplied by OMIM, Mar 2008]

ZKSCAN1 Gene

zinc finger with KRAB and SCAN domains 1

The ZKSCAN1 gene encodes a transcriptional regulator of the KRAB (Kruppel-associated box) subfamily of zinc finger proteins, which contain repeated Cys2-His2 (C2H2) zinc finger domains that are connected by conserved sequences, called H/C links (summarized by Tommerup and Vissing, 1995 [PubMed 7557990]). Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. See ZNF91 (MIM 603971) for general information on zinc finger proteins.[supplied by OMIM, Jul 2010]

ZKSCAN3 Gene

zinc finger with KRAB and SCAN domains 3

ZKSCAN2 Gene

zinc finger with KRAB and SCAN domains 2

ZKSCAN5 Gene

zinc finger with KRAB and SCAN domains 5

This gene encodes a zinc finger protein of the Kruppel family. The protein contains a SCAN box and a KRAB A domain. A similar protein in mouse is differentially expressed in spermatogenesis. Two alternatively spliced transcript variants differing only in the 5' UTR have been described. Additional variants have been found, but their full-length sequences have not been determined. [provided by RefSeq, Jul 2008]

ZKSCAN4 Gene

zinc finger with KRAB and SCAN domains 4

ZKSCAN7 Gene

zinc finger with KRAB and SCAN domains 7

ZKSCAN8 Gene

zinc finger with KRAB and SCAN domains 8

ZNF677 Gene

zinc finger protein 677

ZNF676 Gene

zinc finger protein 676

ZNF675 Gene

zinc finger protein 675

ZNF674 Gene

zinc finger protein 674

This gene encodes a zinc finger protein with an N-terminal Kruppel-associated box-containing (KRAB) domain and 11 Kruppel-type C2H2 zinc finger domains. Like other zinc finger proteins, this gene may function as a transcription factor. This gene resides on an area of chromosome X that has been implicated in nonsyndromic X-linked mental retardation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2010]

ZNF672 Gene

zinc finger protein 672

ZNF671 Gene

zinc finger protein 671

ZNF670 Gene

zinc finger protein 670

ZNF679 Gene

zinc finger protein 679

ZNF678 Gene

zinc finger protein 678

ZFP69 Gene

ZFP69 zinc finger protein

ZFP64 Gene

ZFP64 zinc finger protein

ZFP62 Gene

ZFP62 zinc finger protein

ZNF385C Gene

zinc finger protein 385C

ZNF385B Gene

zinc finger protein 385B

ZNF385A Gene

zinc finger protein 385A

Zinc finger proteins, such as ZNF385A, are regulatory proteins that act as transcription factors, bind single- or double-stranded RNA, or interact with other proteins (Sharma et al., 2004 [PubMed 15527981]).[supplied by OMIM, Oct 2008]

ZNF654 Gene

zinc finger protein 654

ZNF382 Gene

zinc finger protein 382

This gene encodes a KRAB domain zinc finger transcription factor (KZNF). KZNFs play critical roles in the regulation of many cellular processes including differentiation, proliferation and apoptosis. The encoded protein inhibits activating protein 1 (AP-1) and nuclear factor kappa-B (NF-kB) signaling and may function as a tumor suppressor in multiple carcinomas. This gene is found in a cluster with other zinc finger protein genes on the long arm of chromosome 19, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]

ZNF823 Gene

zinc finger protein 823

LOC100419913 Gene

zinc finger protein 678 pseudogene

ZXDB Gene

zinc finger, X-linked, duplicated B

The ZXDB gene is one of a pair of duplicated zinc finger genes on chromosome Xp11.21 (Greig et al., 1993 [PubMed 8268913]); see also ZXDA (MIM 300235).[supplied by OMIM, Jul 2010]

ZXDC Gene

ZXD family zinc finger C

ZXDA Gene

zinc finger, X-linked, duplicated A

This gene encodes one of two duplicated zinc finger genes on chromosome Xp11. This gene is the telomeric copy; GeneID 158586 ZXDB is the more centromeric copy. The two genes have 98% nucleotide sequence similarity, and the predicted proteins contain 10 tandem zinc finger motifs. [provided by RefSeq, Nov 2009]

ZNF702P Gene

zinc finger protein 702, pseudogene

LOC105372373 Gene

zinc finger protein 772

LOC100421332 Gene

zinc finger with KRAB and SCAN domains 1 pseudogene

ZNF215 Gene

zinc finger protein 215

ZNF214 Gene

zinc finger protein 214

ZNF217 Gene

zinc finger protein 217

ZNF211 Gene

zinc finger protein 211

This gene encodes a protein containing a Kruppel-associated box domain and multiple zinc finger domains. This protein may play a role in developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

ZNF212 Gene

zinc finger protein 212

This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions. [provided by RefSeq, Jul 2008]

LOC100132830 Gene

zinc finger CCCH-type containing 14 pseudogene

LOC391813 Gene

zinc finger, DHHC-type containing 3 pseudogene

ZNF534 Gene

zinc finger protein 534

ZNF536 Gene

zinc finger protein 536

ZNF530 Gene

zinc finger protein 530

ZNF532 Gene

zinc finger protein 532

ZBTB3 Gene

zinc finger and BTB domain containing 3

ZBTB1 Gene

zinc finger and BTB domain containing 1

LOC101929206 Gene

zinc finger protein 708-like

LOC100133225 Gene

zinc finger, DHHC-type containing 7 pseudogene

LOC100421074 Gene

ZFP14 zinc finger protein pseudogene

ZC3H8 Gene

zinc finger CCCH-type containing 8

ZC3H3 Gene

zinc finger CCCH-type containing 3

ZC3H4 Gene

zinc finger CCCH-type containing 4

This gene encodes a member of a family of CCCH (C-x8-C-x5-C-x3-H type) zinc finger domain-containing proteins. These zinc finger domains, which coordinate zinc finger binding and are characterized by three cysteine residues and one histidine residue, are nucleic acid-binding. Other family members are known to function in post-transcriptional regulation. [provided by RefSeq, Aug 2011]

LOC100130881 Gene

zinc finger protein 12 pseudogene

ZNF732 Gene

zinc finger protein 732

ZNF730 Gene

zinc finger protein 730

ZNF736 Gene

zinc finger protein 736

ZNF737 Gene

zinc finger protein 737

ZNF738 Gene

zinc finger protein 738

ZNF317P1 Gene

zinc finger protein 317 pseudogene 1

LOC100419679 Gene

zinc finger protein 670 pseudogene

LOC100129947 Gene

zinc finger protein 674 pseudogene

ZFYVE9P2 Gene

zinc finger, FYVE domain containing 9 pseudogene 2

ZFYVE9P1 Gene

zinc finger, FYVE domain containing 9 pseudogene 1

ZDHHC20P4 Gene

zinc finger, DHHC-type containing 20 pseudogene 4

ZDHHC20P2 Gene

zinc finger, DHHC-type containing 20 pseudogene 2

ZDHHC20P1 Gene

zinc finger, DHHC-type containing 20 pseudogene 1

ZNF69 Gene

zinc finger protein 69

ZNF66 Gene

zinc finger protein 66

LOC100287477 Gene

zinc finger protein 420-like

ZBED1 Gene

zinc finger, BED-type containing 1

This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies show that this gene product is localized in the nucleus and functions as a transcription factor. It binds to DNA elements found in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have a role in regulating genes related to cell proliferation. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene. [provided by RefSeq, Jan 2010]

ZBED2 Gene

zinc finger, BED-type containing 2

ZBED3 Gene

zinc finger, BED-type containing 3

ZBED5 Gene

zinc finger, BED-type containing 5

This gene is unusual in that its coding sequence is mostly derived from Charlie-like DNA transposon; however, it does not appear to be an active DNA transposon as it is not flanked by terminal inverted repeats. The encoded protein is conserved among the mammalian Laurasiatheria branch. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009]

