Name

TRP-AGG1-1 Gene

transfer RNA-Pro (AGG) 1-1

TRP-AGG6-1 Gene

transfer RNA-Pro (AGG) 6-1

TRP-TGG3-5 Gene

transfer RNA-Pro (TGG) 3-5

TRP-TGG3-4 Gene

transfer RNA-Pro (TGG) 3-4

TRP-TGG3-3 Gene

transfer RNA-Pro (TGG) 3-3

TRP-TGG3-2 Gene

transfer RNA-Pro (TGG) 3-2

TRP-TGG3-1 Gene

transfer RNA-Pro (TGG) 3-1

TRP-TGG2-1 Gene

transfer RNA-Pro (TGG) 2-1

TRP-AGG4-1 Gene

transfer RNA-Pro (AGG) 4-1

TRP-AGG5-1 Gene

transfer RNA-Pro (AGG) 5-1

TRP-AGG2-3 Gene

transfer RNA-Pro (AGG) 2-3

TRP-AGG2-8 Gene

transfer RNA-Pro (AGG) 2-8

TRP-AGG3-1 Gene

transfer RNA-Pro (AGG) 3-1

TRP-AGG2-5 Gene

transfer RNA-Pro (AGG) 2-5

TRP-CGG1-1 Gene

transfer RNA-Pro (CGG) 1-1

TRP-CGG1-2 Gene

transfer RNA-Pro (CGG) 1-2

TRP-CGG1-3 Gene

transfer RNA-Pro (CGG) 1-3

TRP-AGG2-1 Gene

transfer RNA-Pro (AGG) 2-1

TRP-AGG2-2 Gene

transfer RNA-Pro (AGG) 2-2

TRP-AGG2-4 Gene

transfer RNA-Pro (AGG) 2-4

TRP-AGG2-7 Gene

transfer RNA-Pro (AGG) 2-7

TRP-GGG1-1 Gene

transfer RNA-Pro (GGG) 1-1

TRP-TGG5-1 Gene

transfer RNA-Pro (TGG) 5-1

TRP-TGG4-1 Gene

transfer RNA-Pro (TGG) 4-1

TRP-AGG2-6 Gene

transfer RNA-Pro (AGG) 2-6

TRP-TGG1-1 Gene

transfer RNA-Pro (TGG) 1-1

TRP-CGG2-1 Gene

transfer RNA-Pro (CGG) 2-1

LOC400026 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene

PRKRIR Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)

PRKRIRP8 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 8

PRKRIRP9 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 9

PRKRIRP1 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 1

PRKRIRP2 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 2

PRKRIRP3 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 3

PRKRIRP4 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 4

PRKRIRP5 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 5

PRKRIRP6 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 6

PRKRIRP7 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 7

LOC100533853 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene

PRKRIRP10 Gene

protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor) pseudogene 10

TRW-CCA5-1 Gene

transfer RNA-Trp (CCA) 5-1

TRW-CCA4-1 Gene

transfer RNA-Trp (CCA) 4-1

TRW-CCA7-1 Gene

transfer RNA-Trp (CCA) 7-1

TRW-CCA6-1 Gene

transfer RNA-Trp (CCA) 6-1

TRW-CCA3-3 Gene

transfer RNA-Trp (CCA) 3-3

TRW-CCA3-2 Gene

transfer RNA-Trp (CCA) 3-2

TRW-CCA1-1 Gene

transfer RNA-Trp (CCA) 1-1

TRW-CCA2-1 Gene

transfer RNA-Trp (CCA) 2-1

TRW-CCA3-1 Gene

transfer RNA-Trp (CCA) 3-1

RTFDC1 Gene

replication termination factor 2 domain containing 1

RFC2 Gene

replication factor C (activator 1) 2, 40kDa

This gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Replication factor C, also called activator 1, is a protein complex consisting of five distinct subunits. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP and may help promote cell survival. Disruption of this gene is associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene of this gene has been defined on chromosome 2. [provided by RefSeq, Jul 2013]

RIF1 Gene

replication timing regulatory factor 1

This gene encodes a protein that shares homology with the yeast teleomere binding protein, Rap1 interacting factor 1. This protein localizes to aberrant telomeres may be involved in DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

