Name

CDK1 Gene

cyclin-dependent kinase 1

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

CDK11A Gene

cyclin-dependent kinase 11A

This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDC2L1, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDC2L1, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions, which are thought to be a part of the larger region that has been duplicated. This gene and CDC2L1 were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Many transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of only two have been determined so far. [provided by RefSeq, Jul 2008]

CDK11B Gene

cyclin-dependent kinase 11B

This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]

CDK18 Gene

cyclin-dependent kinase 18

CDK19 Gene

cyclin-dependent kinase 19

This gene encodes a protein that is one of the components of the Mediator co-activator complex. The Mediator complex is a multi-protein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]

CDK12 Gene

cyclin-dependent kinase 12

CDK13 Gene

cyclin-dependent kinase 13

The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.[provided by RefSeq, Dec 2009]

CDK10 Gene

cyclin-dependent kinase 10

The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

CDK16 Gene

cyclin-dependent kinase 16

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It may play a role in signal transduction cascades in terminally differentiated cells; in exocytosis; and in transport of secretory cargo from the endoplasmic reticulum. This gene is thought to escape X inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2009]

CDK17 Gene

cyclin-dependent kinase 17

The protein encoded by this gene belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. It has similarity to a rat protein that is thought to play a role in terminally differentiated neurons. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jul 2010]

CDK14 Gene

cyclin-dependent kinase 14

PFTK1 is a member of the CDC2 (MIM 116940)-related protein kinase family (Yang and Chen, 2001 [PubMed 11313143]).[supplied by OMIM, Mar 2008]

CDK15 Gene

cyclin-dependent kinase 15

cdk1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CDK1 Gene Set

From Hub Proteins Protein-Protein Interactions

interacting proteins for hub protein CDK1 from the curated Hub Proteins Protein-Protein Interactions dataset.

CDK1 Gene Set

From KEA Substrates of Kinases

substrates of the kinase CDK1 from the curated KEA Substrates of Kinases dataset.

CDK1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDK1 from the Pathway Commons Protein-Protein Interactions dataset.

cdk1 Gene Set

From Phosphosite Textmining Biological Term Annotations

proteins co-occuring with the biological term cdk1 in abstracts of publications describing phosphosites from the Phosphosite Textmining Biological Term Annotations dataset.

CDK1 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase CDK1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

cyclin k-cdk12 complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the cyclin k-cdk12 complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

cyclin k-cdk13 complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the cyclin k-cdk13 complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

cyclin b2-cdk1 complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cyclin b2-cdk1 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

cyclin a2-cdk1 complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cyclin a2-cdk1 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

cyclin k-cdk12 complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cyclin k-cdk12 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

cyclin b1-cdk1 complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cyclin b1-cdk1 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

cyclin k-cdk13 complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the cyclin k-cdk13 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

cdk1related Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk1related in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk1nonphosphorylatable Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk1nonphosphorylatable in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk1dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk1dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk1cdc2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk1cdc2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk11p46 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk11p46 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk14 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk14 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk1cyclinb1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk1cyclinb1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk1cyclin Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk1cyclin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk19 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk19 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk12 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk12 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk13 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk13 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk10 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk10 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk11 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk11 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk16 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk16 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk15 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk15 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk11p110 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk11p110 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk10cyclin Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk10cyclin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk1mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk1mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk12mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk12mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk11p58 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk11p58 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

cdk12crkrs Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdk12crkrs in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CDK19_knockdown_164_GSE38061 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the CDK19_knockdown_164_GSE38061 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

CDK19_knockdown_148_GSE32108 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the CDK19_knockdown_148_GSE32108 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

CDK19_knockdown_162_GSE38061 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the CDK19_knockdown_162_GSE38061 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

CDK10_knockdown_116_GSE27869 Gene Set

From GEO Signatures of Differentially Expressed Genes for Kinase Perturbations

genes differentially expressed following the CDK10_knockdown_116_GSE27869 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

cyclin k-cdk12 complex Gene Set

From GO Cellular Component Annotations

proteins localized to the cyclin k-cdk12 complex cellular component from the curated GO Cellular Component Annotations dataset.

cyclin k-cdk13 complex Gene Set

From GO Cellular Component Annotations

proteins localized to the cyclin k-cdk13 complex cellular component from the curated GO Cellular Component Annotations dataset.

