yohimbine-7130 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the yohimbine-7130 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAGAB alpha- and gamma-adaptin binding protein
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ADCK2 aarF domain containing kinase 2
AKR1C1 aldo-keto reductase family 1, member C1
ALDH4A1 aldehyde dehydrogenase 4 family, member A1
ANKRD12 ankyrin repeat domain 12
APH1B APH1B gamma secretase subunit
APLP2 amyloid beta (A4) precursor-like protein 2
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARID3A AT rich interactive domain 3A (BRIGHT-like)
BCAS3 breast carcinoma amplified sequence 3
C1ORF35 chromosome 1 open reading frame 35
C1QL1 complement component 1, q subcomponent-like 1
C7ORF43 chromosome 7 open reading frame 43
C8A complement component 8, alpha polypeptide
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CASP2 caspase 2, apoptosis-related cysteine peptidase
CD58 CD58 molecule
CEP112 centrosomal protein 112kDa
CEP162 centrosomal protein 162kDa
CHMP6 charged multivesicular body protein 6
CIDEC cell death-inducing DFFA-like effector c
CLSPN claspin
CNTNAP2 contactin associated protein-like 2
CTSK cathepsin K
DSCAM Down syndrome cell adhesion molecule
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA1 ephrin-A1
EN2 engrailed homeobox 2
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
FKBP1B FK506 binding protein 1B, 12.6 kDa
FKBP5 FK506 binding protein 5
FLOT2 flotillin 2
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
HLX H2.0-like homeobox
HNF1B HNF1 homeobox B
HOMER2 homer scaffolding protein 2
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
IGSF3 immunoglobulin superfamily, member 3
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KIAA0922 KIAA0922
KIF1A kinesin family member 1A
KLF2 Kruppel-like factor 2
KRIT1 KRIT1, ankyrin repeat containing
KRT34 keratin 34, type I
LIMS2 LIM and senescent cell antigen-like domains 2
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MAPK7 mitogen-activated protein kinase 7
MAST4 microtubule associated serine/threonine kinase family member 4
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MPPE1 metallophosphoesterase 1
MTA1 metastasis associated 1
MTMR12 myotubularin related protein 12
MTMR7 myotubularin related protein 7
NCKIPSD NCK interacting protein with SH3 domain
NF2 neurofibromin 2 (merlin)
NLRX1 NLR family member X1
NOL10 nucleolar protein 10
NPR3 natriuretic peptide receptor 3
PDE4DIP phosphodiesterase 4D interacting protein
PHLDB1 pleckstrin homology-like domain, family B, member 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PRICKLE3 prickle homolog 3 (Drosophila)
PRRC2A proline-rich coiled-coil 2A
PRSS16 protease, serine, 16 (thymus)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAB2A RAB2A, member RAS oncogene family
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RANBP3 RAN binding protein 3
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
RIN1 Ras and Rab interactor 1
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNFT2 ring finger protein, transmembrane 2
SBF1 SET binding factor 1
SEMA3F sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
SGSM2 small G protein signaling modulator 2
SH3BP2 SH3-domain binding protein 2
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SSBP3 single stranded DNA binding protein 3
SSH3 slingshot protein phosphatase 3
ST20 suppressor of tumorigenicity 20
STAG3 stromal antigen 3
STAG3L4 stromal antigen 3-like 4 (pseudogene)
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SUPT7L suppressor of Ty 7 (S. cerevisiae)-like
TBC1D22A TBC1 domain family, member 22A
TBC1D4 TBC1 domain family, member 4
TTC12 tetratricopeptide repeat domain 12
USP19 ubiquitin specific peptidase 19
WDR37 WD repeat domain 37
WIPF1 WAS/WASL interacting protein family, member 1
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF10 zinc finger protein 10
