zaprinast-3226 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the zaprinast-3226 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADGRA2 adhesion G protein-coupled receptor A2
AFAP1 actin filament associated protein 1
AGBL2 ATP/GTP binding protein-like 2
ALDOB aldolase B, fructose-bisphosphate
APOE apolipoprotein E
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATG16L1 autophagy related 16-like 1 (S. cerevisiae)
BARX2 BARX homeobox 2
CA4 carbonic anhydrase IV
CAMK1D calcium/calmodulin-dependent protein kinase ID
CASP1 caspase 1, apoptosis-related cysteine peptidase
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CPA4 carboxypeptidase A4
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DNALI1 dynein, axonemal, light intermediate chain 1
DOCK6 dedicator of cytokinesis 6
FAM182B family with sequence similarity 182, member B
FLJ20712 uncharacterized FLJ20712
FMO5 flavin containing monooxygenase 5
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GDF2 growth differentiation factor 2
HBS1L HBS1-like translational GTPase
HFE hemochromatosis
HIST1H1T histone cluster 1, H1t
ING4 inhibitor of growth family, member 4
INPP5B inositol polyphosphate-5-phosphatase, 75kDa
IQCG IQ motif containing G
IRS2 insulin receptor substrate 2
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1
KLHDC8A kelch domain containing 8A
KLRAP1 killer cell lectin-like receptor subfamily A pseudogene 1
LAT2 linker for activation of T cells family, member 2
LIMD1 LIM domains containing 1
LOC647070 uncharacterized LOC647070
LTA lymphotoxin alpha
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MATN3 matrilin 3
MLXIP MLX interacting protein
MLXIPL MLX interacting protein-like
MYCNOS MYCN opposite strand
NCR2 natural cytotoxicity triggering receptor 2
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NOX1 NADPH oxidase 1
NPM3 nucleophosmin/nucleoplasmin 3
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PBX2 pre-B-cell leukemia homeobox 2
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
PKNOX1 PBX/knotted 1 homeobox 1
PLAU plasminogen activator, urokinase
PLLP plasmolipin
PLXNC1 plexin C1
PMS2P3 postmeiotic segregation increased 2 pseudogene 3
PVR poliovirus receptor
RABEP2 rabaptin, RAB GTPase binding effector protein 2
RANGAP1 Ran GTPase activating protein 1
RCAN1 regulator of calcineurin 1
RGS12 regulator of G-protein signaling 12
RND1 Rho family GTPase 1
RNF208 ring finger protein 208
S100A11 S100 calcium binding protein A11
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFRP4 secreted frizzled-related protein 4
SFRP5 secreted frizzled-related protein 5
SH3BP2 SH3-domain binding protein 2
SHOX2 short stature homeobox 2
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC25A30 solute carrier family 25, member 30
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMIM14 small integral membrane protein 14
SP100 SP100 nuclear antigen
SPON2 spondin 2, extracellular matrix protein
SSBP1 single-stranded DNA binding protein 1, mitochondrial
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
SYN3 synapsin III
TBC1D17 TBC1 domain family, member 17
TESPA1 thymocyte expressed, positive selection associated 1
TFEB transcription factor EB
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TNXB tenascin XB
TP63 tumor protein p63
TSNAXIP1 translin-associated factor X interacting protein 1
UBXN1 UBX domain protein 1
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WDFY3 WD repeat and FYVE domain containing 3
WSB1 WD repeat and SOCS box containing 1
ZNF37BP zinc finger protein 37B, pseudogene
ZNF783 zinc finger family member 783

decreased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABLIM3 actin binding LIM protein family, member 3
ADM adrenomedullin
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
AQP7 aquaporin 7
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BTF3P11 basic transcription factor 3 pseudogene 11
C14ORF105 chromosome 14 open reading frame 105
C17ORF80 chromosome 17 open reading frame 80
C1ORF54 chromosome 1 open reading frame 54
C8ORF60 chromosome 8 open reading frame 60
CA5BP1 carbonic anhydrase VB pseudogene 1
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD82 CD82 molecule
CD83 CD83 molecule
CES1 carboxylesterase 1
CFAP45 cilia and flagella associated protein 45
CFAP69 cilia and flagella associated protein 69
CHML choroideremia-like (Rab escort protein 2)
CIC capicua transcriptional repressor
CLCN6 chloride channel, voltage-sensitive 6
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
DOK2 docking protein 2, 56kDa
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
DYSF dysferlin
EGFL7 EGF-like-domain, multiple 7
FAM53B family with sequence similarity 53, member B
FMOD fibromodulin
FOXN2 forkhead box N2
FRS2 fibroblast growth factor receptor substrate 2
GLTSCR1 glioma tumor suppressor candidate region gene 1
GPC3 glypican 3
GRTP1 growth hormone regulated TBC protein 1
HAMP hepcidin antimicrobial peptide
HDAC11 histone deacetylase 11
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H1B histone cluster 1, H1b
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
IFT140 intraflagellar transport 140
IQSEC2 IQ motif and Sec7 domain 2
ITGA10 integrin, alpha 10
ITPKB inositol-trisphosphate 3-kinase B
LDHB lactate dehydrogenase B
LHX6 LIM homeobox 6
LY6D lymphocyte antigen 6 complex, locus D
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
LYZ lysozyme
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MED9 mediator complex subunit 9
MITF microphthalmia-associated transcription factor
MTERF4 mitochondrial transcription termination factor 4
MUC3B mucin 3B, cell surface associated
NEK11 NIMA-related kinase 11
NLGN1 neuroligin 1
NSD1 nuclear receptor binding SET domain protein 1
ODF2 outer dense fiber of sperm tails 2
PACS1 phosphofurin acidic cluster sorting protein 1
PIGQ phosphatidylinositol glycan anchor biosynthesis, class Q
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
POM121 POM121 transmembrane nucleoporin
R3HCC1L R3H domain and coiled-coil containing 1-like
RAB3A RAB3A, member RAS oncogene family
RAD54L2 RAD54-like 2 (S. cerevisiae)
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RFTN1 raftlin, lipid raft linker 1
RIN1 Ras and Rab interactor 1
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF122 ring finger protein 122
RNF39 ring finger protein 39
SAMD9 sterile alpha motif domain containing 9
SCGB2A2 secretoglobin, family 2A, member 2
SLC22A14 solute carrier family 22, member 14
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
SMR3A submaxillary gland androgen regulated protein 3A
TBC1D19 TBC1 domain family, member 19
TBX19 T-box 19
TEP1 telomerase-associated protein 1
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TFDP3 transcription factor Dp family, member 3
TFF2 trefoil factor 2
TH tyrosine hydroxylase
TICAM1 toll-like receptor adaptor molecule 1
TRPV6 transient receptor potential cation channel, subfamily V, member 6
UPK2 uroplakin 2
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VEGFB vascular endothelial growth factor B
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae)
WNT10B wingless-type MMTV integration site family, member 10B
ZBTB6 zinc finger and BTB domain containing 6
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF282 zinc finger protein 282
ZNF350 zinc finger protein 350
ZSCAN31 zinc finger and SCAN domain containing 31