TICRR Gene

TOPBP1-interacting checkpoint and replication regulator

Treslin is involved in the initiation of DNA replication (Kumagai et al., 2010 [PubMed 20116089]).[supplied by OMIM, Apr 2010]

RFC3P1 Gene

replication factor C (activator 1) 3, 38kDa pseudogene 1

RFC5 Gene

replication factor C (activator 1) 5, 36.5kDa

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 36 kD subunit. This subunit can interact with the C-terminal region of PCNA. It forms a core complex with the 38 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9. [provided by RefSeq, May 2011]

RFC4 Gene

replication factor C (activator 1) 4, 37kDa

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

RFC1 Gene

replication factor C (activator 1) 1, 145kDa

This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Mar 2011]

DSCC1 Gene

DNA replication and sister chromatid cohesion 1

CHTF18 (MIM 613201), CHTF8 (MIM 613202), and DSCC1 are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176]; Bermudez et al., 2003 [PubMed 12930902]).[supplied by OMIM, Dec 2009]

DNA2 Gene

DNA replication helicase/nuclease 2

This gene encodes a member of the DNA2/NAM7 helicase family. The encoded protein is a conserved helicase/nuclease involved in the maintenance of mitochondrial and nuclear DNA stability. Mutations in this gene are associated with autosomal dominant progressive external ophthalmoplegia-6 (PEOA6) and Seckel syndrome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

CDT1 Gene

chromatin licensing and DNA replication factor 1

The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011]

RPA4 Gene

replication protein A4, 30kDa

This gene encodes a single-stranded DNA-binding protein that is the 30-kDa subunit of the replication protein A complex. Replication protein A is an essential factor for DNA double-strand break repair and cell cycle checkpoint activation. The encoded protein localizes to DNA repair foci and may be involved in the cellular DNA damage response. This protein may also play a role in inhibiting viral replication.[provided by RefSeq, Apr 2010]

RPA1 Gene

replication protein A1, 70kDa

RPA3 Gene

replication protein A3, 14kDa

RPA2 Gene

replication protein A2, 32kDa

RFC3 Gene

replication factor C (activator 1) 3, 38kDa

The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kDa. This gene encodes the 38 kDa subunit. This subunit is essential for the interaction between the 140 kDa subunit and the core complex that consists of the 36, 37, and 40 kDa subunits. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

LOC100130403 Gene

replication protein A3, 14kDa pseudogene

LOC100533727 Gene

replication factor C (activator 1) 2, 40kDa pseudogene

KLLN Gene

killin, p53-regulated DNA replication inhibitor

The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53. [provided by RefSeq, Dec 2012]

REPIN1 Gene

replication initiator 1

GMNN Gene

geminin, DNA replication inhibitor

This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011]

LOC442058 Gene

replication protein A3, 14kDa pseudogene

LOC100133127 Gene

geminin, DNA replication inhibitor pseudogene 1

RPA2P1 Gene

replication protein A2 pseudogene 1

RPA2P3 Gene

replication protein A2 pseudogene 3

RPA2P2 Gene

replication protein A2 pseudogene 2

RFC5P1 Gene

replication factor C (activator 1) 5, 36.5kDa pseudogene 1

LOC100133137 Gene

geminin, DNA replication inhibitor pseudogene 2

AHRR Gene

aryl-hydrocarbon receptor repressor

The protein encoded by this gene participates in the aryl hydrocarbon receptor (AhR) signaling cascade, which mediates dioxin toxicity, and is involved in regulation of cell growth and differentiation. It functions as a feedback modulator by repressing AhR-dependent gene expression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2011]

ERF Gene

Ets2 repressor factor

Members of the ETS family of transcription factors, such as ERF, regulate cell proliferation and differentiation. They share a highly conserved DNA-binding domain, the ETS domain, that recognizes the sequence GGAA/T (de Castro et al., 1997 [PubMed 9192842]). For further information on ETS transcription factors, see ETS1 (MIM 164720).[supplied by OMIM, Mar 2008]

RIPPLY1 Gene

ripply transcriptional repressor 1

This gene encodes a protein similar to a zebrafish protein which acts as a transcriptional repressor in and is required for somite segmentation in zebrafish embryos (PMID: 16326386). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

