Name

CDC45 Gene

cell division cycle 45

The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

cdc45 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdc45 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CDC45 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CDC45 from the Pathway Commons Protein-Protein Interactions dataset.

cdc45mcm27gins Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term cdc45mcm27gins in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CDC45 family Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the CDC45 family protein domain from the InterPro Predicted Protein Domain Annotations dataset.