Name

MCM3 Gene

minichromosome maintenance complex component 3

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

MCM3AP-AS1 Gene

MCM3AP antisense RNA 1

MCM3AP Gene

minichromosome maintenance complex component 3 associated protein

The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability. [provided by RefSeq, Jan 2014]

mcm3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mcm3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

MCM3 Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for MCM3 from the NURSA Protein-Protein Interactions dataset.

MCM3 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for MCM3 from the Pathway Commons Protein-Protein Interactions dataset.

mcm3ap Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mcm3ap in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

DNA replication licensing factor Mcm3 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the DNA replication licensing factor Mcm3 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

MCM3AP Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for MCM3AP from the Pathway Commons Protein-Protein Interactions dataset.