ZBED6 Gene

zinc finger, BED-type containing 6

ZBED8 Gene

zinc finger, BED-type containing 8

ZBED9 Gene

zinc finger, BED-type containing 9

ZNF29P Gene

zinc finger protein 29, pseudogene

ZNF736P2Y Gene

zinc finger protein 736 pseudogene 2, Y-linked

GATAD2B Gene

GATA zinc finger domain containing 2B

ZNF296 Gene

zinc finger protein 296

ZNF292 Gene

zinc finger protein 292

ZNF962P Gene

zinc finger protein 962, pseudogene

ZNF37CP Gene

zinc finger protein 37C, pseudogene

ZNF821 Gene

zinc finger protein 821

This gene encodes a protein with two C2H2 zinc finger motifs and a score-and-three (23)-amino acid peptide repeat (STPR) domain. The STPR domain of the encoded protein binds to double stranded DNA and may also contain a nuclear localization signal, suggesting that this protein interacts with chromosomal DNA. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]

ZNF827 Gene

zinc finger protein 827

ZNF829 Gene

zinc finger protein 829

DBF4P1 Gene

DBF4 zinc finger pseudogene 1

ZNF311 Gene

zinc finger protein 311

ZNF316 Gene

zinc finger protein 316

ZNF317 Gene

zinc finger protein 317

ZNF318 Gene

zinc finger protein 318

ZNF319 Gene

zinc finger protein 319

LOC100419748 Gene

zinc finger protein 852 pseudogene

LOC100419741 Gene

zinc finger protein 772 pseudogene

ST18 Gene

suppression of tumorigenicity 18, zinc finger

DBF4B Gene

DBF4 zinc finger B

This gene encodes a regulator of the cell division cycle 7 homolog (S. cerevisiae) protein, a serine-threonine kinase which links cell cycle regulation to genome duplication. This protein localizes to the nucleus and, in complex with the cell division cycle 7 homolog (S. cerevisiae) protein, may facilitate M phase progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

ZNF818P Gene

zinc finger protein 818, pseudogene

ZC3HAV1L Gene

zinc finger CCCH-type, antiviral 1-like

ZFYVE19 Gene

zinc finger, FYVE domain containing 19

ZFYVE16 Gene

zinc finger, FYVE domain containing 16

This gene encodes an endosomal protein that belongs to the FYVE zinc finger family of proteins. The encoded protein is thought to regulate membrane trafficking in the endosome. This protein functions as a scaffold protein in the transforming growth factor-beta signaling pathway and is involved in positive and negative feedback regulation of the bone morphogenetic protein signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

ZC2HC1A Gene

zinc finger, C2HC-type containing 1A

ZNF886P Gene

zinc finger protein 886, pseudogene

ZNF33AP1 Gene

zinc finger protein 33A pseudogene 1

ZNF259P1 Gene

zinc finger protein 259 pseudogene 1

ZNF165 Gene

zinc finger protein 165

This gene encodes a member of the Kruppel family of zinc finger proteins. Members of this DNA-binding protein family act as transcriptional regulators. This gene is located within a cluster of zinc finger family members. The encoded protein may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]

LOC100131411 Gene

zinc finger protein 28 pseudogene

LOC100419896 Gene

zinc finger protein 267 pseudogene

LOC100419894 Gene

zinc finger protein 347 pseudogene

LOC100419895 Gene

zinc finger protein 670 pseudogene

LOC100419892 Gene

zinc finger protein 592 pseudogene

LOC100419890 Gene

zinc finger, MYM-type 4 pseudogene

LOC100419891 Gene

zinc finger protein 114 pseudogene

ZNF404 Gene

zinc finger protein 404

ZNF407 Gene

zinc finger protein 407

This gene encodes a zinc finger protein whose exact function is not known. It may be involved in transcriptional regulation. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

ZNF408 Gene

zinc finger protein 408

ZNF648 Gene

zinc finger protein 648

ZNF649 Gene

zinc finger protein 649

ZNF646 Gene

zinc finger protein 646

ZNF644 Gene

zinc finger protein 644

The protein encoded by this gene is a zinc finger transcription factor that may play a role in eye development. Defects in this gene have been associated with high myopia. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

ZNF645 Gene

zinc finger protein 645

This gene encodes a member of the zinc finger domain-containing protein family. This family member contains both a RING-type and a C2H2-type of zinc finger domain, and it may function as an E3 ubiquitin-protein ligase. Protein localization suggests a role in human sperm production and quality control. [provided by RefSeq, Aug 2011]

ZNF641 Gene

zinc finger protein 641

ZNF398 Gene

zinc finger protein 398

This gene encodes a member of the Kruppel family of C2H2-type zinc-finger transcription factor proteins. The encoded protein acts as a transcriptional activator. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described, but their full length sequence has not been determined. [provided by RefSeq, Jul 2008]

ZNF391 Gene

zinc finger protein 391

ZNF394 Gene

zinc finger protein 394

ZNF395 Gene

zinc finger protein 395

ZNF396 Gene

zinc finger protein 396

ZNF397 Gene

zinc finger protein 397

This gene encodes a protein with a N-terminal SCAN domain, and the longer isoform contains nine C2H2-type zinc finger repeats in the C-terminal domain. The protein localizes to centromeres during interphase and early prophase, and different isoforms can repress or activate transcription in transfection studies. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but their biological validity has not been determined. [provided by RefSeq, Oct 2009]

ZBTB8OSP2 Gene

zinc finger and BTB domain containing 8 opposite strand pseudogene 2

ZFP37 Gene

ZFP37 zinc finger protein

This gene encodes a transcription factor that belongs to a large family of zinc finger proteins. A similar protein in mouse is thought to play a role in regulating the structures of the nucleolus and centromere in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

ZFP30 Gene

ZFP30 zinc finger protein

ZNF774 Gene

zinc finger protein 774

ZNF542P Gene

zinc finger protein 542, pseudogene

ZBBX Gene

zinc finger, B-box domain containing

ZNF619 Gene

zinc finger protein 619

ZNF204P Gene

zinc finger protein 204, pseudogene

This locus represents a transcribed pseudogene, possibly of ZNF79 (GeneID 7633). The protein encoded by this locus would have significant N-terminal truncation, and would lack the KRAB domain and the C2H2 type zinc finger domain, compared to ZNF79. [provided by RefSeq, Jun 2011]

HELZ2 Gene

helicase with zinc finger 2, transcriptional coactivator

The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ZC3H11B Gene

zinc finger CCCH-type containing 11B pseudogene

LOC100887072 Gene

zinc finger protein 470 pseudogene

LOC100887071 Gene

zinc finger protein 845 pseudogene

LOC100887070 Gene

zinc finger protein 729 pseudogene

ZFC3H1 Gene

zinc finger, C3H1-type containing

LOC100419796 Gene

zinc finger protein 146 pseudogene

LOC100419553 Gene

zinc finger protein 35 pseudogene

LOC100419552 Gene

zinc finger protein 57 pseudogene

LOC105379260 Gene

putative zinc finger protein LOC441666

ZNF299P Gene

zinc finger protein 299, pseudogene

ZNF93 Gene

zinc finger protein 93

ZNF859P Gene

zinc finger protein 859, pseudogene

ZFX Gene

zinc finger protein, X-linked

This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]

ZNF321P Gene

zinc finger protein 321, pseudogene

ZC2HC1B Gene

zinc finger, C2HC-type containing 1B

ZC2HC1C Gene

zinc finger, C2HC-type containing 1C

ZNF891 Gene

zinc finger protein 891

LOC100287610 Gene

zinc finger protein 73-like

ZNF488 Gene

zinc finger protein 488

ZNF480 Gene

zinc finger protein 480

ZNF483 Gene

zinc finger protein 483

ZNF484 Gene

zinc finger protein 484

ZNF485 Gene

zinc finger protein 485

ZNF486 Gene

zinc finger protein 486

ZNF487 Gene

zinc finger protein 487

LOC100421368 Gene

zinc finger and SCAN domain containing 5A pseudogene

SNAI2 Gene

snail family zinc finger 2

This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008]

