CCDC88A Gene

coiled-coil domain containing 88A

This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

ccdc88a Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ccdc88a in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

CCDC88A Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for CCDC88A from the Pathway Commons Protein-Protein Interactions dataset.