Name

CDS1 Gene

CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1

Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13. [provided by RefSeq, Jul 2008]

CDS1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDS1 from the Pathway Commons Protein-Protein Interactions dataset.

MUS81-CDS1 complex Gene Set

From CORUM Protein Complexes

proteins in the MUS81-CDS1 complex protein complex from the CORUM Protein Complexes dataset.

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Gene Set

From Reactome Pathways

proteins participating in the Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex pathway from the Reactome Pathways dataset.