ZNF350 zinc finger protein 350
ZNF510 zinc finger protein 510
ZNF839 zinc finger protein 839

decreased expression

Symbol Name
ACTN4 actinin, alpha 4
ACTR3B ARP3 actin-related protein 3 homolog B (yeast)
ADGRF1 adhesion G protein-coupled receptor F1
AGO3 argonaute RISC catalytic component 3
AP1G2 adaptor-related protein complex 1, gamma 2 subunit
BAK1 BCL2-antagonist/killer 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCL2L13 BCL2-like 13 (apoptosis facilitator)
BCL9 B-cell CLL/lymphoma 9
BFAR bifunctional apoptosis regulator
BIK BCL2-interacting killer (apoptosis-inducing)
BIRC3 baculoviral IAP repeat containing 3
C17ORF80 chromosome 17 open reading frame 80
C9ORF91 chromosome 9 open reading frame 91
CALCOCO1 calcium binding and coiled-coil domain 1
CHPF chondroitin polymerizing factor
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CTSV cathepsin V
CXORF56 chromosome X open reading frame 56
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DCLRE1A DNA cross-link repair 1A
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DPH2 DPH2 homolog (S. cerevisiae)
DTX4 deltex 4, E3 ubiquitin ligase
EDC3 enhancer of mRNA decapping 3
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EGLN2 egl-9 family hypoxia-inducible factor 2
EVPL envoplakin
FADS2 fatty acid desaturase 2
FAM155A family with sequence similarity 155, member A
FGD6 FYVE, RhoGEF and PH domain containing 6
FOXD1 forkhead box D1
FPGS folylpolyglutamate synthase
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GMIP GEM interacting protein
GRWD1 glutamate-rich WD repeat containing 1
HIST1H1D histone cluster 1, H1d
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HYAL3 hyaluronoglucosaminidase 3
KIRREL kin of IRRE like (Drosophila)
KPTN kaptin (actin binding protein)
KRT4 keratin 4, type II
KRT6A keratin 6A, type II
LYPLA2P1 lysophospholipase II pseudogene 1
MAN2B2 mannosidase, alpha, class 2B, member 2
MCTP1 multiple C2 domains, transmembrane 1
MECR mitochondrial trans-2-enoyl-CoA reductase
MTG1 mitochondrial ribosome-associated GTPase 1
NABP2 nucleic acid binding protein 2
NME3 NME/NM23 nucleoside diphosphate kinase 3
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae)
NSD1 nuclear receptor binding SET domain protein 1
NXPE3 neurexophilin and PC-esterase domain family, member 3
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OSTM1 osteopetrosis associated transmembrane protein 1
PBLD phenazine biosynthesis-like protein domain containing
PHKG2 phosphorylase kinase, gamma 2 (testis)
PLD2 phospholipase D2
POLH polymerase (DNA directed), eta
POLM polymerase (DNA directed), mu
POMT1 protein-O-mannosyltransferase 1
POU2F1 POU class 2 homeobox 1
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRR3 proline rich 3
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PYCARD PYD and CARD domain containing
RAP1GAP2 RAP1 GTPase activating protein 2
RHOB ras homolog family member B
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
S100A14 S100 calcium binding protein A14
SCML2 sex comb on midleg-like 2 (Drosophila)
SETD1B SET domain containing 1B
SIPA1 signal-induced proliferation-associated 1
SLC25A40 solute carrier family 25, member 40
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SOX12 SRY (sex determining region Y)-box 12
SREK1IP1 SREK1-interacting protein 1
STK16 serine/threonine kinase 16
STX1A syntaxin 1A (brain)
SUN2 Sad1 and UNC84 domain containing 2
THOC6 THO complex 6
TICAM1 toll-like receptor adaptor molecule 1
TOR4A torsin family 4, member A
TPST2 tyrosylprotein sulfotransferase 2
TRIM21 tripartite motif containing 21
TUBA3D tubulin, alpha 3d
UBXN6 UBX domain protein 6
UNKL unkempt family zinc finger-like
ZNF107 zinc finger protein 107
ZNF112 zinc finger protein 112
ZNF212 zinc finger protein 212
ZNF770 zinc finger protein 770
ZNF787 zinc finger protein 787
ZXDC ZXD family zinc finger C