Name

CDK5 Gene

cyclin-dependent kinase 5

This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015]

CDK5R1 Gene

cyclin-dependent kinase 5, regulatory subunit 1 (p35)

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]

CDK5PS Gene

cyclin-dependent kinase 5 pseudogene

CDK5RAP2 Gene

CDK5 regulatory subunit associated protein 2

This gene encodes a regulator of CDK5 (cyclin-dependent kinase 5) activity. The protein encoded by this gene is localized to the centrosome and Golgi complex, interacts with CDK5R1 and pericentrin (PCNT), plays a role in centriole engagement and microtubule nucleation, and has been linked to primary microcephaly and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

CDK5RAP3 Gene

CDK5 regulatory subunit associated protein 3

This gene encodes a protein that has been reported to function in signaling pathways governing transcriptional regulation and cell cycle progression. It may play a role in tumorigenesis and metastasis. A pseudogene of this gene is located on the long arm of chromosome 20. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]

CDK5RAP1 Gene

CDK5 regulatory subunit associated protein 1

This gene encodes a regulator of cyclin-dependent kinase 5 activity. This protein has also been reported to modify RNA by adding a methylthio-group and may thus have a dual function as an RNA methylthiotransferase and as an inhibitor of cyclin-dependent kinase 5 activity. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]

CDK5R2 Gene

cyclin-dependent kinase 5, regulatory subunit 2 (p39)

The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. [provided by RefSeq, Jul 2008]

cdk5 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CDK5 Gene Set

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein CDK5 from the curated Hub Proteins Protein-Protein Interactions dataset.

CDK5 Gene Set

From KEA Substrates of Kinases

substrates of the kinase CDK5 from the curated KEA Substrates of Kinases dataset.

CDK5 Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for CDK5 from the NURSA Protein-Protein Interactions dataset.

CDK5 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDK5 from the Pathway Commons Protein-Protein Interactions dataset.

cdk5 Gene Set

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term cdk5 in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

CDK5 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase CDK5 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Cdk5/p35 complex (Cdk5-Cdk5r1 complex) Gene Set

From CORUM Protein Complexes

proteins in the Cdk5/p35 complex (Cdk5-Cdk5r1 complex) protein complex from the CORUM Protein Complexes dataset.

deregulation of cdk5 in alzheimers disease Gene Set

From Biocarta Pathways

proteins participating in the deregulation of cdk5 in alzheimers disease pathway from the Biocarta Pathways dataset.

phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway Gene Set

From Biocarta Pathways

proteins participating in the phosphorylation of mek1 by cdk5/p35 down regulates the map kinase pathway pathway from the Biocarta Pathways dataset.

regulation of ck1/cdk5 by type 1 glutamate receptors Gene Set

From Biocarta Pathways

proteins participating in the regulation of ck1/cdk5 by type 1 glutamate receptors pathway from the Biocarta Pathways dataset.

Cdk5-c-Abl-Cables complex Gene Set

From CORUM Protein Complexes

proteins in the Cdk5-c-Abl-Cables complex protein complex from the CORUM Protein Complexes dataset.

Cdk5-Cdk5r1-Pctk1 complex Gene Set

From CORUM Protein Complexes

proteins in the Cdk5-Cdk5r1-Pctk1 complex protein complex from the CORUM Protein Complexes dataset.

Cell cycle kinase complex CDK5 Gene Set

From CORUM Protein Complexes

proteins in the Cell cycle kinase complex CDK5 protein complex from the CORUM Protein Complexes dataset.

cdk5p25induced Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk5p25induced in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk5splicing Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk5splicing in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk5nos1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk5nos1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk5cdk5 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk5cdk5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk5r1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk5r1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk5p35binding Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk5p35binding in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk5mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk5mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk5p25 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk5p25 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk5dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk5dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk5p35 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk5p35 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk5rap2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk5rap2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk5rap3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk5rap3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk5stat3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk5stat3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CDK5_knockdown_99_GSE27869 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the CDK5_knockdown_99_GSE27869 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

CDK5 and ABL1 enzyme substrate 1/2 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the CDK5 and ABL1 enzyme substrate 1/2 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

BL2317 (CDK5RAP2) Gene Set

From NURSA Protein Complexes

proteins in the BL2317 (CDK5RAP2) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

BL3564 (CDK5RAP3) Gene Set

From NURSA Protein Complexes

proteins in the BL3564 (CDK5RAP3) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.

CDK5RAP2 Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for CDK5RAP2 from the NURSA Protein-Protein Interactions dataset.

CDK5RAP3 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDK5RAP3 from the Pathway Commons Protein-Protein Interactions dataset.

CDK5RAP1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDK5RAP1 from the Pathway Commons Protein-Protein Interactions dataset.

CDK5RAP2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDK5RAP2 from the Pathway Commons Protein-Protein Interactions dataset.

CDK5R1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDK5R1 from the Pathway Commons Protein-Protein Interactions dataset.

CDK5R2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDK5R2 from the Pathway Commons Protein-Protein Interactions dataset.