wortmannin-977 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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199 genes differentially expressed following the wortmannin-977 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACOT8 acyl-CoA thioesterase 8
ADCK3 aarF domain containing kinase 3
ADM adrenomedullin
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKMY1 ankyrin repeat and MYND domain containing 1
ARID4A AT rich interactive domain 4A (RBP1-like)
ATF3 activating transcription factor 3
ATP9A ATPase, class II, type 9A
BAG1 BCL2-associated athanogene
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRD8 bromodomain containing 8
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C16ORF45 chromosome 16 open reading frame 45
C6ORF48 chromosome 6 open reading frame 48
CALHM2 calcium homeostasis modulator 2
CARF calcium responsive transcription factor
CCDC170 coiled-coil domain containing 170
CCDC186 coiled-coil domain containing 186
CCDC28A coiled-coil domain containing 28A
CCNG2 cyclin G2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK19 cyclin-dependent kinase 19
CEMIP cell migration inducing protein, hyaluronan binding
CYLD cylindromatosis (turban tumor syndrome)
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DEPTOR DEP domain containing MTOR-interacting protein
DSCAM Down syndrome cell adhesion molecule
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
FAM174B family with sequence similarity 174, member B
FAXDC2 fatty acid hydroxylase domain containing 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXN3 forkhead box N3
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GPR87 G protein-coupled receptor 87
GRB7 growth factor receptor-bound protein 7
HBP1 HMG-box transcription factor 1
HECA headcase homolog (Drosophila)
HIST1H2AJ histone cluster 1, H2aj
HIST1H2BJ histone cluster 1, H2bj
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
INO80B INO80 complex subunit B
INPP5K inositol polyphosphate-5-phosphatase K
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
KIAA0141 KIAA0141
KIAA0430 KIAA0430
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KLHL24 kelch-like family member 24
LDAH lipid droplet associated hydrolase
LGALS8 lectin, galactoside-binding, soluble, 8
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MXD4 MAX dimerization protein 4
MYC v-myc avian myelocytomatosis viral oncogene homolog
NBR1 neighbor of BRCA1 gene 1
NDRG1 N-myc downstream regulated 1
NUDT13 nudix (nucleoside diphosphate linked moiety X)-type motif 13
NUPR1 nuclear protein, transcriptional regulator, 1
PBX1 pre-B-cell leukemia homeobox 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PGPEP1 pyroglutamyl-peptidase I
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRKAB2 protein kinase, AMP-activated, beta 2 non-catalytic subunit
PSPC1 paraspeckle component 1
RAB27B RAB27B, member RAS oncogene family
RAB2A RAB2A, member RAS oncogene family
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1CC1 RB1-inducible coiled-coil 1
REPS2 RALBP1 associated Eps domain containing 2
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RTN2 reticulon 2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SHARPIN SHANK-associated RH domain interactor
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SMOX spermine oxidase
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
STON1 stonin 1
TM4SF1 transmembrane 4 L six family member 1
TRIM23 tripartite motif containing 23
TRIM36 tripartite motif containing 36
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAMP4 vesicle-associated membrane protein 4
WDR19 WD repeat domain 19
YPEL5 yippee-like 5 (Drosophila)
ZNF16 zinc finger protein 16
ZNF227 zinc finger protein 227
ZNF571 zinc finger protein 571

decreased expression

Symbol Name
ADRA2C adrenoceptor alpha 2C
AEN apoptosis enhancing nuclease
AKIRIN1 akirin 1
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ASB9 ankyrin repeat and SOCS box containing 9
ASPHD1 aspartate beta-hydroxylase domain containing 1
ATP7B ATPase, Cu++ transporting, beta polypeptide
BCL7C B-cell CLL/lymphoma 7C
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
CCDC22 coiled-coil domain containing 22
CCNE1 cyclin E1
CCNL2 cyclin L2
CDC6 cell division cycle 6
CENPQ centromere protein Q
CERK ceramide kinase
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHUK conserved helix-loop-helix ubiquitous kinase
CIC capicua transcriptional repressor
CLEC16A C-type lectin domain family 16, member A
CORO1A coronin, actin binding protein, 1A
CRY1 cryptochrome circadian clock 1
CTAGE9 CTAGE family, member 9
CTPS1 CTP synthase 1
DHRS11 dehydrogenase/reductase (SDR family) member 11
DUSP8 dual specificity phosphatase 8
EGR3 early growth response 3
EHD3 EH-domain containing 3
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
EVPL envoplakin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FJX1 four jointed box 1 (Drosophila)
FMO4 flavin containing monooxygenase 4
GHR growth hormone receptor
GMPPB GDP-mannose pyrophosphorylase B
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GOLGA8B golgin A8 family, member B
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
HELLS helicase, lymphoid-specific
HPS6 Hermansky-Pudlak syndrome 6
HSPA2 heat shock 70kDa protein 2
IFT22 intraflagellar transport 22
IL17RB interleukin 17 receptor B
INHBB inhibin, beta B
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
LYPD1 LY6/PLAUR domain containing 1
MAGEH1 melanoma antigen family H1
MAMLD1 mastermind-like domain containing 1
MAT2A methionine adenosyltransferase II, alpha
MCM10 minichromosome maintenance complex component 10
MCM3AP-AS1 MCM3AP antisense RNA 1
METTL2B methyltransferase like 2B
MIR22HG MIR22 host gene
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MOGS mannosyl-oligosaccharide glucosidase
MUM1 melanoma associated antigen (mutated) 1
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NBEAL2 neurobeachin-like 2
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAQR4 progestin and adipoQ receptor family member IV
PGP phosphoglycolate phosphatase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIBF1 progesterone immunomodulatory binding factor 1
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLR1B polymerase (RNA) I polypeptide B, 128kDa
PRMT7 protein arginine methyltransferase 7
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1
RAB23 RAB23, member RAS oncogene family
RANGRF RAN guanine nucleotide release factor
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RARS arginyl-tRNA synthetase
RBL1 retinoblastoma-like 1
RIBC2 RIB43A domain with coiled-coils 2
RNF25 ring finger protein 25
RPIA ribose 5-phosphate isomerase A
SCAMP4 secretory carrier membrane protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SLBP stem-loop binding protein
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC2A4RG SLC2A4 regulator
SNORA21 small nucleolar RNA, H/ACA box 21
SOBP sine oculis binding protein homolog (Drosophila)
SSSCA1 Sjogren syndrome/scleroderma autoantigen 1
STXBP1 syntaxin binding protein 1
THOP1 thimet oligopeptidase 1
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TM7SF3 transmembrane 7 superfamily member 3
TPST2 tyrosylprotein sulfotransferase 2
TUBA3D tubulin, alpha 3d
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
YRDC yrdC N(6)-threonylcarbamoyltransferase domain containing
ZBTB39 zinc finger and BTB domain containing 39
ZMAT3 zinc finger, matrin-type 3
ZNF573 zinc finger protein 573