SNAI3 Gene

snail family zinc finger 3

SNAI3 is a member of the SNAIL gene family, named for the Drosophila snail gene, which plays roles in mesodermal formation during embryogenesis (Katoh and Katoh, 2003 [PubMed 12579345]).[supplied by OMIM, Apr 2009]

SNAI1 Gene

snail family zinc finger 1

The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008]

LOC100533634 Gene

zinc finger protein 737 pseudogene

DZIP3 Gene

DAZ interacting zinc finger protein 3

DZIP1 Gene

DAZ interacting zinc finger protein 1

ZNHIT1P1 Gene

zinc finger, HIT-type containing 1 pseudogene 1

ZNF587P1 Gene

zinc finger protein 587 pseudogene 1

ZNF569 Gene

zinc finger protein 569

ZNF568 Gene

zinc finger protein 568

ZNF567 Gene

zinc finger protein 567

ZNF566 Gene

zinc finger protein 566

ZNF565 Gene

zinc finger protein 565

ZNF564 Gene

zinc finger protein 564

ZNF563 Gene

zinc finger protein 563

ZNF562 Gene

zinc finger protein 562

ZNF561 Gene

zinc finger protein 561

ZNF849P Gene

zinc finger protein 849, pseudogene

LOC100996670 Gene

zinc finger, FYVE domain containing 9 pseudogene

ZNF169 Gene

zinc finger protein 169

ZNF286A Gene

zinc finger protein 286A

ZNF286B Gene

zinc finger protein 286B

ZNF160 Gene

zinc finger protein 160

The protein encoded by this gene is a Kruppel-related zinc finger protein which is characterized by the presence of an N-terminal repressor domain, the Kruppel-associated box (KRAB). The KRAB domain is a potent repressor of transcription; thus this protein may function in transcription regulation. Three alternative transcripts encoding the same protein have been described. [provided by RefSeq, Jul 2008]

ZNF768 Gene

zinc finger protein 768

ZNF765 Gene

zinc finger protein 765

ZNF764 Gene

zinc finger protein 764

ZNF766 Gene

zinc finger protein 766

ZNF761 Gene

zinc finger protein 761

ZNF763 Gene

zinc finger protein 763

ZNF34 Gene

zinc finger protein 34

ZNF35 Gene

zinc finger protein 35

ZNF32 Gene

zinc finger protein 32

ZNF30 Gene

zinc finger protein 30

ZNF804A Gene

zinc finger protein 804A

ZNF804B Gene

zinc finger protein 804B

ZNF658B Gene

zinc finger protein 658B, pseudogene

LOC441528 Gene

zinc finger protein 839-like

LOC401261 Gene

zinc finger protein ZIC 5

CIZ1 Gene

CDKN1A interacting zinc finger protein 1

The protein encoded by this gene is a zinc finger DNA binding protein that interacts with CIP1, part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

ZC4H2 Gene

zinc finger, C4H2 domain containing

This gene encodes a member of the zinc finger domain-containing protein family. This family member has a C-terminal zinc finger domain that is characterized by four cysteine residues and two histidine residues, and it also includes a coiled-coil region. This protein has been detected as an autoantigen in hepatocellular carcinoma patients. This gene has been identified as a potential candidate for X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

LOC100133252 Gene

zinc finger protein 131 pseudogene

ZNF264 Gene

zinc finger protein 264

This gene encodes a zinc finger protein and belongs to the krueppel C2H2-type zinc-finger protein family. Zinc finger proteins are often localized in the nucleus, bind nucleic acids, and regulate transcription. [provided by RefSeq, Jan 2010]

ZNF266 Gene

zinc finger protein 266

This gene encodes a protein containing many tandem zinc-finger motifs. Zinc fingers are protein or nucleic acid-binding domains, and may be involved in a variety of functions, including regulation of transcription. This gene is located in a cluster of similar genes encoding zinc finger proteins on chromosome 19. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Sep 2012]

ZNF260 Gene

zinc finger protein 260

ZNF263 Gene

zinc finger protein 263

ZNF268 Gene

zinc finger protein 268

ZBTB26 Gene

zinc finger and BTB domain containing 26

ZBTB24 Gene

zinc finger and BTB domain containing 24

This gene encodes a protein similar to a protein in rodents which is induced by bone morphogenic protein 2 in vitro. [provided by RefSeq, Aug 2011]

MZF1 Gene

myeloid zinc finger 1

LOC100419845 Gene

zinc finger protein 415 pseudogene

LOC100419844 Gene

zinc finger protein 610 pseudogene

LOC100419847 Gene

zinc finger protein 436 pseudogene

LOC100419841 Gene

zinc finger protein 107 pseudogene

LOC100419840 Gene

zinc finger protein 446 pseudogene

LOC100419842 Gene

zinc finger protein 396 pseudogene

LOC100128601 Gene

zinc finger protein 770 pseudogene

IKZF5 Gene

IKAROS family zinc finger 5 (Pegasus)

Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Pegasus, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]

IKZF4 Gene

IKAROS family zinc finger 4 (Eos)

Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Eos, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]

IKZF1 Gene

IKAROS family zinc finger 1 (Ikaros)

This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014]

IKZF3 Gene

IKAROS family zinc finger 3 (Aiolos)

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]

IKZF2 Gene

IKAROS family zinc finger 2 (Helios)

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

WIZ Gene

widely interspaced zinc finger motifs

ZNF879 Gene

zinc finger protein 879

ZNF878 Gene

zinc finger protein 878

LOC100421087 Gene

zinc finger, CCHC domain containing 9 pseudogene

ZC3H15 Gene

zinc finger CCCH-type containing 15

ZFP82 Gene

ZFP82 zinc finger protein

TSHZ2 Gene

teashirt zinc finger homeobox 2

TSHZ3 Gene

teashirt zinc finger homeobox 3

TSHZ1 Gene

teashirt zinc finger homeobox 1

This gene encodes a colon cancer antigen that was defined by serological analysis of recombinant cDNA expression libraries. The encoded protein is a member of the teashirt C2H2-type zinc-finger protein family and may be involved in transcriptional regulation of developmental processes. Mutations in this gene may be associated with congenital aural atresia syndrome. [provided by RefSeq, Jan 2012]

ZFAND6 Gene

zinc finger, AN1-type domain 6

ZFAND5 Gene

zinc finger, AN1-type domain 5

ZFAND4 Gene

zinc finger, AN1-type domain 4

ZFAND3 Gene

zinc finger, AN1-type domain 3

ZFAND1 Gene

zinc finger, AN1-type domain 1

ZNF92P1Y Gene

zinc finger protein 92 pseudogene 1, Y-linked

ZFYVE27 Gene

zinc finger, FYVE domain containing 27

This gene encodes a protein with several transmembrane domains, a Rab11-binding domain and a lipid-binding FYVE finger domain. The encoded protein appears to promote neurite formation. A mutation in this gene has been reported to be associated with hereditary spastic paraplegia, however the pathogenicity of the mutation, which may simply represent a polymorphism, is unclear. [provided by RefSeq, Mar 2010]

ZFYVE26 Gene

zinc finger, FYVE domain containing 26

This gene encodes a protein which contains a FYVE zinc finger binding domain. The presence of this domain is thought to target these proteins to membrane lipids through interaction with phospholipids in the membrane. Mutations in this gene are associated with autosomal recessive spastic paraplegia-15. [provided by RefSeq, Oct 2008]

