Name

CDK8 Gene

cyclin-dependent kinase 8

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq, Jul 2008]

CDK8PS Gene

cyclin-dependent kinase 8 pseudogene

cdk8 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk8 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CDK8 Gene Set

From KEA Substrates of Kinases

substrates of the kinase CDK8 from the curated KEA Substrates of Kinases dataset.

CDK8 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDK8 from the Pathway Commons Protein-Protein Interactions dataset.

CDK8 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase CDK8 from the curated PhosphoSitePlus Substrates of Kinases dataset.

hMediator complex (MED23, CDK8, CCNC, MED7) Gene Set

From CORUM Protein Complexes

proteins in the hMediator complex (MED23, CDK8, CCNC, MED7) protein complex from the CORUM Protein Complexes dataset.

RNA polymerase II complex (CBP, PCAF, RPB1, BAF47, CYCC, CDK8), chromatin structure modifying Gene Set

From CORUM Protein Complexes

proteins in the RNA polymerase II complex (CBP, PCAF, RPB1, BAF47, CYCC, CDK8), chromatin structure modifying protein complex from the CORUM Protein Complexes dataset.

CDK8-MED6-PARP1 complex Gene Set

From CORUM Protein Complexes

proteins in the CDK8-MED6-PARP1 complex protein complex from the CORUM Protein Complexes dataset.

CCNC-CDK8-MED1-MED6-MED7 xcomplex Gene Set

From CORUM Protein Complexes

proteins in the CCNC-CDK8-MED1-MED6-MED7 xcomplex protein complex from the CORUM Protein Complexes dataset.

RNA polymerase II complex, incomplete (CDK8 complex), chromatin structure modifying Gene Set

From CORUM Protein Complexes

proteins in the RNA polymerase II complex, incomplete (CDK8 complex), chromatin structure modifying protein complex from the CORUM Protein Complexes dataset.

CDK8-CyclinC-Mediator complex Gene Set

From CORUM Protein Complexes

proteins in the CDK8-CyclinC-Mediator complex protein complex from the CORUM Protein Complexes dataset.

RNA polymerase II complex (RPB1, RAP74, CDK8, CYCC, SRB7, BAF190, BAF47), chromatin structure modifying Gene Set

From CORUM Protein Complexes

proteins in the RNA polymerase II complex (RPB1, RAP74, CDK8, CYCC, SRB7, BAF190, BAF47), chromatin structure modifying protein complex from the CORUM Protein Complexes dataset.

hMediator complex (MED23, CDK8, CCNC) Gene Set

From CORUM Protein Complexes

proteins in the hMediator complex (MED23, CDK8, CCNC) protein complex from the CORUM Protein Complexes dataset.

cdk8mediator Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk8mediator in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk8cycc Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk8cycc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk8cyclin Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk8cyclin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CDK8_knockdown_161_GSE38061 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the CDK8_knockdown_161_GSE38061 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

CDK8_knockdown_129_GSE30816 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the CDK8_knockdown_129_GSE30816 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

CDK8_knockdown_163_GSE38061 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the CDK8_knockdown_163_GSE38061 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

CDK8_knockdown_88_GSE27869 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the CDK8_knockdown_88_GSE27869 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

CDK8_knockdown_147_GSE32108 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the CDK8_knockdown_147_GSE32108 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

CDK8_knockdown_63_GSE19199 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the CDK8_knockdown_63_GSE19199 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

CDK8_knockdown_130_GSE30816 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the CDK8_knockdown_130_GSE30816 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

CDK8_knockdown_128_GSE30815 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the CDK8_knockdown_128_GSE30815 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.