RIPPLY3 Gene

ripply transcriptional repressor 3

RIPPLY2 Gene

ripply transcriptional repressor 2

CICP18 Gene

capicua transcriptional repressor pseudogene 18

CICP19 Gene

capicua transcriptional repressor pseudogene 19

CICP10 Gene

capicua transcriptional repressor pseudogene 10

CICP13 Gene

capicua transcriptional repressor pseudogene 13

CICP14 Gene

capicua transcriptional repressor pseudogene 14

CICP15 Gene

capicua transcriptional repressor pseudogene 15

CICP16 Gene

capicua transcriptional repressor pseudogene 16

CICP17 Gene

capicua transcriptional repressor pseudogene 17

CREG1 Gene

cellular repressor of E1A-stimulated genes 1

The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008]

CREG2 Gene

cellular repressor of E1A-stimulated genes 2

GFI1B Gene

growth factor independent 1B transcription repressor

This gene encodes a zinc-finger containing transcriptional regulator that is primarily expressed in cells of hematopoietic lineage. The encoded protein complexes with numerous other transcriptional regulatory proteins including GATA-1, runt-related transcription factor 1 and histone deacetylases to control expression of genes involved in the development and maturation of erythrocytes and megakaryocytes. Mutations in this gene are the cause of the autosomal dominant platelet disorder, platelet-type bleeding disorder-17. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]

CICP3 Gene

capicua transcriptional repressor pseudogene 3

LOC100131680 Gene

52 kDa repressor of the inhibitor of the protein kinase-like

CICP8 Gene

capicua transcriptional repressor pseudogene 8

CICP9 Gene

capicua transcriptional repressor pseudogene 9

CICP6 Gene

capicua transcriptional repressor pseudogene 6

CICP7 Gene

capicua transcriptional repressor pseudogene 7

CICP4 Gene

capicua transcriptional repressor pseudogene 4

CICP5 Gene

capicua transcriptional repressor pseudogene 5

CICP2 Gene

capicua transcriptional repressor pseudogene 2

CICP1 Gene

capicua transcriptional repressor pseudogene 1

NRON Gene

non-protein coding RNA, repressor of NFAT

CICP28 Gene

capicua transcriptional repressor pseudogene 28

CICP25 Gene

capicua transcriptional repressor pseudogene 25

CICP24 Gene

capicua transcriptional repressor pseudogene 24

CICP27 Gene

capicua transcriptional repressor pseudogene 27

CICP26 Gene

capicua transcriptional repressor pseudogene 26

CICP21 Gene

capicua transcriptional repressor pseudogene 21

CICP23 Gene

capicua transcriptional repressor pseudogene 23

CICP22 Gene

capicua transcriptional repressor pseudogene 22

CIART Gene

circadian associated repressor of transcription

SPEN Gene

spen family transcriptional repressor

This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors. [provided by RefSeq, Jul 2008]

RTE1 Gene

repressor of telomerase expression 1

CIC Gene

capicua transcriptional repressor

The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]

GFI1 Gene

growth factor independent 1 transcription repressor

This gene encodes a nuclear zinc finger protein that functions as a transcriptional repressor. This protein plays a role in diverse developmental contexts, including hematopoiesis and oncogenesis. It functions as part of a complex along with other cofactors to control histone modifications that lead to silencing of the target gene promoters. Mutations in this gene cause autosomal dominant severe congenital neutropenia, and also dominant nonimmune chronic idiopathic neutropenia of adults, which are heterogeneous hematopoietic disorders that cause predispositions to leukemias and infections. Multiple alternatively spliced variants, encoding the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

NOL3 Gene

nucleolar protein 3 (apoptosis repressor with CARD domain)

This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

CICP11 Gene

capicua transcriptional repressor pseudogene 11

MNT Gene

MAX network transcriptional repressor

The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]

CICP12 Gene

capicua transcriptional repressor pseudogene 12

LOC390937 Gene

Ets2 repressor factor-like

CICP20 Gene

capicua transcriptional repressor pseudogene 20

LOC100131884 Gene

capicua transcriptional repressor pseudogene