Name

CDK4 Gene

cyclin-dependent kinase 4

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]

CDK4PS Gene

cyclin-dependent kinase 4 pseudogene

cdk4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CDK4 Gene Set

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein CDK4 from the curated Hub Proteins Protein-Protein Interactions dataset.

CDK4 Gene Set

From KEA Substrates of Kinases

substrates of the kinase CDK4 from the curated KEA Substrates of Kinases dataset.

CDK4 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDK4 from the Pathway Commons Protein-Protein Interactions dataset.

CDK4 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase CDK4 from the curated PhosphoSitePlus Substrates of Kinases dataset.

cyclin d2-cdk4 complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cyclin d2-cdk4 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

cyclin d1-cdk4 complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cyclin d1-cdk4 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

cyclin d3-cdk4 complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cyclin d3-cdk4 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

CyclinD3-CDK4-CDK6 complex Gene Set

From CORUM Protein Complexes

proteins in the CyclinD3-CDK4-CDK6 complex protein complex from the CORUM Protein Complexes dataset.

p18-Cdk4 complex Gene Set

From CORUM Protein Complexes

proteins in the p18-Cdk4 complex protein complex from the CORUM Protein Complexes dataset.

p16-cyclin D2-CDK4 complex Gene Set

From CORUM Protein Complexes

proteins in the p16-cyclin D2-CDK4 complex protein complex from the CORUM Protein Complexes dataset.

CycD1-Cdk4 complex Gene Set

From CORUM Protein Complexes

proteins in the CycD1-Cdk4 complex protein complex from the CORUM Protein Complexes dataset.

CyclinD3-CDK4-CDK6-p21 complex Gene Set

From CORUM Protein Complexes

proteins in the CyclinD3-CDK4-CDK6-p21 complex protein complex from the CORUM Protein Complexes dataset.

p19-Cdk4 complex Gene Set

From CORUM Protein Complexes

proteins in the p19-Cdk4 complex protein complex from the CORUM Protein Complexes dataset.

CyclinD1-CDK4-CDK6 complex Gene Set

From CORUM Protein Complexes

proteins in the CyclinD1-CDK4-CDK6 complex protein complex from the CORUM Protein Complexes dataset.

p19-Cdk4-cyclinD2 complex Gene Set

From CORUM Protein Complexes

proteins in the p19-Cdk4-cyclinD2 complex protein complex from the CORUM Protein Complexes dataset.

p34(SEI-1)-CDK4-CyclinD2 complex Gene Set

From CORUM Protein Complexes

proteins in the p34(SEI-1)-CDK4-CyclinD2 complex protein complex from the CORUM Protein Complexes dataset.

Cell cycle kinase complex CDK4 Gene Set

From CORUM Protein Complexes

proteins in the Cell cycle kinase complex CDK4 protein complex from the CORUM Protein Complexes dataset.

CCND2-CDK4 complex Gene Set

From CORUM Protein Complexes

proteins in the CCND2-CDK4 complex protein complex from the CORUM Protein Complexes dataset.

CDK4-CCND1 complex Gene Set

From CORUM Protein Complexes

proteins in the CDK4-CCND1 complex protein complex from the CORUM Protein Complexes dataset.

CCND1-CDK4 complex Gene Set

From CORUM Protein Complexes

proteins in the CCND1-CDK4 complex protein complex from the CORUM Protein Complexes dataset.

CCND3-CDK4 complex Gene Set

From CORUM Protein Complexes

proteins in the CCND3-CDK4 complex protein complex from the CORUM Protein Complexes dataset.

cdk4mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk4mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk46 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk46 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk4i Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk4i in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk46foxm1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk46foxm1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk4cyclin Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk4cyclin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk4activating Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk4activating in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk4r24c Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk4r24c in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk4p21 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk4p21 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CDK4_knockdown_133_GSE31534 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the CDK4_knockdown_133_GSE31534 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

CDK4_knockdown_225_GSE8866 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the CDK4_knockdown_225_GSE8866 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

CDK4_knockdown_85_GSE27869 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the CDK4_knockdown_85_GSE27869 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

CDK4_knockdown_143_GSE31912 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the CDK4_knockdown_143_GSE31912 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

EPI-2341-1 (CDK4) Gene Set

From NURSA Protein Complexes

proteins in the EPI-2341-1 (CDK4) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.