Name

STAT3 Gene

signal transducer and activator of transcription 3 (acute-phase response factor)

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

STAT3 Gene Set

From CHEA Transcription Factor Targets

target genes of the STAT3 transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

STAT3 Gene Set

From ENCODE Transcription Factor Targets

target genes of the STAT3 transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

stat3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

STAT3 Gene Set

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein STAT3 from the curated Hub Proteins Protein-Protein Interactions dataset.

STAT3 Gene Set

From JASPAR Predicted Transcription Factor Targets

target genes of the STAT3 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.

STAT3 Gene Set

From MotifMap Predicted Transcription Factor Targets

target genes of the STAT3 transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

STAT3 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for STAT3 from the Pathway Commons Protein-Protein Interactions dataset.

stat3 Gene Set

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term stat3 in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

STAT3 Gene Set

From TRANSFAC Curated Transcription Factor Targets

target genes of the STAT3 transcription factor in low- or high-throughput transcription factor functional studies from the TRANSFAC Curated Transcription Factor Targets dataset.

STAT3 Gene Set

From TRANSFAC Predicted Transcription Factor Targets

target genes of the STAT3 transcription factor predicted using known transcription factor binding site motifs from the TRANSFAC Predicted Transcription Factor Targets dataset.

STAT3:STAT3 Gene Set

From MotifMap Predicted Transcription Factor Targets

target genes of the STAT3:STAT3 transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

stat3 signaling pathway Gene Set

From Biocarta Pathways

proteins participating in the stat3 signaling pathway pathway from the Biocarta Pathways dataset.

STAT3-1855785-MESC-mouse Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the STAT3-1855785-MESC-mouse transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

STAT3-18555785-MESC-MOUSE Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the STAT3-18555785-MESC-MOUSE transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

STAT3-20064451-CD4+T-MOUSE Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the STAT3-20064451-CD4+T-MOUSE transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

STAT3-22323479-MACROPHAGE-MOUSE Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the STAT3-22323479-MACROPHAGE-MOUSE transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

STAT3-19079543-MESC-mouse Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the STAT3-19079543-MESC-mouse transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

STAT3-23295773-U87-HUMAN Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the STAT3-23295773-U87-HUMAN transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

IL6ST-PRKCD-STAT3 complex Gene Set

From CORUM Protein Complexes

proteins in the IL6ST-PRKCD-STAT3 complex protein complex from the CORUM Protein Complexes dataset.

STAT3 homodimer copmplex Gene Set

From CORUM Protein Complexes

proteins in the STAT3 homodimer copmplex protein complex from the CORUM Protein Complexes dataset.

Stat3-Crebbp complex Gene Set

From CORUM Protein Complexes

proteins in the Stat3-Crebbp complex protein complex from the CORUM Protein Complexes dataset.

Isl1-Jak1-Stat3 complex Gene Set

From CORUM Protein Complexes

proteins in the Isl1-Jak1-Stat3 complex protein complex from the CORUM Protein Complexes dataset.

STAT3-NLK-MAP3K7 complex Gene Set

From CORUM Protein Complexes

proteins in the STAT3-NLK-MAP3K7 complex protein complex from the CORUM Protein Complexes dataset.

STAT3_HeLa-S3_hg19_1 Gene Set

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the STAT3_HeLa-S3_hg19_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

STAT3_GM12878_hg19_1 Gene Set

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the STAT3_GM12878_hg19_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

STAT3_MCF 10A_hg19_3 Gene Set

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the STAT3_MCF 10A_hg19_3 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

STAT3_MCF 10A_hg19_1 Gene Set

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the STAT3_MCF 10A_hg19_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

STAT3_MCF 10A_hg19_2 Gene Set

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the STAT3_MCF 10A_hg19_2 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

stat3rantes Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3rantes in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3deficient Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3deficient in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3skp2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3skp2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3bound Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3bound in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3interleukin6 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3interleukin6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3ape1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3ape1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3pim1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3pim1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3re Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3re in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3regulated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3regulated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3beta Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3beta in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3microrna Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3microrna in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3prl3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3prl3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3usp7p53 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3usp7p53 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3survivin Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3survivin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat35 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat35 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3hsp90 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3hsp90 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3depleted Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3depleted in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3sclip Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3sclip in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3lgr4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3lgr4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3jak2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3jak2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3activating Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3activating in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3pim1nfat Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3pim1nfat in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3induced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3induced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3p63jaggednotch Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3p63jaggednotch in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3signaling Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3signaling in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3alpha Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3alpha in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3gp130 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3gp130 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3nfkappab Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3nfkappab in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3androgen Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3androgen in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3pias3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3pias3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3betacatenin Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3betacatenin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat3ptpn13 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat3ptpn13 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

stat35dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term stat35dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

STAT3_OE_GDS3444_576_mouse_Cultured embryonic stem (ES) cells Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the STAT3_OE_GDS3444_576_mouse_Cultured embryonic stem (ES) cells gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

STAT3_deficiency_GDS3106_58_mouse_type II alveolar cells Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the STAT3_deficiency_GDS3106_58_mouse_type II alveolar cells gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

stat3_18070348_alveolar_type_2_epithelial_lof_mouse_gpl1261_gds3106 Gene Set

From GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations

genes differentially expressed following the stat3_18070348_alveolar_type_2_epithelial_lof_mouse_gpl1261_gds3106 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

stat3_00000000_a549_lof_human_gpl571_gse42979 Gene Set

From GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations

genes differentially expressed following the stat3_00000000_a549_lof_human_gpl571_gse42979 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

stat3_18500982_mesc_gof_mouse_gpl83_gds3446 Gene Set

From GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations

genes differentially expressed following the stat3_18500982_mesc_gof_mouse_gpl83_gds3446 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

positive regulation of tyrosine phosphorylation of stat3 protein Gene Set

From GO Biological Process Annotations

genes participating in the positive regulation of tyrosine phosphorylation of stat3 protein biological process from the curated GO Biological Process Annotations dataset.

serine phosphorylation of stat3 protein Gene Set

From GO Biological Process Annotations

genes participating in the serine phosphorylation of stat3 protein biological process from the curated GO Biological Process Annotations dataset.

tyrosine phosphorylation of stat3 protein Gene Set

From GO Biological Process Annotations

genes participating in the tyrosine phosphorylation of stat3 protein biological process from the curated GO Biological Process Annotations dataset.

negative regulation of tyrosine phosphorylation of stat3 protein Gene Set

From GO Biological Process Annotations

genes participating in the negative regulation of tyrosine phosphorylation of stat3 protein biological process from the curated GO Biological Process Annotations dataset.

regulation of tyrosine phosphorylation of stat3 protein Gene Set

From GO Biological Process Annotations

genes participating in the regulation of tyrosine phosphorylation of stat3 protein biological process from the curated GO Biological Process Annotations dataset.

Signalling to STAT3 Gene Set

From Reactome Pathways

proteins participating in the Signalling to STAT3 pathway from the Reactome Pathways dataset.

Serotonin Receptor 2 and STAT3 Signaling(Homo sapiens) Gene Set

From Wikipathways Pathways

proteins participating in the Serotonin Receptor 2 and STAT3 Signaling(Homo sapiens) pathway from the Wikipathways Pathways dataset.