TIFA_HUMAN Protein

Name TRAF-interacting protein with FHA domain-containing protein A
Description Adapter protein which mediates the IRAK1 and TRAF6 interaction following IL-1 stimulation, resulting in the downstream activation of NF-kappa-B and AP-1 pathways. Induces the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism.
UniProt ID Q96CG3
Gene TIFA