Name

CDK11A Gene

cyclin-dependent kinase 11A

This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Many transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of only two have been determined so far. [provided by RefSeq, Jul 2008]

CDK11A Gene Set

From KEA Substrates of Kinases

substrates of the kinase CDK11A from the curated KEA Substrates of Kinases dataset.

CDK11A Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for CDK11A from the NURSA Protein-Protein Interactions dataset.

CDK11A Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDK11A from the Pathway Commons Protein-Protein Interactions dataset.

CDK11A Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase CDK11A from the curated PhosphoSitePlus Substrates of Kinases dataset.