CDK18 Gene Set

From KEA Substrates of Kinases

substrates of the kinase CDK18 from the curated KEA Substrates of Kinases dataset.

CDK19 Gene Set

From KEA Substrates of Kinases

substrates of the kinase CDK19 from the curated KEA Substrates of Kinases dataset.

CDK12 Gene Set

From KEA Substrates of Kinases

substrates of the kinase CDK12 from the curated KEA Substrates of Kinases dataset.

CDK10 Gene Set

From KEA Substrates of Kinases

substrates of the kinase CDK10 from the curated KEA Substrates of Kinases dataset.

CDK16 Gene Set

From KEA Substrates of Kinases

substrates of the kinase CDK16 from the curated KEA Substrates of Kinases dataset.

CDK17 Gene Set

From KEA Substrates of Kinases

substrates of the kinase CDK17 from the curated KEA Substrates of Kinases dataset.

CDK14 Gene Set

From KEA Substrates of Kinases

substrates of the kinase CDK14 from the curated KEA Substrates of Kinases dataset.

CDK11A Gene Set

From KEA Substrates of Kinases

substrates of the kinase CDK11A from the curated KEA Substrates of Kinases dataset.

CDK11B Gene Set

From KEA Substrates of Kinases

substrates of the kinase CDK11B from the curated KEA Substrates of Kinases dataset.

CDK13 Gene Set

From MSigDB Cancer Gene Co-expression Modules

co-expressed genes for CDK13 from the MSigDB Cancer Gene Co-expression Modules dataset.

CDK11A Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for CDK11A from the NURSA Protein-Protein Interactions dataset.

CDK11B Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for CDK11B from the NURSA Protein-Protein Interactions dataset.

CDK18 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDK18 from the Pathway Commons Protein-Protein Interactions dataset.

CDK12 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDK12 from the Pathway Commons Protein-Protein Interactions dataset.

CDK13 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDK13 from the Pathway Commons Protein-Protein Interactions dataset.

CDK10 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDK10 from the Pathway Commons Protein-Protein Interactions dataset.

CDK16 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDK16 from the Pathway Commons Protein-Protein Interactions dataset.

CDK15 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDK15 from the Pathway Commons Protein-Protein Interactions dataset.

CDK19 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDK19 from the Pathway Commons Protein-Protein Interactions dataset.

CDK17 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDK17 from the Pathway Commons Protein-Protein Interactions dataset.

CDK14 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDK14 from the Pathway Commons Protein-Protein Interactions dataset.

CDK11A Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDK11A from the Pathway Commons Protein-Protein Interactions dataset.

CDK11B Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDK11B from the Pathway Commons Protein-Protein Interactions dataset.

CDK19 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase CDK19 from the curated PhosphoSitePlus Substrates of Kinases dataset.

CDK12 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase CDK12 from the curated PhosphoSitePlus Substrates of Kinases dataset.

CDK13 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase CDK13 from the curated PhosphoSitePlus Substrates of Kinases dataset.

CDK10 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase CDK10 from the curated PhosphoSitePlus Substrates of Kinases dataset.

CDK16 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase CDK16 from the curated PhosphoSitePlus Substrates of Kinases dataset.

CDK14 Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase CDK14 from the curated PhosphoSitePlus Substrates of Kinases dataset.

CDK11A Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase CDK11A from the curated PhosphoSitePlus Substrates of Kinases dataset.

CDK11B Gene Set

From PhosphoSitePlus Substrates of Kinases

substrates of the kinase CDK11B from the curated PhosphoSitePlus Substrates of Kinases dataset.

Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Gene Set

From Reactome Pathways

proteins participating in the Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex pathway from the Reactome Pathways dataset.