Name

MCM10 Gene

minichromosome maintenance complex component 10

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and it may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein can interact with MCM2 and MCM6, as well as with the origin recognition protein ORC2. It is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. Studies of a similar protein in Xenopus suggest that the chromatin binding of this protein at the onset of DNA replication is after pre-RC assembly and before origin unwinding. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]

mcm10 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mcm10 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

MCM10 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for MCM10 from the Pathway Commons Protein-Protein Interactions dataset.

Zinc finger, Mcm10/DnaG-type Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Zinc finger, Mcm10/DnaG-type protein domain from the InterPro Predicted Protein Domain Annotations dataset.

Replication factor Mcm10 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Replication factor Mcm10 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

BL531 (MCM10) Gene Set

From NURSA Protein Complexes

proteins in the BL531 (MCM10) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.