RN185_HUMAN Protein

Name E3 ubiquitin-protein ligase RNF185
Description E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2.
UniProt ID Q96GF1
Gene RNF185