ZFYVE28 Gene

zinc finger, FYVE domain containing 28

LOC105372810 Gene

putative zinc finger protein 355P

ZNF157 Gene

zinc finger protein 157

This gene product is a likely zinc finger family transcription factor. It contains KRAB-A and KRAB-B domains that act as transcriptional repressors in related proteins, and multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. This gene is part of a gene cluster on chromosome Xp11.23. [provided by RefSeq, Jul 2008]

ZNF154 Gene

zinc finger protein 154

This gene encodes a protein that belongs to the zinc finger Kruppel family of transcriptional regulators, whose members are thought to function in normal and abnormal cell growth and differentiation. Hypermethylation of this gene is associated with the recurrence of non muscle invasive bladder cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

ZNF155 Gene

zinc finger protein 155

LOC105369224 Gene

zinc finger protein 806 pseudogene

ZNF444P1 Gene

zinc finger protein 444 pseudogene 1

LOC344065 Gene

zinc finger protein 184 pseudogene

LOC100301990 Gene

zinc finger protein 610 pseudogene

ZNF887P Gene

zinc finger protein 887, pseudogene

LOC101060181 Gene

zinc finger protein ZnFP12

ZC3H7A Gene

zinc finger CCCH-type containing 7A

ZNF699 Gene

zinc finger protein 699

ZNF691 Gene

zinc finger protein 691

ZNF692 Gene

zinc finger protein 692

ZNF695 Gene

zinc finger protein 695

ZNF697 Gene

zinc finger protein 697

ZNF696 Gene

zinc finger protein 696

LOC100419712 Gene

zinc finger protein 12 pseudogene

LOC100419715 Gene

zinc finger protein 626 pseudogene

LOC100419716 Gene

zinc finger protein 709 pseudogene

ZNF343 Gene

zinc finger protein 343

ZNF341 Gene

zinc finger protein 341

ZNF347 Gene

zinc finger protein 347

ZNF346 Gene

zinc finger protein 346

The protein encoded by this gene is a nucleolar, zinc finger protein that preferentially binds to double-stranded (ds) RNA or RNA/DNA hybrids, rather than DNA alone. Mutational studies indicate that the zinc finger domains are not only essential for dsRNA binding, but are also required for its nucleolar localization. The encoded protein may be involved in cell growth and survival. It plays a role in protecting neurons by inhibiting cell cycle re-entry via stimulation of p21 gene expression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

ZNF345 Gene

zinc finger protein 345

LOC100421071 Gene

zinc finger, CCHC domain containing 10 pseudogene

ZBTB39 Gene

zinc finger and BTB domain containing 39

ZBTB38 Gene

zinc finger and BTB domain containing 38

The protein encoded by this gene is a zinc finger transcriptional activator that binds methylated DNA. The encoded protein can form homodimers or heterodimers through the zinc finger domains. In mouse, inhibition of this protein has been associated with apoptosis in some cell types. [provided by RefSeq, Jun 2010]

ZBTB33 Gene

zinc finger and BTB domain containing 33

This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, May 2010]

ZBTB32 Gene

zinc finger and BTB domain containing 32

ZBTB34 Gene

zinc finger and BTB domain containing 34

ZBTB37 Gene

zinc finger and BTB domain containing 37

LOC101929598 Gene

zinc finger CCHC domain-containing protein 10 pseudogene

LOC645749 Gene

zinc finger protein 131 pseudogene

LOC100419690 Gene

zinc finger protein 114 pseudogene

LOC100419691 Gene

zinc finger protein 114 pseudogene

LOC100419692 Gene

zinc finger protein 791 pseudogene

LOC100419693 Gene

zinc finger protein 114 pseudogene

DBF4 Gene

DBF4 zinc finger

ZNF75CP Gene

zinc finger protein 75C, pseudogene

ZGRF1 Gene

zinc finger, GRF-type containing 1

ZNF354A Gene

zinc finger protein 354A

ZNF354C Gene

zinc finger protein 354C

ZNF354B Gene

zinc finger protein 354B

ZNF602P Gene

zinc finger protein 602, pseudogene

ZNF90P2 Gene

zinc finger protein 90 pseudogene 2

ZNF90P3 Gene

zinc finger protein 90 pseudogene 3

ZNF90P1 Gene

zinc finger protein 90 pseudogene 1

GLIS2 Gene

GLIS family zinc finger 2

This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys.[provided by RefSeq, Jan 2010]

GLIS3 Gene

GLIS family zinc finger 3

This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2008]

GLIS1 Gene

GLIS family zinc finger 1

GLIS1 is a GLI (MIM 165220)-related Kruppel-like zinc finger protein that functions as an activator and repressor of transcription (Kim et al., 2002 [PubMed 12042312]).[supplied by OMIM, Mar 2008]

ZNF324B Gene

zinc finger protein 324B

ZNF324 Gene

zinc finger protein 324

ZNF320 Gene

zinc finger protein 320

ZNF320 encodes a Kruppel-like zinc finger protein. Members of this protein family are involved in activation or repression of transcription.[supplied by OMIM, Jul 2002]

FLYWCH1P1 Gene

FLYWCH-type zinc finger 1 pseudogene 1

LOC100419774 Gene

zinc finger protein 383 pseudogene

ZNF451 Gene

zinc finger protein 451

ZNF454 Gene

zinc finger protein 454

DBF4P2 Gene

DBF4 zinc finger pseudogene 2

DZIP1L Gene

DAZ interacting zinc finger protein 1-like

ZNF723P Gene

zinc finger protein 723, pseudogene

ZBTB8OSP1 Gene

zinc finger and BTB domain containing 8 opposite strand pseudogene 1

ZFAT Gene

zinc finger and AT hook domain containing

This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]

ZNF611 Gene

zinc finger protein 611

ZNF610 Gene

zinc finger protein 610

ZNF613 Gene

zinc finger protein 613

ZNF615 Gene

zinc finger protein 615

ZNF614 Gene

zinc finger protein 614

ZNF616 Gene

zinc finger protein 616

ZNF618 Gene

zinc finger protein 618

LOC100419791 Gene

zinc finger protein 449 pseudogene

LOC100419790 Gene

zinc finger protein 670 pseudogene

LOC100419795 Gene

zinc finger, MYM-type 1 pseudogene

LOC100419794 Gene

zinc finger protein 449 pseudogene

ZSCAN29 Gene

zinc finger and SCAN domain containing 29

ZSCAN25 Gene

zinc finger and SCAN domain containing 25

This gene encodes a protein that bears some similarity to zinc finger proteins, which are involved in DNA binding and protein-protein interactions. Multiple alternatively spliced transcript variants have been identified, but the full-length nature for most of them has not been determined. [provided by RefSeq, Jul 2008]

ZSCAN26 Gene

zinc finger and SCAN domain containing 26

ZSCAN20 Gene

zinc finger and SCAN domain containing 20

ZSCAN21 Gene

zinc finger and SCAN domain containing 21

ZSCAN22 Gene

zinc finger and SCAN domain containing 22

ZSCAN23 Gene

zinc finger and SCAN domain containing 23

LOC100533637 Gene

zinc finger protein 83 pseudogene

LOC100533633 Gene

zinc finger protein 257 pseudogene

LOC100533632 Gene

zinc finger protein 736 pseudogene

ZNF518B Gene

zinc finger protein 518B

ZNF518A Gene

zinc finger protein 518A

The protein encoded by this gene is a member of the krueppel C2H2-type zinc finger protein family. The encoded protein contains five zinc fingers and is likely a nuclear transcriptional regulator. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

