withaferin A-3902 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the withaferin A-3902 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABHD3 abhydrolase domain containing 3
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AMPD3 adenosine monophosphate deaminase 3
APOL3 apolipoprotein L, 3
ATF3 activating transcription factor 3
BAIAP2 BAI1-associated protein 2
BDKRB2 bradykinin receptor B2
BIN1 bridging integrator 1
C14ORF79 chromosome 14 open reading frame 79
CEND1 cell cycle exit and neuronal differentiation 1
CEP41 centrosomal protein 41kDa
CFP complement factor properdin
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CPEB1 cytoplasmic polyadenylation element binding protein 1
CREM cAMP responsive element modulator
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DAPK2 death-associated protein kinase 2
DDIT3 DNA-damage-inducible transcript 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNASE1L3 deoxyribonuclease I-like 3
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EHD2 EH-domain containing 2
EPHA2 EPH receptor A2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
ETV5 ets variant 5
EXOC6B exocyst complex component 6B
FAM63B family with sequence similarity 63, member B
FOSL1 FOS-like antigen 1
FUT2 fucosyltransferase 2 (secretor status included)
FXYD5 FXYD domain containing ion transport regulator 5
GABARAPL1 GABA(A) receptor-associated protein like 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GCLM glutamate-cysteine ligase, modifier subunit
GEM GTP binding protein overexpressed in skeletal muscle
GRB10 growth factor receptor-bound protein 10
HBEGF heparin-binding EGF-like growth factor
HIST1H4A histone cluster 1, H4a
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IL6R interleukin 6 receptor
ING1 inhibitor of growth family, member 1
INHBE inhibin, beta E
KIAA0232 KIAA0232
KLF2 Kruppel-like factor 2
KRT16 keratin 16, type I
LEPR leptin receptor
LRP12 low density lipoprotein receptor-related protein 12
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP1B microtubule-associated protein 1B
MIR22HG MIR22 host gene
MR1 major histocompatibility complex, class I-related
MST1R macrophage stimulating 1 receptor
MXD1 MAX dimerization protein 1
NDRG1 N-myc downstream regulated 1
NECAB2 N-terminal EF-hand calcium binding protein 2
NEUROD4 neuronal differentiation 4
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTF3 neurotrophin 3
OBSL1 obscurin-like 1
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
OSGIN1 oxidative stress induced growth inhibitor 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PDE3A phosphodiesterase 3A, cGMP-inhibited
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLTP phospholipid transfer protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPARD peroxisome proliferator-activated receptor delta
PPP2R5B protein phosphatase 2, regulatory subunit B', beta
RIOK3 RIO kinase 3
RNF32 ring finger protein 32
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SERHL2 serine hydrolase-like 2
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC6A9 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
TES testin LIM domain protein
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TREX1 three prime repair exonuclease 1
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
UBR4 ubiquitin protein ligase E3 component n-recognin 4
ULBP1 UL16 binding protein 1
ULBP2 UL16 binding protein 2
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACBD4 acyl-CoA binding domain containing 4
ADTRP androgen-dependent TFPI-regulating protein
AIM1 absent in melanoma 1
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APLP1 amyloid beta (A4) precursor-like protein 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BLNK B-cell linker
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3
C5AR2 complement component 5a receptor 2
CALML5 calmodulin-like 5
CD82 CD82 molecule
CD83 CD83 molecule
CDC7 cell division cycle 7
CDK3 cyclin-dependent kinase 3
CORO7 coronin 7
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP2B7P cytochrome P450, family 2, subfamily B, polypeptide 7, pseudogene
DBF4B DBF4 zinc finger B
DGAT1 diacylglycerol O-acyltransferase 1
DLEU1 deleted in lymphocytic leukemia 1 (non-protein coding)
DSCAM Down syndrome cell adhesion molecule
EPHA4 EPH receptor A4
EXTL2 exostosin-like glycosyltransferase 2
FAM120C family with sequence similarity 120C
FAM46C family with sequence similarity 46, member C
FOXI1 forkhead box I1
GBP2 guanylate binding protein 2, interferon-inducible
GDAP1 ganglioside induced differentiation associated protein 1
GHR growth hormone receptor
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPR19 G protein-coupled receptor 19
H2AFJ H2A histone family, member J
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HOXC6 homeobox C6
ITM2C integral membrane protein 2C
ITPKB inositol-trisphosphate 3-kinase B
KCNK5 potassium channel, two pore domain subfamily K, member 5
KIAA0125 KIAA0125
KRT15 keratin 15, type I
LINC00115 long intergenic non-protein coding RNA 115
LMO2 LIM domain only 2 (rhombotin-like 1)
LY6G5C lymphocyte antigen 6 complex, locus G5C
LYPD1 LY6/PLAUR domain containing 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MEFV Mediterranean fever
MEIS2 Meis homeobox 2
MKS1 Meckel syndrome, type 1
MMP17 matrix metallopeptidase 17 (membrane-inserted)
MPPED2 metallophosphoesterase domain containing 2
MUC3A mucin 3A, cell surface associated
N4BP3 NEDD4 binding protein 3
NOD1 nucleotide-binding oligomerization domain containing 1
NPY1R neuropeptide Y receptor Y1
ONECUT2 one cut homeobox 2
PCDHB3 protocadherin beta 3
PHC1 polyhomeotic homolog 1 (Drosophila)
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha
PLCD1 phospholipase C, delta 1
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6
PPT2 palmitoyl-protein thioesterase 2
PROCR protein C receptor, endothelial
PROS1 protein S (alpha)
PRR15L proline rich 15-like
PRR3 proline rich 3
RAI14 retinoic acid induced 14
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RFXAP regulatory factor X-associated protein
RNF122 ring finger protein 122
RWDD3 RWD domain containing 3
SCARA3 scavenger receptor class A, member 3
SCD5 stearoyl-CoA desaturase 5
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SPIDR scaffolding protein involved in DNA repair
STON1 stonin 1
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TEX40 testis expressed 40
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TMC5 transmembrane channel-like 5
TXNIP thioredoxin interacting protein
UNC93B1 unc-93 homolog B1 (C. elegans)
VAV3 vav 3 guanine nucleotide exchange factor
XK X-linked Kx blood group
ZIC3 Zic family member 3
ZNF804A zinc finger protein 804A
ZSCAN2 zinc finger and SCAN domain containing 2