wortmannin-911 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the wortmannin-911 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
ADCK3 aarF domain containing kinase 3
AKR1C3 aldo-keto reductase family 1, member C3
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2
ANKZF1 ankyrin repeat and zinc finger domain containing 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APC adenomatous polyposis coli
ATRX alpha thalassemia/mental retardation syndrome X-linked
BAG4 BCL2-associated athanogene 4
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BRWD1 bromodomain and WD repeat domain containing 1
BTF3P12 basic transcription factor 3 pseudogene 12
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CALCOCO1 calcium binding and coiled-coil domain 1
CALHM2 calcium homeostasis modulator 2
CCNG2 cyclin G2
CCP110 centriolar coiled coil protein 110kDa
CDC25C cell division cycle 25C
CDK13 cyclin-dependent kinase 13
CHKB choline kinase beta
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLCN5 chloride channel, voltage-sensitive 5
CSNK1G1 casein kinase 1, gamma 1
CUL4B cullin 4B
CXCR4 chemokine (C-X-C motif) receptor 4
DICER1 dicer 1, ribonuclease type III
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
ERCC5 excision repair cross-complementation group 5
ESR1 estrogen receptor 1
FAM189A2 family with sequence similarity 189, member A2
FAM46C family with sequence similarity 46, member C
FAS Fas cell surface death receptor
FCMR Fc fragment of IgM receptor
FNDC3A fibronectin type III domain containing 3A
FOXJ3 forkhead box J3
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GLI3 GLI family zinc finger 3
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPATCH2L G patch domain containing 2-like
HBP1 HMG-box transcription factor 1
HNMT histamine N-methyltransferase
HRASLS2 HRAS-like suppressor 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IFT74 intraflagellar transport 74
INHBA inhibin, beta A
IPO8 importin 8
IRS2 insulin receptor substrate 2
KLHL24 kelch-like family member 24
LAMP1 lysosomal-associated membrane protein 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MB myoglobin
MBNL2 muscleblind-like splicing regulator 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MOCS3 molybdenum cofactor synthesis 3
NBR1 neighbor of BRCA1 gene 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEB nebulin
NEK2 NIMA-related kinase 2
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCM1 pericentriolar material 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDLIM5 PDZ and LIM domain 5
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PNRC1 proline-rich nuclear receptor coactivator 1
PTCH1 patched 1
PTPRA protein tyrosine phosphatase, receptor type, A
R3HCC1L R3H domain and coiled-coil containing 1-like
RABEP1 rabaptin, RAB GTPase binding effector protein 1
RAD51B RAD51 paralog B
REPS1 RALBP1 associated Eps domain containing 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RSRP1 arginine/serine-rich protein 1
S100A8 S100 calcium binding protein A8
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SMAD3 SMAD family member 3
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SNTA1 syntrophin, alpha 1
SOS2 son of sevenless homolog 2 (Drosophila)
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SSPN sarcospan
STON1 stonin 1
TMPRSS2 transmembrane protease, serine 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAK1 trafficking protein, kinesin binding 1
TREX1 three prime repair exonuclease 1
TRIM23 tripartite motif containing 23
TSPAN1 tetraspanin 1
TXNIP thioredoxin interacting protein
UBE3B ubiquitin protein ligase E3B
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4
ZNF16 zinc finger protein 16
ZNF227 zinc finger protein 227
ZNF37BP zinc finger protein 37B, pseudogene

decreased expression

Symbol Name
ABCA11P ATP-binding cassette, sub-family A (ABC1), member 11, pseudogene
ACTL8 actin-like 8
ADGRE5 adhesion G protein-coupled receptor E5
ALKBH1 alkB, alkylation repair homolog 1 (E. coli)
APLP1 amyloid beta (A4) precursor-like protein 1
ARMC6 armadillo repeat containing 6
ATF3 activating transcription factor 3
BAK1 BCL2-antagonist/killer 1
C5AR2 complement component 5a receptor 2
C9ORF114 chromosome 9 open reading frame 114
CCDC86 coiled-coil domain containing 86
CD3EAP CD3e molecule, epsilon associated protein
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDK20 cyclin-dependent kinase 20
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
CLSPN claspin
CORT cortistatin
CTPS1 CTP synthase 1
CUEDC1 CUE domain containing 1
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DHDDS dehydrodolichyl diphosphate synthase
DMTN dematin actin binding protein
DSPP dentin sialophosphoprotein
EAF2 ELL associated factor 2
EFHD2 EF-hand domain family, member D2
FAM155B family with sequence similarity 155, member B
FBRS fibrosin
FBXW12 F-box and WD repeat domain containing 12
FSD1 fibronectin type III and SPRY domain containing 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GRWD1 glutamate-rich WD repeat containing 1
HGH1 HGH1 homolog (S. cerevisiae)
HOXC10 homeobox C10
HOXC8 homeobox C8
IFRD1 interferon-related developmental regulator 1
IFT140 intraflagellar transport 140
IL17RA interleukin 17 receptor A
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
KDM5C lysine (K)-specific demethylase 5C
KIAA0020 KIAA0020
LIN7B lin-7 homolog B (C. elegans)
LINS lines homolog (Drosophila)
LPPR2 lipid phosphate phosphatase-related protein type 2
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRP5 low density lipoprotein receptor-related protein 5
MAP6D1 MAP6 domain containing 1
MAP7D1 MAP7 domain containing 1
MAPKBP1 mitogen-activated protein kinase binding protein 1
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MTSS1L metastasis suppressor 1-like
MYBBP1A MYB binding protein (P160) 1a
NES nestin
NPIPB15 nuclear pore complex interacting protein family, member B15
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PALM paralemmin
PAQR4 progestin and adipoQ receptor family member IV
PCDHB13 protocadherin beta 13
PER3 period circadian clock 3
PGP phosphoglycolate phosphatase
PHACTR4 phosphatase and actin regulator 4
PHLDA2 pleckstrin homology-like domain, family A, member 2
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PMP22 peripheral myelin protein 22
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
PRICKLE3 prickle homolog 3 (Drosophila)
PRSS22 protease, serine, 22
PTDSS2 phosphatidylserine synthase 2
PYCRL pyrroline-5-carboxylate reductase-like
RBL1 retinoblastoma-like 1
RFTN1 raftlin, lipid raft linker 1
RHOBTB2 Rho-related BTB domain containing 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RRP9 ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast)
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SPHK1 sphingosine kinase 1
SPIDR scaffolding protein involved in DNA repair
TARP TCR gamma alternate reading frame protein
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TRAF2 TNF receptor-associated factor 2
UBQLN4 ubiquilin 4
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae)
USB1 U6 snRNA biogenesis 1
USP27X ubiquitin specific peptidase 27, X-linked
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VWA1 von Willebrand factor A domain containing 1
XYLT2 xylosyltransferase II
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZFP30 ZFP30 zinc finger protein
ZNF254 zinc finger protein 254
ZNF268 zinc finger protein 268
ZNF35 zinc finger protein 35
ZNF76 zinc finger protein 76