withdrawal disorder Gene Set

Dataset DISEASES Text-mining Gene-Disease Assocation Evidence Scores
Category disease or phenotype associations
Type disease
Description A substance-related disorder that occurs upon the abrupt discontinuation/separation or a decrease in dosage of the intake of medications, recreational drugs, and alcohol. (Human Disease Ontology, DOID_0060001)
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Genes

123 genes co-occuring with the disease withdrawal disorder in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
OPRM1 opioid receptor, mu 1 1.78624
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 1.51194
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 1.4755
FOS FBJ murine osteosarcoma viral oncogene homolog 1.44342
PDYN prodynorphin 1.32541
CNR1 cannabinoid receptor 1 (brain) 1.30139
CRH corticotropin releasing hormone 1.24993
KLK3 kallikrein-related peptidase 3 1.20353
NPFF neuropeptide FF-amide peptide precursor 1.19143
AR androgen receptor 1.19143
POMC proopiomelanocortin 1.14263
ADCY2 adenylate cyclase 2 (brain) 1.02945
MME membrane metallo-endopeptidase 1.01427
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) 1.01216
CCK cholecystokinin 1.00794
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 0.975482
PENK proenkephalin 0.946186
HCRTR1 hypocretin (orexin) receptor 1 0.944106
PRLHR prolactin releasing hormone receptor 0.931656
NPS neuropeptide S 0.922561
HCRTR2 hypocretin (orexin) receptor 2 0.881882
PNOC prepronociceptin 0.872462
NPY neuropeptide Y 0.829869
HCRT hypocretin (orexin) neuropeptide precursor 0.819616
TH tyrosine hydroxylase 0.818385
TNRC6A trinucleotide repeat containing 6A 0.789262
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled 0.765535
TF transferrin 0.759008
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 0.752492
GRM2 glutamate receptor, metabotropic 2 0.730976
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.724907
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.724098
CCKBR cholecystokinin B receptor 0.72127
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.718039
OXR1 oxidation resistance 1 0.716828
MASTL microtubule associated serine/threonine kinase-like 0.695905
ACPT acid phosphatase, testicular 0.691896
GGT1 gamma-glutamyltransferase 1 0.686691
GRM4 glutamate receptor, metabotropic 4 0.686691
SP6 Sp6 transcription factor 0.672722
OPRL1 opiate receptor-like 1 0.671925
CRCP CGRP receptor component 0.657234
ADORA1 adenosine A1 receptor 0.654463
DRD2 dopamine receptor D2 0.638676
TADA3 transcriptional adaptor 3 0.628065
GRK5 G protein-coupled receptor kinase 5 0.604591
PRLH prolactin releasing hormone 0.592895
BET1 Bet1 golgi vesicular membrane trafficking protein 0.570718
TDO2 tryptophan 2,3-dioxygenase 0.560227
NLE1 notchless homolog 1 (Drosophila) 0.543155
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 0.529994
CALCA calcitonin-related polypeptide alpha 0.516879
EPRS glutamyl-prolyl-tRNA synthetase 0.513033
MAOB monoamine oxidase B 0.505356
FAAH fatty acid amide hydrolase 0.498467
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 0.482844
ARC activity-regulated cytoskeleton-associated protein 0.481705
ABAT 4-aminobutyrate aminotransferase 0.477151
TAC1 tachykinin, precursor 1 0.474498
GGT2 gamma-glutamyltransferase 2 0.468819
CAMK2G calcium/calmodulin-dependent protein kinase II gamma 0.459751
MGAM maltase-glucoamylase 0.459751
KARS lysyl-tRNA synthetase 0.458241
CREB1 cAMP responsive element binding protein 1 0.450701
UCN3 urocortin 3 0.448817
CRHR1 corticotropin releasing hormone receptor 1 0.438658
ANKK1 ankyrin repeat and kinase domain containing 1 0.430393
FBXW2 F-box and WD repeat domain containing 2 0.40904
GRIA1 glutamate receptor, ionotropic, AMPA 1 0.396725
LY96 lymphocyte antigen 96 0.395235
MGLL monoglyceride lipase 0.390025
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.390025
IGLV2-8 immunoglobulin lambda variable 2-8 0.344758
OXT oxytocin/neurophysin I prepropeptide 0.343106
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 0.337975
CSNK2A1 casein kinase 2, alpha 1 polypeptide 0.327375
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 0.326646
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 0.326281
FDX1 ferredoxin 1 0.325916
MAEA macrophage erythroblast attacher 0.322637
AP1M2 adaptor-related protein complex 1, mu 2 subunit 0.322637
TACR1 tachykinin receptor 1 0.317545
FLCN folliculin 0.317545
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 0.307757
DLG4 discs, large homolog 4 (Drosophila) 0.298731
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.292616
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.291539
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.279724
ACOT13 acyl-CoA thioesterase 13 0.279724
FKBP5 FK506 binding protein 5 0.278654
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 0.277227
PTK7 protein tyrosine kinase 7 (inactive) 0.274021
RPIA ribose 5-phosphate isomerase A 0.272953
PCSK7 proprotein convertase subtilisin/kexin type 7 0.269398
MAOA monoamine oxidase A 0.267267
ADRA2A adrenoceptor alpha 2A 0.266558
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 0.264431
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 0.25207
FGD1 FYVE, RhoGEF and PH domain containing 1 0.251366
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.24715
NRL neural retina leucine zipper 0.214297
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.212945
FADS2 fatty acid desaturase 2 0.211261
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1 0.210925
PRL prolactin 0.210589
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.209918
NPR1 natriuretic peptide receptor 1 0.207912
GUCY2C guanylate cyclase 2C 0.207245
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 0.201962
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.199681
FLT1 fms-related tyrosine kinase 1 0.197099
MAN2A1 mannosidase, alpha, class 2A, member 1 0.1936
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae) 0.192971
PPP4C protein phosphatase 4, catalytic subunit 0.189859
TRH thyrotropin-releasing hormone 0.183248
TRAF3 TNF receptor-associated factor 3 0.181798
OXTR oxytocin receptor 0.177576
COMT catechol-O-methyltransferase 0.174093
CYP2D7 cytochrome P450, family 2, subfamily D, polypeptide 7 (gene/pseudogene) 0.169812
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 0.163729
ACTN4 actinin, alpha 4 0.163523
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 0.160021
NOS2 nitric oxide synthase 2, inducible 0.160021