ANKZF1 Gene

ankyrin repeat and zinc finger domain containing 1

ZNF556 Gene

zinc finger protein 556

ZNF557 Gene

zinc finger protein 557

ZNF554 Gene

zinc finger protein 554

ZNF555 Gene

zinc finger protein 555

ZNF552 Gene

zinc finger protein 552

ZNF550 Gene

zinc finger protein 550

ZNF551 Gene

zinc finger protein 551

ZNF558 Gene

zinc finger protein 558

ZNF559 Gene

zinc finger protein 559

ZNF209P Gene

zinc finger protein 209, pseudogene

LOC100131832 Gene

ZFP91 zinc finger protein pseudogene

LOC729532 Gene

zinc finger protein 207 pseudogene

ZNF790 Gene

zinc finger protein 790

ZNF791 Gene

zinc finger protein 791

ZNF792 Gene

zinc finger protein 792

ZNF793 Gene

zinc finger protein 793

ZNF799 Gene

zinc finger protein 799

ZNF833P Gene

zinc finger protein 833, pseudogene

ZNF185 Gene

zinc finger protein 185 (LIM domain)

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a LIM-domain zinc finger protein. The LIM domain is composed of two contiguous zinc finger domains, separated by a two-amino acid residue hydrophobic linker. The LIM domain mediates protein:protein interactions. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, May 2010]

ZNF184 Gene

zinc finger protein 184

ZNF181 Gene

zinc finger protein 181

Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See MIM 604749 for additional information on zinc finger proteins.[supplied by OMIM, Jul 2003]

ZNF180 Gene

zinc finger protein 180

Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See MIM 604749 for additional information on zinc finger proteins.[supplied by OMIM, Jul 2002]

ZNF182 Gene

zinc finger protein 182

Zinc-finger proteins bind nucleic acids and play important roles in various cellular functions, including cell proliferation, differentiation, and apoptosis. This gene encodes a zinc finger protein, and belongs to the krueppel C2H2-type zinc-finger protein family. It may be involved in transcriptional regulation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, May 2010]

ZNF189 Gene

zinc finger protein 189

Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a variable number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al., 1998 [PubMed 9653648]). Approximately 30% of human Kruppel-like zinc finger proteins contain an N-terminal Kruppel-associated box (KRAB) domain. The KRAB domain consists of approximately 75 amino acids that may be subdivided into an A box, which is present in every KRAB domain and is essential for transcriptional repression, and a B box, which is not always present.[supplied by OMIM, May 2010]

ZNF239 Gene

zinc finger protein 239

MOK2 proteins are DNA- and RNA-binding proteins that are mainly associated with nuclear RNP components, including the nucleoli and extranucleolar structures (Arranz et al., 1997 [PubMed 9121460]).[supplied by OMIM, Mar 2008]

ZNF236 Gene

zinc finger protein 236

ZNF235 Gene

zinc finger protein 235

This gene product belongs to the zinc finger protein superfamily, members of which are regulatory proteins characterized by nucleic acid-binding zinc finger domains. The encoded protein is a member of the Kruppel family of zinc finger proteins, and contains Kruppel-associated box (KRAB) A and B domains and 15 tandemly arrayed C2H2-type zinc fingers. It is an ortholog of the mouse Zfp93 protein. This gene is located in a cluster of zinc finger genes on 19q13.2. [provided by RefSeq, Jul 2008]

ZNF234 Gene

zinc finger protein 234

ZNF233 Gene

zinc finger protein 233

ZNF232 Gene

zinc finger protein 232

ZNF230 Gene

zinc finger protein 230

LOC100129734 Gene

zinc finger, AN1-type domain 1 pseudogene

LOC100419870 Gene

zinc finger protein 717 pseudogene

LOC100419872 Gene

zinc finger, MYM-type 4 pseudogene

LOC100418549 Gene

zinc finger protein 93 pseudogene

ZNF880 Gene

zinc finger protein 880

ZNF883 Gene

zinc finger protein 883

LOC100132599 Gene

zinc finger protein 114 pseudogene

ZNF718 Gene

zinc finger protein 718

ZNF714 Gene

zinc finger protein 714

ZNF716 Gene

zinc finger protein 716

ZNF710 Gene

zinc finger protein 710

ZNF711 Gene

zinc finger protein 711

This gene encodes a zinc finger protein of unknown function. It bears similarity to a zinc finger protein which acts as a transcriptional activator. This gene lies in a region of the X chromosome which has been associated with mental retardation. [provided by RefSeq, Jul 2008]

ZNF713 Gene

zinc finger protein 713

The protein encoded by this gene contains C2H2 zinc finger domains. In some individuals a CGG-repeat expansion mutation has been identified in the first intron of this gene. This mutation is thought to effect the expression of this gene and it has been proposed that it may be associated with Autistic Spectrum Disorder. [provided by RefSeq, Feb 2015]

ZNF45 Gene

zinc finger protein 45

ZNF44 Gene

zinc finger protein 44

ZNF43 Gene

zinc finger protein 43

This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions. [provided by RefSeq, Jul 2008]

ZNF41 Gene

zinc finger protein 41

This gene product is a likely zinc finger family transcription factor. It contains KRAB-A and KRAB-B domains that act as transcriptional repressors in related proteins, and multiple zinc finger DNA binding motifs and finger linking regions characteristic of the Kruppel family. This gene is part of a gene cluster on chromosome Xp11.23. Several alternatively spliced transcript variants have been described, however, the full-length nature of only some of them is known. [provided by RefSeq, Jul 2008]

ZNF48 Gene

zinc finger protein 48

ZNF717 Gene

zinc finger protein 717

VEZF1 Gene

vascular endothelial zinc finger 1

Transcriptional regulatory proteins containing tandemly repeated zinc finger domains are thought to be involved in both normal and abnormal cellular proliferation and differentiation. ZNF161 is a C2H2-type zinc finger protein (Koyano-Nakagawa et al., 1994 [PubMed 8035792]). See MIM 603971 for general information on zinc finger proteins.[supplied by OMIM, Sep 2008]

LOC100631319 Gene

zinc finger protein 273 pseudogene

LOC100631318 Gene

zinc finger protein 85 pseudogene

LOC100131257 Gene

zinc finger protein 655 pseudogene

ZNF734P Gene

zinc finger protein 734, pseudogene

ZNF107 Gene

zinc finger protein 107

This gene encodes a protein containing multiple C2H2-type zinc finger regions. Proteins containing zinc fingers may act as transcriptional regulators, but may also have other cellular functions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

ZNF106 Gene

zinc finger protein 106

ZNF101 Gene

zinc finger protein 101

Zinc finger proteins (ZNFs), such as ZNF101, bind nucleic acids and perform many key functions, the most important of which is regulating transcription (summary by Bellefroid et al., 1993 [PubMed 8467795]). See ZNF91 (MIM 603971) for general information on ZNFs.[supplied by OMIM, Nov 2010]

ZNF100 Gene

zinc finger protein 100

TRAFD1 Gene

TRAF-type zinc finger domain containing 1

The innate immune system confers host defense against viral and microbial infection, and TRAFD1 is a negative feedback regulator that controls excessive immune responses (Sanada et al., 2008 [PubMed 18849341]).[supplied by OMIM, Dec 2009]

ZFP64P1 Gene

ZFP64 zinc finger protein pseudogene 1

LOC100289569 Gene

zinc finger protein 736 pseudogene

LOC645937 Gene

zinc finger protein 598 pseudogene

ZNF75A Gene

zinc finger protein 75a

ZNF560 Gene

zinc finger protein 560

LOC105379617 Gene

zinc finger protein 430-like

ZNF808 Gene

zinc finger protein 808

ZNF805 Gene

zinc finger protein 805

ZNF806 Gene

zinc finger protein 806

ZNF807 Gene

zinc finger protein 807

ZNF800 Gene

zinc finger protein 800

LOC100419721 Gene

zinc finger protein 670 pseudogene

ZNF37A Gene

zinc finger protein 37A

LOC105372319 Gene

putative zinc finger protein 56

ZBTB40 Gene

zinc finger and BTB domain containing 40

ZBTB41 Gene

zinc finger and BTB domain containing 41

ZBTB42 Gene

zinc finger and BTB domain containing 42

The protein encoded by this gene is a member of the C2H2 zinc finger protein family. This protein is predicted to have a pox virus and zinc finger (POZ) domain at the N-terminus and four zinc finger domains at the C-terminus. In human and mouse, the protein localizes to the nuclei of skeletal muscle cells. Knockdown of this gene in zebrafish results in abnormal skeletal muscle development and myofibrillar disorganization. A novel homozygous variant of the human gene has been associated with lethal congenital contracture syndrome, an autosomal recessive disorder that results in muscle wasting. [provided by RefSeq, Mar 2015]

