Name

CCDC88C Gene

coiled-coil domain containing 88C

This gene encodes a ubiquitously expressed coiled-coil domain-containing protein that interacts with the dishevelled protein and is a negative regulator of the Wnt signalling pathway. The protein encoded by this gene has a PDZ-domain binding motif in its C-terminus with which it interacts with the dishevelled protein. Dishevelled is a scaffold protein involved in the regulation of the Wnt signaling pathway. The Wnt signaling pathway plays an important role in embryonic development, tissue maintenance, and cancer progression. Mutations in this gene cause autosomal recessive, primary non-syndromic congenital hydrocephalus; a condition characterized by excessive accumulation of cerebrospinal fluid in the ventricles of the brain. [provided by RefSeq, Jan 2013]

ccdc88c Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ccdc88c in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CCDC88C Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for CCDC88C from the NURSA Protein-Protein Interactions dataset.

CCDC88C Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CCDC88C from the Pathway Commons Protein-Protein Interactions dataset.