Name

MECOM Gene

MDS1 and EVI1 complex locus

The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

MECOM Gene Set

From CHEA Transcription Factor Targets

target genes of the MECOM transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

MECOM Gene Set

From JASPAR Predicted Transcription Factor Targets

target genes of the MECOM transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.

MECOM Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for MECOM from the Pathway Commons Protein-Protein Interactions dataset.

MECOM Gene Set

From TRANSFAC Curated Transcription Factor Targets

target genes of the MECOM transcription factor in low- or high-throughput transcription factor functional studies from the TRANSFAC Curated Transcription Factor Targets dataset.

MECOM-23826213-KASUMI-MOUSE Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the MECOM-23826213-KASUMI-MOUSE transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

MECOM_KO_GDS3343_554_mouse_Hematopoietic stem cells Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the MECOM_KO_GDS3343_554_mouse_Hematopoietic stem cells gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.