ZBTB43 Gene

zinc finger and BTB domain containing 43

ZBTB44 Gene

zinc finger and BTB domain containing 44

ZBTB45 Gene

zinc finger and BTB domain containing 45

ZBTB46 Gene

zinc finger and BTB domain containing 46

ZBTB47 Gene

zinc finger and BTB domain containing 47

ZBTB48 Gene

zinc finger and BTB domain containing 48

ZBTB49 Gene

zinc finger and BTB domain containing 49

ZNF816 Gene

zinc finger protein 816

ZNF814 Gene

zinc finger protein 814

ZNF101P2 Gene

zinc finger protein 101 pseudogene 2

ZNF101P1 Gene

zinc finger protein 101 pseudogene 1

LOC399783 Gene

zinc finger protein 532 pseudogene

LOC100128948 Gene

zinc finger protein 607 pseudogene

ZIK1P1 Gene

zinc finger protein interacting with K protein 1 pseudogene 1

ZNF736P8Y Gene

zinc finger protein 736 pseudogene 8, Y-linked

ZFY Gene

zinc finger protein, Y-linked

This gene encodes a zinc finger-containing protein that may function as a transcription factor. This gene was once a candidate gene for the testis-determining factor (TDF) and was erroneously referred to as TDF. [provided by RefSeq, Jul 2008]

ZNF888 Gene

zinc finger protein 888

ZDHHC1 Gene

zinc finger, DHHC-type containing 1

ZDHHC2 Gene

zinc finger, DHHC-type containing 2

ZDHHC5 Gene

zinc finger, DHHC-type containing 5

ZDHHC4 Gene

zinc finger, DHHC-type containing 4

ZDHHC7 Gene

zinc finger, DHHC-type containing 7

ZDHHC6 Gene

zinc finger, DHHC-type containing 6

ZDHHC9 Gene

zinc finger, DHHC-type containing 9

This gene encodes an integral membrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein forms a complex with golgin subfamily A member 7 and functions as a palmitoyltransferase. This protein specifically palmitoylates HRAS and NRAS. Mutations in this gene are associated with X-linked mental retardation. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, May 2010]

ZDHHC8 Gene

zinc finger, DHHC-type containing 8

This gene encodes a four transmembrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein may function as a palmitoyltransferase. Defects in this gene may be associated with a susceptibility to schizophrenia. Alternate splicing of this gene results in multiple transcript variants. A pseudogene of this gene is found on chromosome 22.[provided by RefSeq, May 2010]

ZNF468 Gene

zinc finger protein 468

ZNF469 Gene

zinc finger protein 469

This gene encodes a zinc-finger protein. Low-percent homology to certain collagens suggests that it may function as a transcription factor or extra-nuclear regulator factor for the synthesis or organization of collagen fibers. Mutations in this gene cause brittle cornea syndrome. [provided by RefSeq, Jul 2008]

ZNF462 Gene

zinc finger protein 462

ZNF461 Gene

zinc finger protein 461

ZNF467 Gene

zinc finger protein 467

ZDHHC4P1 Gene

zinc finger, DHHC-type containing 4 pseudogene 1

LOC100130990 Gene

zinc finger protein 561-like

ZNF668 Gene

zinc finger protein 668

ZNF669 Gene

zinc finger protein 669

ZNF660 Gene

zinc finger protein 660

ZNF662 Gene

zinc finger protein 662

ZNF664 Gene

zinc finger protein 664

ZNF665 Gene

zinc finger protein 665

ZNF667 Gene

zinc finger protein 667

ZBTB12P1 Gene

zinc finger and BTB domain containing 12 pseudogene 1

ZFP57 Gene

ZFP57 zinc finger protein

The protein encoded by this gene is a zinc finger protein containing a KRAB domain. Studies in mouse suggest that this protein may function as a transcriptional repressor. Mutations in this gene have been associated with transient neonatal diabetes mellitus type 1 (TNDM1).[provided by RefSeq, Sep 2009]

LOC441666 Gene

zinc finger protein 91 pseudogene

ZEB2 Gene

zinc finger E-box binding homeobox 2

The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]

ZNF890P Gene

zinc finger protein 890, pseudogene

ZNF652P1 Gene

zinc finger protein 652 pseudogene 1

ZNF587B Gene

zinc finger protein 587B

ZBED1P1 Gene

zinc finger, BED-type containing 1 pseudogene 1

FLYWCH1 Gene

FLYWCH-type zinc finger 1

LOC100419908 Gene

zinc finger protein 585A pseudogene

AZFP Gene

AML-associated zinc finger protein

ZNF415P1 Gene

zinc finger protein 415 pseudogene 1

ZNF207 Gene

zinc finger protein 207

ZNF205 Gene

zinc finger protein 205

ZNF202 Gene

zinc finger protein 202

ZNF200 Gene

zinc finger protein 200

ZNF208 Gene

zinc finger protein 208

Zinc finger proteins (ZNFs), such as ZNF208, bind DNA and, through this binding, regulate gene transcription. Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. A conserved protein motif, termed the Kruppel-associated box (KRAB) domain, mediates protein-protein interactions (Eichler et al., 1998 [PubMed 9724325]). See ZNF91 (MIM 603971) for further information on ZNFs.[supplied by OMIM, Aug 2009]

ZNF839P1 Gene

zinc finger protein 839 pseudogene 1

ZFYVE9 Gene

zinc finger, FYVE domain containing 9

This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

ZFYVE1 Gene

zinc finger, FYVE domain containing 1

The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

ZNF114P1 Gene

zinc finger protein 114 pseudogene 1

ZNF492 Gene

zinc finger protein 492

ZNF491 Gene

zinc finger protein 491

ZSCAN5D Gene

zinc finger and SCAN domain containing 5D

ZSCAN5A Gene

zinc finger and SCAN domain containing 5A

ZSCAN5B Gene

zinc finger and SCAN domain containing 5B

LOC105370704 Gene

putative zinc finger protein 355P

ZNF501 Gene

zinc finger protein 501

ZNF500 Gene

zinc finger protein 500

ZNF503 Gene

zinc finger protein 503

ZNF502 Gene

zinc finger protein 502

ZNF507 Gene

zinc finger protein 507

ZNF506 Gene

zinc finger protein 506

ZNF847P Gene

zinc finger protein 847, pseudogene

ZBTB8OS Gene

zinc finger and BTB domain containing 8 opposite strand

ZBTB2 Gene

zinc finger and BTB domain containing 2

ZBTB6 Gene

zinc finger and BTB domain containing 6

ZBTB5 Gene

zinc finger and BTB domain containing 5

ZBTB4 Gene

zinc finger and BTB domain containing 4

ZBTB9 Gene

zinc finger and BTB domain containing 9

PATZ1 Gene

POZ (BTB) and AT hook containing zinc finger 1

The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene. [provided by RefSeq, Jul 2008]

