withaferin A-4554 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the withaferin A-4554 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACVR1B activin A receptor, type IB
ADM adrenomedullin
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ARG2 arginase 2
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
BBC3 BCL2 binding component 3
CCL19 chemokine (C-C motif) ligand 19
CCNO cyclin O
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CREM cAMP responsive element modulator
CRYAB crystallin, alpha B
CSF1R colony stimulating factor 1 receptor
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
CSRP2 cysteine and glycine-rich protein 2
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DUSP1 dual specificity phosphatase 1
ERO1LB ERO1-like beta (S. cerevisiae)
FGF5 fibroblast growth factor 5
FKBP4 FK506 binding protein 4, 59kDa
FLJ42627 uncharacterized LOC645644
GABARAPL1 GABA(A) receptor-associated protein like 1
GARNL3 GTPase activating Rap/RanGAP domain-like 3
GCLM glutamate-cysteine ligase, modifier subunit
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GLS glutaminase
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPC3 glypican 3
GPR22 G protein-coupled receptor 22
GSK3A glycogen synthase kinase 3 alpha
HBEGF heparin-binding EGF-like growth factor
HIST1H2AI histone cluster 1, H2ai
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA1L heat shock 70kDa protein 1-like
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
IL11 interleukin 11
IL1RL1 interleukin 1 receptor-like 1
IQCK IQ motif containing K
KHDRBS2 KH domain containing, RNA binding, signal transduction associated 2
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KLF2 Kruppel-like factor 2
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MIR22HG MIR22 host gene
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NCF2 neutrophil cytosolic factor 2
NKX3-1 NK3 homeobox 1
NRP2 neuropilin 2
OSGIN1 oxidative stress induced growth inhibitor 1
OXTR oxytocin receptor
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PADI1 peptidyl arginine deiminase, type I
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PDGFA platelet-derived growth factor alpha polypeptide
PECAM1 platelet/endothelial cell adhesion molecule 1
PLAC4 placenta-specific 4
PXDC1 PX domain containing 1
RASAL2 RAS protein activator like 2
RBMS2 RNA binding motif, single stranded interacting protein 2
RHOB ras homolog family member B
RPS3A ribosomal protein S3A
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAND2P SCAN domain containing 2 pseudogene
SGK2 serum/glucocorticoid regulated kinase 2
SH2B1 SH2B adaptor protein 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX15 SRY (sex determining region Y)-box 15
SPHK1 sphingosine kinase 1
SQSTM1 sequestosome 1
STK24 serine/threonine kinase 24
STYK1 serine/threonine/tyrosine kinase 1
TMBIM1 transmembrane BAX inhibitor motif containing 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TOP3B topoisomerase (DNA) III beta
TRIM15 tripartite motif containing 15
TRIM16 tripartite motif containing 16
TTLL7 tubulin tyrosine ligase-like family member 7
TYRO3 TYRO3 protein tyrosine kinase
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VPS16 vacuolar protein sorting 16 homolog (S. cerevisiae)
ZFP36 ZFP36 ring finger protein
ZNF76 zinc finger protein 76
ZNF804A zinc finger protein 804A
ZXDB zinc finger, X-linked, duplicated B

decreased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ALPK1 alpha-kinase 1
ANKRD40 ankyrin repeat domain 40
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARL14 ADP-ribosylation factor-like 14
BCL2A1 BCL2-related protein A1
C16ORF59 chromosome 16 open reading frame 59
C17ORF70 chromosome 17 open reading frame 70
C22ORF29 chromosome 22 open reading frame 29
C9ORF40 chromosome 9 open reading frame 40
CCNA1 cyclin A1
CFAP44 cilia and flagella associated protein 44
CLDN14 claudin 14
CLUHP3 clustered mitochondria (cluA/CLU1) homolog pseudogene 3
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CNKSR1 connector enhancer of kinase suppressor of Ras 1
COQ6 coenzyme Q6 monooxygenase
CUL9 cullin 9
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL6 chemokine (C-X-C motif) ligand 6
DNA2 DNA replication helicase/nuclease 2
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22
DPY19L2P2 DPY19L2 pseudogene 2
E2F8 E2F transcription factor 8
ELAVL2 ELAV like neuron-specific RNA binding protein 2
EPN3 epsin 3
FAM105A family with sequence similarity 105, member A
FAM186A family with sequence similarity 186, member A
FJX1 four jointed box 1 (Drosophila)
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
FZD4 frizzled class receptor 4
GLI3 GLI family zinc finger 3
GLTSCR1 glioma tumor suppressor candidate region gene 1
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GRHL2 grainyhead-like 2 (Drosophila)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUSBP3 glucuronidase, beta pseudogene 3
H1F0 H1 histone family, member 0
HAS2 hyaluronan synthase 2
HDAC7 histone deacetylase 7
HELLS helicase, lymphoid-specific
HOXB5 homeobox B5
HYMAI hydatidiform mole associated and imprinted (non-protein coding)
IL1B interleukin 1, beta
KRT75 keratin 75, type II
LAMA3 laminin, alpha 3
LIMCH1 LIM and calponin homology domains 1
LOC100272216 uncharacterized LOC100272216
LPPR4 lipid phosphate phosphatase-related protein type 4
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAGEF1 melanoma antigen family F1
MAGEH1 melanoma antigen family H1
MARC1 mitochondrial amidoxime reducing component 1
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MICALL2 MICAL-like 2
NDE1 nudE neurodevelopment protein 1
NDP Norrie disease (pseudoglioma)
NOL12 nucleolar protein 12
NPY1R neuropeptide Y receptor Y1
NT5DC3 5'-nucleotidase domain containing 3
NUAK1 NUAK family, SNF1-like kinase, 1
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PARP3 poly (ADP-ribose) polymerase family, member 3
PELI1 pellino E3 ubiquitin protein ligase 1
PER1 period circadian clock 1
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PPAP2B phosphatidic acid phosphatase type 2B
PPARG peroxisome proliferator-activated receptor gamma
PRKCH protein kinase C, eta
PRMT7 protein arginine methyltransferase 7
PRR15L proline rich 15-like
PRR3 proline rich 3
PTGFR prostaglandin F receptor (FP)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
RAB20 RAB20, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIBC2 RIB43A domain with coiled-coils 2
RIPPLY3 ripply transcriptional repressor 3
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPGR retinitis pigmentosa GTPase regulator
RUNDC3B RUN domain containing 3B
SDAD1 SDA1 domain containing 1
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SH3TC2 SH3 domain and tetratricopeptide repeats 2
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SOX9 SRY (sex determining region Y)-box 9
STAG3 stromal antigen 3
STON1 stonin 1
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TBXAS1 thromboxane A synthase 1 (platelet)
TENM4 teneurin transmembrane protein 4
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TOE1 target of EGR1, member 1 (nuclear)
TOR4A torsin family 4, member A
TRIM9 tripartite motif containing 9
TXNIP thioredoxin interacting protein
ZNF37BP zinc finger protein 37B, pseudogene