zymogen granule Gene Set

Dataset COMPARTMENTS Text-mining Protein Localization Evidence Scores
Category structural or functional annotations
Type cellular component
Description A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme. (Gene Ontology, GO_0042588)
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Genes

130 proteins co-occuring with the zymogen granule cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

Symbol Name Standardized Value
GP2 glycoprotein 2 (zymogen granule membrane) 2.50731
CCK cholecystokinin 2.0098
SYCN syncollin 1.60069
REG1A regenerating islet-derived 1 alpha 1.38239
RAB3D RAB3D, member RAS oncogene family 1.35375
PNLIP pancreatic lipase 1.29906
REG3A regenerating islet-derived 3 alpha 1.26392
CTSB cathepsin B 1.13369
VAMP8 vesicle-associated membrane protein 8 1.04481
CELA1 chymotrypsin-like elastase family, member 1 0.927483
CELA3B chymotrypsin-like elastase family, member 3B 0.916709
AMY2A amylase, alpha 2A (pancreatic) 0.912045
TMPRSS15 transmembrane protease, serine 15 0.895331
UMOD uromodulin 0.874107
PRSS1 protease, serine, 1 (trypsin 1) 0.858933
DPEP3 dipeptidase 3 0.856635
DPEP2 dipeptidase 2 0.85388
GCG glucagon 0.829548
UBQLN3 ubiquilin 3 0.817158
DMBT1 deleted in malignant brain tumors 1 0.815322
ETV6 ets variant 6 0.809817
STX4 syntaxin 4 0.801104
RAB27B RAB27B, member RAS oncogene family 0.800187
INS insulin 0.79652
PLA2G1B phospholipase A2, group IB (pancreas) 0.782326
PPY pancreatic polypeptide 0.776841
SPINK1 serine peptidase inhibitor, Kazal type 1 0.766349
STX3 syntaxin 3 0.757253
TBC1D10B TBC1 domain family, member 10B 0.741416
CEL carboxyl ester lipase 0.728389
STX2 syntaxin 2 0.696026
SST somatostatin 0.693393
AQP12A aquaporin 12A 0.682899
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1) 0.673762
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2) 0.667693
CCKAR cholecystokinin A receptor 0.66726
SSFA2 sperm specific antigen 2 0.633732
CPB1 carboxypeptidase B1 (tissue) 0.611625
ZG16B zymogen granule protein 16B 0.60444
REG1B regenerating islet-derived 1 beta 0.600644
AQP1 aquaporin 1 (Colton blood group) 0.590133
TPD52 tumor protein D52 0.583849
GAST gastrin 0.579669
GRP gastrin-releasing peptide 0.575912
RGS19 regulator of G-protein signaling 19 0.564262
DPEP1 dipeptidase 1 (renal) 0.540294
CPA6 carboxypeptidase A6 0.528388
ANXA13 annexin A13 0.487307
BHLHA15 basic helix-loop-helix family, member a15 0.481661
ACPP acid phosphatase, prostate 0.475223
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 0.456809
SYP synaptophysin 0.446862
RAB26 RAB26, member RAS oncogene family 0.445275
CTRB2 chymotrypsinogen B2 0.444085
RAB15 RAB15, member RAS oncogene family 0.442896
TBC1D10A TBC1 domain family, member 10A 0.438146
STXBP3 syntaxin binding protein 3 0.43617
ANXA4 annexin A4 0.434985
SNAP23 synaptosomal-associated protein, 23kDa 0.430253
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) 0.421212
RAB3A RAB3A, member RAS oncogene family 0.413773
CLPS colipase, pancreatic 0.409089
TALDO1 transaldolase 1 0.405971
SLC30A2 solute carrier family 30 (zinc transporter), member 2 0.398587
CTRB1 chymotrypsinogen B1 0.395485
ENO2 enolase 2 (gamma, neuronal) 0.386208
TRAP1 TNF receptor-associated protein 1 0.378891
KCNK6 potassium channel, two pore domain subfamily K, member 6 0.378507
RBM23 RNA binding motif protein 23 0.367006
PRSS3 protease, serine, 3 0.365095
VIP vasoactive intestinal peptide 0.362422
SRGN serglycin 0.333979
RAP2B RAP2B, member of RAS oncogene family 0.331342
AQP11 aquaporin 11 0.329461
PRSS58 protease, serine, 58 0.329084
AZGP1 alpha-2-glycoprotein 1, zinc-binding 0.328332
ENTPD8 ectonucleoside triphosphate diphosphohydrolase 8 0.326829
NSF N-ethylmaleimide-sensitive factor 0.326453
SAR1A secretion associated, Ras related GTPase 1A 0.324576
ARF3 ADP-ribosylation factor 3 0.324201
RAB1B RAB1B, member RAS oncogene family 0.321575
VPS33B vacuolar protein sorting 33 homolog B (yeast) 0.318205
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.315212
MTA1 metastasis associated 1 0.304027
SH3PXD2B SH3 and PX domains 2B 0.301054
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 0.298455
C1QBP complement component 1, q subcomponent binding protein 0.298455
RAB28 RAB28, member RAS oncogene family 0.289938
CHGA chromogranin A 0.286983
SRRM1 serine/arginine repetitive matrix 1 0.284032
PTF1A pancreas specific transcription factor, 1a 0.282926
MYO5C myosin VC 0.27998
SYPL1 synaptophysin-like 1 0.278509
TMED10 transmembrane emp24-like trafficking protein 10 (yeast) 0.277406
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.275202
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 0.262025
SEC23A Sec23 homolog A (S. cerevisiae) 0.26166
VMP1 vacuole membrane protein 1 0.248578
CPD carboxypeptidase D 0.24713
MRPL13 mitochondrial ribosomal protein L13 0.241716
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.241356
RAB11A RAB11A, member RAS oncogene family 0.240636
AFP alpha-fetoprotein 0.238478
KRT7 keratin 7, type II 0.235249
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1 0.234174
GH1 growth hormone 1 0.225976
VAMP3 vesicle-associated membrane protein 3 0.225622
ENGASE endo-beta-N-acetylglucosaminidase 0.217511
CHN2 chimerin 2 0.209169
ALB albumin 0.204378
EEA1 early endosome antigen 1 0.199659
POMC proopiomelanocortin 0.196339
GGT2 gamma-glutamyltransferase 2 0.195681
SCARF1 scavenger receptor class F, member 1 0.194371
NT5E 5'-nucleotidase, ecto (CD73) 0.192746
PCCA propionyl CoA carboxylase, alpha polypeptide 0.189857
RAB8A RAB8A, member RAS oncogene family 0.181823
LIPA lipase A, lysosomal acid, cholesterol esterase 0.181524
PCSK1 proprotein convertase subtilisin/kexin type 1 0.180045
PDX1 pancreatic and duodenal homeobox 1 0.177724
POU2F3 POU class 2 homeobox 3 0.176305
GGT1 gamma-glutamyltransferase 1 0.175188
SEC23B Sec23 homolog B (S. cerevisiae) 0.175188
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.173273
SBDS Shwachman-Bodian-Diamond syndrome 0.171673
KTN1 kinectin 1 (kinesin receptor) 0.171149
SYT3 synaptotagmin III 0.165463
TGOLN2 trans-golgi network protein 2 0.165231
CSN1S1 casein alpha s1 0.161484
RAP1GAP RAP1 GTPase activating protein 0.160254