LOC100419831 Gene

zinc finger protein 420 pseudogene

LOC100419833 Gene

zinc finger protein 709 pseudogene

LOC100419835 Gene

zinc finger protein 160 pseudogene

ZCCHC9 Gene

zinc finger, CCHC domain containing 9

ZCCHC8 Gene

zinc finger, CCHC domain containing 8

ZCCHC3 Gene

zinc finger, CCHC domain containing 3

ZCCHC2 Gene

zinc finger, CCHC domain containing 2

ZCCHC7 Gene

zinc finger, CCHC domain containing 7

ZCCHC6 Gene

zinc finger, CCHC domain containing 6

ZCCHC5 Gene

zinc finger, CCHC domain containing 5

This gene is a member of a family of gag-related retrotransposon genes. These genes appear to have lost the ability to retrotranspose; however, their open reading frames have remained intact, which may indicate that these genes have acquired new functions in the cell. [provided by RefSeq, Nov 2009]

ZCCHC4 Gene

zinc finger, CCHC domain containing 4

ZNF747 Gene

zinc finger protein 747

ZNF746 Gene

zinc finger protein 746

ZNF740 Gene

zinc finger protein 740

ZNF749 Gene

zinc finger protein 749

LOC100419642 Gene

zinc finger protein 85 pseudogene

ZNF18 Gene

zinc finger protein 18

ZNF19 Gene

zinc finger protein 19

The protein encoded by this gene contains a zinc finger, a nucleic acid-binding domain present in many transcription factors. This gene is located in a region next to ZNF23, a gene also encoding a zinc finger protein, on chromosome 16. [provided by RefSeq, Jul 2008]

ZNF14 Gene

zinc finger protein 14

The protein encoded by this gene contains a zinc finger and a Kruppel-associated box (KRAB) domain. KRAB domain is known to be involved in the transcriptional repression of a number of zinc finger proteins. [provided by RefSeq, Jul 2008]

ZNF16 Gene

zinc finger protein 16

The protein encoded by this gene contains multiple tandem zinc finger motifs. The encoded protein is involved in the differentiation of erythroid and megakaryocytic cells. This gene is located in a cluster of related genes on chromosome 8 encoding zinc finger proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

ZNF17 Gene

zinc finger protein 17

ZNF10 Gene

zinc finger protein 10

The protein encoded by this gene contains a C2H2 zinc finger, and has been shown to function as a transcriptional repressor. The Kruppel-associated box (KRAB) domain of this protein is found to be responsible for its transcriptional repression activity. RING finger containing protein TIF1 was reported to interact with the KRAB domain, and may serve as a mediator for the repression activity of this protein. [provided by RefSeq, Jul 2008]

ZNF12 Gene

zinc finger protein 12

This gene is a member of the krueppel C2H2-type zinc-finger protein family and encodes a protein with eight C2H2-type zinc fingers and a KRAB domain. This nuclear protein is involved in developmental control of gene expression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

ZC3H11A Gene

zinc finger CCCH-type containing 11A

LOC100631320 Gene

zinc finger protein 486 pseudogene

LOC100631321 Gene

zinc finger protein 100 pseudogene

BAZ1B Gene

bromodomain adjacent to zinc finger domain, 1B

This gene encodes a member of the bromodomain protein family. The bromodomain is a structural motif characteristic of proteins involved in chromatin-dependent regulation of transcription. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23. [provided by RefSeq, Jul 2008]

ZZEF1 Gene

zinc finger, ZZ-type with EF-hand domain 1

ZNF287 Gene

zinc finger protein 287

This gene encodes a member of the krueppel family of zinc finger proteins, suggesting a role as a transcription factor. Its specific function has not been determined. This gene is located near the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

ZNF284 Gene

zinc finger protein 284

ZNF285 Gene

zinc finger protein 285

ZNF282 Gene

zinc finger protein 282

ZNF283 Gene

zinc finger protein 283

ZNF281 Gene

zinc finger protein 281

SNAI1P1 Gene

snail family zinc finger 1 pseudogene 1

LOC101930105 Gene

zinc finger protein 839-like

LOC100419825 Gene

zinc finger protein 655 pseudogene

ZNF37BP Gene

zinc finger protein 37B, pseudogene

ZNF780A Gene

zinc finger protein 780A

ZNF780B Gene

zinc finger protein 780B

ZMAT1 Gene

zinc finger, matrin-type 1

This gene encodes a protein containing Cys2-His2 (C2H2)-type zinc fingers, which are similar to those found in the nuclear matrix protein matrin 3. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

ZMAT3 Gene

zinc finger, matrin-type 3

This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008]

ZMAT2 Gene

zinc finger, matrin-type 2

ZMAT5 Gene

zinc finger, matrin-type 5

ZMAT4 Gene

zinc finger, matrin-type 4

ZNF720P1 Gene

zinc finger protein 720 pseudogene 1

ZNF853 Gene

zinc finger protein 853

ZNF852 Gene

zinc finger protein 852

ZNF850 Gene

zinc finger protein 850

ZNF581 Gene

zinc finger protein 581

ZNF580 Gene

zinc finger protein 580

ZNF583 Gene

zinc finger protein 583

ZNF582 Gene

zinc finger protein 582

ZNF584 Gene

zinc finger protein 584

ZNF587 Gene

zinc finger protein 587

ZNF586 Gene

zinc finger protein 586

ZNF589 Gene

zinc finger protein 589

ZNF326 Gene

zinc finger protein 326

ZNF322 Gene

zinc finger protein 322

ZNF322A is a member of the zinc-finger transcription factor family and may regulate transcriptional activation in MAPK (see MAPK1; MIM 176948) signaling pathways (Li et al., 2004 [PubMed 15555580]).[supplied by OMIM, Mar 2008]

ZNF329 Gene

zinc finger protein 329

LOC100419779 Gene

zinc finger protein 195 pseudogene

LOC100419775 Gene

zinc finger protein 519 pseudogene

LOC100419773 Gene

zinc finger protein 33B pseudogene

ZNF517 Gene

zinc finger protein 517

ZSCAN12P1 Gene

zinc finger and SCAN domain containing 12 pseudogene 1

ZNF123P Gene

zinc finger protein 123, pseudogene

GZF1 Gene

GDNF-inducible zinc finger protein 1

LOC100287754 Gene

zinc finger protein 44 pseudogene

ZNF90 Gene

zinc finger protein 90

ZNF91 Gene

zinc finger protein 91

The ZNF91 gene encodes a zinc finger protein of the KRAB (Kruppel-associated box) subfamily (Bellefroid et al., 1991, 1993 [PubMed 2023909] [PubMed 8467795]).[supplied by OMIM, May 2010]

ZNF92 Gene

zinc finger protein 92

ZNF98 Gene

zinc finger protein 98

ZNF99 Gene

zinc finger protein 99

ZCWPW2 Gene

zinc finger, CW type with PWWP domain 2

ZCWPW1 Gene

zinc finger, CW type with PWWP domain 1

LOC101269108 Gene

zinc finger, FYVE domain containing 9 pseudogene

ZRANB1 Gene

zinc finger, RAN-binding domain containing 1

ZRANB3 Gene

zinc finger, RAN-binding domain containing 3

ZRANB2 Gene

zinc finger, RAN-binding domain containing 2

ZNF845 Gene

zinc finger protein 845

ZNF731P Gene

zinc finger protein 731, pseudogene

ZNF597 Gene

zinc finger protein 597

ZNF594 Gene

zinc finger protein 594

ZDHHC15 Gene

zinc finger, DHHC-type containing 15

The protein encoded by this gene belongs to the DHHC palmitoyltransferase family. Mutations in this gene are associated with mental retardatio X-linked type 91 (MRX91). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

