Name

MCM6 Gene

minichromosome maintenance complex component 6

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012]

mcm6 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mcm6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

MCM6 Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for MCM6 from the NURSA Protein-Protein Interactions dataset.

MCM6 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for MCM6 from the Pathway Commons Protein-Protein Interactions dataset.

MCM2-MCM4-MCM6-MCM7 complex Gene Set

From CORUM Protein Complexes

proteins in the MCM2-MCM4-MCM6-MCM7 complex protein complex from the CORUM Protein Complexes dataset.

MCM4-MCM6-MCM7 complex Gene Set

From CORUM Protein Complexes

proteins in the MCM4-MCM6-MCM7 complex protein complex from the CORUM Protein Complexes dataset.

MCM2-MCM6-MCM7 complex Gene Set

From CORUM Protein Complexes

proteins in the MCM2-MCM6-MCM7 complex protein complex from the CORUM Protein Complexes dataset.

DNA replication licensing factor Mcm6 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the DNA replication licensing factor Mcm6 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

BL262 (MCM6) Gene Set

From NURSA Protein Complexes

proteins in the BL262 (MCM6) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.