vorinostat-4444 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the vorinostat-4444 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ADRB2 adrenoceptor beta 2, surface
AGTR1 angiotensin II receptor, type 1
ANGPTL4 angiopoietin-like 4
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASMTL acetylserotonin O-methyltransferase-like
ATP7A ATPase, Cu++ transporting, alpha polypeptide
AVPI1 arginine vasopressin-induced 1
BAIAP2 BAI1-associated protein 2
BAMBI BMP and activin membrane-bound inhibitor
CA5B carbonic anhydrase VB, mitochondrial
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFAP69 cilia and flagella associated protein 69
CORO1A coronin, actin binding protein, 1A
CPM carboxypeptidase M
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CTH cystathionine gamma-lyase
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DENND3 DENN/MADD domain containing 3
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
EFNB2 ephrin-B2
EGR2 early growth response 2
EIF5A2 eukaryotic translation initiation factor 5A2
ELOVL4 ELOVL fatty acid elongase 4
ENOX1 ecto-NOX disulfide-thiol exchanger 1
EPHB3 EPH receptor B3
FABP4 fatty acid binding protein 4, adipocyte
FOS FBJ murine osteosarcoma viral oncogene homolog
GADD45B growth arrest and DNA-damage-inducible, beta
GMPR guanosine monophosphate reductase
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTF2B general transcription factor IIB
HOXA1 homeobox A1
IL11 interleukin 11
IL1RAP interleukin 1 receptor accessory protein
INSIG1 insulin induced gene 1
IRF6 interferon regulatory factor 6
ITGA7 integrin, alpha 7
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIF5C kinesin family member 5C
LIFR leukemia inhibitory factor receptor alpha
LINC00312 long intergenic non-protein coding RNA 312
LINC00341 long intergenic non-protein coding RNA 341
LMCD1 LIM and cysteine-rich domains 1
LPPR4 lipid phosphate phosphatase-related protein type 4
LTB4R leukotriene B4 receptor
MAK male germ cell-associated kinase
MAP2 microtubule-associated protein 2
MAP3K13 mitogen-activated protein kinase kinase kinase 13
MERTK MER proto-oncogene, tyrosine kinase
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MMP1 matrix metallopeptidase 1
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NEU1 sialidase 1 (lysosomal sialidase)
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
OASL 2'-5'-oligoadenylate synthetase-like
PDE4DIP phosphodiesterase 4D interacting protein
PELI2 pellino E3 ubiquitin protein ligase family member 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAI2 retinoic acid induced 2
RGCC regulator of cell cycle
RGL1 ral guanine nucleotide dissociation stimulator-like 1
RGS4 regulator of G-protein signaling 4
RND1 Rho family GTPase 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3GL3 SH3-domain GRB2-like 3
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STAT4 signal transducer and activator of transcription 4
STC1 stanniocalcin 1
STK17B serine/threonine kinase 17b
STOM stomatin
SYT1 synaptotagmin I
TAOK3 TAO kinase 3
TMEM47 transmembrane protein 47
TOM1L2 target of myb1-like 2 (chicken)
TUBB2B tubulin, beta 2B class IIb
TUFT1 tuftelin 1
VWA5A von Willebrand factor A domain containing 5A
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARSJ arylsulfatase family, member J
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
BCAR3 breast cancer anti-estrogen resistance 3
C19ORF40 chromosome 19 open reading frame 40
C19ORF54 chromosome 19 open reading frame 54
C1ORF56 chromosome 1 open reading frame 56
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CASD1 CAS1 domain containing 1
CBR3 carbonyl reductase 3
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CLCF1 cardiotrophin-like cytokine factor 1
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CPEB1 cytoplasmic polyadenylation element binding protein 1
CTCF CCCTC-binding factor (zinc finger protein)
CUL1 cullin 1
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DBF4B DBF4 zinc finger B
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DEAF1 DEAF1 transcription factor
DEPDC1 DEP domain containing 1
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35
EXOSC10 exosome component 10
FAIM Fas apoptotic inhibitory molecule
FAM53B family with sequence similarity 53, member B
FJX1 four jointed box 1 (Drosophila)
FOSL1 FOS-like antigen 1
FOXA1 forkhead box A1
FST follistatin
GMEB1 glucocorticoid modulatory element binding protein 1
GTF2I general transcription factor IIi
GTF2IRD1 GTF2I repeat domain containing 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
H2AFY2 H2A histone family, member Y2
HAS2 hyaluronan synthase 2
HMGA2 high mobility group AT-hook 2
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IL17RB interleukin 17 receptor B
IL4R interleukin 4 receptor
IL7R interleukin 7 receptor
INHBB inhibin, beta B
ITPKB inositol-trisphosphate 3-kinase B
KAT6B K(lysine) acetyltransferase 6B
KEAP1 kelch-like ECH-associated protein 1
KLHL3 kelch-like family member 3
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LIF leukemia inhibitory factor
LMNB1 lamin B1
LPAR1 lysophosphatidic acid receptor 1
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LRP3 low density lipoprotein receptor-related protein 3
LRRC41 leucine rich repeat containing 41
MCM9 minichromosome maintenance complex component 9
MED24 mediator complex subunit 24
MEPCE methylphosphate capping enzyme
MTA2 metastasis associated 1 family, member 2
NDP Norrie disease (pseudoglioma)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NME6 NME/NM23 nucleoside diphosphate kinase 6
NMI N-myc (and STAT) interactor
NNMT nicotinamide N-methyltransferase
NOD1 nucleotide-binding oligomerization domain containing 1
NRIP1 nuclear receptor interacting protein 1
PALMD palmdelphin
PARP12 poly (ADP-ribose) polymerase family, member 12
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PLK1 polo-like kinase 1
PPAN peter pan homolog (Drosophila)
PPAP2B phosphatidic acid phosphatase type 2B
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
RBM23 RNA binding motif protein 23
RIN2 Ras and Rab interactor 2
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SIM2 single-minded family bHLH transcription factor 2
SMG9 SMG9 nonsense mediated mRNA decay factor
SNRNP35 small nuclear ribonucleoprotein 35kDa (U11/U12)
SPHK1 sphingosine kinase 1
SRSF4 serine/arginine-rich splicing factor 4
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TARBP2 TAR (HIV-1) RNA binding protein 2
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TRIB3 tribbles pseudokinase 3
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TUBGCP3 tubulin, gamma complex associated protein 3
UNKL unkempt family zinc finger-like
VEGFC vascular endothelial growth factor C
ZBED1 zinc finger, BED-type containing 1
ZC3H4 zinc finger CCCH-type containing 4
ZFP69B ZFP69 zinc finger protein B
ZMYM3 zinc finger, MYM-type 3
ZNF165 zinc finger protein 165
ZNF239 zinc finger protein 239
ZNF248 zinc finger protein 248
ZNF33B zinc finger protein 33B
ZNF787 zinc finger protein 787
ZNF804A zinc finger protein 804A