ZDHHC14 Gene

zinc finger, DHHC-type containing 14

ZDHHC17 Gene

zinc finger, DHHC-type containing 17

ZDHHC16 Gene

zinc finger, DHHC-type containing 16

ZDHHC11 Gene

zinc finger, DHHC-type containing 11

ZDHHC13 Gene

zinc finger, DHHC-type containing 13

ZDHHC12 Gene

zinc finger, DHHC-type containing 12

ZDHHC19 Gene

zinc finger, DHHC-type containing 19

ZDHHC18 Gene

zinc finger, DHHC-type containing 18

ZNF174 Gene

zinc finger protein 174

ZNF175 Gene

zinc finger protein 175

ZNF177 Gene

zinc finger protein 177

ZDBF2 Gene

zinc finger, DBF-type containing 2

ZZZ3 Gene

zinc finger, ZZ-type containing 3

ZNF436 Gene

zinc finger protein 436

ZNF431 Gene

zinc finger protein 431

ZNF430 Gene

zinc finger protein 430

ZNF433 Gene

zinc finger protein 433

ZNF432 Gene

zinc finger protein 432

ZNF439 Gene

zinc finger protein 439

ZNF438 Gene

zinc finger protein 438

LOC400682 Gene

zinc finger protein 100-like

ZNF885P Gene

zinc finger protein 885, pseudogene

LOC100631243 Gene

zinc finger protein 211 pseudogene

LOC100631242 Gene

zinc finger protein 852 pseudogene

LOC724084 Gene

zinc finger protein 706 pseudogene

ZFP28 Gene

ZFP28 zinc finger protein

ZNF736P9Y Gene

zinc finger protein 736 pseudogene 9, Y-linked

ZNF280D Gene

zinc finger protein 280D

ZNF280C Gene

zinc finger protein 280C

This gene encodes a member of the zinc finger domain-containing protein family. This family member contains multiple Cys2-His2(C2H2)-type zinc finger domains, the most common type of zinc finger domain that self-folds to form a beta-beta-alpha structure that binds a zinc ion. [provided by RefSeq, Aug 2011]

ZNF280B Gene

zinc finger protein 280B

The protein encoded by this gene is a transcription factor that upregulates expression of MDM2, which negatively regulates p53 expression. This gene is highly expressed in prostate cancer cells, which leads to a reduction in p53 levels and an increase in growth of the cancer cells. Several transcript variants have been found for this gene, but only one of them is protein-coding. [provided by RefSeq, Jan 2015]

ZNF280A Gene

zinc finger protein 280A

This gene encodes a zinc finger protein. The encoded protein contains 4 C2H2-type zinc fingers, which are commonly found in transcription factors. A variety of functions may be performed by this type of zinc finger protein, including the binding of DNA or RNA. [provided by RefSeq, Apr 2014]

ZBTB12 Gene

zinc finger and BTB domain containing 12

ZBTB11 Gene

zinc finger and BTB domain containing 11

ZBTB17 Gene

zinc finger and BTB domain containing 17

This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq, Jul 2008]

ZBTB16 Gene

zinc finger and BTB domain containing 16

This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]

ZBTB14 Gene

zinc finger and BTB domain containing 14

ZBTB18 Gene

zinc finger and BTB domain containing 18

This gene encodes a C2H2-type zinc finger protein which acts a transcriptional repressor of genes involved in neuronal development. The encoded protein recognizes a specific sequence motif and recruits components of chromatin to target genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

LOC100421184 Gene

zinc finger and BTB domain containing 2 pseudogene

LOC105372277 Gene

zinc finger protein 799-like

LOC100419545 Gene

zinc finger protein 35 pseudogene

ZSWIM4 Gene

zinc finger, SWIM-type containing 4

ZSWIM5 Gene

zinc finger, SWIM-type containing 5

ZSWIM6 Gene

zinc finger, SWIM-type containing 6

ZSWIM7 Gene

zinc finger, SWIM-type containing 7

ZSWIM1 Gene

zinc finger, SWIM-type containing 1

ZSWIM2 Gene

zinc finger, SWIM-type containing 2

ZSWIM3 Gene

zinc finger, SWIM-type containing 3

ZSWIM8 Gene

zinc finger, SWIM-type containing 8

MAZ Gene

MYC-associated zinc finger protein (purine-binding transcription factor)

ZBTB10 Gene

zinc finger and BTB domain containing 10

UNK Gene

unkempt family zinc finger

LOC100421372 Gene

zinc finger and SCAN domain containing 29 pseudogene

ZNF876P Gene

zinc finger protein 876, pseudogene

ZNF137P Gene

zinc finger protein 137, pseudogene

ZNF639 Gene

zinc finger protein 639

This gene encodes a member of the Kruppel-like zinc finger family of proteins. Amplification and overexpression of this gene have been observed in esophageal squamous cell carcinoma. The encoded protein has been shown to bind DNA in a sequence-specific manner and may regulate HIV-1 gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

ZNF638 Gene

zinc finger protein 638

The protein encoded by this gene is a nucleoplasmic protein. It binds cytidine-rich sequences in double-stranded DNA. This protein has three types of domains: MH1, MH2 (repeated three times) and MH3. It is associated with packaging, transferring, or processing transcripts. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]

ZNF630 Gene

zinc finger protein 630

This gene encodes a protein containing an N-terminal Kruppel-associated box-containing (KRAB) domain and 13 Kruppel-type C2H2 zinc finger domains. This gene resides on an area of chromosome X that has been implicated in nonsyndromic X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

LOC100418555 Gene

zinc finger protein 70 pseudogene

SCRT1 Gene

scratch family zinc finger 1

This gene encodes a C2H2-type zinc finger transcriptional repressor that binds to E-box motifs. The encoded protein may promote neural differention and may be involved in cancers with neuroendocrine features. [provided by RefSeq, Jul 2013]

SCRT2 Gene

scratch family zinc finger 2

LOC389906 Gene

zinc finger protein 839 pseudogene

LOC730110 Gene

zinc finger protein 492 pseudogene

LOC728587 Gene

zinc finger protein 736 pseudogene

ZNF570 Gene

zinc finger protein 570

ZNF571 Gene

zinc finger protein 571

ZNF572 Gene

zinc finger protein 572

ZNF573 Gene

zinc finger protein 573

ZNF574 Gene

zinc finger protein 574

ZNF575 Gene

zinc finger protein 575

ZNF576 Gene

zinc finger protein 576

ZNF577 Gene

zinc finger protein 577

ZNF578 Gene

zinc finger protein 578

ZNF579 Gene

zinc finger protein 579

LOC105376056 Gene

putative zinc finger protein LOC441666

OVOL3 Gene

ovo-like zinc finger 3

JAZF1 Gene

JAZF zinc finger 1

This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized [provided by RefSeq, Jul 2008]

ZCCHC13 Gene

zinc finger, CCHC domain containing 13

This gene appears to represent an intronless retrocopy of a related multi-exon gene located on chromosome 3. However, the CDS of this intronless gene remains relatively intact, it is conserved in other mammalian species, it is known to be transcribed, and it is therefore thought to encode a functional protein. The encoded protein contains six CCHC-type zinc fingers, and is thus thought to function as a transcription factor. [provided by RefSeq, May 2010]

ZNF778 Gene

zinc finger protein 778

The protein encoded by this gene is a member of the krueppel C2H2-type zinc-finger protein family, and it contains one KRAB domain and eighteen C2H2-type zinc fingers. This gene is a candidate gene for autism and variable cognitive impairment in the 16q24.3 microdeletion syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2011]

ZNF776 Gene

zinc finger protein 776

ZNF777 Gene

zinc finger protein 777

ZNF775 Gene

zinc finger protein 775

ZNF772 Gene

zinc finger protein 772

ZNF773 Gene

zinc finger protein 773

ZNF770 Gene

zinc finger protein 770

ZNF771 Gene

zinc finger protein 771

BAZ2A Gene

bromodomain adjacent to zinc finger domain, 2A

BAZ2B Gene

bromodomain adjacent to zinc finger domain, 2B

ZNF25